Citations for
1CDKN1A, FUBP1, FUSE, MYC
Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1
Ni X, Knapp S, Chaikuad A.
Sci Rep Aug 10;10(1):13459. doi: 10.1038/s41598-020-69832-z. 2020
2CCN3, CDKN1A
CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage
Kuwahara M, Kadoya K, Kondo S, Fu S, Miyake Y, Ogo A, Ono M, Furumatsu T, Nakata E, Sasaki T, Minagi S, Takigawa M, Kubota S, Hattori T.
Int J Mol Sci. Oct 13;21(20):7556. doi: 10.3390/ijms21207556. 2020
3CCND1, CDKN1A, NFIC
NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development. 2020 PMID:
Lee DS, Roh SY, Choi H, Park JC.
Mol Cells. Aug 31;43(8):739-748. doi: 10.14348/molcells.2020.2272. 2020
4CDKN1A, MELK
Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice.
Seong HA, Ha H.
Cell Death Dis 10(6):380. doi: 10.1038/s41419-019-1616-z. 2019
5CDKN1A, SMG1, SMG7, TRIM71, UPF1
The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21
Torres-Fernández LA, Jux B, Bille M, Port Y, Schneider K, Geyer M, Mayer G, Kolanus W.
Nucleic Acids Res. Dec 16;47(22):11861-11879. doi: 10.1093/nar/gkz1057. 2019
6CDKN1A, TBX3
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor.
Willmer T, Hare S, Peres J, Prince S.
Cell Div 11:6. doi: 10.1186/s13008-016-0019-0. eCollection 2016. 2016
7CDKN1A, TGM2, TP53
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
Yeo SY, Itahana Y, Guo AK, Han R, Iwamoto K, Nguyen HT, Bao Y, Kleiber K, Wu YJ, Bay BH, Voorhoeve M, Itahana K.
Elife 5:e07101. doi: 10.7554/eLife.07101. 2016
8CDKN1A, OLA1
OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression
Ding Z, Liu Y, Rubio V, He J, Minze LJ, Shi ZZ.
Mol Cell Biol. Sep 26;36(20):2568-82. doi: 10.1128/MCB.00137-16. 2016
9CDKN1A, TWIST2
Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia.
Zhang X, Ma W, Cui J, Yao H, Zhou H, Ge Y, Xiao L, Hu X, Liu BH, Yang J, Li YY, Chen S, Eaves CJ, Wu D, Zhao Y.
Oncogene 34(23):3000-10. doi: 10.1038/onc.2014.241. Epub 2014 Aug 4. 2015
10BMI1, CCNE1, CDKN1A
p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells.
Deng W, Zhou Y, Tiwari AF, Su H, Yang J, Zhu D, Lau VM, Hau PM, Yip YL, Cheung AL, Guan XY, Tsao SW.
Int J Cancer 136(6):1361-70. doi: 10.1002/ijc.29114. Epub 2014 Aug 7. 2015
11ANKHD1, CDKN1A
ANKHD1 represses p21 (WAF1/CIP1) promoter and promotes multiple myeloma cell growth.
Dhyani A, Machado-Neto JA, Favaro P, Saad ST.
Eur J Cancer 51(2):252-9. doi: 10.1016/j.ejca.2014.11.012. Epub 2014 Dec 4. 2015
12CDKN1A, MORC2
By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.
Zhang Q, Song Y, Chen W, Wang X, Miao Z, Cao L, Li F, Wang G.
Oncotarget 6(18):16461-70. 2015
13CDKN1A, FOXA1, NR5A2
LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression.
Bianco S, Jangal M, Garneau D, Gévry N.
Oncogene 34(34):4509-18. doi: 10.1038/onc.2014.382. Epub 2014 Dec 1. 2015
14CDKN1A, RASSF6
RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma.
Liang YY, Zheng LS, Wu YZ, Peng LX, Cao Y, Cao X, Xie P, Huang BJ, Qian CN.
Cell Cycle 13(9):1440-9. doi: 10.4161/cc.28416. Epub 2014 Mar 10. 2014
15CDKN1A, DUX4
Dux4 induces cell cycle arrest at G1 phase through upregulation of p21 expression.
Xu H, Wang Z, Jin S, Hao H, Zheng L, Zhou B, Zhang W, Lv H, Yuan Y.
Biochem Biophys Res Commun 446(1):235-40. doi: 10.1016/j.bbrc.2014.02.105. Epub 2014 Feb 28. Erratum in: Biochem Biophys Res Commun. 2014 Jul 18;450(1):927 2014
16CDKN1A, NFYA, PLK1
Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage.
Lin YC, Chen YN, Lin KF, Wang FF, Chou TY, Chen MY.
Cell Death Dis 5:e987. doi: 10.1038/cddis.2013.527. 2014
17CDKN1A, RBM24, TP53
Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
Jiang Y, Zhang M, Qian Y, Xu E, Zhang J, Chen X.
J Biol Chem 289(6):3164-75. doi: 10.1074/jbc.M113.524413. Epub 2013 Dec 19. 2014
18CDKN1A, TOP3A, TP53
DNA topoisomerase III alpha regulates p53-mediated tumor suppression.
Hsieh MY, Fan JR, Chang HW, Chen HC, Shen TL, Teng SC, Yeh YH, Li TK.
Clin Cancer Res 20(6):1489-501. doi: 10.1158/1078-0432.CCR-13-1997. Epub 2014 Feb 13. 2014
19CDKN1A, TAF1
Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
Wu Y, Lin JC, Piluso LG, Dhahbi JM, Bobadilla S, Spindler SR, Liu X.
Mol Cell 53(1):63-74. doi: 10.1016/j.molcel.2013.10.031. Epub 2013 Nov 27. 2014
20CDKN1A, KDM8
JMJD5 regulates cell cycle and pluripotency in human embryonic stem cells.
Zhu H, Hu S, Baker J.
Stem Cells 32(8):2098-110. doi: 10.1002/stem.1724. 2014
21CDKN1A, FMN2
FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21.
Yamada K, Ono M, Bensaddek D, Lamond AI, Rocha S.
Cell Cycle 12(15):2348-54. doi: 10.4161/cc.25511. Epub 2013 Jul 1. 2013
22CDKN1A, FMN2
Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21.
Yamada K, Ono M, Perkins ND, Rocha S, Lamond AI.
Mol Cell 49(5):922-33. doi: 10.1016/j.molcel.2012.12.023. Epub 2013 Jan 31. 2013
23CDKN1A, RNF144B, TP63
PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63.
Conforti F, Yang AL, Piro MC, Mellone M, Terrinoni A, Candi E, Tucci P, Thomas GJ, Knight RA, Melino G, Sayan BS.
Oncogene 32(40):4758-65. doi: 10.1038/onc.2012.497. Epub 2012 Nov 5. 2013
24CDKN1A, HIC1
Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).
Dehennaut V, Loison I, Boulay G, Van Rechem C, Leprince D.
Biochem Biophys Res Commun 430(1):49-53. doi: 10.1016/j.bbrc.2012.11.045. Epub 2012 Nov 22. 2013
25CDKN1A, HSPA9
A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase.
Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI.
Mol Cell Biol 33(20):4051-67. doi: 10.1128/MCB.00021-13. Epub 2013 Aug 19. 2013
26CDKN1A, TSG101
Identification of TSG101 functional domains and p21 loci required for TSG101-mediated p21 gene regulation.
Lin YS, Chen YJ, Cohen SN, Cheng TH.
PLoS One 8(11):e79674. doi: 10.1371/journal.pone.0079674. eCollection 2013. 2013
27BMP2, CDKN1A
Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenance.
Porlan E, Morante-Redolat JM, Marqués-Torrejón MÁ, Andreu-Agulló C, Carneiro C, Gómez-Ibarlucea E, Soto A, Vidal A, Ferrón SR, Fariñas I.
Nat Neurosci 16(11):1567-75. doi: 10.1038/nn.3545. Epub 2013 Oct 6. 2013
28CDKN1A, CDKN32A, HNRNPD
p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.
Al-Khalaf HH, Aboussekhra A.
PLoS One 8(7):e70133. doi: 10.1371/journal.pone.0070133. Print 2013. 2013
29CDKN1A, MAPK14
A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibition.
Kumari G, Ulrich T, Gaubatz S.
Cell Cycle 12(13):2051-60. doi: 10.4161/cc.25100. Epub 2013 Jun 6. 2013
30CDKN1A, RNF114
ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
Han J, Kim YL, Lee KW, Her NG, Ha TK, Yoon S, Jeong SI, Lee JH, Kang MJ, Lee MG, Ryu BK, Baik JH, Chi SG.
Cell Death Differ 20(8):1055-67. doi: 10.1038/cdd.2013.33. Epub 2013 May 3. 2013
31AURKB, CDKN1A
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).
Trakala M, Fernández-Miranda G, Pérez de Castro I, Heeschen C, Malumbres M.
Cell Cycle 12(7):1030-41. doi: 10.4161/cc.24004. Epub 2013 Feb 21. 2013
32CDKN1A, KAT5
Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response.
Lee MS, Seo J, Choi DY, Lee EW, Ko A, Ha NC, Yoon JB, Lee HW, Kim KP, Song J.
Cell Death Differ 20(4):620-9. doi: 10.1038/cdd.2012.159. Epub 2012 Dec 14. 2013
33AKT2, CDKN1A
Characterization of the Akt2 domain essential for binding nuclear p21cip1 to promote cell cycle arrest during myogenic differentiation.
Heron-Milhavet L, Franckhauser C, Fernandez A, Lamb NJ.
PLoS One 8(10):e76987. doi: 10.1371/journal.pone.0076987. eCollection 2013. 2013
34CDKN1A, TGFBR1, UCHL5
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells.
Ko YM, Chang CY, Chiou SJ, Hsu FJ, Huang JS, Yang YL, Guh JY, Chuang LY.
Arch Biochem Biophys 535(2):177-86. doi: 10.1016/j.abb.2013.03.003. Epub 2013 Mar 13. 2013
35ARID3A, CDKN1A, TP53
Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage.
Lestari W, Ichwan SJ, Otsu M, Yamada S, Iseki S, Shimizu S, Ikeda MA.
Biochem Biophys Res Commun 417(2):710-6. doi: 10.1016/j.bbrc.2011.12.003. Epub 2011 Dec 8. 2012
36CDKN1A, PLAGL1
A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions.
Liu ST, Chang YL, Wang WM, Chung MH, Lin WS, Chou WY, Huang SM.
Int J Biochem Cell Biol 44(3):547-55. doi: 10.1016/j.biocel.2011.12.012. Epub 2011 Dec 27. 2012
37CDKN1A, TRIM39
TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.
Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H.
Proc Natl Acad Sci U S A 109(51):20937-42. doi: 10.1073/pnas.1214156110. Epub 2012 Dec 4. Erratum in: Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4148. 2012
38CDKN1A
p21 as a transcriptional co-repressor of S-phase and mitotic control genes.
Ferrándiz N, Caraballo JM, García-Gutierrez L, Devgan V, Rodriguez-Paredes M, Lafita MC, Bretones G, Quintanilla A, Muñoz-Alonso MJ, Blanco R, Reyes JC, Agell N, Delgado MD, Dotto GP, León J.
PLoS One 7(5):e37759. doi: 10.1371/journal.pone.0037759. Epub 2012 May 25. 2012
39CDKN1A, HIF1A
Cell free expression of hif1α and p21 in maternal peripheral blood as a marker for preeclampsia and fetal growth restriction.
Ashur-Fabian O, Yerushalmi GM, Mazaki-Tovi S, Steinberg DM, Goldshtein I, Yackobovitch-Gavan M, Schiff E, Amariglio N, Rechavi G.
PLoS One 7(5):e37273. doi: 10.1371/journal.pone.0037273. Epub 2012 May 16. 2012
40CDKN1A, KDM8
Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression.
Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T, Suzuki T.
Development 139(4):749-59. doi: 10.1242/dev.074138. Epub 2012 Jan 12. 2012
41ATG7, CDKN1A, TP53
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
Lee IH, Kawai Y, Fergusson MM, Rovira II, Bishop AJ, Motoyama N, Cao L, Finkel T.
Science 336(6078):225-8. doi: 10.1126/science.1218395. Erratum in: Science. 2013 Aug 2;341(6145):457. Science. 2012 Aug 24;337(6097):911 2012
42CDKN1A, POLD3, SHROMM2
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
Dunlop MG, Dobbins SE, Farrington SM, Jones AM, Palles C, Whiffin N, Tenesa A, Spain S, Broderick P, Ooi LY, Domingo E, Smillie C, Henrion M, Frampton M, Martin L, Grimes G, Gorman M, Semple C, Ma YP, Barclay E, Prendergast J, Cazier JB, Olver B, Penegar S, Lubbe S, Chander I, Carvajal-Carmona LG, Ballereau S, Lloyd A, Vijayakrishnan J, Zgaga L, Rudan I, Theodoratou E; Colorectal Tumour Gene Identification (CORGI) Consortium, Starr JM, Deary I, Kirac I, Kovacević D, Aaltonen LA, Renkonen-Sinisalo L, Mecklin JP, Matsuda K, Nakamura Y, Okada Y, Gallinger S, Duggan DJ, Conti D, Newcomb P, Hopper J, Jenkins MA, Schumacher F, Casey G, Easton D, Shah M, Pharoah P, Lindblom A, Liu T; Swedish Low-Risk Colorectal Cancer Study Group, Smith CG, West H, Cheadle JP; COIN Collaborative Group, Midgley R, Kerr DJ, Campbell H, Tomlinson IP, Houlston RS.
Nat Genet 44(7):770-6. doi: 10.1038/ng.2293. 2012
43CDKN1A, NEUROG3
Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.
Miyatsuka T, Kosaka Y, Kim H, German MS.
Proc Natl Acad Sci U S A 108(1):185-90. Epub 2010 Dec 20. 2011
44CDKN1A, SSBP1
hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas.
Xu S, Feng Z, Zhang M, Wu Y, Sang Y, Xu H, Lv X, Hu K, Cao J, Zhang R, Chen L, Liu M, Yun JP, Zeng YX, Kang T.
Oncogene 30(19):2219-29. Epub 2011 Jan 17. 2011
45CDKN1A, SRSF2
SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines.
Edmond V, Brambilla C, Brambilla E, Gazzeri S, Eymin B.
Cell Cycle 10(12):1968-77. Epub 2011 Jun 15. 2011
46CDKN1A, DHX8, PRPF19, SNW1
SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing.
Chen Y, Zhang L, Jones KA.
Genes Dev 25(7):701-16. doi: 10.1101/gad.2002611. 2011
47CDKN1A, POU5F1
Oct-4 controls cell-cycle progression of embryonic stem cells.
Lee J, Go Y, Kang I, Han YM, Kim J.
Biochem J 426(2):171-81. 2010
48CDKN1A, HDAC1
The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.
Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C.
Mol Cell Biol 30(5):1171-81. Epub 2009 Dec 22.PMID: 20028735 2010
49CDKN1A, ELAVL1, RBM38
RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability.
Cho SJ, Zhang J, Chen X.
Nucleic Acids Res 38(7):2256-67. Epub 2010 Jan 11.PMID: 20064878 2010
50CDKN1A
Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines.
Watanabe M, Nakahata S, Hamasaki M, Saito Y, Kawano Y, Hidaka T, Yamashita K, Umeki K, Taki T, Taniwaki M, Okayama A, Morishita K.
J Virol 84(14):6966-77. Epub 2010 May 5.PMID: 20444901 2010
51CDKN1A, KLF1
EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation.
Siatecka M, Lohmann F, Bao S, Bieker JJ.
Mol Cell Biol 30(11):2811-22. Epub 2010 Apr 5.PMID: 20368355 2010
52CDKN1A, TFAP2A
Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter.
Scibetta AG, Wong PP, Chan KV, Canosa M, Hurst HC.
Cell Cycle 9(22):4525-32. 2010
53CDKN1A, PIM2
Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.
Wang Z, Zhang Y, Gu JJ, Davitt C, Reeves R, Magnuson NS.
Int J Biochem Cell Biol 42(6):1030-8. doi: 10.1016/j.biocel.2010.03.012. Epub 2010 Mar 20. 2010
54CDKN1A, HDAC4
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.
Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, Bellahcène A, Verdin E, Castronovo V.
Oncogene 28(2):243-56. Epub 2008 Oct 13. 2009
55CDKN1A, DNMT1, EP300
p21(WAF1) negatively regulates DNMT1 expression in mammalian cells.
Tan HH, Porter AG.
Biochem Biophys Res Commun 382(1):171-6. Epub 2009 Mar 9. 2009
56CDKN1A, SP1, TP53, ZBTB2
ZBTB2, a Novel Master Regulator of the p53 Pathway.
Jeon BN, Choi WI, Yu MY, Yoon AR, Kim MH, Yun CO, Hur MW.
J Biol Chem 284(27):17935-46. Epub 2009 Apr 20. 2009
57CDKN1A, FBXO5
DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.
Lee J, Kim JA, Barbier V, Fotedar A, Fotedar R.
Mol Biol Cell 20(7):1891-902. Epub 2009 Feb 11. 2009
58CDKN1A, ZBTB5
A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene.
Koh DI, Choi WI, Jeon BN, Lee CE, Yun CO, Hur MW.
J Biol Chem 284(30):19856-66. Epub 2009 Jun 2. 2009
59BCCIP, CDKN1A
BCCIP is required for the nuclear localization of the p21 protein.
Fan J, Wray J, Meng X, Shen Z.
Cell Cycle 8(18):3019-24. Epub 2009 Sep 25.PMID: 19713748 2009
60CASK, CDKN1A, TCF3
Human calcium/calmodulin-dependent serine protein kinase regulates the expression of p21 via the E2A transcription factor.
Sun R, Su Y, Zhao X, Qi J, Luo X, Yang Z, Yao Y, Luo X, Xia Z.
Biochem J 419(2):457-66. Erratum in: Biochem J. 2009 Jun 15;420(3):493. PMID: 19125693 2009
61BCL11B, CDKN1A, SUV39H1
p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.
Cherrier T, Suzanne S, Redel L, Calao M, Marban C, Samah B, Mukerjee R, Schwartz C, Gras G, Sawaya BE, Zeichner SL, Aunis D, Van Lint C, Rohr O.
Oncogene 28(38):3380-9. Epub 2009 Jul 6.PMID: 19581932 2009
62ZBTB4, CDKN1A, ZBTB17, ZBTB33
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.
Weber A, Marquardt J, Elzi D, Forster N, Starke S, Glaum A, Yamada D, Defossez PA, Delrow J, Eisenman RN, Christiansen H, Eilers M.
EMBO J 27(11):1563-74. Epub 2008 May 1. 2008
63CDKN1A
Chloride ions control the G1/S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells.
Miyazaki H, Shiozaki A, Niisato N, Ohsawa R, Itoi H, Ueda Y, Otsuji E, Yamagishi H, Iwasaki Y, Nakano T, Nakahari T, Marunaka Y.
Biochem Biophys Res Commun 366(2):506-12. Epub 2007 Dec 5. 2008
64CDKN1A, DDX58, DHX58
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
Cui S, Eisenächer K, Kirchhofer A, Brzózka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.
Mol Cell 29(2):169-79.PMID: 18243112 2008
65CCND3, CDK14, CDKN1A
Functional characterization of human PFTK1 as a cyclin-dependent kinase.
Shu F, Lv S, Qin Y, Ma X, Wang X, Peng X, Luo Y, Xu BE, Sun X, Wu J.
Proc Natl Acad Sci U S A 104(22):9248-53. Epub 2007 May 21. 2007
66CDKN1A, MEOX2
The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.
Chen Y, Leal AD, Patel S, Gorski DH.
J Biol Chem 282(1):507-17. Epub 2006 Oct 30.PMID: 17074759 2007
67CDKN1A, CDKN1B, CDKN2A, RB1
Age differences in cyclin-dependent kinase inhibitor expression and rb hyperphosphorylation in human corneal endothelial cells.
Enomoto K, Mimura T, Harris DL, Joyce NC.
Invest Ophthalmol Vis Sci 47(10):4330-40. 2006
68CDK2, CDKN1A
Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis.
Bao GC, Wang JG, Jong A.
FEBS Lett 580(15):3687-93. Epub 2006 Jun 2. 2006
69PPM1G, CDKN1A
PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1).
Suh EJ, Kim TY, Kim SH.
FEBS Lett 580(26):6100-4. Epub 2006 Oct 12. 2006
70SP3, CDKN1A
The D-domain of Sp3 modulates its protein levels and activation of the p21(CIP1/WAF1) promoter.
Hammill D, Jain N, Armstrong S, Mueller CR.
Biochem Biophys Res Commun 335(2):377-84. 2005
71RUNX3, CDKN1A
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.
Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y, Bae SC.
Mol Cell Biol 25(18):8097-107. 2005
72CDKN1A, MRPL41
Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1).
Kim MJ, Yoo YA, Kim HJ, Kang S, Kim YG, Kim JS, Yoo YD.
Biochem Biophys Res Commun 338(2):1179-84. Epub 2005 Oct 21. 2005
73CDKN1A, MRPL41, TP53
Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1.
Yoo YA, Kim MJ, Park JK, Chung YM, Lee JH, Chi SG, Kim JS, Yoo YD.
Mol Cell Biol 25(15):6603-16. 2005
74CDKN1A, SSX1, SS18
Induction of p21(WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1.
Tsuda M, Watanabe T, Seki T, Kimura T, Sawa H, Minami A, Akagi T, Isobe K, Nagashima K, Tanaka S.
Oncogene 24(54):7984-90. 2005
75CDKN1A, EP400
The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway.
Chan HM, Narita M, Lowe SW, Livingston DM.
Genes Dev 19(2):196-201. 2005
76CDKN1A, FKBPL, HSP90AA1
Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein.
Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A.
Mol Cell 17(2):237-49. 2005
77RAD9A, CDKN1a
Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.
Yin Y, Zhu A, Jin YJ, Liu YX, Zhang X, Hopkins KM, Lieberman HB.
Proc Natl Acad Sci U S A 101(24):8864-9. Epub 2004 Jun 07. 2004
78RB1, SMARCA4, CDKN1A
BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI.
Kang H, Cui K, Zhao K.
Mol Cell Biol 24(3):1188-99. 2004
79SNAI1, TWIST1, TCF3, CDKN1A
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist.
Takahashi E, Funato N, Higashihori N, Hata Y, Gridley T, Nakamura M.
Biochem Biophys Res Commun 325(4):1136-44. 2004
80CDKN1A, BCCIP
Inhibition of G1 to S cell cycle progression by BCCIP beta.
Meng X, Liu J, Shen Z.
Cell Cycle 3(3):343-8. Epub 2004 Mar 1. 2004
81CDKN1A, CDKN1B
CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma.
Kibel AS, Suarez BK, Belani J, Oh J, Webster R, Brophy-Ebbers M, Guo C, Catalona WJ, Picus J, Goodfellow PJ.
Cancer Res 63(9):2033-6. 2003
82AATF, CDKN1A, HDAC1
Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.
Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M.
J Biol Chem 278(38):36496-504. Epub 2003 Jul 7. 2003
83CDKN1A
Prognostic significance of p21WAF1/CIP1 expression in tongue squamous cell carcinomas.
Xie X, Clausen OP, Boysen M.
Arch Otolaryngol Head Neck Surg 128(8):897-902. 2002
84CDKN1A
Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women.
Harima Y, Sawada S, Nagata K, Sougawa M, Ostapenko V, Ohnishi T.
Int J Mol Med 7(3):261-4. 2001
85CDKN1A, TYMS
Downregulation of p21/WAF1 expression by thymidylate synthase.
Kastanos EK, Zajac-Kaye M, Dennis PA, Allegra CJ.
Biochem Biophys Res Commun 285(2):195-200. 2001
86BCL2, CCNA1, CCNB1, CCND1, CDKN1A, CDKN2A, MKI67, RB1
Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus.
Kanavaros P, Stefanaki K, Rontogianni D, Papalazarou D, Sgantzos M, Arvanitis D, Vamvouka C, Gorgoulis V, Siatitsas I, Agnantis NJ, Bai M.
Histol Histopathol 16(4):1005-12. 2001
87CDKN1A
Novel polymorphism in p21(waf1/cip1) cyclin dependent kinase inhibitor gene: association with human esophageal cancer.
Bahl R, Arora S, Nath N, Mathur M, Shukla NK, Ralhan R.
Oncogene 19(3):323-8. 2000
88CDKN1A
p21WAF1/CIP1 protein expression in primary ovarian cancer.
Ferrandina G, Stoler A, Fagotti A, Fanfani F, Sacco R, De Pasqua A, Mancuso S, Scambia G.
Int J Oncol 17(6):1231-5. 2000
89CDKN1A
Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation.
Asada M, et al.
EMBO J 18(5):1223-1234. 1999
90CDKN1A, CDKN1C
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Zhang P, et al.
Genes Dev 13(2):213-24. 1999
91CDKN1A
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.
Weinberg WC, et al.
Cancer Res 59(9):2050-4. 1999
92CDKN1A
p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential.
Topley GI, et al.
Proc Natl Acad Sci U S A 96(16):9089-94. 1999
93CDKN1B, CDKN1A
Expression of p21(Cip1/Waf1/Sdi1) and p27(Kip1) cyclin-dependent kinase inhibitors during human hematopoiesis.
Taniguchi T, et al.
Blood 93(12):4167-78. 1999
94CDKN1A
p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells.
Mantel C, Braun SE, Reid S, Henegariu O, Liu L, Hangoc G, Broxmeyer HE.
Blood 93(4):1390-8. 1999
95BAK1, CDKN1A, CPNE5, GLO1, HKE@, HMGA1, KIFC1, MAPK14, PPIL1, RPS10, TCTE1, ZNF76
Physical map of human 6p21.2-6p21.3 : region flanking the centromeric end of the major histocompatibility complex.
Tripodis N, et al.
Genome Res 8 : 631-643. 1998
96CDH1, CDKN1A, KIT, MMP2, TFAP2A
Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells.
Jean D, et al.
J Biol Chem 273 : 16501-16508. 1998
97CDKN1A, CDKN2A
Mutation of p16, p21 or cyclin dependent kinase 4 is rare in acute lymphoblastic leukaemia.
Qari MH, et al.
Br J Haematol 103 : 467-472. 1998
98CASP3, CDKN1A
Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.
Park JA, Kim KW, Kim SI, Lee SK.
Eur J Biochem 257(1):242-8. 1998
99CDKN1A, CDKN2A, TSG9A
Deletions and loss of expression of P16INK4a and P21Waf1 genes are associated with agressive variants of mantle cell lymphomas.
Pinyol M, et al.
Blood 89 : 272-280. 1997
100CDKN1A
Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94-Trp) identified in a human breast carcinoma.
Balbin M, et al.
J Biol Chem 271 : 15782-15786. 1996
101CDKN1A, PCNA
Structure of the C-terminal region of p21WAF1/CIP1 complexed with human PCNA.
Gulbis JM, et al.
Cell 87 : 297-306. 1996
102CDKN1A
Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas.
Shi Y, et al.
Br J Cancer 74 : 1336-1341. 1996
103CDKN1A, GADD45B, PCNA
The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.
Vairapandi M, Balliet AG, Fornace AJ Jr, Hoffman B, Liebermann DA.
Oncogene 12(12):2579-94. 1996
104CDKN1A
Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer.
Li YJ, et al.
Oncogene 10 : 599-601. 1995
105CDKN1A
Somatic mutations of the WAF1/CIP1 gene in primary prostate cancer.
Gao X, et al.
Oncogene 11 : 1395-1398. 1995
106CDKN1A
Molecular analysis of the Cip1/Waf1 (p21) gene in diverse types of human tumors.
Watanabe H, et al.
Biochim Biophys Acta 1263 : 275-280. 1995
107CDKN1A
Identification of a PstI polymorphism in the p21Cip1/Waf1 cyclin-dependent kinase inhibitor gene.
Law JC, et al.
Hum Genet 95 : 459-460. 1995
108CCNC, CCNE1, CDKN1A, CDKN3
Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).
Demetrick DJ, et al.
Cytogenet Cell Genet 69 : 190-192. 1995
109CDKN1A
Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.
Mousses S, et al.
Hum Mol Genet 4 : 1089-1092. 1995
110CDKN1A
A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the P53-inducible gene WAF1/CIP1.
Chedid M, et al.
Oncogene 9 : 3021-3024. 1994
111CDKN1A
Absence of WAF1 mutations in a variety of human malignancies.
Shiohara M, et al.
Blood 84 : 3781-3784. 1994
112CDKN1A
WAF1, a potential mediator of p53 tumor suppression.
El-Deiry WS, et al.
Cell 75 : 817-825. 1993
113CDKN1A
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Harper JW, et al.
Cell 75 : 805-816. 1993
114CDKN1A
P21 is a universal inhibitor of cyclin kinases.
Xiong Y, et al.
Nature 366 : 701-704. 1993