1 | CDKN1A, FUBP1, FUSE, MYC
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| Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1
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| Ni X, Knapp S, Chaikuad A.
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| Sci Rep Aug 10;10(1):13459. doi: 10.1038/s41598-020-69832-z. 2020
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2 | CCN3, CDKN1A
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| CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage
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| Kuwahara M, Kadoya K, Kondo S, Fu S, Miyake Y, Ogo A, Ono M, Furumatsu T, Nakata E, Sasaki T, Minagi S, Takigawa M, Kubota S, Hattori T.
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| Int J Mol Sci. Oct 13;21(20):7556. doi: 10.3390/ijms21207556. 2020
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3 | CCND1, CDKN1A, NFIC
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| NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development. 2020 PMID:
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| Lee DS, Roh SY, Choi H, Park JC.
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| Mol Cells. Aug 31;43(8):739-748. doi: 10.14348/molcells.2020.2272. 2020
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4 | CDKN1A, MELK
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| Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice.
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| Seong HA, Ha H.
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| Cell Death Dis 10(6):380. doi: 10.1038/s41419-019-1616-z.
2019
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5 | CDKN1A, SMG1, SMG7, TRIM71, UPF1
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| The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21
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| Torres-Fernández LA, Jux B, Bille M, Port Y, Schneider K, Geyer M, Mayer G, Kolanus W.
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| Nucleic Acids Res. Dec 16;47(22):11861-11879. doi: 10.1093/nar/gkz1057. 2019
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6 | CDKN1A, TBX3
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| The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor.
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| Willmer T, Hare S, Peres J, Prince S.
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| Cell Div 11:6. doi: 10.1186/s13008-016-0019-0. eCollection 2016.
2016
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7 | CDKN1A, TGM2, TP53
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| Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
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| Yeo SY, Itahana Y, Guo AK, Han R, Iwamoto K, Nguyen HT, Bao Y, Kleiber K, Wu YJ, Bay BH, Voorhoeve M, Itahana K.
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| Elife 5:e07101. doi: 10.7554/eLife.07101.
2016
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8 | CDKN1A, OLA1
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| OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression
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| Ding Z, Liu Y, Rubio V, He J, Minze LJ, Shi ZZ.
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| Mol Cell Biol. Sep 26;36(20):2568-82. doi: 10.1128/MCB.00137-16. 2016
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9 | CDKN1A, TWIST2
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| Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia.
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| Zhang X, Ma W, Cui J, Yao H, Zhou H, Ge Y, Xiao L, Hu X, Liu BH, Yang J, Li YY, Chen S, Eaves CJ, Wu D, Zhao Y.
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| Oncogene 34(23):3000-10. doi: 10.1038/onc.2014.241. Epub 2014 Aug 4.
2015
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10 | BMI1, CCNE1, CDKN1A
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| p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells.
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| Deng W, Zhou Y, Tiwari AF, Su H, Yang J, Zhu D, Lau VM, Hau PM, Yip YL, Cheung AL, Guan XY, Tsao SW.
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| Int J Cancer 136(6):1361-70. doi: 10.1002/ijc.29114. Epub 2014 Aug 7.
2015
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11 | ANKHD1, CDKN1A
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| ANKHD1 represses p21 (WAF1/CIP1) promoter and promotes multiple myeloma cell growth.
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| Dhyani A, Machado-Neto JA, Favaro P, Saad ST.
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| Eur J Cancer 51(2):252-9. doi: 10.1016/j.ejca.2014.11.012. Epub 2014 Dec 4.
2015
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12 | CDKN1A, MORC2
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| By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.
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| Zhang Q, Song Y, Chen W, Wang X, Miao Z, Cao L, Li F, Wang G.
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| Oncotarget 6(18):16461-70.
2015
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13 | CDKN1A, FOXA1, NR5A2
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| LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression.
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| Bianco S, Jangal M, Garneau D, Gévry N.
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| Oncogene 34(34):4509-18. doi: 10.1038/onc.2014.382. Epub 2014 Dec 1.
2015
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14 | CDKN1A, RASSF6
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| RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma.
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| Liang YY, Zheng LS, Wu YZ, Peng LX, Cao Y, Cao X, Xie P, Huang BJ, Qian CN.
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| Cell Cycle 13(9):1440-9. doi: 10.4161/cc.28416. Epub 2014 Mar 10.
2014
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15 | CDKN1A, DUX4
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| Dux4 induces cell cycle arrest at G1 phase through upregulation of p21 expression.
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| Xu H, Wang Z, Jin S, Hao H, Zheng L, Zhou B, Zhang W, Lv H, Yuan Y.
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| Biochem Biophys Res Commun 446(1):235-40. doi: 10.1016/j.bbrc.2014.02.105. Epub 2014 Feb 28. Erratum in: Biochem Biophys Res Commun. 2014 Jul 18;450(1):927 2014
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16 | CDKN1A, NFYA, PLK1
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| Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage.
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| Lin YC, Chen YN, Lin KF, Wang FF, Chou TY, Chen MY.
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| Cell Death Dis 5:e987. doi: 10.1038/cddis.2013.527.
2014
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17 | CDKN1A, RBM24, TP53
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| Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
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| Jiang Y, Zhang M, Qian Y, Xu E, Zhang J, Chen X.
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| J Biol Chem 289(6):3164-75. doi: 10.1074/jbc.M113.524413. Epub 2013 Dec 19.
2014
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18 | CDKN1A, TOP3A, TP53
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| DNA topoisomerase III alpha regulates p53-mediated tumor suppression.
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| Hsieh MY, Fan JR, Chang HW, Chen HC, Shen TL, Teng SC, Yeh YH, Li TK.
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| Clin Cancer Res 20(6):1489-501. doi: 10.1158/1078-0432.CCR-13-1997. Epub 2014 Feb 13.
2014
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19 | CDKN1A, TAF1
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| Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
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| Wu Y, Lin JC, Piluso LG, Dhahbi JM, Bobadilla S, Spindler SR, Liu X.
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| Mol Cell 53(1):63-74. doi: 10.1016/j.molcel.2013.10.031. Epub 2013 Nov 27.
2014
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20 | CDKN1A, KDM8
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| JMJD5 regulates cell cycle and pluripotency in human embryonic stem cells.
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| Zhu H, Hu S, Baker J.
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| Stem Cells 32(8):2098-110. doi: 10.1002/stem.1724.
2014
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21 | CDKN1A, FMN2
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| FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21.
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| Yamada K, Ono M, Bensaddek D, Lamond AI, Rocha S.
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| Cell Cycle 12(15):2348-54. doi: 10.4161/cc.25511. Epub 2013 Jul 1.
2013
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22 | CDKN1A, FMN2
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| Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21.
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| Yamada K, Ono M, Perkins ND, Rocha S, Lamond AI.
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| Mol Cell 49(5):922-33. doi: 10.1016/j.molcel.2012.12.023. Epub 2013 Jan 31.
2013
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23 | CDKN1A, RNF144B, TP63
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| PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63.
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| Conforti F, Yang AL, Piro MC, Mellone M, Terrinoni A, Candi E, Tucci P, Thomas GJ, Knight RA, Melino G, Sayan BS.
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| Oncogene 32(40):4758-65. doi: 10.1038/onc.2012.497. Epub 2012 Nov 5.
2013
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24 | CDKN1A, HIC1
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| Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).
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| Dehennaut V, Loison I, Boulay G, Van Rechem C, Leprince D.
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| Biochem Biophys Res Commun 430(1):49-53. doi: 10.1016/j.bbrc.2012.11.045. Epub 2012 Nov 22.
2013
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25 | CDKN1A, HSPA9
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| A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase.
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| Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI.
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| Mol Cell Biol 33(20):4051-67. doi: 10.1128/MCB.00021-13. Epub 2013 Aug 19.
2013
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26 | CDKN1A, TSG101
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| Identification of TSG101 functional domains and p21 loci required for TSG101-mediated p21 gene regulation.
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| Lin YS, Chen YJ, Cohen SN, Cheng TH.
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| PLoS One 8(11):e79674. doi: 10.1371/journal.pone.0079674. eCollection 2013.
2013
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27 | BMP2, CDKN1A
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| Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenance.
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| Porlan E, Morante-Redolat JM, Marqués-Torrejón MÁ, Andreu-Agulló C, Carneiro C, Gómez-Ibarlucea E, Soto A, Vidal A, Ferrón SR, Fariñas I.
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| Nat Neurosci 16(11):1567-75. doi: 10.1038/nn.3545. Epub 2013 Oct 6.
2013
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28 | CDKN1A, CDKN32A, HNRNPD
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| p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.
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| Al-Khalaf HH, Aboussekhra A.
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| PLoS One 8(7):e70133. doi: 10.1371/journal.pone.0070133. Print 2013.
2013
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29 | CDKN1A, MAPK14
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| A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibition.
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| Kumari G, Ulrich T, Gaubatz S.
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| Cell Cycle 12(13):2051-60. doi: 10.4161/cc.25100. Epub 2013 Jun 6.
2013
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30 | CDKN1A, RNF114
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| ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
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| Han J, Kim YL, Lee KW, Her NG, Ha TK, Yoon S, Jeong SI, Lee JH, Kang MJ, Lee MG, Ryu BK, Baik JH, Chi SG.
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| Cell Death Differ 20(8):1055-67. doi: 10.1038/cdd.2013.33. Epub 2013 May 3.
2013
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31 | AURKB, CDKN1A
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| Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).
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| Trakala M, Fernández-Miranda G, Pérez de Castro I, Heeschen C, Malumbres M.
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| Cell Cycle 12(7):1030-41. doi: 10.4161/cc.24004. Epub 2013 Feb 21.
2013
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32 | CDKN1A, KAT5
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| Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response.
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| Lee MS, Seo J, Choi DY, Lee EW, Ko A, Ha NC, Yoon JB, Lee HW, Kim KP, Song J.
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| Cell Death Differ 20(4):620-9. doi: 10.1038/cdd.2012.159. Epub 2012 Dec 14.
2013
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33 | AKT2, CDKN1A
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| Characterization of the Akt2 domain essential for binding nuclear p21cip1 to promote cell cycle arrest during myogenic differentiation.
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| Heron-Milhavet L, Franckhauser C, Fernandez A, Lamb NJ.
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| PLoS One 8(10):e76987. doi: 10.1371/journal.pone.0076987. eCollection 2013.
2013
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34 | CDKN1A, TGFBR1, UCHL5
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| Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells.
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| Ko YM, Chang CY, Chiou SJ, Hsu FJ, Huang JS, Yang YL, Guh JY, Chuang LY.
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| Arch Biochem Biophys 535(2):177-86. doi: 10.1016/j.abb.2013.03.003. Epub 2013 Mar 13.
2013
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35 | ARID3A, CDKN1A, TP53
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| Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage.
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| Lestari W, Ichwan SJ, Otsu M, Yamada S, Iseki S, Shimizu S, Ikeda MA.
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| Biochem Biophys Res Commun 417(2):710-6. doi: 10.1016/j.bbrc.2011.12.003. Epub 2011 Dec 8.
2012
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36 | CDKN1A, PLAGL1
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| A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions.
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| Liu ST, Chang YL, Wang WM, Chung MH, Lin WS, Chou WY, Huang SM.
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| Int J Biochem Cell Biol 44(3):547-55. doi: 10.1016/j.biocel.2011.12.012. Epub 2011 Dec 27.
2012
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37 | CDKN1A, TRIM39
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| TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.
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| Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H.
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| Proc Natl Acad Sci U S A 109(51):20937-42. doi: 10.1073/pnas.1214156110. Epub 2012 Dec 4. Erratum in: Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4148.
2012
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38 | CDKN1A
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| p21 as a transcriptional co-repressor of S-phase and mitotic control genes.
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| Ferrándiz N, Caraballo JM, García-Gutierrez L, Devgan V, Rodriguez-Paredes M, Lafita MC, Bretones G, Quintanilla A, Muñoz-Alonso MJ, Blanco R, Reyes JC, Agell N, Delgado MD, Dotto GP, León J.
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| PLoS One 7(5):e37759. doi: 10.1371/journal.pone.0037759. Epub 2012 May 25.
2012
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39 | CDKN1A, HIF1A
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| Cell free expression of hif1α and p21 in maternal peripheral blood as a marker for preeclampsia and fetal growth restriction.
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| Ashur-Fabian O, Yerushalmi GM, Mazaki-Tovi S, Steinberg DM, Goldshtein I, Yackobovitch-Gavan M, Schiff E, Amariglio N, Rechavi G.
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| PLoS One 7(5):e37273. doi: 10.1371/journal.pone.0037273. Epub 2012 May 16.
2012
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40 | CDKN1A, KDM8
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| Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression.
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| Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T, Suzuki T.
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| Development 139(4):749-59. doi: 10.1242/dev.074138. Epub 2012 Jan 12.
2012
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41 | ATG7, CDKN1A, TP53
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| Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
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| Lee IH, Kawai Y, Fergusson MM, Rovira II, Bishop AJ, Motoyama N, Cao L, Finkel T.
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| Science 336(6078):225-8. doi: 10.1126/science.1218395. Erratum in: Science. 2013 Aug 2;341(6145):457. Science. 2012 Aug 24;337(6097):911 2012
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42 | CDKN1A, POLD3, SHROMM2
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| Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
|
| Dunlop MG, Dobbins SE, Farrington SM, Jones AM, Palles C, Whiffin N, Tenesa A, Spain S, Broderick P, Ooi LY, Domingo E, Smillie C, Henrion M, Frampton M, Martin L, Grimes G, Gorman M, Semple C, Ma YP, Barclay E, Prendergast J, Cazier JB, Olver B, Penegar S, Lubbe S, Chander I, Carvajal-Carmona LG, Ballereau S, Lloyd A, Vijayakrishnan J, Zgaga L, Rudan I, Theodoratou E; Colorectal Tumour Gene Identification (CORGI) Consortium, Starr JM, Deary I, Kirac I, Kovacević D, Aaltonen LA, Renkonen-Sinisalo L, Mecklin JP, Matsuda K, Nakamura Y, Okada Y, Gallinger S, Duggan DJ, Conti D, Newcomb P, Hopper J, Jenkins MA, Schumacher F, Casey G, Easton D, Shah M, Pharoah P, Lindblom A, Liu T; Swedish Low-Risk Colorectal Cancer Study Group, Smith CG, West H, Cheadle JP; COIN Collaborative Group, Midgley R, Kerr DJ, Campbell H, Tomlinson IP, Houlston RS.
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| Nat Genet 44(7):770-6. doi: 10.1038/ng.2293.
2012
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43 | CDKN1A, NEUROG3
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| Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.
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| Miyatsuka T, Kosaka Y, Kim H, German MS.
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| Proc Natl Acad Sci U S A 108(1):185-90. Epub 2010 Dec 20.
2011
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44 | CDKN1A, SSBP1
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| hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas.
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| Xu S, Feng Z, Zhang M, Wu Y, Sang Y, Xu H, Lv X, Hu K, Cao J, Zhang R, Chen L, Liu M, Yun JP, Zeng YX, Kang T.
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| Oncogene 30(19):2219-29. Epub 2011 Jan 17.
2011
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45 | CDKN1A, SRSF2
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| SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines.
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| Edmond V, Brambilla C, Brambilla E, Gazzeri S, Eymin B.
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| Cell Cycle 10(12):1968-77. Epub 2011 Jun 15.
2011
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46 | CDKN1A, DHX8, PRPF19, SNW1
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| SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing.
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| Chen Y, Zhang L, Jones KA.
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| Genes Dev 25(7):701-16. doi: 10.1101/gad.2002611.
2011
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47 | CDKN1A, POU5F1
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| Oct-4 controls cell-cycle progression of embryonic stem cells.
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| Lee J, Go Y, Kang I, Han YM, Kim J.
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| Biochem J 426(2):171-81.
2010
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48 | CDKN1A, HDAC1
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| The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.
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| Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C.
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| Mol Cell Biol 30(5):1171-81. Epub 2009 Dec 22.PMID: 20028735 2010
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49 | CDKN1A, ELAVL1, RBM38
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| RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability.
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| Cho SJ, Zhang J, Chen X.
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| Nucleic Acids Res 38(7):2256-67. Epub 2010 Jan 11.PMID: 20064878 2010
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50 | CDKN1A
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| Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines.
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| Watanabe M, Nakahata S, Hamasaki M, Saito Y, Kawano Y, Hidaka T, Yamashita K, Umeki K, Taki T, Taniwaki M, Okayama A, Morishita K.
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| J Virol 84(14):6966-77. Epub 2010 May 5.PMID: 20444901 2010
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51 | CDKN1A, KLF1
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| EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation.
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| Siatecka M, Lohmann F, Bao S, Bieker JJ.
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| Mol Cell Biol 30(11):2811-22. Epub 2010 Apr 5.PMID: 20368355 2010
|
52 | CDKN1A, TFAP2A
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| Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter.
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| Scibetta AG, Wong PP, Chan KV, Canosa M, Hurst HC.
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| Cell Cycle 9(22):4525-32.
2010
|
53 | CDKN1A, PIM2
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| Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.
|
| Wang Z, Zhang Y, Gu JJ, Davitt C, Reeves R, Magnuson NS.
|
| Int J Biochem Cell Biol 42(6):1030-8. doi: 10.1016/j.biocel.2010.03.012. Epub 2010 Mar 20.
2010
|
54 | CDKN1A, HDAC4
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| HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.
|
| Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, Bellahcène A, Verdin E, Castronovo V.
|
| Oncogene 28(2):243-56. Epub 2008 Oct 13.
2009
|
55 | CDKN1A, DNMT1, EP300
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| p21(WAF1) negatively regulates DNMT1 expression in mammalian cells.
|
| Tan HH, Porter AG.
|
| Biochem Biophys Res Commun 382(1):171-6. Epub 2009 Mar 9.
2009
|
56 | CDKN1A, SP1, TP53, ZBTB2
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| ZBTB2, a Novel Master Regulator of the p53 Pathway.
|
| Jeon BN, Choi WI, Yu MY, Yoon AR, Kim MH, Yun CO, Hur MW.
|
| J Biol Chem 284(27):17935-46. Epub 2009 Apr 20.
2009
|
57 | CDKN1A, FBXO5
|
| DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.
|
| Lee J, Kim JA, Barbier V, Fotedar A, Fotedar R.
|
| Mol Biol Cell 20(7):1891-902. Epub 2009 Feb 11.
2009
|
58 | CDKN1A, ZBTB5
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| A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene.
|
| Koh DI, Choi WI, Jeon BN, Lee CE, Yun CO, Hur MW.
|
| J Biol Chem 284(30):19856-66. Epub 2009 Jun 2.
2009
|
59 | BCCIP, CDKN1A
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| BCCIP is required for the nuclear localization of the p21 protein.
|
| Fan J, Wray J, Meng X, Shen Z.
|
| Cell Cycle 8(18):3019-24. Epub 2009 Sep 25.PMID: 19713748 2009
|
60 | CASK, CDKN1A, TCF3
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| Human calcium/calmodulin-dependent serine protein kinase regulates the expression of p21 via the E2A transcription factor.
|
| Sun R, Su Y, Zhao X, Qi J, Luo X, Yang Z, Yao Y, Luo X, Xia Z.
|
| Biochem J 419(2):457-66. Erratum in: Biochem J. 2009 Jun 15;420(3):493. PMID: 19125693 2009
|
61 | BCL11B, CDKN1A, SUV39H1
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| p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.
|
| Cherrier T, Suzanne S, Redel L, Calao M, Marban C, Samah B, Mukerjee R, Schwartz C, Gras G, Sawaya BE, Zeichner SL, Aunis D, Van Lint C, Rohr O.
|
| Oncogene 28(38):3380-9. Epub 2009 Jul 6.PMID: 19581932 2009
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62 | ZBTB4, CDKN1A, ZBTB17, ZBTB33
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| Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.
|
| Weber A, Marquardt J, Elzi D, Forster N, Starke S, Glaum A, Yamada D, Defossez PA, Delrow J, Eisenman RN, Christiansen H, Eilers M.
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| EMBO J 27(11):1563-74. Epub 2008 May 1. 2008
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63 | CDKN1A
|
| Chloride ions control the G1/S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells.
|
| Miyazaki H, Shiozaki A, Niisato N, Ohsawa R, Itoi H, Ueda Y, Otsuji E, Yamagishi H, Iwasaki Y, Nakano T, Nakahari T, Marunaka Y.
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| Biochem Biophys Res Commun 366(2):506-12. Epub 2007 Dec 5.
2008
|
64 | CDKN1A, DDX58, DHX58
|
| The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
|
| Cui S, Eisenächer K, Kirchhofer A, Brzózka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.
|
| Mol Cell 29(2):169-79.PMID: 18243112 2008
|
65 | CCND3, CDK14, CDKN1A
|
| Functional characterization of human PFTK1 as a cyclin-dependent kinase.
|
| Shu F, Lv S, Qin Y, Ma X, Wang X, Peng X, Luo Y, Xu BE, Sun X, Wu J.
|
| Proc Natl Acad Sci U S A 104(22):9248-53. Epub 2007 May 21. 2007
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66 | CDKN1A, MEOX2
|
| The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.
|
| Chen Y, Leal AD, Patel S, Gorski DH.
|
| J Biol Chem 282(1):507-17. Epub 2006 Oct 30.PMID: 17074759 2007
|
67 | CDKN1A, CDKN1B, CDKN2A, RB1
|
| Age differences in cyclin-dependent kinase inhibitor expression and rb hyperphosphorylation in human corneal endothelial cells.
|
| Enomoto K, Mimura T, Harris DL, Joyce NC.
|
| Invest Ophthalmol Vis Sci 47(10):4330-40. 2006
|
68 | CDK2, CDKN1A
|
| Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis.
|
| Bao GC, Wang JG, Jong A.
|
| FEBS Lett 580(15):3687-93. Epub 2006 Jun 2. 2006
|
69 | PPM1G, CDKN1A
|
| PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1).
|
| Suh EJ, Kim TY, Kim SH.
|
| FEBS Lett 580(26):6100-4. Epub 2006 Oct 12. 2006
|
70 | SP3, CDKN1A
|
| The D-domain of Sp3 modulates its protein levels and activation of the p21(CIP1/WAF1) promoter.
|
| Hammill D, Jain N, Armstrong S, Mueller CR.
|
| Biochem Biophys Res Commun 335(2):377-84. 2005
|
71 | RUNX3, CDKN1A
|
| RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.
|
| Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y, Bae SC.
|
| Mol Cell Biol 25(18):8097-107. 2005
|
72 | CDKN1A, MRPL41
|
| Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1).
|
| Kim MJ, Yoo YA, Kim HJ, Kang S, Kim YG, Kim JS, Yoo YD.
|
| Biochem Biophys Res Commun 338(2):1179-84. Epub 2005 Oct 21. 2005
|
73 | CDKN1A, MRPL41, TP53
|
| Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1.
|
| Yoo YA, Kim MJ, Park JK, Chung YM, Lee JH, Chi SG, Kim JS, Yoo YD.
|
| Mol Cell Biol 25(15):6603-16. 2005
|
74 | CDKN1A, SSX1, SS18
|
| Induction of p21(WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1.
|
| Tsuda M, Watanabe T, Seki T, Kimura T, Sawa H, Minami A, Akagi T, Isobe K, Nagashima K, Tanaka S.
|
| Oncogene 24(54):7984-90. 2005
|
75 | CDKN1A, EP400
|
| The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway.
|
| Chan HM, Narita M, Lowe SW, Livingston DM.
|
| Genes Dev 19(2):196-201.
2005
|
76 | CDKN1A, FKBPL, HSP90AA1
|
| Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein.
|
| Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A.
|
| Mol Cell 17(2):237-49.
2005
|
77 | RAD9A, CDKN1a
|
| Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.
|
| Yin Y, Zhu A, Jin YJ, Liu YX, Zhang X, Hopkins KM, Lieberman HB.
|
| Proc Natl Acad Sci U S A 101(24):8864-9. Epub 2004 Jun 07. 2004
|
78 | RB1, SMARCA4, CDKN1A
|
| BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI.
|
| Kang H, Cui K, Zhao K.
|
| Mol Cell Biol 24(3):1188-99. 2004
|
79 | SNAI1, TWIST1, TCF3, CDKN1A
|
| Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist.
|
| Takahashi E, Funato N, Higashihori N, Hata Y, Gridley T, Nakamura M.
|
| Biochem Biophys Res Commun 325(4):1136-44. 2004
|
80 | CDKN1A, BCCIP
|
| Inhibition of G1 to S cell cycle progression by BCCIP beta.
|
| Meng X, Liu J, Shen Z.
|
| Cell Cycle 3(3):343-8. Epub 2004 Mar 1. 2004
|
81 | CDKN1A, CDKN1B
|
| CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma.
|
| Kibel AS, Suarez BK, Belani J, Oh J, Webster R, Brophy-Ebbers M, Guo C, Catalona WJ, Picus J, Goodfellow PJ.
|
| Cancer Res 63(9):2033-6. 2003
|
82 | AATF, CDKN1A, HDAC1
|
| Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.
|
| Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M.
|
| J Biol Chem 278(38):36496-504. Epub 2003 Jul 7. 2003
|
83 | CDKN1A
|
| Prognostic significance of p21WAF1/CIP1 expression in tongue squamous cell carcinomas.
|
| Xie X, Clausen OP, Boysen M.
|
| Arch Otolaryngol Head Neck Surg 128(8):897-902. 2002
|
84 | CDKN1A
|
| Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women.
|
| Harima Y, Sawada S, Nagata K, Sougawa M, Ostapenko V, Ohnishi T.
|
| Int J Mol Med 7(3):261-4. 2001
|
85 | CDKN1A, TYMS
|
| Downregulation of p21/WAF1 expression by thymidylate synthase.
|
| Kastanos EK, Zajac-Kaye M, Dennis PA, Allegra CJ.
|
| Biochem Biophys Res Commun 285(2):195-200. 2001
|
86 | BCL2, CCNA1, CCNB1, CCND1, CDKN1A, CDKN2A, MKI67, RB1
|
| Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus.
|
| Kanavaros P, Stefanaki K, Rontogianni D, Papalazarou D, Sgantzos M, Arvanitis D, Vamvouka C, Gorgoulis V, Siatitsas I, Agnantis NJ, Bai M.
|
| Histol Histopathol 16(4):1005-12. 2001
|
87 | CDKN1A
|
| Novel polymorphism in p21(waf1/cip1) cyclin dependent kinase inhibitor gene: association with human esophageal cancer.
|
| Bahl R, Arora S, Nath N, Mathur M, Shukla NK, Ralhan R.
|
| Oncogene 19(3):323-8. 2000
|
88 | CDKN1A
|
| p21WAF1/CIP1 protein expression in primary ovarian cancer.
|
| Ferrandina G, Stoler A, Fagotti A, Fanfani F, Sacco R, De Pasqua A, Mancuso S, Scambia G.
|
| Int J Oncol 17(6):1231-5. 2000
|
89 | CDKN1A
|
| Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation.
|
| Asada M, et al.
|
| EMBO J 18(5):1223-1234. 1999
|
90 | CDKN1A, CDKN1C
|
| p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
|
| Zhang P, et al.
|
| Genes Dev 13(2):213-24. 1999
|
91 | CDKN1A
|
| Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.
|
| Weinberg WC, et al.
|
| Cancer Res 59(9):2050-4. 1999
|
92 | CDKN1A
|
| p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential.
|
| Topley GI, et al.
|
| Proc Natl Acad Sci U S A 96(16):9089-94. 1999
|
93 | CDKN1B, CDKN1A
|
| Expression of p21(Cip1/Waf1/Sdi1) and p27(Kip1) cyclin-dependent kinase inhibitors during human hematopoiesis.
|
| Taniguchi T, et al.
|
| Blood 93(12):4167-78. 1999
|
94 | CDKN1A
|
| p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells.
|
| Mantel C, Braun SE, Reid S, Henegariu O, Liu L, Hangoc G, Broxmeyer HE.
|
| Blood 93(4):1390-8. 1999
|
95 | BAK1, CDKN1A, CPNE5, GLO1, HKE@, HMGA1, KIFC1, MAPK14, PPIL1, RPS10, TCTE1, ZNF76
|
| Physical map of human 6p21.2-6p21.3 : region flanking the centromeric end of the major histocompatibility complex.
|
| Tripodis N, et al.
|
| Genome Res 8 : 631-643. 1998
|
96 | CDH1, CDKN1A, KIT, MMP2, TFAP2A
|
| Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells.
|
| Jean D, et al.
|
| J Biol Chem 273 : 16501-16508. 1998
|
97 | CDKN1A, CDKN2A
|
| Mutation of p16, p21 or cyclin dependent kinase 4 is rare in acute lymphoblastic leukaemia.
|
| Qari MH, et al.
|
| Br J Haematol 103 : 467-472. 1998
|
98 | CASP3, CDKN1A
|
| Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.
|
| Park JA, Kim KW, Kim SI, Lee SK.
|
| Eur J Biochem 257(1):242-8. 1998
|
99 | CDKN1A, CDKN2A, TSG9A
|
| Deletions and loss of expression of P16INK4a and P21Waf1 genes are associated with agressive variants of mantle cell lymphomas.
|
| Pinyol M, et al.
|
| Blood 89 : 272-280. 1997
|
100 | CDKN1A
|
| Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94-Trp) identified in a human breast carcinoma.
|
| Balbin M, et al.
|
| J Biol Chem 271 : 15782-15786. 1996
|
101 | CDKN1A, PCNA
|
| Structure of the C-terminal region of p21WAF1/CIP1 complexed with human PCNA.
|
| Gulbis JM, et al.
|
| Cell 87 : 297-306. 1996
|
102 | CDKN1A
|
| Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas.
|
| Shi Y, et al.
|
| Br J Cancer 74 : 1336-1341. 1996
|
103 | CDKN1A, GADD45B, PCNA
|
| The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.
|
| Vairapandi M, Balliet AG, Fornace AJ Jr, Hoffman B, Liebermann DA.
|
| Oncogene 12(12):2579-94. 1996
|
104 | CDKN1A
|
| Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer.
|
| Li YJ, et al.
|
| Oncogene 10 : 599-601. 1995
|
105 | CDKN1A
|
| Somatic mutations of the WAF1/CIP1 gene in primary prostate cancer.
|
| Gao X, et al.
|
| Oncogene 11 : 1395-1398. 1995
|
106 | CDKN1A
|
| Molecular analysis of the Cip1/Waf1 (p21) gene in diverse types of human tumors.
|
| Watanabe H, et al.
|
| Biochim Biophys Acta 1263 : 275-280. 1995
|
107 | CDKN1A
|
| Identification of a PstI polymorphism in the p21Cip1/Waf1 cyclin-dependent kinase inhibitor gene.
|
| Law JC, et al.
|
| Hum Genet 95 : 459-460. 1995
|
108 | CCNC, CCNE1, CDKN1A, CDKN3
|
| Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).
|
| Demetrick DJ, et al.
|
| Cytogenet Cell Genet 69 : 190-192. 1995
|
109 | CDKN1A
|
| Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.
|
| Mousses S, et al.
|
| Hum Mol Genet 4 : 1089-1092. 1995
|
110 | CDKN1A
|
| A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the P53-inducible gene WAF1/CIP1.
|
| Chedid M, et al.
|
| Oncogene 9 : 3021-3024. 1994
|
111 | CDKN1A
|
| Absence of WAF1 mutations in a variety of human malignancies.
|
| Shiohara M, et al.
|
| Blood 84 : 3781-3784. 1994
|
112 | CDKN1A
|
| WAF1, a potential mediator of p53 tumor suppression.
|
| El-Deiry WS, et al.
|
| Cell 75 : 817-825. 1993
|
113 | CDKN1A
|
| The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
|
| Harper JW, et al.
|
| Cell 75 : 805-816. 1993
|
114 | CDKN1A
|
| P21 is a universal inhibitor of cyclin kinases.
|
| Xiong Y, et al.
|
| Nature 366 : 701-704. 1993
|