Citations for
1AIRE, CDK9
FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).
Shao W, Zumer K, Fujinaga K, Peterlin BM.
J Biol Chem 291(34):17953-63. doi: 10.1074/jbc.M116.724401. Epub 2016 Jun 30. 2016
2CCNT1, CDK9, HEXIM1
An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb.
Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O.
Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2016 Oct 25. pii: 201612331. [Epub ahead of print] 2016
3BCL11B, CDK9
CTIP2 is a negative regulator of P-TEFb.
Cherrier T, Le Douce V, Eilebrecht S, Riclet R, Marban C, Dequiedt F, Goumon Y, Paillart JC, Mericskay M, Parlakian A, Bausero P, Abbas W, Herbein G, Kurdistani SK, Grana X, Van Driessche B, Schwartz C, Candolfi E, Benecke AG, Van Lint C, Rohr O.
Proc Natl Acad Sci U S A 110(31):12655-60. doi: 10.1073/pnas.1220136110. Epub 2013 Jul 12. 2013
4BRD4, CDK9, JMJD6
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.
Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, Aggarwal A, Rosenfeld MG.
Cell 155(7):1581-1595. doi: 10.1016/j.cell.2013.10.056. 2013
5BRD4, CDK9
BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.
Devaiah BN, Lewis BA, Cherman N, Hewitt MC, Albrecht BK, Robey PG, Ozato K, Sims RJ 3rd, Singer DS.
Proc Natl Acad Sci U S A 109(18):6927-32. doi: 10.1073/pnas.1120422109. Epub 2012 Apr 16. 2012
6CDK9, CIITA, GTF2H1, TAF7
The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.
Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
Mol Cell Biol 32(10):1984-97. doi: 10.1128/MCB.06305-11. Epub 2012 Mar 12. 2012
7CDK7, CDK9, GTF2E1, GTF2E2, SUP5TH
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.
Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP.
Nat Struct Mol Biol 19(11):1108-15. doi: 10.1038/nsmb.2399. Epub 2012 Oct 14. 2012
8AIRE, CDK9
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.
Žumer K, Plemenitaš A, Saksela K, Peterlin BM.
Nucleic Acids Res 39(18):7908-19. Epub 2011 Jun 30. 2011
9CCNK, CDK9
A role for CDK9-cyclin K in maintaining genome integrity.
Yu DS, Cortez D.
Cell Cycle 10(1):28-32. Epub 2011 Jan 1. Review. 2011
10CCNK, CDK9
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.
Yu DS, Zhao R, Hsu EL, Cayer J, Ye F, Guo Y, Shyr Y, Cortez D.
EMBO Rep 11(11):876-82. Epub 2010 Oct 8. 2010
11AR, CDK9
CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.
Gordon V, Bhadel S, Wunderlich W, Zhang J, Ficarro SB, Mollah SA, Shabanowitz J, Hunt DF, Xenarios I, Hahn WC, Conaway M, Carey MF, Gioeli D.
Mol Endocrinol 24(12):2267-80. doi: 10.1210/me.2010-0238. Epub 2010 Oct 27. 2010
12CCNT1, CDK9, HEXIM1, RNS7SK
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
Dow EC, Liu H, Rice AP.
J Cell Physiol 224(1):84-93. doi: 10.1002/jcp.22096. 2010
13BRD4, CDK9, RELA
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.
Huang B, Yang XD, Zhou MM, Ozato K, Chen LF.
Mol Cell Biol 29(5):1375-87. Epub 2008 Dec 22. 2009
14BRD4, CDK9
Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.
Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, Kashanchi F, Pise-Masison CA, Brady JN.
J Virol 83(2):1036-44. Epub 2008 Oct 29. 2009
15CCNT1, CDK9
Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells.
De Falco G, Leucci E, Onnis A, Bellan C, Tigli C, Wirths S, Cerino G, Cocco M, Crupi D, De Luca A, Lanzavecchia A, Tosi P, Leoncini L, Giordano A.
J Cell Physiol 215(1):276-82.PMID: 18205180 2008
16CDK9
Expression, purification, and circular dichroism analysis of human CDK9.
Leopoldino AM, Canduri F, Cabral H, Junqueira M, de Marqui AB, Apponi LH, da Fonseca IO, Domont GB, Santos DS, Valentini S, Bonilla-Rodriguez GO, Fossey MA, de Azevedo WF Jr, Tajara EH.
Protein Expr Purif 47(2):614-20. Epub 2006 Mar 10. 2006
17CDK9
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure.
Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, Taffet GE, Hamamori Y, Michael LH, Craigen WJ, Schneider MD.
EMBO J 23(17):3559-69. Epub 2004 Aug 5. 2004
18CDK9
Identification of a novel isoform of Cdk9.
Shore SM, Byers SA, Maury W, Price DH.
Gene 307:175-82. 2003
19CCNK, CCNT2, CDK9, CCNT1
P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.
Lin X, Taube R, Fujinaga K, Peterlin BM.
J Biol Chem 277(19):16873-8. 2002
20CDK9
Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.
Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, Michael LH, DeMayo FJ, Schneider MD.
Nat Med 8(11):1310-7. 2002
21CDK9, PIN1, SUPT5H
The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.
Lavoie SB, Albert AL, Handa H, Vincent M, Bensaude O.
J Mol Biol 312(4):675-85. 2001
22CDK9
Genomic organization and characterization of promoter function of the human CDK9 gene.
Liu H, Rice AP.
Gene 252(1-2):51-9. 2000
23CDK9
The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes.
Garriga J, Mayol X, Grana X.
Biochem J 319 ( Pt 1):293-8. 1996
24CDK9
The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function.
Yang X, Herrmann CH, Rice AP.
J Virol 70(7):4576-84. 1996
25CDK10, CDK9, CDK3, CDK6, CDKN1B
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.
Bullrich F, et al.
Cancer Res 55 : 1199-1205. 1995
26CDK9
Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells.
Best JL, Presky DH, Swerlick RA, Burns DK, Chu W.
Biochem Biophys Res Commun 208(2):562-8. 1995
27CDK9, RB1
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.
Graña X, De Luca A, Sang N, Fu Y, Claudio PP, Rosenblatt J, Morgan DO, Giordano A.
Proc Natl Acad Sci U S A 91 : 3834-3838. 1994