Citations for
1CDK19, CDK8
De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy
Chung HL, Mao X, Wang H, Park YJ, Marcogliese PC, Rosenfeld JA, Burrage LC, Liu P, Murdock DR, Yamamoto S, Wangler MF; Undiagnosed Diseases Network, Chao HT, Long H, Feng L, Bacino CA, Bellen HJ, Xiao B
Am J Hum Genet. May 7;106(5):717-725. doi: 10.1016/j.ajhg.2020.04.001. Epub 2020 Apr 23 2020
2CDK8, MRSCF
De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.
Calpena E, Hervieu A, Kaserer T, Swagemakers SMA, Goos JAC, Popoola O, Ortiz-Ruiz MJ, Barbaro-Dieber T, Bownass L, Brilstra EH, Brimble E, Foulds N, Grebe TA, Harder AVE, Lees MM, Monaghan KG, Newbury-Ecob RA, Ong KR, Osio D, Reynoso Santos FJ, Ruzhnikov MRZ, Telegrafi A, van Binsbergen E, van Dooren MF; Deciphering Developmental Disorders Study, van der Spek PJ, Blagg J, Twigg SRF, Mathijssen IMJ, Clarke PA, Wilkie AOM.
Am J Hum Genet 104(4):709-720. doi: 10.1016/j.ajhg.2019.02.006. Epub 2019 Mar 21. 2019
3CDK19, CDK8
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules.
Dannappel MV, Sooraj D, Loh JJ, Firestein R.
Front Cell Dev Biol 6:171. doi: 10.3389/fcell.2018.00171. eCollection 2018. Review. 2019
4CDK8
CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
Xi M, Chen T, Wu C, Gao X, Wu Y, Luo X, Du K, Yu L, Cai T, Shen R, Sun H.
Eur J Med Chem 164:77-91. doi: 10.1016/j.ejmech.2018.11.076. Epub 2018 Dec 21. Review. 2019
5CDK19, CDK8
Regulatory functions of the Mediator kinases CDK8 and CDK19.
Fant CB, Taatjes DJ.
Transcription 10(2):76-90. doi: 10.1080/21541264.2018.1556915. Epub 2018 Dec 26. Review. 2019
6CDK8, YAP1, ZYX
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
Zhou J, Zeng Y, Cui L, Chen X, Stauffer S, Wang Z, Yu F, Lele SM, Talmon GA, Black AR, Chen Y, Dong J.
Proc Natl Acad Sci U S A 115(29):E6760-E6769. doi: 10.1073/pnas.1800621115. Epub 2018 Jul 2. 2018
7CDK8
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses.
Witalisz-Siepracka A, Gotthardt D, Prchal-Murphy M, Didara Z, Menzl I, Prinz D, Edlinger L, Putz EM, Sexl V.
Cancer Immunol Res 6(4):458-466. doi: 10.1158/2326-6066.CIR-17-0183. Epub 2018 Jan 31. 2018
8CDK19, CDK8
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.
Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K.
Oncogene 37(35):4792-4808. doi: 10.1038/s41388-018-0316-y. Epub 2018 May 21. 2018
9CDK19, CDK8
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB.
Proc Natl Acad Sci U S A 114(38):10208-10213. doi: 10.1073/pnas.1710467114. Epub 2017 Aug 30. 2017
10CDK19, CDK8
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ.
Nat Chem Biol 13(10):1102-1108. doi: 10.1038/nchembio.2458. Epub 2017 Aug 14. 2017
11CCNC, CDK19, CDK8, MED12, MED13
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.
Broude EV, Győrffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB.
Curr Cancer Drug Targets 15(8):739-49. Review. 2015
12CDK8
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
Feng D, Youn DY, Zhao X, Gao Y, Quinn WJ 3rd, Xiaoli AM, Sun Y, Birnbaum MJ, Pessin JE, Yang F.
PLoS One 10(6):e0126240. doi: 10.1371/journal.pone.0126240. eCollection 2015. 2015
13CDK8
The two faces of Cdk8, a positive/negative regulator of transcription.
Nemet J, Jelicic B, Rubelj I, Sopta M.
Biochimie 97:22-7. doi: 10.1016/j.biochi.2013.10.004. Epub 2013 Oct 15. Review. 2014
14CDK8, HIF1A
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.
Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM.
Cell 153(6):1327-39. doi: 10.1016/j.cell.2013.04.048. 2013
15CDK8
Emerging roles of Cdk8 in cell cycle control.
Szilagyi Z, Gustafsson CM.
Biochim Biophys Acta 1829(9):916-20. doi: 10.1016/j.bbagrm.2013.04.010. Epub 2013 May 1. Review. 2013
16CDK8
Structural flexibility and functional interaction of mediator Cdk8 module.
Wang X, Wang J, Ding Z, Ji J, Sun Q, Cai G.
Protein Cell rotein Cell. 2013 Sep 16. [Epub ahead of print] 2013
17CDK8
Tumor-suppressive effects of CDK8 in endometrial cancer cells.
Gu W, Wang C, Li W, Hsu FN, Tian L, Zhou J, Yuan C, Xie XJ, Jiang T, Addya S, Tai Y, Kong B, Ji JY.
Cell Cycle 12(6):987-99. doi: 10.4161/cc.24003. Epub 2013 Mar 1. 2013
18CCNC, CDK8
Structure-kinetic relationship study of CDK8/CycC specific compounds.
Schneider EV, Böttcher J, Huber R, Maskos K, Neumann L.
Proc Natl Acad Sci U S A 110(20):8081-6. doi: 10.1073/pnas.1305378110. Epub 2013 Apr 29. 2013
19CDK8, FBXW7, MED13, MED13L
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.
Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.
Genes Dev 27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15. 2013
20CDK19, CDK8, PRMT5, WDR77
Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.
Tsutsui T, Fukasawa R, Shinmyouzu K, Nakagawa R, Tobe K, Tanaka A, Ohkuma Y.
J Biol Chem 288(29):20955-65. doi: 10.1074/jbc.M113.486746. Epub 2013 Jun 9. 2013
21CDK8
CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.
Adler AS, McCleland ML, Truong T, Lau S, Modrusan Z, Soukup TM, Roose-Girma M, Blackwood EM, Firestein R.
Cancer Res 72(8):2129-39. doi: 10.1158/0008-5472.CAN-11-3886. Epub 2012 Feb 16. 2012
22CDK8, FGS1, GLI3, LJFS1, MED12
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling.
Zhou H, Spaeth JM, Kim NH, Xu X, Friez MJ, Schwartz CE, Boyer TG.
Proc Natl Acad Sci U S A 109(48):19763-8. doi: 10.1073/pnas.1121120109. Epub 2012 Oct 22. 2012
23CDK8, MAML1, RBPJ
Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1.
Popko-Scibor AE, Lindberg MJ, Hansson ML, Holmlund T, Wallberg AE.
Biochem Biophys Res Commun 416(3-4):300-6. doi: 10.1016/j.bbrc.2011.11.030. Epub 2011 Nov 12. 2011
24CCNC, CDK8
The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.
Schneider EV, Böttcher J, Blaesse M, Neumann L, Huber R, Maskos K.
J Mol Biol 412(2):251-66. doi: 10.1016/j.jmb.2011.07.020. Epub 2011 Jul 23. 2011
25CCNC, CDK8
Dysregulation of CDK8 and Cyclin C in tumorigenesis.
Xu W, Ji JY.
J Genet Genomics 38(10):439-52. doi: 10.1016/j.jgg.2011.09.002. Epub 2011 Sep 16. Review. 2011
26CDK19, CDK8
Identification of target genes for the CDK subunits of the Mediator complex.
Tsutsui T, Fukasawa R, Tanaka A, Hirose Y, Ohkuma Y.
Genes Cells 16(12):1208-18. doi: 10.1111/j.1365-2443.2011.01565.x. 2011
27CDK8, MED12, MED13
A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
Gobert V, Osman D, Bras S, Augé B, Boube M, Bourbon HM, Horn T, Boutros M, Haenlin M, Waltzer L.
Mol Cell Biol 30(11):2837-48. Epub 2010 Apr 5.PMID: 20368357 2010
28CDK8
Role of CDK8 and beta-catenin in colorectal adenocarcinoma.
Seo JO, Han SI, Lim SC.
Oncol Rep 24(1):285-91. 2010
29CDK8
CDK8 is a positive regulator of transcriptional elongation within the serum response network.
Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM.
Nat Struct Mol Biol 17(2):194-201. doi: 10.1038/nsmb.1752. Epub 2010 Jan 24. 2010
30CDK8
The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.
Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ.
Mol Cell Biol. 29(3):650-61 2009
31CCNC, CDK8, MED12, MED13
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.
Knuesel MT, Meyer KD, Bernecky C, Taatjes DJ.
Genes Dev 23(4):439-51.PMID: 19240132 2009
32CDK8
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S, Bojarski E, Mermel C, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE, Fuchs CS, Loda M, Shivdasani RA, Meyerson M, Hahn WC.
Nature 455(7212):547-51. Epub 2008 Sep 14. 2008
33CDK8, E2F1
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.
Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ.
Nature 455(7212):552-6. Epub 2008 Sep 14. 2008
34CDK8
Cdk8 is essential for preimplantation mouse development.
Westerling T, Kuuluvainen E, Mäkelä TP.
Mol Cell Biol. 27(17):6177-82 2007
35CDK8, MED1, MED17
CDK8 is a stimulus-specific positive coregulator of p53 target genes.
Donner AJ, Szostek S, Hoover JM, Espinosa JM.
Mol Cell 27(1):121-33. 2007
36CDK8, CDK7
TFIIH is negatively regulated by cdk8-containing mediator complexes.
Akoulitchev S, Chuikov S, Reinberg D.
Nature 407(6800):102-6. 2000
37CDK8
Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7.
Di Pietro C, Rapisarda A, Bonaiuto C, Lizzio MN, Engel H, Amico V, Scalia M, Amato A, Grzeschik KH, Sichel G, Purrello M.
Somat Cell Mol Genet 25(3):185-9. 1999
38CDK8
Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases.
Rickert P, Corden JL, Lees E.
Oncogene 18(4):1093-102. 1999
39CDK8
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.
Tassan JP, Jaquenoud M, Leopold P, Schultz SJ, Nigg EA.
Proc Natl Acad Sci U S A 92(19):8871-5. 1995