1 | CDK5, TET3
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| Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation.
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| Rao VK, Swarnaseetha A, Tham GH, Lin WQ, Han BB, Benoukraf T, Xu GL, Ong CT.
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| Nucleic Acids Res 48(3):1225-1238. doi: 10.1093/nar/gkz1144.
2020
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2 | C2CD5, CDK5, NDEL1, YWHAE
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| Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528.
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| Chapman DE, Reddy BJN, Huy B, Bovyn MJ, Cruz SJS, Al-Shammari ZM, Han H, Wang W, Smith DS, Gross SP.
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| Nat Commun 10(1):228. doi: 10.1038/s41467-018-08110-z.
2019
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3 | ALDH1A1, CDK5
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| Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer's Disease Pathogenesis
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| Nikhil K, Viccaro K, Shah K.
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| Mol Neurobiol. Feb;56(2):1366-1390. doi: 10.1007/s12035-018-1114-9. Epub 2018 Jun 8. 2019
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4 | CDK5, FIBP, MRSHFD, TMEM94
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| Bi-allelic TMEM94 Truncating Variants Are Associated with Neurodevelopmental Delay, Congenital Heart Defects, and Distinct Facial Dysmorphism.
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| Stephen J, Maddirevula S, Nampoothiri S, Burke JD, Herzog M, Shukla A, Steindl K, Eskin A, Patil SJ, Joset P, Lee H, Garrett LJ, Yokoyama T, Balanda N, Bodine SP, Tolman NJ, Zerfas PM, Zheng A, Ramantani G, Girisha KM, Rivas C, Suresh PV, Elkahloun A, Alsaif HS, Wakil SM, Mahmoud L, Ali R, Prochazkova M; Undiagnosed Diseases Network members, Kulkarni AB, Ben-Omran T, Colak D, Morris HD, Rauch A, Martinez-Agosto JA, Nelson SF, Alkuraya FS, Gahl WA, Malicdan MCV.
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| Am J Hum Genet 103(6):948-967. doi: 10.1016/j.ajhg.2018.11.001. 2018
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5 | CDK5, PTN
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| Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.
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| Lampropoulou E, Logoviti I, Koutsioumpa M, Hatziapostolou M, Polytarchou C, Skandalis SS, Hellman U, Fousteris M, Nikolaropoulos S, Choleva E, Lamprou M, Skoura A, Megalooikonomou V, Papadimitriou E.
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| Sci Rep 8(1):5893. doi: 10.1038/s41598-018-24326-x.
2018
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6 | C2CD5, CDK5, GDF15
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| CDP138 silencing inhibits TGF-β/Smad signaling to impair radioresistance and metastasis via GDF15 in lung cancer.
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| Lu Y, Ma J, Li Y, Huang J, Zhang S, Yin Z, Ren J, Huang K, Wu G, Yang K, Xu S.
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| Cell Death Dis 8(9):e3036. doi: 10.1038/cddis.2017.434.
2017
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7 | CDK5, PPFIA1
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| Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development
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| Huang H, Lin X, Liang Z, Zhao T, Du S, Loy MMT, Lai KO, Fu AKY, Ip NY.
|
| Proc Natl Acad Sci U S A. Aug 15;114(33):E6992-E7001. doi: 10.1073/pnas.1708240114. Epub 2017 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 23 2017
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8 | CDK5, CDK5R1
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| Functional characterization of CDK5 and CDK5R1 mutations identified in patients with non-syndromic intellectual disability.
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| Moncini S, Castronovo P, Murgia A, Russo S, Bedeschi MF, Lunghi M, Selicorni A, Bonati MT, Riva P, Venturin M.
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| J Hum Genet 61(4):283-93. doi: 10.1038/jhg.2015.144. Epub 2015 Dec 10.
2016
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9 | CDK5, CDK5R1
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| p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing.
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| Posada-Duque RA, López-Tobón A, Piedrahita D, González-Billault C, Cardona-Gomez GP.
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| J Neurochem 134(2):354-70. doi: 10.1111/jnc.13127. Epub 2015 May 4.
2015
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10 | CCNI, CDK5, CDK5R1
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| Cyclin I and p35 determine the subcellular distribution of Cdk5.
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| Hagmann H, Taniguchi Y, Pippin JW, Kauerz HM, Benzing T, Shankland SJ, Brinkkoetter PT.
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| Am J Physiol Cell Physiol 308(4):C339-47. doi: 10.1152/ajpcell.00168.2014. Epub 2014 Dec 10.
2015
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11 | CDK5, CDK5R1
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| Sumoylation of p35 modulates p35/cyclin-dependent kinase (Cdk) 5 complex activity.
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| Büchner A, Krumova P, Ganesan S, Bähr M, Eckermann K, Weishaupt JH.
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| Neuromolecular Med 17(1):12-23. doi: 10.1007/s12017-014-8336-4. Epub 2014 Nov 13.
2015
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12 | CCDC88A, CDK5
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| Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.
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| Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P.
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| Proc Natl Acad Sci U S A 112(35):E4874-83. doi: 10.1073/pnas.1514157112. Epub 2015 Aug 18.
2015
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13 | BACE1, CDK5, TPPP
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| Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease.
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| Song WJ, Son MY, Lee HW, Seo H, Kim JH, Chung SH.
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| PLoS One 10(8):e0136950. doi: 10.1371/journal.pone.0136950. eCollection 2015.
2015
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14 | CDK5, LIS7
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| Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with a loss-of-function mutation in CDK5.
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| Magen D, Ofir A, Berger L, Goldsher D, Eran A, Katib N, Nijem Y, Vlodavsky E, Tzur S, Behar DM, Fellig Y, Mandel H.
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| Hum Genet 134(3):305-14. doi: 10.1007/s00439-014-1522-5. Epub 2015 Jan 6. Erratum in: Hum Genet. 2015 Mar;134(3):315. Katib, Nassser [corr 2015
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15 | CDK5, RAP1A, RAPGEF2
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| Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.
|
| Ye T, Ip JP, Fu AK, Ip NY.
|
| Nat Commun 5:4826. doi: 10.1038/ncomms5826.
2014
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16 | CDK5, SOX6
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| Regulation of Sox6 by cyclin dependent kinase 5 in brain.
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| Rudrabhatla P, Utreras E, Jaffe H, Kulkarni AB.
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| PLoS One 9(3):e89310. doi: 10.1371/journal.pone.0089310. eCollection 2014.
2014
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17 | CDK5, SYN1
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| Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
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| Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, Benfenati F.
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| J Neurosci 34(21):7266-80. doi: 10.1523/JNEUROSCI.3973-13.2014.
2014
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18 | ATXN2, CDK5
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| Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2.
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| Asada A, Yamazaki R, Kino Y, Saito T, Kimura T, Miyake M, Hasegawa M, Nukina N, Hisanaga S.
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| Neurosci Lett 563:112-7. doi: 10.1016/j.neulet.2014.01.046. Epub 2014 Jan 31.
2014
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19 | CDK5, CDK5R1
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| Cdk5/p35 functions as a crucial regulator of spatial learning and memory.
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| Mishiba T, Tanaka M, Mita N, He X, Sasamoto K, Itohara S, Ohshima T.
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| Mol Brain 7:82. doi: 10.1186/s13041-014-0082-x.
2014
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20 | CDK5, CDK5R1, ZNF335
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| p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).
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| Zhao XS, Fu WY, Chien WW, Li Z, Fu AK, Ip NY.
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| PLoS One 9(10):e110584. doi: 10.1371/journal.pone.0110584. eCollection 2014.
2014
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21 | CDK5, CDK5R1
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| Cdk5/p35 is required for motor coordination and cerebellar plasticity.
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| He X, Ishizeki M, Mita N, Wada S, Araki Y, Ogura H, Abe M, Yamazaki M, Sakimura K, Mikoshiba K, Inoue T, Ohshima T.
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| J Neurochem 131(1):53-64. doi: 10.1111/jnc.12756. Epub 2014 May 28.
2014
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22 | CDK5, GPHN
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| Cyclin-dependent kinase 5 is involved in the phosphorylation of gephyrin and clustering of GABAA receptors at inhibitory synapses of hippocampal neurons.
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| Kalbouneh H, Schlicksupp A, Kirsch J, Kuhse J.
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| PLoS One 9(8):e104256. doi: 10.1371/journal.pone.0104256.
2014
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23 | CDK5, DLC1
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| CDK5 is a major regulator of the tumor suppressor DLC1.
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| Tripathi BK, Qian X, Mertins P, Wang D, Papageorge AG, Carr SA, Lowy DR.
|
| J Cell Biol 207(5):627-42. doi: 10.1083/jcb.201405105. Epub 2014 Dec 1.
2014
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24 | C2CD5, CDK5, FIBP
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| Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration.
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| Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J.
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| Mol Cell Proteomics 13(11):2986-3000. doi: 10.1074/mcp.M113.036699. Epub 2014 Aug 5.
2014
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25 | CDK1, CDK4, CDK5, UCHL1
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| Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
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| Kabuta T, Mitsui T, Takahashi M, Fujiwara Y, Kabuta C, Konya C, Tsuchiya Y, Hatanaka Y, Uchida K, Hohjoh H, Wada K.
|
| J Biol Chem 288(18):12615-26. doi: 10.1074/jbc.M112.435701. Epub 2013 Mar 29.
2013
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26 | CDK5, DRD2
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| Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling.
|
| Jeong J, Park YU, Kim DK, Lee S, Kwak Y, Lee SA, Lee H, Suh YH, Gho YS, Hwang D, Park SK.
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| PLoS One 8(12):e84482. doi: 10.1371/journal.pone.0084482. eCollection 2013.
2013
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27 | CDK5
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| Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.
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| Zhang J, Li H, Zhou T, Zhou J, Herrup K.
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| J Biol Chem. 287(31):25985-94. 2012
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28 | ASH1L, CDK5
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| Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway.
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| Demelash A, Rudrabhatla P, Pant HC, Wang X, Amin ND, McWhite CD, Naizhen X, Linnoila RI.
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| Mol Biol Cell 23(15):2856-66. doi: 10.1091/mbc.E10-12-1010. Epub 2012 Jun 13.
2012
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29 | CDK5, CDK5R1
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| p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity.
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| Zhang L, Liu W, Szumlinski KK, Lew J.
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| Proc Natl Acad Sci U S A 109(49):20041-6. doi: 10.1073/pnas.1212914109. Epub 2012 Nov 14.
2012
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30 | CCNI, CDK5, CDK5R1
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| Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes.
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| Taniguchi Y, Pippin JW, Hagmann H, Krofft RD, Chang AM, Zhang J, Terada Y, Brinkkoetter P, Shankland SJ.
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| Am J Physiol Renal Physiol 302(9):F1161-71. doi: 10.1152/ajprenal.00614.2011. Epub 2012 Jan 18.
2012
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31 | ARHGEF9, CDK5, GPHN
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| Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin.
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| Kuhse J, Kalbouneh H, Schlicksupp A, Mükusch S, Nawrotzki R, Kirsch J.
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| J Biol Chem 287(37):30952-66. doi: 10.1074/jbc.M112.349597.
2012
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32 | CAST, CDK5
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| Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
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| Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga S.
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| J Neurochem 117(3):504-15. doi: 10.1111/j.1471-4159.2011.07222.x. Epub 2011 Mar 15. 2011
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33 | CDK1, CDK2, CDK5, DNMT1
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| Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.
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| Lavoie G, St-Pierre Y.
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| Biochem Biophys Res Commun 409(2):187-92. Epub 2011 May 1.
2011
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34 | CDK5
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| Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death.
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| Chang KH, Multani PS, Sun KH, Vincent F, de Pablo Y, Ghosh S, Gupta R, Lee HP, Lee HG, Smith MA, Shah K.
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| Mol Biol Cell 22(9):1452-62. Epub 2011 Mar 9.
2011
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35 | CDK5, GSTP1
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| Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity.
|
| Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K.
|
| J Neurochem. 118(5):902-14 2011
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36 | CDK5, TFAP2B
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| Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons.
|
| Bianchetta MJ, Lam TT, Jones SN, Morabito MA.
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| J Neurosci 31(33):12029-35.
2011
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37 | CDK5
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| Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development.
|
| Fang WQ, Ip JP, Li R, Ng YP, Lin SC, Chen Y, Fu AK, Ip NY.
|
| J Neurosci 31(38):13613-24.
2011
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38 | CDK5, NDEL1, PAFAH1B1
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| A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.
|
| Pandey JP, Smith DS.
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| J Neurosci 31(47):17207-19. doi: 10.1523/JNEUROSCI.4108-11.2011.
2011
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39 | CDK16, CDK5
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| Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development.
|
| Fu WY, Cheng K, Fu AK, Ip NY.
|
| Neuroscience 180:353-9. doi: 10.1016/j.neuroscience.2011.02.024. Epub 2011 Feb 16.
2011
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40 | CDK5, DLGAP1
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| CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton
|
| Roselli F, Livrea P, Almeida OF.
|
| PLoS One. 6(7):e23097. doi: 10.1371/journal.pone.0023097. Epub 2011 Jul 29. 2011
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41 | CDK5
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| Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.
|
| Poore CP, Sundaram JR, Pareek TK, Fu A, Amin N, Mohamed NE, Zheng YL, Goh AX, Lai MK, Ip NY, Pant HC, Kesavapany S.
|
| J Neurosci 30(25):8457-67.PMID: 20573893 2010
|
42 | CDK5, CDK5R1, RB1
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| p35 is required for CDK5 activation in cellular senescence.
|
| Mao D, Hinds PW.
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| J Biol Chem 285(19):14671-80. Epub 2010 Feb 24.PMID: 20181942 2010
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43 | CDK5
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| Cdk5: A regulator of epithelial cell adhesion and migration.
|
| Tripathi BK, Zelenka PS.
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| Cell Adh Migr 4(3). [Epub ahead of print]PMID: 20190570 2010
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44 | CDK5, SNTB2
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| β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules.
|
| Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M.
|
| PLoS One 5(9):e12929. doi: 10.1371/journal.pone.0012929.
2010
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45 | CDK5, SMURF1
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| Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
|
| Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH.
|
| Nat Cell Biol 11(5):624-30. Epub 2009 Apr 12.
2009
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46 | CDK5, CDK5R1
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| Cloning and spatio-temporal expression of porcine CDK5 and CDK5R1(p35) genes.
|
| Long H, Zhao S, Lei T, Han J, Yuan J, Qi Y, Yang Z.
|
| Anim Biotechnol 20(3):133-43.PMID: 19544209 2009
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47 | CDK5
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| Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
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| Hawasli AH, Koovakkattu D, Hayashi K, Anderson AE, Powell CM, Sinton CM, Bibb JA, Cooper DC.
|
| PLoS One 4(6):e5808.PMID: 19529798 2009
|
48 | CDK5
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| Recent advances in understanding the roles of Cdk5 in synaptic plasticity.
|
| Lai KO, Ip NY.
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| Biochim Biophys Acta 1792(8):741-5. Epub 2009 May 13. Review.PMID: 19442718 2009
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49 | CDK5
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| Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
|
| Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH.
|
| Nat Cell Biol. 11(5):624-30. 2009
|
50 | CDK5, ESYT1
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| The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes.
|
| Lalioti V, Muruais G, Dinarina A, van Damme J, Vandekerckhove J, Sandoval IV.
|
| Proc Natl Acad Sci U S A 106(11):4249-53. doi: 10.1073/pnas.0900218106. Epub 2009 Mar 2.
2009
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51 | CDK5
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| Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons.
|
| Zhang J, Cicero SA, Wang L, Romito-Digiacomo RR, Yang Y, Herrup K.
|
| Proc Natl Acad Sci U S A 105(25):8772-7. Epub 2008 Jun 12. 2008
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52 | CDK5, CDK5R1
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| Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology.
|
| Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O'Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, Bibb JA.
|
| Proc Natl Acad Sci U S A 105(47):18561-6. Epub 2008 Nov 18.
2008
|
53 | CDK5
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| Cdk5 is essential for adult hippocampal neurogenesis.
|
| Lagace DC, Benavides DR, Kansy JW, Mapelli M, Greengard P, Bibb JA, Eisch AJ.
|
| Proc Natl Acad Sci U S A 105(47):18567-71. Epub 2008 Nov 18.
2008
|
54 | CDK5, KALRN
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| Regulation of Kalirin by Cdk5.
|
| Xin X, Wang Y, Ma XM, Rompolas P, Keutmann HT, Mains RE, Eipper BA.
|
| J Cell Sci 121(Pt 15):2601-11. Epub 2008 Jul 15.
2008
|
55 | CDK5
|
| Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease.
|
| Sun KH, de Pablo Y, Vincent F, Johnson EO, Chavers AK, Shah K.
|
| Mol Biol Cell 19(7):3052-69. Epub 2008 May 14.
2008
|
56 | CCNB1, CCNG1, CDK5
|
| Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1.
|
| Seo HR, Kim J, Bae S, Soh JW, Lee YS.
|
| J Biol Chem 283(23):15601-10. doi: 10.1074/jbc.M800987200. Epub 2008 Apr 11.
2008
|
57 | CDK5, HTT
|
| Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.
|
| Anne SL, Saudou F, Humbert S.
|
| J Neurosci 27(27):7318-28. 2007
|
58 | CDK5,STAT3
|
| Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells.
|
| Lin H, Chen MC, Chiu CY, Song YM, Lin SY.
|
| J Biol Chem 282(5):2776-84. Epub 2006 Dec 4. 2007
|
59 | CDK5, PRDX2
|
| Peroxiredoxin-2 links Cdk5 to neurodegeneration.
|
| Przedborski S.
|
| Nat Med 13(8):907-9. No abstract available. 2007
|
60 | GRIN2B, CDK5
|
| Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.
|
| Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA.
|
| Nat Neurosci 10(7):880-6. Epub 2007 May 27. 2007
|
61 | CDK5, PPPR19A
|
| Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration.
|
| Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M.
|
| Mol Biol Cell 18(11):4327-42. Epub 2007 Aug 15.
2007
|
62 | CDK5
|
| Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.
|
| Lee JH, Kim HS, Lee SJ, Kim KT.
|
| J Cell Sci. 120(Pt 13):2259-71. 2007
|
63 | CDK5
|
| Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.
|
| Avraham E, Rott R, Liani E, Szargel R, Engelender S.
|
| J Biol Chem. 282(17):12842-50 2007
|
64 | AMPH, CDK5
|
| Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis.
|
| Liang S, Wei FY, Wu YM, Tanabe K, Abe T, Oda Y, Yoshida Y, Yamada H, Matsui H, Tomizawa K, Takei K.
|
| J Neurochem 102(5):1466-76. Epub 2007 Apr 10.
2007
|
65 | CDK5, WASF1
|
| Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.
|
| Kim Y, Sung JY, Ceglia I, Lee KW, Ahn JH, Halford JM, Kim AM, Kwak SP, Park JB, Ho Ryu S, Schenck A, Bardoni B, Scott JD, Nairn AC, Greengard P.
|
| Nature 442(7104):814-7. Epub 2006 Jul 16. 2006
|
66 | CDK5,MAPT
|
| Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.
|
| Sengupta A, Novak M, Grundke-Iqbal I, Iqbal K.
|
| FEBS Lett 580(25):5925-33. Epub 2006 Oct 5. 2006
|
67 | CDK5,CDK5R1
|
| Identification of nuclear import mechanisms for the neuronal Cdk5 activator.
|
| Fu X, Choi YK, Qu D, Yu Y, Cheung NS, Qi RZ.
|
| J Biol Chem 281(51):39014-21. Epub 2006 Oct 23. 2006
|
68 | CDK5
|
| Cyclin-dependent kinase 5 activity regulates pain signaling.
|
| Pareek TK, Keller J, Kesavapany S, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB.
|
| Proc Natl Acad Sci U S A. 103(3):791-6. 2006
|
69 | CDK5
|
| Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.
|
| Lacy ER, Wang Y, Post J, Nourse A, Webb W, Mapelli M, Musacchio A, Siuzdak G, Kriwacki RW.
|
| J Mol Biol. 349(4):764-73 2005
|
70 | CDK5
|
| Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice.
|
| Fu AK, Ip FC, Fu WY, Cheung J, Wang JH, Yung WH, Ip NY.
|
| Proc Natl Acad Sci U S A. 102(42):15224-9 2005
|
71 | CDK5, SYNJ1
|
| Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.
|
| Lee SY, Wenk MR, Kim Y, Nairn AC, De Camilli P.
|
| Proc Natl Acad Sci U S A 101(2):546-51. Epub 2004 Jan 2. 2004
|
72 | CDK5, CHN1
|
| Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain.
|
| Qi RZ, Ching YP, Kung HF, Wang JH.
|
| FEBS Lett 561(1-3):177-80.
2004
|
73 | CDK5
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| Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.
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74 | CDK5
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| Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects.
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| Proc Natl Acad Sci U S A. 101(16):6249-54. 2004
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75 | CDK5, LIS1, NDEL1, YWHAE
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| 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.
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| Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A.
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| Nat Genet 34(3):274-85. 2003
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76 | CDK5, NES
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| Cdk5 regulates the organization of Nestin and its association with p35.
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| Sahlgren CM, Mikhailov A, Vaittinen S, Pallari HM, Kalimo H, Pant HC, Eriksson JE.
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| Mol Cell Biol. 23(14):5090-106. 2003
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77 | CDK5
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| Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.
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| Li BS, Ma W, Jaffe H, Zheng Y, Takahashi S, Zhang L, Kulkarni AB, Pant HC.
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78 | CDK5
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| Cdk5 is essential for synaptic vesicle endocytosis.
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79 | CDK5, POU3F2, POU3F3
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| Transcriptional regulation of cortical neuron migration by POU domain factors.
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| McEvilly RJ, de Diaz MO, Schonemann MD, Hooshmand F, Rosenfeld MG.
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| Science 295(5559):1528-32. 2002
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80 | CDK5, SET
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| The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity.
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| Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ.
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81 | CDK5, CDK5R1, CDK5R2
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82 | CDK16, CDK5
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| Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY.
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83 | CDK5
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| ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.
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| Sato H, Nishimoto I, Matsuoka M.
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| Biochim Biophys Acta. 1574(2):157-63. 2002
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84 | CDK5
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| The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.
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| Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH.
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| J Neurosci. 22(18):7879-91. 2002
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85 | CDK5
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| Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway.
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| Sharma P, Veeranna, Sharma M, Amin ND, Sihag RK, Grant P, Ahn N, Kulkarni AB, Pant HC.
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| J Biol Chem. 277(1):528-34 2002
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86 | CDK5
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| Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.
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| Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y.
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| Neuron. 35(5):907-20. 2002
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87 | CDK5
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| Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.
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88 | CDK5
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| Eur J Biochem 268(6):1534-46. Review. 2001
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89 | CDK5, EIF5A
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| Maccioni RB, Otth C, Concha II, Munoz JP.
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| Eur J Biochem 268(6):1518-27. Review. 2001
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90 | CDK5, FOSB
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| Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
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| Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P.
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| Nature 410(6826):376-80. 2001
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91 | CDK5
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| Regulation of NMDA receptors by cyclin-dependent kinase-5.
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| Li BS, Sun MK, Zhang L, Takahashi S, Ma W, Vinade L, Kulkarni AB, Brady RO, Pant HC.
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| Proc Natl Acad Sci U S A. 98(22):12742-7. 2001
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92 | CDK5
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| Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology.
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| Rashid T, Banerjee M, Nikolic M.
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93 | CDK5
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| Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2.
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| J Biol Chem. 276(26):23712-8. 2001
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94 | CDK5, NDEL1, PAFAH1B1
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| NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.
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| Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, TsaiLH.
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| Neuron 28(3):697-711. 2000
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95 | ABL1, CDK5
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| Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.
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| Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Wu CL, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai LH.
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| Neuron. 26(3):633-46. 2000
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96 | CDK5
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| p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.
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| Humbert S, Dhavan R, Tsai L.
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| J Cell Sci. 113 ( Pt 6):975-83. 2000
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97 | CDK5
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| Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.
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| Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T.
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98 | CDK5
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| Identification of a common protein association region in the neuronal Cdk5 activator.
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| Wang X, Ching YP, Lam WH, Qi Z, Zhang M, Wang JH.
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99 | CDK5, CDK5R1
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| Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.
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| Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH.
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| Nature 402(6762):615-22 1999
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100 | CDK5, PPP1R1B
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| Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
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| Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC Jr, Nairn AC, Greengard P.
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| Nature 402(6762):669-71. 1999
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101 | CDK5
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| Sharma P, Sharma M, Amin ND, Albers RW, Pant HC.
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102 | CDK5
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| Identification of a human cDNA encoding a kinase-defective cdk5 isoform.
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| Biochem Biophys Res Commun 253(2):305-10. 1998
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103 | BRCA1, CDK5, E2F1
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| BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
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| Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN.
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| Oncogene. 15(2):143-57. 1997
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104 | CDK5
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| GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain.
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| Kanaoka Y, Kimura SH, Okazaki I, Ikeda M, Nojima H.
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105 | CDK5
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| Identification of functional domains in the neuronal Cdk5 activator protein.
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| Poon RY, Lew J, Hunter T.
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106 | CDK5
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| Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.
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| Ohshima T, Ward JM, Huh CG, Longenecker G, Veeranna, Pant HC, Brady RO, Martin LJ, Kulkarni AB.
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107 | CDK2, CDK4, CDK5
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| Chromosomal mapping of human CDK2,CDK4, and CDK5 cell cycle kinase genes.
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| Demetrick DJ, et al.
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108 | CDK5, CDK5R1
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| p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.
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| Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E.
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| Nature 371(6496):419-23 1994
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109 | CDK5
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| Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems.
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| Ino H, Ishizuka T, Chiba T, Tatibana M.
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