| 1 | CDH5, FABP1
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| Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.
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| Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, Gpfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, Uhln M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I.
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| Liver Int 37(1):132-140. doi: 10.1111/liv.13174. Epub 2016 Jun 22.
2017
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| 2 | ADAM10, CDH5, TSPAN17, TSPAN5
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| ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.
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| Reyat JS, Chimen M, Noy PJ, Szyroka J, Rainger GE, Tomlinson MG.
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| J Immunol 199(2):666-676. doi: 10.4049/jimmunol.1600713. Epub 2017 Jun 9.
2017
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| 3 | CDH5, CGNL1
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| Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis.
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| Chrifi I, Hermkens D, Brandt MM, van Dijk CGM, Brgisser PE, Haasdijk R, Pei J, van de Kamp EHM, Zhu C, Blonden L, Kros JM, Duncker DJ, Duckers HJ, Cheng C.
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| Cardiovasc Res 113(14):1776-1788. doi: 10.1093/cvr/cvx175.
2017
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| 4 | CDH5, GPSM2
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| VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.
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| Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA.
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| Curr Biol 27(14):2219-2225.e5. doi: 10.1016/j.cub.2017.06.020. Epub 2017 Jul 14. Erratum in: Curr Biol. 2017 Sep 11;27(17):2727.
2017
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| 5 | CDH5, CMTM3
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| CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions.
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| Chrifi I, Louzao-Martinez L, Brandt M, van Dijk CGM, Burgisser P, Zhu C, Kros JM, Duncker DJ, Cheng C.
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| Arterioscler Thromb Vasc Biol 37(6):1098-1114. doi: 10.1161/ATVBAHA.116.308792. Epub 2017 Apr 20.
2017
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| 6 | CDH5, PACSIN2
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| The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions.
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| Dorland YL, Malinova TS, van Stalborch AM, Grieve AG, van Geemen D, Jansen NS, de Kreuk BJ, Nawaz K, Kole J, Geerts D, Musters RJ, de Rooij J, Hordijk PL, Huveneers S.
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| Nat Commun 7:12210. doi: 10.1038/ncomms12210.
2016
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| 7 | CDH5, CTNNB1
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| The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression.
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| de Bruin RG, van der Veer EP, Prins J, Lee DH, Dane MJ, Zhang H, Roeten MK, Bijkerk R, de Boer HC, Rabelink TJ, van Zonneveld AJ, van Gils JM.
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| Sci Rep 6:21643. doi: 10.1038/srep21643.
2016
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| 8 | CDH5, PALS1, PARD3
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| VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.
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| Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K.
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| Mol Biol Cell. Sep 15;27(18):2811-21. doi: 10.1091/mbc.E16-02-0127. Epub 2016 Jul 27. 2016
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| 9 | CCDC88A, CDH5, RRAS
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| Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.
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| Ichimiya H, Maeda K, Enomoto A, Weng L, Takahashi M, Murohara T.
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| Biochem Biophys Res Commun 461(2):260-7. doi: 10.1016/j.bbrc.2015.04.012. Epub 2015 Apr 11.
2015
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| 10 | CDH5, RAC1, TRIO
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| A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.
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| Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD.
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| J Cell Sci 128(16):3041-54. doi: 10.1242/jcs.168674. Epub 2015 Jun 26. Erratum in: J Cell Sci. 2015 Sep 15;128(18):3514.
2015
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| 11 | CDH5, EPS8, YAP1
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| The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.
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| Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E.
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| J Cell Biol 211(6):1177-92. doi: 10.1083/jcb.201501089. Epub 2015 Dec 14.
2015
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| 12 | CDH5
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| Endothelial permeability and VE-cadherin: a wacky comradeship.
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| Gavard J.
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| Cell Adh Migr 8(2):158-64. Review.
2014
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| 13 | CDH5
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| Cdh5/VE-cadherin promotes endothelial cell interface elongation via cortical actin polymerization during angiogenic sprouting.
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| Sauteur L, Krudewig A, Herwig L, Ehrenfeuchter N, Lenard A, Affolter M, Belting HG.
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| Cell Rep 9(2):504-13. doi: 10.1016/j.celrep.2014.09.024. Epub 2014 Oct 16.
2014
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| 14 | AMOTL2, CDH5
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| AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.
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| Hultin S, Zheng Y, Mojallal M, Vertuani S, Gentili C, Balland M, Milloud R, Belting HG, Affolter M, Helker CS, Adams RH, Herzog W, Uhlen P, Majumdar A, Holmgren L.
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| Nat Commun 5:3743. doi: 10.1038/ncomms4743.
2014
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| 15 | CDH5, CHRM3, IQGAP1, RAC1
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| M3 muscarinic acetylcholine receptor dysfunction inhibits Rac1 activity and disrupts VE-cadherin/β-catenin and actin cytoskeleton interaction.
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| Jiao ZY, Wu J, Wen B, Zhao WZ, Du XL.
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| Biochem Cell Biol 92(2):137-44. doi: 10.1139/bcb-2013-0042. Epub 2014 Jan 8.
2014
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| 16 | CDH5, CTNNB1, CTNND1
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| p120-catenin and β-catenin differentially regulate cadherin adhesive function.
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| Oas RG, Nanes BA, Esimai CC, Vincent PA, Garca AJ, Kowalczyk AP.
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| Mol Biol Cell 24(6):704-14. doi: 10.1091/mbc.E12-06-0471. Epub 2013 Jan 16.
2013
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| 17 | CDH5
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| VE-cadherin status as an indicator of microvascular permeability.
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| Monaghan-Benson E, Burridge K.
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| Methods Mol Biol 1046:335-42. doi: 10.1007/978-1-62703-538-5_20.
2013
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| 18 | CDH5, CLDN5, NECTIN2
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| Human chorionic gonadotropin controls luteal vascular permeability via vascular endothelial growth factor by down-regulation of a cascade of adhesion proteins.
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| Herr D, Fraser HM, Konrad R, Holzheu I, Kreienberg R, Wulff C.
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| Fertil Steril 99(6):1749-58. doi: 10.1016/j.fertnstert.2013.01.120. Epub 2013 Mar 7.
2013
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| 19 | CDH5
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| Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.
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| Huveneers S, Oldenburg J, Spanjaard E, van der Krogt G, Grigoriev I, Akhmanova A, Rehmann H, de Rooij J.
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| J Cell Biol 196(5):641-52.
2012
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| 20 | CDH5
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| Vascular endothelial cadherin modulates renal interstitial fibrosis.
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| Yamaguchi I, Tchao BN, Burger ML, Yamada M, Hyodo T, Giampietro C, Eddy AA.
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| Nephron Exp Nephrol 120(1):e20-31. Epub 2011 Nov 25.
2012
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| 21 | CDH5, SOX7
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| SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development.
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| Costa G, Mazan A, Gandillet A, Pearson S, Lacaud G, Kouskoff V.
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| Development 139(9):1587-98.
2012
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| 22 | CDH5, CTNNB1, PTPN11
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| The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation.
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| Timmerman I, Hoogenboezem M, Bennett AM, Geerts D, Hordijk PL, van Buul JD.
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| Mol Biol Cell 23(21):4212-25. doi: 10.1091/mbc.E12-01-0038. Epub 2012 Sep 5.
2012
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| 23 | CDH5, MAPRE3
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| VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule growth and assemble adherens junctions.
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| Komarova YA, Huang F, Geyer M, Daneshjou N, Garcia A, Idalino L, Kreutz B, Mehta D, Malik AB.
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| Mol Cell 48(6):914-25. doi: 10.1016/j.molcel.2012.10.011. Epub 2012 Nov 15.
2012
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| 24 | CDH5, JCAD
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| A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions.
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| Akashi M, Higashi T, Masuda S, Komori T, Furuse M.
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| Biochem Biophys Res Commun 413(2):224-9. Epub 2011 Aug 22.
2011
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| 25 | CDH5, CTNNA1
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| Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability.
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| Schulte D, Kppers V, Dartsch N, Broermann A, Li H, Zarbock A, Kamenyeva O, Kiefer F, Khandoga A, Massberg S, Vestweber D.
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| EMBO J 30(20):4157-70. doi: 10.1038/emboj.2011.304.
2011
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| 26 | CDH5
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| Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation.
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| Hatanaka K, Simons M, Murakami M.
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| Am J Physiol Heart Circ Physiol 300(1):H162-72. Epub 2010 Oct 29.
2011
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| 27 | CDH5, CEACAM1, PECAM1
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| Angiopoietins-1 and -2 play opposing roles in endothelial sprouting of embryoid bodies in 3D culture and their receptor Tie-2 associates with the cell-cell adhesion molecule PECAM1.
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| Gu A, Shively JE.
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| Exp Cell Res 317(15):2171-82. Epub 2011 Jun 23.
2011
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| 28 | CDH5, KLF4
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| Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function.
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| Cowan CE, Kohler EE, Dugan TA, Mirza MK, Malik AB, Wary KK.
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| Circ Res 107(8):959-66. Epub 2010 Aug 19.
2010
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| 29 | CDH5, PECAM1
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| VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers.
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| Akers SM, O'Leary HA, Minnear FL, Craig MD, Vos JA, Coad JE, Gibson LF.
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| Exp Hematol 38(9):733-43. Epub 2010 May 12.
2010
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| 30 | CDH5
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| Differential expression of VE-cadherin and VEGFR2 in placental syncytiotrophoblast during preeclampsia - New perspectives to explain the pathophysiology.
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| Groten T, Gebhard N, Kreienberg R, Schleussner E, Reister F, Huppertz B.
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| Placenta 31(4):339-43. Epub 2010 Feb 18.
2010
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| 31 | CDH5
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| VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation.
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| Abraham S, Yeo M, Montero-Balaguer M, Paterson H, Dejana E, Marshall CJ, Mavria G.
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| Curr Biol 19(8):668-74. Epub 2009 Apr 2.
2009
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| 32 | CDH5
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| Breaking the VE-cadherin bonds.
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| Gavard J.
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| FEBS Lett 583(1):1-6. Epub 2008 Dec 4. Review.
2009
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| 33 | CDH5
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| Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling.
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| Labelle M, Schnittler HJ, Aust DE, Friedrich K, Baretton G, Vestweber D, Breier G.
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| Cancer Res 68(5):1388-97. 2008
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| 34 | VEGFA, CDH5
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| A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor.
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| Ha CH, Bennett AM, Jin ZG.
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| J Biol Chem 283(11):7261-70. Epub 2008 Jan 7. 2008
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| 35 | CDH5
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| VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
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| Rudini N, Felici A, Giampietro C, Lampugnani M, Corada M, Swirsding K, Garr M, Liebner S, Letarte M, ten Dijke P, Dejana E.
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| EMBO J 27(7):993-1004. Epub 2008 Mar 13. 2008
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| 36 | CDH5, CLDN5
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| Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
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| Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, Potente M, Daly C, Dimmeler S, Dejana E.
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| Nat Cell Biol 10(8):923-34. Epub 2008 Jul 6.
2008
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| 37 | CSK, CDH5
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| Association of Csk to VE-cadherin and inhibition of cell proliferation.
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| Baumeister U, Funke R, Ebnet K, Vorschmitt H, Koch S, Vestweber D.
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| EMBO J 24(9):1686-95. Epub 2005 Apr 7. 2005
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| 38 | CDH5
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| CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system.
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| Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM.
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| Oncogene 22(7):1002-11. 2003
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| 39 | CDH5, CHD6
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| CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases.
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| Schuster EF, Stoger R.
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| Mamm Genome 13(2):117-9. No abstract available. 2002
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| 40 | CDH1, CDH10, CDH11, CDH12, CDH12P, CDH13, CDH15, CDH16, CDH17, CDH18, CDH19, CDH2, CDH20, CDH23, CDH3, CDH4, CDH5, CDH6, CDH7, CDH8, CDH9, PCDH11Y, PCDHA@, PCDHA1, PCDHA10, PCDHA11, PCDHA12, PCDHA13, PCDHA14, PCDHA2, PCDHA3, PCDHA4, PCDHA5, PCDHA6, PCDHA7, PCDHA8, PCDHA9, PCDHACT, PCDHB1, PCDHB10, PCDHB11, PCDHB12, PCDHB13, PCDHB14, PCDHB15, PCDHB16, PCDHB2, PCDHB3, PCDHB4, PCDHB5, PCDHB6, PCDHB7, PCDHB8, PCDHB9, PCDHAC1, PCDHAC2, PCDHGA1, PCDHGA10, PCDHGA11, PCDHGA12, PCDHGA2, PCDHGA3, PCDHGA4, PCDHGA5, PCDHGA6, PCDHGA7, PCDHGA8, PCDHGA9, PCDHGB1, PCDHGB2, PCDHGB3, PCDHGB4, PCDHGB5, PCDHGB6, PCDHGB7, PCDHGC3, PCDHGC4, PCDHGC5, PCDHGCT
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| Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.
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| Nollet F, Kools P, van Roy F.
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| J Mol Biol 299(3):551-72. Review. 2000
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| 41 | CDH19, CDH15, CDH12, CDH10, CDH9, CDH8, CDH7, CDH7, CDH6, CDH5, CDH18
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| Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.
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| Shimoyama Y, Tsujimoto G, Kitajima M, Natori M.
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| Biochem J 349(Pt 1):159-67. 2000
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| 42 | CDH5
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| Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo.
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| Corada M, et al.
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| Proc Natl Acad Sci U S A 96(17):9815-20 1999
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| 43 | CDH3, CDH5, CDH6, CDH7, CDH8, CDH11, CDH13, CDH15, CDH17
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| Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.
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| Kremmidiotis G, et al.
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| Genomics 49 : 467-471. 1998
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| 44 | CDH5
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| Diversity of the cadherin family : evidence for eight new cadherins in nervous tissue.
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| Suzuki S, et al.
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| Cell Regul 2 : 261-270. 1991
|