Citations for
1CDC73, LEO1, PAF1, RTF1, RTF1
Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin.
Wier AD, Mayekar MK, Hroux A, Arndt KM, VanDemark AP.
Proc Natl Acad Sci U S A 110(43):17290-5. doi: 10.1073/pnas.1314754110. Epub 2013 Oct 7. 2013
2CDC73, RNF40, rNF20
The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination.
Hahn MA, Dickson KA, Jackson S, Clarkson A, Gill AJ, Marsh DJ.
Hum Mol Genet 21(3):559-68. Epub 2011 Oct 21. 2012
3CDC73, RTF1
Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.
Amrich CG, Davis CP, Rogal WP, Shirra MK, Heroux A, Gardner RG, Arndt KM, VanDemark AP.
J Biol Chem 287(14):10863-75. doi: 10.1074/jbc.M111.325647. Epub 2012 Feb 8. 2012
4CDC73
Parafibromin expression is an independent prognostic factor for colorectal carcinomas.
Zheng HC, Wei ZL, Xu XY, Nie XC, Yang X, Takahashi H, Takano Y.
Hum Pathol 42(8):1089-102. Epub 2011 Feb 11. 2011
5CDC73
Absence of nucleolar parafibromin immunoreactivity in subsets of parathyroid malignant tumours.
Juhlin CC, Haglund F, Obara T, Arnold A, Larsson C, Hg A.
Virchows Arch 459(1):47-53. Epub 2011 Jan 8. 2011
6CDC73, PTPN11
SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.
Takahashi A, Tsutsumi R, Kikuchi I, Obuse C, Saito Y, Seidi A, Karisch R, Fernandez M, Cho T, Ohnishi N, Rozenblatt-Rosen O, Meyerson M, Neel BG, Hatakeyama M.
Mol Cell 43(1):45-56. 2011
7CDC73, CPEB1
Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.
Zhang JH, Panicker LM, Seigneur EM, Lin L, House CD, Morgan W, Chen WC, Mehta H, Haj-Ali M, Yu ZX, Simonds WF.
Cell Death Differ 17(10):1551-65. Epub 2010 Mar 26. 2010
8CDC73, HRPT2
Cell division cycle protein 73 homolog (CDC73) mutations in the hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid tumors.
Newey PJ, Bowl MR, Cranston T, Thakker RV.
Hum Mutat 31(3):295-307. 2010
9CDC73, CPSF2, CPSF3, CSTF3
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.
Rozenblatt-Rosen O, Nagaike T, Francis JM, Kaneko S, Glatt KA, Hughes CM, LaFramboise T, Manley JL, Meyerson M.
Proc Natl Acad Sci U S A 106(3):755-60. Epub 2009 Jan 9. 2009
10BTK, CDC73
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT.
Sci Signal 2(72):ra25. 2009
11CDC73, HRPT2, PAF1
The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.
Lin L, Zhang JH, Panicker LM, Simonds WF.
Proc Natl Acad Sci U S A 105(45):17420-5. Epub 2008 Nov 5. 2008
12CDC73, RTF1
Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.
Nordick K, Hoffman MG, Betz JL, Jaehning JA.
Eukaryot Cell 7(7):1158-67. doi: 10.1128/EC.00434-07. Epub 2008 May 9. 2008
13CDC73
Parafibromin is a nuclear protein with a functional monopartite nuclear localization signal.
Bradley KJ, Bowl MR, Williams SE, Ahmad BN, Partridge CJ, Patmanidi AL, Kennedy AM, Loh NY, Thakker RV.
Oncogene 26(8):1213-21. Epub 2006 Sep 11. 2007
14CDC73
Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function.
Lin L, Czapiga M, Nini L, Zhang JH, Simonds WF.
Mol Cancer Res 5(2):183-93. 2007
15CDC73
Sporadic human renal tumors display frequent allelic imbalances and novel mutations of the HRPT2 gene.
Zhao J, Yart A, Frigerio S, Perren A, Schraml P, Weisstanner C, Stallmach T, Krek W, Moch H.
Oncogene 26(23):3440-9. Epub 2006 Nov 27. 2007
16CDC73
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Mosimann C, Hausmann G, Basler K.
Cell 125(2):327-41. 2006
17CDC73
Parafibromin inhibits cancer cell growth and causes G1 phase arrest.
Zhang C, Kong D, Tan MH, Pappas DL Jr, Wang PF, Chen J, Farber L, Zhang N, Koo HM, Weinreich M, Williams BO, Teh BT.
Biochem Biophys Res Commun 350(1):17-24. Epub 2006 Sep 7. 2006
18PAF1, LEO1, CDC73, CTR9
The parafibromin tumor suppressor protein is part of a human Paf1 complex.
Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, Shanmugam KS, Copeland TD, Guszczynski T, Resau JH, Meyerson M.
Mol Cell Biol 25(2):612-20. 2005
19CDC73, HRPT2
A Novel IVS2-1G>A mutation causes aberrant splicing of the HRPT2 gene in a family with hyperparathyroidism-jaw tumor syndrome.
Moon SD, Park JH, Kim EM, Kim JH, Han JH, Yoo SJ, Yoon KH, Kang MI, Lee KW, Son HY, Kang SK, Oh SJ, Kim KM, Yoon SJ, Park JG, Kim IJ, Kang HC, Hong SW, Kim KR, Cha BY.
J Clin Endocrinol Metab 90(2):878-83. Epub 2004 Dec 21. 2005
20CDC73
Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression.
Woodard GE, Lin L, Zhang JH, Agarwal SK, Marx SJ, Simonds WF.
Oncogene 24(7):1272-6. 2005
21CDC73, PAF1, LEO1, CTR9
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
Yart A, Gstaiger M, Wirbelauer C, Pecnik M, Anastasiou D, Hess D, Krek W.
Mol Cell Biol 25(12):5052-60. 2005
22HRPT2, CDC73
HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome.
Wang PF, Tan MH, Zhang C, Morreau H, Teh BT.
Horm Metab Res 37(6):380-3. Review. 2005
23CDC73
Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin.
Hahn MA, Marsh DJ.
Oncogene 24(41):6241-8. Erratum in: Oncogene. 2007 Feb 1;26(5):788. 2005
24CDC73
HRPT2, a marker of parathyroid cancer.
Weinstein LS, Simonds WF.
N Engl J Med 349(18):1691-2. No abstract available. 2003
25CDC73, HRPT2
Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma.
Shattuck TM, Valimaki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A.
N Engl J Med 349(18):1722-9. 2003
26CDC73, HRPT2
HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours.
Howell VM, Haven CJ, Kahnoski K, Khoo SK, Petillo D, Chen J, Fleuren GJ, Robinson BG, Delbridge LW, Philips J, Nelson AE, Krause U, Hammje K, Dralle H, Hoang-Vu C, Gimm O, Marsh DJ, Morreau H, Teh BT.
J Med Genet 40(9):657-63. Erratum in: J Med Genet. 2004 Jan;41(1):20. 2003
27HRPT2, CDC73
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome.
Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Hoog A, Heath H 3rd, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, Teh BT, Larsson C, Hobbs MR.
Nat Genet 32(4):676-80. Epub 2002 Nov 18. 2002
28C1orf14, C1orf18, C1orf20, C1orf21, C1orf23, C1orf26, C1orf27, CDC73, EDEM3, FAM129A, GLT25D2, NMNAT2, NPL, RGS8, SMG7, TRM1L, TSEN15
Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.
Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD,Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, KlingerKW, Landes GM, Trent JM, Carpten JD.
Genomics 73(2):211-22. 2001
29CDC73
Hyperparathyroidism-Jaw Tumor Syndrome: The HRPT2 Locus Is within a 0.7-cM Region on Chromosome 1q.
Hobbs MR, et al.
Am J Hum Genet 64(2):518-525. 1999
30CDC73
Mapping the gene causing hereditary primary hyperparathyroidism in a Portuguese kindred to chromosome 1q22-q31.
Williamson C, et al.
J Bone Miner Res 14(2):230-9. 1999
31CDC73, TSG1F, HRPT1
Familial isolated hyperparathyroidism maps to the hyperparathyroidism-jaw tumor locus in 1q21-q32 in a subset of families.
Teh BT, et al.
J Clin Endocrinol Metab 83 : 2114-2120. 1998
32CDC73
Autosomal dominant primary hyperparathyroidism and jaw tumor syndrome associated with renal hamartomas and cystic kidney disease : linkage to 1q21-q32 and loss of the wild type allele in renal hamartomas.
Teh BT, et al.
J Clin Endocrinol Metab 81 : 4204-4211. 1996
33CDC73
Hereditary hyperparathyroidism-Jaw tumor syndrome : the endocrine tumor gene HRPT2 maps to chromosome 1q21-q31.
Szabo J, et al.
Am J Hum Genet 56 : 944-950. 1995