Citations for
Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation.
Gao Y, Yao J, Poudel S, Romer E, Abu-Niaaj L, Leffak M.
J Biol Chem 289(52):35987-6000. doi: 10.1074/jbc.M114.589119. Epub 2014 Sep 25. 2014
Mcm2 phosphorylation and the response to replicative stress.
Stead BE, Brandl CJ, Sandre MK, Davey MJ.
BMC Genet 13:36. doi: 10.1186/1471-2156-13-36. 2012
Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition.
Kitamura R, Fukatsu R, Kakusho N, Cho YS, Taniyama C, Yamazaki S, Toh GT, Yanagi K, Arai N, Chang HJ, Masai H.
J Biol Chem 286(26):23031-43. Epub 2011 May 2. 2011
Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication.
Day TA, Palle K, Barkley LR, Kakusho N, Zou Y, Tateishi S, Verreault A, Masai H, Vaziri C.
J Cell Biol 191(5):953-66. Epub 2010 Nov 22. 2010
Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.
Chen YC, Weinreich M.
J Biol Chem 285(53):41244-54. Epub 2010 Oct 29. 2010
Targeting cell division cycle 7 kinase: a new approach for cancer therapy.
Montagnoli A, Moll J, Colotta F.
Clin Cancer Res 16(18):4503-8. Epub 2010 Jul 20. Review. 2010
7CDC45, CDC7, CDT1
Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase.
Ballabeni A, Zamponi R, Caprara G, Melixetian M, Bossi S, Masiero L, Helin K.
J Biol Chem 284(5):3028-36. Epub 2008 Dec 3. 2009
Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.
Miller CT, Gabrielse C, Chen YC, Weinreich M.
PLoS Genet 5(5):e1000498. Epub 2009 May 29. 2009
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.
Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, Rodriguez-Acebes S, Prevost AT, Ledermann JA, Stoeber K, Williams GH.
Clin Cancer Res 15(7):2417-25. Epub 2009 Mar 24. 2009
Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.
Kim JM, Kakusho N, Yamada M, Kanoh Y, Takemoto N, Masai H.
Oncogene 27(24):3475-82. Epub 2007 Dec 17.PMID: 18084324 2008
11CDC7, DBF4, MCM2
Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells.
Charych DH, Coyne M, Yabannavar A, Narberes J, Chow S, Wallroth M, Shafer C, Walter AO.
J Cell Biochem 104(3):1075-86. 2008
Identification and characterization of human cdc7 nuclear retention and export sequences in the context of chromatin binding.
Kim BJ, Kim SY, Lee H.
J Biol Chem 282(41):30029-38. Epub 2007 Aug 20. 2007
Cdc7 is an active kinase in human cancer cells undergoing replication stress.
Tenca P, Brotherton D, Montagnoli A, Rainoldi S, Albanese C, Santocanale C.
J Biol Chem 282(1):208-15. Epub 2006 Oct 24. 2007
14MCM2, MCM4, MCM6, CDC7
Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
Masai H, Taniyama C, Ogino K, Matsui E, Kakusho N, Matsumoto S, Kim JM, Ishii A, Tanaka T, Kobayashi T, Tamai K, Ohtani K, Arai K.
J Biol Chem 281(51):39249-61. Epub 2006 Oct 17. 2006
Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
Tsuji T, Ficarro SB, Jiang W.
Mol Biol Cell 17(10):4459-72. Epub 2006 Aug 9. 2006
CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein.
Cho WH, Lee YJ, Kong SI, Hurwitz J, Lee JK.
Proc Natl Acad Sci U S A 103(31):11521-6. Epub 2006 Jul 24. 2006
The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen.
Gˇrard A, Koundrioukoff S, Ramillon V, Serg¸re JC, Mailand N, Quivy JP, Almouzni G.
EMBO Rep 7(8):817-23. Epub 2006 Jul 7. 2006
Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis.
Kim JM, Takemoto N, Arai K, Masai H.
EMBO J 22(19):5260-72. 2003
A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines.
Hess GF, Drong RF, Weiland KL, Slightom JL, Sclafani RA, Hollingsworth RE.
Gene 211(1):133-40. 1998
Human and xenopus cDNAs encoding budding yeast Cdc7-related kinases : in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7.
Sato N, et al.
EMBO J 16 : 4340-4351. 1997
21CDC7, MCM3
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7.
Sato N, Arai K, Masai H.
EMBO J 16(14):4340-51. 1997
Identification and characterization of a human protein kinase related to budding yeast Cdc7p.
Jiang W, Hunter T.
Proc Natl Acad Sci U S A 94(26):14320-5. 1997