Citations for
1CDC42, PAK2
PAK2 activated by Cdc42 and caspase 3 mediates different cellular responses to oxidative stress-induced apoptosis
Huang J, Huang A, Poplawski A, DiPino F Jr, Traugh JA, Ling J.
Biochim Biophys Acta Mol Cell Res. Apr;1867(4):118645. doi: 10.1016/j.bbamcr.2020.118645. Epub 2020 Jan 8. 2020
2CDC42, ODF2
CCDC42 Localizes to Manchette, HTCA and Tail and Interacts With ODF1 and ODF2 in the Formation of the Male Germ Cell Cytoskeleton.
Tapia Contreras C, Hoyer-Fender S.
Front Cell Dev Biol. Aug 14;7:151. doi: 10.3389/fcell.2019.00151. eCollection 2019. 2019
3CDC42, MTCMR
Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes.
Martinelli S, Krumbach OHF, Pantaleoni F, Coppola S, Amin E, Pannone L, Nouri K, Farina L, Dvorsky R, Lepri F, Buchholzer M, Konopatzki R, Walsh L, Payne K, Pierpont ME, Vergano SS, Langley KG, Larsen D, Farwell KD, Tang S, Mroske C, Gallotta I, Di Schiavi E, Della Monica M, Lugli L, Rossi C, Seri M, Cocchi G, Henderson L, Baskin B, Alders M, Mendoza-Londono R, Dupuis L, Nickerson DA, Chong JX; University of Washington Center for Mendelian Genomics, Meeks N, Brown K, Causey T, Cho MT, Demuth S, Digilio MC, Gelb BD, Bamshad MJ, Zenker M, Ahmadian MR, Hennekam RC, Tartaglia M, Mirzaa GM.
Am J Hum Genet m J Hum Genet. 2018 Jan 17. pii: S0002-9297(17)30504-9. doi: 10.1016/j.ajhg.2017.12.015. [Epub ahead of print] 2018
4CDC42, WNT4
An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation.
Chen XF, Zhu DL, Yang M, Hu WX, Duan YY, Lu BJ, Rong Y, Dong SS, Hao RH, Chen JB, Chen YX, Yao S, Thynn HN, Guo Y, Yang TL.
Am J Hum Genet 102(5):776-793. doi: 10.1016/j.ajhg.2018.03.001. Epub 2018 Apr 26. 2018
5CDC42, RASIP1
Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions.
Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, Cleaver O, Oliver G.
Development 145(17). pii: dev165092. doi: 10.1242/dev.165092. 2018
6CDC42, ITSN1, ITSN2
Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.
Ashraf S, Kudo H, Rao J, Kikuchi A, Widmeier E, Lawson JA, Tan W, Hermle T, Warejko JK, Shril S, Airik M, Jobst-Schwan T, Lovric S, Braun DA, Gee HY, Schapiro D, Majmundar AJ, Sadowski CE, Pabst WL, Daga A, van der Ven AT, Schmidt JM, Low BC, Gupta AB, Tripathi BK, Wong J, Campbell K, Metcalfe K, Schanze D, Niihori T, Kaito H, Nozu K, Tsukaguchi H, Tanaka R, Hamahira K, Kobayashi Y, Takizawa T, Funayama R, Nakayama K, Aoki Y, Kumagai N, Iijima K, Fehrenbach H, Kari JA, El Desoky S, Jalalah S, Bogdanovic R, Stajić N, Zappel H, Rakhmetova A, Wassmer SR, Jungraithmayr T, Strehlau J, Kumar AS, Bagga A, Soliman NA, Mane SM, Kaufman L, Lowy DR, Jairajpuri MA, Lifton RP, Pei Y, Zenker M, Kure S, Hildebrandt F.
Nat Commun 9(1):1960. doi: 10.1038/s41467-018-04193-w. 2018
7CDC42, DOCK8, LURAP1
DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction.
Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y.
J Biol Chem 292(6):2191-2202. doi: 10.1074/jbc.M116.736306. Epub 2016 Dec 27. 2017
8CDC42, DOCK8, LRCH1
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis
Xu X, Han L, Zhao G, Xue S, Gao Y, Xiao J, Zhang S, Chen P, Wu ZY, Ding J, Hu R, Wei B, Wang H.
J Exp Med. Jan;214(1):209-226. doi: 10.1084/jem.20160068. 2017
9CDC42, GOPC, GRID2
Potential of GRID2 receptor gene for preventing TNF-induced neurodegeneration in autism.
Kalkan Z, Durasi İM, Sezerman U, Atasever-Arslan B.
Neurosci Lett 620:62-9. doi: 10.1016/j.neulet.2016.03.043. Epub 2016 Mar 25. 2016
10CDC42, MTCMR
Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
Takenouchi T, Okamoto N, Ida S, Uehara T, Kosaki K.
Am J Med Genet A 170A(4):852-5. doi: 10.1002/ajmg.a.37526. Epub 2015 Dec 28. 2016
11CDC42, WASL, YAP1
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Huang Z, Zhang L, Chen Y, Zhang H, Zhang Q, Li R, Ma J, Li Z, Yu C, Lai Y, Lin T, Zhao X, Zhang B, Ye Z, Liu S, Wang W, Liang X, Liao R, Shi W.
Cell Death Dis 7:e2142. doi: 10.1038/cddis.2016.51. 2016
12CDC42, WASL
The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.
Palazzo A, Bluteau O, Messaoudi K, Marangoni F, Chang Y, Souquere S, Pierron G, Lapierre V, Zheng Y, Vainchenker W, Raslova H, Debili N.
J Thromb Haemost 14(12):2524-2535. doi: 10.1111/jth.13519. Epub 2016 Nov 15. 2016
13CDC42, ERRFI1
Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF.
Jiang X, Niu M, Chen D, Chen J, Cao Y, Li X, Ying H, Bergholz J, Zhang Y, Xiao ZX.
Oncotarget 7(31):49180-49193. doi: 10.18632/oncotarget.10205. 2016
14CDC42, PICK1, RAC1
PICK1 links AMPA receptor stimulation to Cdc42.
Rocca DL, Hanley JG.
Neurosci Lett 585:155-9. doi: 10.1016/j.neulet.2014.11.046. Epub 2014 Dec 2. 2015
15CDC42, MARCKS, RAC1
Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation.
Yu D, Makkar G, Strickland DK, Blanpied TA, Stumpo DJ, Blackshear PJ, Sarkar R, Monahan TS.
J Am Heart Assoc 4(10):e002255. doi: 10.1161/JAHA.115.002255. 2015
16CDC42, EPHB2, PAK3
Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation.
Hussain NK, Thomas GM, Luo J, Huganir RL.
Proc Natl Acad Sci U S A 112(43):E5883-90. doi: 10.1073/pnas.1518382112. Epub 2015 Oct 12. 2015
17CDC42, MTCMR
Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.
Takenouchi T, Kosaki R, Niizuma T, Hata K, Kosaki K.
Am J Med Genet A 167A(11):2822-5. doi: 10.1002/ajmg.a.37275. Epub 2015 Aug 6. 2015
18ATP8B1, CDC42
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL.
J Cell Biol 210(7):1055-63. doi: 10.1083/jcb.201505118. 2015
19CDC42, PTBP1
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
He X, Yuan C, Yang J.
Oncotarget 6(30):29651-63. doi: 10.18632/oncotarget.4865. 2015
20ARF1, ARHGAP21, CDC42
CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.
Schultz ML, Tecedor L, Stein CS, Stamnes MA, Davidson BL.
PLoS One 9(5):e96647. doi: 10.1371/journal.pone.0096647. eCollection 2014. 2014
21CDC42
DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding.
Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H, Grosse F.
Nucleic Acids Res 42(4):2308-19. doi: 10.1093/nar/gkt1217. Epub 2013 Nov 28. 2014
22CDC42, SH3PXD2A
Cdc42 and Tks5: a minimal and universal molecular signature for functional invadosomes.
Di Martino J, Paysan L, Gest C, Lagrée V, Juin A, Saltel F, Moreau V.
Cell Adh Migr 8(3):280-92. 2014
23CDC42, RAC1, RACGAP1
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
Lorès P, Vernet N, Kurosaki T, Van de Putte T, Huylebroeck D, Hikida M, Gacon G, Touré A.
Dev Biol 386(2):419-27. doi: 10.1016/j.ydbio.2013.12.006. 2014
24CDC42, RHOA, STARD13
StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion.
Hanna S, Khalil B, Nasrallah A, Saykali BA, Sobh R, Nasser S, El-Sibai M.
Int J Oncol 44(5):1499-511. doi: 10.3892/ijo.2014.2330. Epub 2014 Mar 7. 2014
25CDC42, ITSN1, NCK1, WASL
Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation.
Humphries AC, Donnelly SK, Way M.
J Cell Sci 127(Pt 3):673-85. doi: 10.1242/jcs.141366. Epub 2013 Nov 27. 2014
26CDC42, EXOC5
Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys.
Choi SY, Chacon-Heszele MF, Huang L, McKenna S, Wilson FP, Zuo X, Lipschutz JH.
J Am Soc Nephrol Am Soc Nephrol. 2013 Jun 13. [Epub ahead of print] 2013
27BAIAP2, CDC42, TGFBR3, WAS
The Type III TGF-β receptor regulates filopodia formation via a Cdc42-mediated IRSP53: NWASP interaction in epithelial cells.
Oh SY, Knelson EH, Blobe GC, Mythreye K.
Biochem J iochem J. 2013 Jun 10. [Epub ahead of print] 2013
28CDC42, DOCK7
Prenylation and Membrane Localization of Cdc42 Are Essential for Activation by DOCK7.
Zhou Y, Johnson JL, Cerione RA, Erickson JW.
Biochemistry iochemistry. 2013 Jun 14. [Epub ahead of print] 2013
29CDC42
Cdc42 promotes host defenses against fatal infection.
Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R.
Infect Immun nfect Immun. 2013 May 20. [Epub ahead of print] 2013
30CDC42, RAC1
Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.
Blattner SM, Hodgin JB, Nishio M, Wylie SA, Saha J, Soofi AA, Vining C, Randolph A, Herbach N, Wanke R, Atkins KB, Gyung Kang H, Henger A, Brakebusch C, Holzman LB, Kretzler M.
Kidney Int idney Int. 2013 May 15. doi: 10.1038/ki.2013.175. [Epub ahead of print] 2013
31CDC42
Cdc42 interacts with the exocyst complex to promote phagocytosis.
Mohammadi S, Isberg RR.
J Cell Biol 200(1):81-93. doi: 10.1083/jcb.201204090. 2013
32CDC42, RAC1
Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis.
Vadodaria KC, Brakebusch C, Suter U, Jessberger S.
J Neurosci 33(3):1179-89. doi: 10.1523/JNEUROSCI.2103-12.2013. 2013
33CDC42
CDC42 is required for structural patterning of the lung during development.
Wan H, Liu C, Wert SE, Xu W, Liao Y, Zheng Y, Whitsett JA.
Dev Biol 374(1):46-57. doi: 10.1016/j.ydbio.2012.11.030. Epub 2012 Dec 5. 2013
34ARHGAP21, CDC42, TUBA1B
ARHGAP21 protein, a new partner of α-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition.
Barcellos KS, Bigarella CL, Wagner MV, Vieira KP, Lazarini M, Langford PR, Machado-Neto JA, Call SG, Staley DM, Chung JY, Hansen MD, Saad ST.
J Biol Chem 288(4):2179-89. doi: 10.1074/jbc.M112.432716. Epub 2012 Dec 12. 2013
35CDC42, ITSN1
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
Friesland A, Zhao Y, Chen YH, Wang L, Zhou H, Lu Q.
Proc Natl Acad Sci U S A 110(4):1261-6. doi: 10.1073/pnas.1116051110. Epub 2013 Jan 2. 2013
36CDC42, FGF8
Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein.
Hulstrand AM, Houston DW.
Dev Biol 382(2):385-99. doi: 10.1016/j.ydbio.2013.08.020. Epub 2013 Aug 29. 2013
37CDC42, GNAQ
Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling.
Vowinckel J, Stahlberg S, Paulmann N, Bluemlein K, Grohmann M, Ralser M, Walther DJ.
FEBS Lett 586(21):3819-24. doi: 10.1016/j.febslet.2012.09.027. Epub 2012 Sep 26. 2012
38CDC42
Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.
Reymond N, Im JH, Garg R, Vega FM, Borda d'Agua B, Riou P, Cox S, Valderrama F, Muschel RJ, Ridley AJ.
J Cell Biol 199(4):653-68. doi: 10.1083/jcb.201205169. 2012
39CDC42, EDN1
Endothelin-1 stimulates human trophoblast cell migration through Cdc42 activation.
Liu S, Li Q, Na Q, Liu C.
Placenta 33(9):712-6. doi: 10.1016/j.placenta.2012.06.010. Epub 2012 Jul 6. 2012
40CDC42
Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting.
Stengel KR, Zheng Y.
PLoS One 7(6):e37317. doi: 10.1371/journal.pone.0037317. Epub 2012 Jun 18. 2012
41CDC42
Podocyte-specific loss of Cdc42 leads to congenital nephropathy.
Scott RP, Hawley SP, Ruston J, Du J, Brakebusch C, Jones N, Pawson T.
J Am Soc Nephrol 23(7):1149-54. doi: 10.1681/ASN.2011121206. Epub 2012 Apr 19. 2012
42CDC42, PTK2
Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues.
Myers JP, Robles E, Ducharme-Smith A, Gomez TM.
J Cell Sci 125(Pt 12):2918-29. doi: 10.1242/jcs.100107. Epub 2012 Mar 5. 2012
43CDC42
Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth.
Das M, Drake T, Wiley DJ, Buchwald P, Vavylonis D, Verde F.
Science 337(6091):239-43. doi: 10.1126/science.1218377. Epub 2012 May 17. 2012
44CDC42, PARD3, PARD6A
Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3.
Cadot B, Gache V, Vasyutina E, Falcone S, Birchmeier C, Gomes ER.
EMBO Rep 13(8):741-9. doi: 10.1038/embor.2012.89. Epub 2012 Jun 26. 2012
45CDC42, DOCK8
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y.
Blood 119(19):4451-61. doi: 10.1182/blood-2012-01-407098. Epub 2012 Mar 28. 2012
46CDC42, OPHN1, RAC1, RHOA
The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets.
Elvers M, Beck S, Fotinos A, Ziegler M, Gawaz M.
Cardiovasc Res 94(3):526-36. doi: 10.1093/cvr/cvs079. Epub 2012 Feb 1. 2012
47CDC42, SYNCRIP
hnRNP Q regulates Cdc42-mediated neuronal morphogenesis.
Chen HH, Yu HI, Chiang WC, Lin YD, Shia BC, Tarn WY.
Mol Cell Biol 32(12):2224-38. doi: 10.1128/MCB.06550-11. Epub 2012 Apr 9. 2012
48CD2AP, CDC42, CGNL1, SH3BP1
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
Elbediwy A, Zihni C, Terry SJ, Clark P, Matter K, Balda MS.
J Cell Biol 198(4):677-93. doi: 10.1083/jcb.201202094. Epub 2012 Aug 13. 2012
49CDC42, PRKCI
Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis.
Qi Y, Liu J, Wu X, Brakebusch C, Leitges M, Han Y, Corbett SA, Lowry SF, Graham AM, Li S.
Arterioscler Thromb Vasc Biol 31(8):1861-70. Epub 2011 Jun 9. 2011
50ARHGEF9, CDC42
Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.
Tyagarajan SK, Ghosh H, Harvey K, Fritschy JM.
J Cell Sci 124(Pt 16):2786-96. 2011
51CDC42, NPC1L1
The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
Xie C, Li N, Chen ZJ, Li BL, Song BL.
J Biol Chem 286(41):35933-42. doi: 10.1074/jbc.M111.270199. Epub 2011 Aug 15. 2011
52CDC42
Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.
Fairn GD, Hermansson M, Somerharju P, Grinstein S.
Nat Cell Biol 13(12):1424-30. doi: 10.1038/ncb2351. 2011
53CDC42
Cdc42 localization and cell polarity depend on membrane traffic.
Osmani N, Peglion F, Chavrier P, Etienne-Manneville S.
J Cell Biol 191(7):1261-9. Epub 2010 Dec 20. 2010
54CDC42, CXCR4, UBE2I
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
Zhu S, Sachdeva M, Wu F, Lu Z, Mo YY.
Oncogene 29(12):1763-72. doi: 10.1038/onc.2009.459. Epub 2009 Dec 21. 2010
55ARHGDIA, CDC42
Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion.
Wang Z, Thurmond DC.
J Biol Chem 285(9):6186-97. doi: 10.1074/jbc.M109.072421. Epub 2009 Dec 22. 2010
56CDC42
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.
Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B.
Blood 115(16):3364-73. doi: 10.1182/blood-2009-09-242271. Epub 2010 Feb 4. 2010
57CDC42, DLG1, DLGAP1
Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity
Manneville JB, Jehanno M, Etienne-Manneville S.
J Cell Biol. Nov 1;191(3):585-98. doi: 10.1083/jcb.201002151. 2010
58BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
Microtubule assembly, organization and dynamics in axons and dendrites.
Conde C, Caceres A.
Nat Rev Neurosci. 10(5):319-32. 2009
59CDC42, IQGAP1
IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway.
Wang JB, Sonn R, Tekletsadik YK, Samorodnitsky D, Osman MA.
J Cell Sci 122(Pt 12):2024-33. Epub 2009 May 19. 2009
60CDC42, PAK1, PAK2
Dual role of Cdc42 in spindle orientation control of adherent cells.
Mitsushima M, Toyoshima F, Nishida E.
Mol Cell Biol 29(10):2816-27. Epub 2009 Mar 9. 2009
61CDC42, OBSCN, RAC1, RHOQ, TCP10
TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.
Coisy-Quivy M, Touzet O, Bourret A, Hipskind RA, Mercier J, Fort P, Philips A.
J Cell Sci 122(Pt 7):947-56. Epub 2009 Mar 3. 2009
62ARHGAP32, CDC42, GABARAP
PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.
Nakamura T, Hayashi T, Nasu-Nishimura Y, Sakaue F, Morishita Y, Okabe T, Ohwada S, Matsuura K, Akiyama T.
Genes Dev 22(9):1244-56. 2008
63CDC42, CDH1
Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway.
Shen Y, Hirsch DS, Sasiela CA, Wu WJ.
J Biol Chem 283(8):5127-37. Epub 2007 Dec 5. 2008
64ARHGAP1, CDC42, NDEL1
Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X.
Dev Cell 14(3):342-53. 2008
65CDC42, DOCK10
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ.
Curr Biol 18(19):1456-65. Epub 2008 Oct 2. 2008
66CDC42
Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
Chen L, Liao G, Yang L, Campbell K, Nakafuku M, Kuan CY, Zheng Y.
Proc Natl Acad Sci U S A 103(44):16520-5. Epub 2006 Oct 18. 2006
67CDC42
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C.
Genes Dev. 20(5):571-85. 2006
68WASP, CDC42
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Leung DW, Rosen MK.
Proc Natl Acad Sci U S A 102(16):5685-90. Epub 2005 Apr 8. 2005
69CDC42
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.
Baird D, Feng Q, Cerione RA.
Curr. Biol. 15(1):1-10. 2005
70WASL, CDC42, FNBP1L
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.
Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW.
Cell 118(2):203-16. 2004
71CDC42, IQGAP1
Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator.
Grohmanova K, Schlaepfer D, Hess D, Gutierrez P, Beck M, Kroschewski R.
J Biol Chem 279(47):48495-504. Epub 2004 Sep 7. 2004
72CDC42, RHOA
DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.
Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F.
Exp Cell Res. 294(2):335-44. 2004
73CDC42, RHOA
Protein profile of tax-associated complexes.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F.
J Biol Chem. 279(1):495-508. 2004
74CDC42, DOCK9
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
Meller N, Irani-Tehrani M, Kiosses WB, Del Pozo MA, Schwartz MA.
Nat Cell Biol 4(9):639-47. 2002
75CDC42
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.
Buchwald G, Friebel A, Galán JE, Hardt WD, Wittinghofer A, Scheffzek K.
EMBO J. 21(13):3286-95. 2002
76CDC42
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J.
EMBO J. 21(6):1315-26. 2002
77CDC42
AR and ER interaction with a p21-activated kinase (PAK6).
Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP.
Mol Endocrinol. 16(1):85-99. 2002
78CDC42, CLIP1
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170.
Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K.
Dev Cell. 3(1):2-4. 2002
79CDC42, COPG
cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network.
Musch A, Cohen D, Kreitzer G, Rodriguez-Boulan E.
EMBO J 20(9):2171-2179. 2001
80CDC42, EKD1, PARD6A, PARD6B, PARD6G, RAC1
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H.
Genes Cells 6(2):107-19. 2001
81CDC42, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5
A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.
Hirsch DS, Pirone DM, Burbelo PD.
J Biol Chem 276(2):875-83. 2001
82CDC42, ITSN2, WAS
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA.
J Exp Med 194(12):1777-87. 2001
83CDC42, RAC1, WAS
Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
Westerberg L, Greicius G, Snapper SB, Aspenstrom P, Severinson E.
Blood 98(4):1086-94. 2001
84CDC42
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A.
Curr. Biol. 11(21):1645-55 2001
85CDC42
Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1.
Richnau N, Aspenström P.
J Biol Chem. 276(37):35060-70. 2001
86CDC42, COPG2
The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation.
Wu WJ, Erickson JW, Lin R, Cerione RA.
Nature 405(6788):800-4. 2000
87CDC42
Developmental control of endocytosis in dendritic cells by Cdc42.
Garrett WS, Chen LM, Kroschewski R, Ebersold M, Turley S, Trombetta S, Galan JE, Mellman I.
Cell 102(3):325-34. 2000
88CDC42, MAP3K11
Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation.
Bock BC, Vacratsis PO, Qamirani E, Gallo KA.
J Biol Chem 275(19):14231-41. 2000
89CDC42, EKD1, PARD3, PARD6A, PARD6B, PARD6G
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.
Joberty G, Petersen C, Gao L, Macara IG.
Nat Cell Biol 2(8):531-9. 2000
90CDC42, RHOJ
Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.
Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P.
J Biol Chem 275(46):36457-64. 2000
91CDC42, CDC42SE1, CDC42SE2
SPECs, small binding proteins for Cdc42.
Pirone DM, Fukuhara S, Gutkind JS, Burbelo PD.
J Biol Chem 275(30):22650-6. 2000
92CDC42
Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress.
Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM.
J Biol Chem. 275(23):17838-47. 2000
93CDC42
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
Hoffman GR, Nassar N, Cerione RA.
Cell 100(3):345-56. 2000
94CDC42
Activation of phospholipase D1 by Cdc42 requires the Rho insert region.
Walker SJ, Wu WJ, Cerione RA, Brown HA.
J Biol Chem. 275(21):15665-8 2000
95CDC42
Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss.
Coghlan MP, Chou MM, Carpenter CL.
Mol Cell Biol. 20(8):2880-9. 2000
96ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGAP8, CDC42, RAC1, RAC2, RAC3
Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement.
Nobes CD, et al.
J Cell Biol 144(6):1235-1244. 1999
97CDC42, WASP
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Abdul-Manan N, et al.
Nature 399(6734):379-83. 1999
98CDC42, CDC42P
The human CDC42 gene: genomic organization, evidence for the existence of a putative pseudogene and exclusion as a SJS1 candidate gene.
Nicole S, et al.
Hum Genet 105(1-2):98-103. 1999
99WASP, CDC42
Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages.
Linder S, et al.
Proc Natl Acad Sci U S A 96(17):9648-53 1999
100GSD3, CDC42, MSUD2, FCER1A, GNAI3, GUCA2A, ITPKB, MATN1, MCL1, NGF, PRDX1, PTPN7, S100A10
A comprehensive view of human chromosome 1.
White PS, Sulman EP, Porter CJ, Matise TC.
Genome Res 9(10):978-88 1999
101BNIP2, CDC42
Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42.
Low BC, Lim YP, Lim J, Wong ES, Guy GR.
J Biol Chem 274(46):33123-30. 1999
102CDC42, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5
The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
Joberty G, Perlungher RR, Macara IG.
Mol Cell Biol 19(10):6585-97. 1999
103CDC42, PAK4
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.
Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A.
EMBO J 17(22):6527-40. 1998
104ARHGAP31, CDC42
CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac.
Lamarche-Vane N, Hall A.
J Biol Chem 273(44):29172-7. 1998
105CDC42
The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42
Ma L, Rohatgi R, Kirschner MW.
Proc Natl Acad Sci U S A. 95(26):15362-7. 1998
106CDC42, RHOA
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.
Alberts AS, Bouquin N, Johnston LH, Treisman R.
J Biol Chem. 273(15):8616-22. 1998
107CDC42
Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation.
Zhang B, Zheng Y.
J Biol Chem. 273(40):25728-33. 1998
108CDC42, SRSF4, TRIM23
An integrated transcript map of human chromosome 1p35-p36.
Jensen SJ, Sulman EP, Maris JM, Matise TC, Vojta PJ, Barrett JC, Brodeur GM, White PS.
Genomics 42(1):126-36. 1997
109TRIP10, CDC42
A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton.
Aspenstrom P.
Curr Biol 7(7):479-87. 1997
110CDC42
Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains.
Zhang B, Wang ZX, Zheng Y.
J Biol Chem. 272(35):21999-2007 1997
111CDC42
RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.
Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B.
Proc Natl Acad Sci U S A. 94(9):4279-84. 1997
112CDC42
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.
Gerwins P, Blank JL, Johnson GL.
J Biol Chem. 272(13):8288-95. 1997
113CDC42, WASP
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Symons M, et al.
Cell 84 : 723-734. 1996
114CDC42, IQGAP1, IQGAP2
Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2.
McCallum SJ, et al.
J Biol Chem 271(36):21732-7 1996
115CDC42
Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus.
Erickson JW, Zhang Cj, Kahn RA, Evans T, Cerione RA.
J Biol Chem 271(43):26850-4. 1996
116CALM1, CDC42, IQGAP1, IQGAP2
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.
Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ.
Mol Cell Biol 16(9):4869-78. 1996
117BB1L1, BB1L2, BB1L3, BB1L4, BB1L5, CDC42
Southern hybridization analyses of somatic cell hybrids reveal that human BB1 is a member of a multigene family dispersed throughout the human genome and appears to be linked to the human G25K genes.
Moats-Staats BM, Stiles AD.
DNA Cell Biol 14 : 465-474. 1995
118CDC42, RAC1, RAC2, RAC3
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway.
Coso OA, et al.
Cell 81 : 1137-1146. 1995
119CDC42, RAC1, RAC2, RAC3
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs.
Minden A, et al.
Cell 81 : 1147-1157. 1995
120CDC42
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.
Nobes CD, Hall A.
Cell 81(1):53-62. 1995
121CDC42
A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils.
Prigmore E, Ahmed S, Best A, Kozma R, Manser E, Segal AW, Lim L.
J Biol Chem. 270(18):10717-22 1995
122CDC42
Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K) : identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
Shinjo K, et al.
Proc Natl Acad Sci U S A 87 : 9853-9857. 1990