| 1 | CDC37, HSP90AA1, RIPK3
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| A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.
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| Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z.
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| Proc Natl Acad Sci U S A 112(16):5017-22. doi: 10.1073/pnas.1505244112. Epub 2015 Apr 7.
2015
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| 2 | CDC37, MAPT, TARDBP
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| Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.
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| Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA.
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| J Biol Chem 287(29):24814-20. doi: 10.1074/jbc.M112.367268. Epub 2012 Jun 6.
2012
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| 3 | CDC37, MAPT
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| The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.
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| Jinwal UK, Trotter JH, Abisambra JF, Koren J 3rd, Lawson LY, Vestal GD, O'Leary JC 3rd, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA.
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| J Biol Chem 286(19):16976-83. Epub 2011 Mar 2.
2011
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| 4 | CDC37, FGFR3
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| Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation.
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| Laederich MB, Degnin CR, Lunstrum GP, Holden P, Horton WA.
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| J Biol Chem 286(22):19597-604. Epub 2011 Apr 12.
2011
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| 5 | CDC37
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| Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors.
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| Gaiser AM, Kretzschmar A, Richter K.
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| J Biol Chem 285(52):40921-32. Epub 2010 Sep 29.
2010
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| 6 | CDC37, HSP90AA1
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| The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.
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| Sreeramulu S, Jonker HR, Langer T, Richter C, Lancaster CR, Schwalbe H.
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| J Biol Chem. 284(6):3885-96 2009
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| 7 | CDC37, HSP90AA2
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| The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.
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| Gould CM, Kannan N, Taylor SS, Newton AC.
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| J Biol Chem 284(8):4921-35. Epub 2008 Dec 17.
2009
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| 8 | CDC37
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| Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.
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| Smith JR, Clarke PA, de Billy E, Workman P.
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| Oncogene 28(2):157-69. Epub 2008 Oct 20.
2009
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| 9 | CDC37, RYK
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| Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular domain.
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| Lyu J, Wesselschmidt RL, Lu W.
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| J Biol Chem 284(19):12940-8. Epub 2009 Mar 5.
2009
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| 10 | CDC37
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| Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37
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| Vaughan, C. K.; Mollapour, M.; Smith, J. R.; Truman, A.; Hu, B.; Good, V. M.; Panaretou, B.; Neckers, L.; Clarke, P. A.; Workman, P.; Piper, P. W.; Prodromou, C.; Pearl, L. H.
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| Mol Cell. 31: 886-895 2008
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| 11 | CDC37
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| Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells.
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| Gray PJ Jr, Stevenson MA, Calderwood SK.
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| Cancer Res 67(24):11942-50.
2007
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| 12 | CDC37
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| Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.
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| Terasawa K, Yoshimatsu K, Iemura S, Natsume T, Tanaka K, Minami Y.
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| Mol Cell Biol 26(9):3378-89.
2006
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| 13 | CDC37, HSP90AA1
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| Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.
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| Xu W, Yuan X, Xiang Z, Mimnaugh E, Marcu M, Neckers L.
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| Nat Struct Mol Biol. 12(2):120-6 2005
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| 14 | CDC37
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| Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase.
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| Tatebe H, Shiozaki K.
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| Mol Cell Biol 23(15):5132-42. 2003
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| 15 | Cdc37, HSP90AA1, STK11
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| Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
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| Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR.
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| Biochem J. 370(Pt 3):849-57 2003
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| 16 | CDC37
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| The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically.
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| Abbas-Terki T, Briand PA, Donzé O, Picard D.
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| Biol Chem. 383(9):1335-42 2002
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| 17 | CDC37
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| TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
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| Chen, G.; Cao, P.; Goeddel, D. V.
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| Mol Cell. 9: 401-410 2002
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| 18 | CDC37
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| Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor.
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| Rao J, Lee P, Benzeno S, Cardozo C, Albertus J, Robins DM, Caplan AJ.
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| J Biol Chem. 276(8):5814-20 2001
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| 19 | ABCC11, ABCC6P1, ABCC6P2, ACYP2, APOB48R, CCL22, CCP110, CDC37, CIAPIN1, CLN3, COQ9, CX3CL1, CXCR3, DDX28, DHX38, DOK4, EARS2, EARS2, EIF3CL, GDE1, GTF3C1, LKAP, MAZ, NOMO1, NOMO2, NPIPA1, NUPR1, ORIPL, PMFBP1, RBKH, SLC7A5P1, TCCK, UBFD1, XPO6, ZG16, ZP2
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| Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
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| Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T,Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL,Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD.
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| Genomics 60(3):295-308. 1999
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| 20 | CDC37
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| p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site.
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| Silverstein AM, Grammatikakis N, Cochran BH, Chinkers M, Pratt WB.
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| J Biol Chem. 273(32):20090-5 1998
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| 21 | CDC37
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| Physical interaction of mammalian CDC37 with CDK4.
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| Dai K, et al.
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| J Biol Chem 271(36):22030-4 1996
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| 22 | CDC37
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| Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
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| Stepanova L, et al.
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| Genes Dev 10(12):1491-502 1996
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| 23 | CDC37
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| The selection of S. cerevisiae mutants defective in the start event of cell division
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| Reed SI.
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| Genetics. 95(3):561-77 1980
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