| 1 | CD2AP, GPRC5B, LMAN2
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| Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.
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| Kwon SH, Oh S, Nacke M, Mostov KE, Lipschutz JH.
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| J Biol Chem 291(49):25462-25475. Epub 2016 Oct 20. Erratum in: J Biol Chem. 2017 Oct 6;292(40):16523.
2016
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| 2 | CD2AP
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| Podocyte proteins in congenital and minimal change nephrotic syndrome.
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| Suvanto M, Jahnukainen T, Kestilä M, Jalanko H.
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| Clin Exp Nephrol lin Exp Nephrol. 2014 Aug 14. [Epub ahead of print]
2014
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| 3 | CD2AP
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| Role of CD2-associated protein in podocyte apoptosis and proteinuria induced by angiotensin II.
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| Huang L, You YS, Wu W.
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| Ren Fail 36(8):1328-32. doi: 10.3109/0886022X.2014.934177. Epub 2014 Jul 2.
2014
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| 4 | CD2AP
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| Diabetic conditions downregulate the expression of CD2AP in podocytes via PI3-K/Akt signaling.
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| Ha TS, Hong EJ, Han GD.
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| Diabetes Metab Res Rev iabetes Metab Res Rev. 2014 May 20. doi: 10.1002/dmrr.2562. [Epub ahead of print]
2014
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| 5 | CD2AP
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| Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy.
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| Adair BD, Altintas MM, Möller CC, Arnaout MA, Reiser J.
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| J Am Soc Nephrol 25(7):1465-73. doi: 10.1681/ASN.2013090949. Epub 2014 Feb 7.
2014
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| 6 | CD2AP, PAX2
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| The potential signal pathway between PAX2 and CD2AP in the renal interstitial fibrosis disease.
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| Xu HL, Ou C, Rong L, Zhou TB.
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| J Recept Signal Transduct Res 34(4):290-8. doi: 10.3109/10799893.2013.876045. Epub 2014 Jan 28.
2014
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| 7 | CD2AP, CTTN
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| CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia.
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| Zhao J, Bruck S, Cemerski S, Zhang L, Butler B, Dani A, Cooper JA, Shaw AS.
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| Mol Cell Biol 33(1):38-47. doi: 10.1128/MCB.00734-12. Epub 2012 Oct 22.
2013
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| 8 | CD2AP, FSGS3
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| FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions.
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| Tang VW, Brieher WM.
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| J Cell Biol 203(5):815-33. doi: 10.1083/jcb.201304143.
2013
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| 9 | CD2AP
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| CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production.
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| Srivatsan S, Swiecki M, Otero K, Cella M, Shaw AS.
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| J Immunol 191(12):5933-40. doi: 10.4049/jimmunol.1300454. Epub 2013 Nov 11.
2013
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| 10 | CD2AP
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| CD2AP is associated with end-stage renal disease in patients with type 1 diabetes.
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| Hyvönen ME, Ihalmo P, Sandholm N, Stavarachi M, Forsblom C, McKnight AJ, Lajer M, Maestroni A, Lewis G, Tarnow L, Maestroni S, Zerbini G, Parving HH, Maxwell AP, Groop PH, Lehtonen S.
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| Acta Diabetol 50(6):887-97. doi: 10.1007/s00592-013-0475-9. Epub 2013 May 17.
2013
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| 11 | CD2AP, NPHS1, SEPTIN7
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| Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.
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| Wasik AA, Polianskyte-Prause Z, Dong MQ, Shaw AS, Yates JR 3rd, Farquhar MG, Lehtonen S.
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| Mol Biol Cell 23(17):3370-9. doi: 10.1091/mbc.E11-12-1010. Epub 2012 Jul 18. 2012
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| 12 | CD2AP, E2F1
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| Transcriptional activation of the human CD2AP promoter by E2F1.
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| Zou L, Xu HG, Ren W, Jin R, Wang Y, Zhou GP.
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| PLoS One 7(8):e42774. doi: 10.1371/journal.pone.0042774. Epub 2012 Aug 3.
2012
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| 13 | CD2AP, SH3KBP1
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| CD2AP regulates SUMOylation of CIN85 in podocytes.
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| Tossidou I, Niedenthal R, Klaus M, Teng B, Worthmann K, King BL, Peterson KJ, Haller H, Schiffer M.
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| Mol Cell Biol 32(6):1068-79. doi: 10.1128/MCB.06106-11. Epub 2011 Dec 27.
2012
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| 14 | CD2AP, SP1, SP3
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| Transcriptional control of human CD2AP expression: the role of Sp1 and Sp3.
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| Xu HG, Ren W, Zou L, Wang Y, Jin R, Zhou GP.
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| Mol Biol Rep 39(2):1479-86. doi: 10.1007/s11033-011-0885-0. Epub 2011 May 22.
2012
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| 15 | CD2AP, CDC42, CGNL1, SH3BP1
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| Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
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| Elbediwy A, Zihni C, Terry SJ, Clark P, Matter K, Balda MS.
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| J Cell Biol 198(4):677-93. doi: 10.1083/jcb.201202094. Epub 2012 Aug 13.
2012
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| 16 | ABCA7, CD2AP, CD33
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| Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
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| Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC; Alzheimer's Disease Neuroimaging Initiative, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S; CHARGE consortium, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M; EADI1 consortium, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J.
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| Nat Genet 43(5):429-35. Epub 2011 Apr 3.
2011
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| 17 | CD2AP
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| Regulation of CD2-associated protein influences podocyte endoplasmic reticulum stress-mediated apoptosis induced by albumin overload.
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| He F, Chen S, Wang H, Shao N, Tian X, Jiang H, Liu J, Zhu Z, Meng X, Zhang C.
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| Gene 484(1-2):18-25. Epub 2011 Jun 12.
2011
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| 18 | CD2AP, NPHS1, SH3KBP1
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| CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.
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| Tossidou I, Teng B, Drobot L, Meyer-Schwesinger C, Worthmann K, Haller H, Schiffer M.
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| J Biol Chem 285(33):25285-95. Epub 2010 May 10. 2010
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| 19 | CD2AP
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| CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS).
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| Gigante M, Pontrelli P, Montemurno E, Roca L, Aucella F, Penza R, Caridi G, Ranieri E, Ghiggeri GM, Gesualdo L.
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| Nephrol Dial Transplant 24(6):1858-64. Epub 2009 Jan 7.
2009
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| 20 | CD2AP
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| Functional characterization of the regulatory region of human CD2-associated protein promoter in HEK 293 cells.
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| Su XM, Ren W, Lu C, Chen JQ, Wu SH, Chen RH, Zhou GP.
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| Am J Nephrol 29(3):203-12. Epub 2008 Sep 15.
2009
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| 21 | CD2AP
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| EGF-recruited JunD/c-fos complexes activate CD2AP gene promoter and suppress apoptosis in renal tubular epithelial cells.
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| Lu C, Ren W, Su XM, Chen JQ, Wu SH, Zhou GP.
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| Gene. 433(1-2):56-64. 2009
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| 22 | CD2AP, FSGS2, FSGS3, NPHS3, PLCE1, SRN3, TRPC6
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| Genetics of nephrotic syndrome: connecting molecular genetics to podocyte physiology.
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| Machuca E, Benoit G, Antignac C.
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| Hum Mol Genet 18(R2):R185-94. Review.PMID: 19808795 2009
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| 23 | CD2AP, SP1
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| CREB and Sp1 regulate the human CD2AP gene promoter activity in renal tubular epithelial cells.
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| Lu C, Ren W, Su XM, Chen JQ, Wu SH, Guo XR, Huang SM, Chen LH, Zhou GP.
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| Arch Biochem Biophys 474(1):143-9. Epub 2008 Mar 31. 2008
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| 24 | CBLC, CD2AP, RET
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| CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.
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| Tsui CC, Pierchala BA.
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| J Neurosci 28(35):8789-800. doi: 10.1523/JNEUROSCI.2738-08.2008.
2008
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| 25 | CD2AP,DDN,WWC1
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| Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes.
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| Asanuma K, Campbell KN, Kim K, Faul C, Mundel P.
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| Proc Natl Acad Sci U S A 104(24):10134-9. Epub 2007 May 30. 2007
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| 26 | PDCD6IP, CEP55, TSG101, ROCK1, IQGAP1, CD2AP
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| Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
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| Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
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| EMBO J 26(19):4215-27. Epub 2007 Sep 13. 2007
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| 27 | CD2Ap, FSGS3
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| Focal segmental glomerulosclerosis in a patient homozygous for a CD2AP mutation.
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| Löwik MM, Groenen PJ, Pronk I, Lilien MR, Goldschmeding R, Dijkman HB, Levtchenko EN, Monnens LA, van den Heuvel LP.
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| Kidney Int 72(10):1198-203. Epub 2007 Aug 22.PMID: 17713465 2007
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| 28 | CD2AP, MVB12A
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| CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.
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| Konishi H, Tashiro K, Murata Y, Nabeshi H, Yamauchi E, Taniguchi H.
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| J Biol Chem 281(39):28919-31. Epub 2006 Aug 7. 2006
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| 29 | ACTN4, CD2AP, NPHS1, NPHS2, SRN1, SRN4, WT1
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| Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9.
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| Mucha B, Ozaltin F, Hinkes BG, Hasselbacher K, Ruf RG, Schultheiss M, Hangan D, Hoskins BE, Everding AS, Bogdanovic R, Seeman T, Hoppe B, Hildebrandt F; Members of the APN Study Group.
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| Pediatr Res 59(2):325-31. 2006
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| 30 | ACTN4, NPHS1, NPHS2, CD2AP
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| The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte.
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| Fan Q, Xing Y, Ding J, Guan N, Zhang J.
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| Kidney Int 69(7):1207-15. 2006
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| 31 | CD2AP
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| Clues to CD2-associated protein involvement in cytokinesis.
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| Monzo P, Gauthier NC, Keslair F, Loubat A, Field CM, Le Marchand-Brustel Y, Cormont M.
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| Mol Biol Cell 16(6):2891-902. Epub 2005 Mar 30. 2005
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| 32 | CD2AP
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| A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis.
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| Schiffer M, Mundel P, Shaw AS, Böttinger EP.
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| J Biol Chem. 279(35):37004-12. 2004
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| 33 | CD2AP
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| A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.
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| Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ.
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| J Biol Chem 278(24):21805-13. Epub 2003 Apr 02. 2003
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| 34 | CD2AP, FSGS3
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| CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.
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| Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS.
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| Science 300(5623):1298-300. 2003
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| 35 | CD2AP
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| CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
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| Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y.
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| Traffic. 4(2):97-112. 2003
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| 36 | CD2AP
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| The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.
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| Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H.
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| J Biol Chem. 276(7):4957-63. 2001
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| 37 | CD2AP
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| Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.
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| Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P.
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| J Clin Invest. 108(11):1621-9. 2001
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| 38 | CD2AP
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| CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.
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| Li C, Ruotsalainen V, Tryggvason K, Shaw AS, Miner JH.
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| Am J Physiol Renal Physiol. 279(4):F785-92. 2000
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| 39 | CD2AP, PKD2
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| In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.
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| Lehtonen S, Ora A, Olkkonen VM, Geng L, Zerial M, Somlo S, Lehtonen E.
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| J Biol Chem. 275(42):32888-93. 2000
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| 40 | CD2AP, NPHS1
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| Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein.
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| Shih, N.-Y.; Li, J.; Karpitskii, V.; Nguyen, A.; Dustin, M. L.; Kanagawa, O.; Miner, J. H.; Shaw, A. S.
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| Science 286(5438):312-315 1999
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| 41 | CD2AP
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| CMS: an adapter molecule involved in cytoskeletal rearrangements.
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| Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H.
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| Proc Natl Acad Sci U S A. 96(11):6211-6. 1999
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| 42 | CD2AP
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| A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
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| Dustin ML, Olszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, Rosenberger F, van der Merwe PA, Allen PM, Shaw AS.
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| Cell. 94(5):667-77. 1998
|