| 1 | CD274, USP22
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| The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
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| Wang Y, Sun Q, Mu N, Sun X, Wang Y, Fan S, Su L, Liu X.
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| Cell Commun Signal. Jul 14;18(1):112. doi: 10.1186/s12964-020-00612-y. 2020
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| 2 | CD274, VGLL4, YAP1
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| Loss of VGLL4 suppresses tumor PD-L1 expression and immune evasion
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| Wu A, Wu Q, Deng Y, Liu Y, Lu J, Liu L, Li X, Liao C, Zhao B, Song H
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| EMBO J Jan 3;38(1):e99506. doi: 10.15252/embj.201899506. Epub 2018 Nov 5 2019
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| 3 | CD274, USP22
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| USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity
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| Huang X, Zhang Q, Lou Y, Wang J, Zhao X, Wang L, Zhang X, Li S, Zhao Y, Chen Q, Liang T, Bai X.
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| Cancer Immunol Res. Oct;7(10):1580-1590. doi: 10.1158/2326-6066.CIR-18-0910. Epub 2019 Aug 9. 2019
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| 4 | CD274, IFNB1, IRF9, PDCD1
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| Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells.
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| Morimoto Y, Kishida T, Kotani SI, Takayama K, Mazda O.
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| Biochem Biophys Res Commun 507(1-4):330-336. doi: 10.1016/j.bbrc.2018.11.035. Epub 2018 Nov 14.
2018
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| 5 | ARL4D, CD274
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| The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production. 2018 PMID:
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| Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp LC, Knolle PA, Kolanus W, Diehl L.
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| Sci Rep. Oct 31;8(1):16123. doi: 10.1038/s41598-018-34522-4. 2018
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| 6 | CD274, SREBF1
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| PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma.
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| Wang Y, Wang H, Zhao Q, Xia Y, Hu X, Guo J.
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| Med Oncol 32(8):212. doi: 10.1007/s12032-015-0655-2. Epub 2015 Jul 4.
2015
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| 7 | CD274
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| Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.
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| Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata S.
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| Oncotarget 6(7):4704-16.
2015
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| 8 | CD274, PDCD1
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| Association between PD-1/PD-L1 and T regulate cells in early recurrent miscarriage.
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| Li G, Lu C, Gao J, Wang X, Wu H, Lee C, Xing B, Zhang Q.
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| Int J Clin Exp Pathol 8(6):6512-8.
2015
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| 9 | CD274, PDCD1, PDCD1LG2
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| Human PD-1 binds differently to its human ligands: a comprehensive modeling study.
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| Viricel C, Ahmed M, Barakat K.
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| J Mol Graph Model 57:131-42. doi: 10.1016/j.jmgm.2015.01.015.
2015
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| 10 | CD274, IFNG, JAK1, JAK2
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| Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression.
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| Bellucci R, Martin A, Bommarito D, Wang K, Hansen SH, Freeman GJ, Ritz J.
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| Oncoimmunology Mar 2;4(6):e1008824. doi: 10.1080/2162402X.2015.1008824. eCollection 2015 Jun. 2015
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| 11 | CD274, DOK3
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| Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands.
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| Ou X, Xu S, Li YF, Lam KP.
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| Proc Natl Acad Sci U S A 111(31):11431-6. doi: 10.1073/pnas.1400539111. Epub 2014 Jul 22.
2014
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| 12 | CD274, PDCD1LG2
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| TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.
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| Beswick EJ, Johnson JR, Saada JI, Humen M, House J, Dann S, Qiu S, Brasier AR, Powell DW, Reyes VE, Pinchuk IV.
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| J Immunol 193(5):2218-29. doi: 10.4049/jimmunol.1203441. Epub 2014 Jul 28.
2014
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| 13 | CD274
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| Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes.
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| Okiyama N, Katz SI.
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| J Autoimmun 53:1-9. doi: 10.1016/j.jaut.2014.06.005. Epub 2014 Jul 18.
2014
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| 14 | CD274
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| Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer.
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| Muenst S, Schaerli AR, Gao F, Däster S, Trella E, Droeser RA, Muraro MG, Zajac P, Zanetti R, Gillanders WE, Weber WP, Soysal SD.
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| Breast Cancer Res Treat 146(1):15-24. doi: 10.1007/s10549-014-2988-5. Epub 2014 May 20.
2014
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| 15 | CD274
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| Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma.
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| Tamai K, Nakamura M, Mizuma M, Mochizuki M, Yokoyama M, Endo H, Yamaguchi K, Nakagawa T, Shiina M, Unno M, Muramoto K, Sato I, Satoh K, Sugamura K, Tanaka N.
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| Cancer Sci 105(6):667-74. doi: 10.1111/cas.12406. Epub 2014 May 8.
2014
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| 16 | CD274
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| Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke.
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| Li P, Mao L, Liu X, Gan Y, Zheng J, Thomson AW, Gao Y, Chen J, Hu X.
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| Stroke 45(3):857-64. doi: 10.1161/STROKEAHA.113.004100. Epub 2014 Feb 4.
2014
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| 17 | CD274
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| PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.
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| Bodhankar S, Chen Y, Vandenbark AA, Murphy SJ, Offner H.
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| J Neuroinflammation 10:111. doi: 10.1186/1742-2094-10-111.
2013
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| 18 | CD274
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| The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia.
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| Brusa D, Serra S, Coscia M, Rossi D, D'Arena G, Laurenti L, Jaksic O, Fedele G, Inghirami G, Gaidano G, Malavasi F, Deaglio S.
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| Haematologica 98(6):953-63. doi: 10.3324/haematol.2012.077537. Epub 2013 Jan 8.
2013
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| 19 | CD274, PDCD1
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| Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.
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| Gianchecchi E, Delfino DV, Fierabracci A.
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| Autoimmun Rev 12(11):1091-100. doi: 10.1016/j.autrev.2013.05.003.
2013
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| 20 | CD274, PIK3CD
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| PI3K-delta mediates double-stranded RNA-induced upregulation of B7-H1 in BEAS-2B airway epithelial cells.
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| Kan-o K, Matsumoto K, Asai-Tajiri Y, Fukuyama S, Hamano S, Seki N, Nakanishi Y, Inoue H.
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| Biochem Biophys Res Commun 435(2):195-201. doi: 10.1016/j.bbrc.2013.04.082. Epub 2013 May 6.
2013
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| 21 | CD274, CD276, HLA-G
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| Immunomodulatory molecules are released from the first trimester and term placenta via exosomes.
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| Kshirsagar SK, Alam SM, Jasti S, Hodes H, Nauser T, Gilliam M, Billstrand C, Hunt JS, Petroff MG.
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| Placenta 33(12):982-90. doi: 10.1016/j.placenta.2012.10.005. Epub 2012 Oct 26.
2012
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| 22 | CD274
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| Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway.
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| Luz-Crawford P, Noël D, Fernandez X, Khoury M, Figueroa F, Carrión F, Jorgensen C, Djouad F.
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| PLoS One 7(9):e45272. doi: 10.1371/journal.pone.0045272. Epub 2012 Sep 17.
2012
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| 23 | CD274, PDCD1
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| Reduced tumor-antigen density leads to PD-1/PD-L1-mediated impairment of partially exhausted CD8⁺ T cells.
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| Kaiser AD, Schuster K, Gadiot J, Borkner L, Daebritz H, Schmitt C, Andreesen R, Blank C.
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| Eur J Immunol 42(3):662-71. doi: 10.1002/eji.201141931.
2012
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| 24 | CD274
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| Immunoregulatory molecule B7-H1 (CD274) contributes to skin carcinogenesis.
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| Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M.
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| Cancer Res 71(14):4737-41. Epub 2011 Jul 5. Review.
2011
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| 25 | CD274
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| Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis.
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| Pittet CL, Newcombe J, Prat A, Arbour N.
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| J Neuroinflammation 8:155. doi: 10.1186/1742-2094-8-155.
2011
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| 26 | CD274, PDCD1
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| PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.
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| Ishizaki Y, Yukaya N, Kusuhara K, Kira R, Torisu H, Ihara K, Sakai Y, Sanefuji M, Pipo-Deveza JR, Silao CL, Sanchez BC, Lukban MB, Salonga AM, Hara T.
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| Hum Genet um Genet. 2010 Jan 12. [Epub ahead of print]PMID: 20066438 2010
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| 27 | CD274, PDCD1LG2
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| PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.
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| Ghiotto M, Gauthier L, Serriari N, Pastor S, Truneh A, Nunès JA, Olive D.
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| Int Immunol 22(8):651-60. Epub 2010 Jun 29.
2010
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| 28 | CD274
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| Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility.
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| Mitchell AL, Cordell HJ, Soemedi R, Owen K, Skinningsrud B, Wolff AB, Ericksen M, Undlien D, Husebye E, Pearce SH.
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| J Clin Endocrinol Metab 94(12):5139-45. Epub 2009 Oct 22.PMID: 19850680 2009
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| 29 | CD274
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| B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders.
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| Wilcox RA, Feldman AL, Wada DA, Yang ZZ, Comfere NI, Dong H, Kwon ED, Novak AJ, Markovic SN, Pittelkow MR, Witzig TE, Ansell SM.
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| Blood 114(10):2149-58. Epub 2009 Jul 13.PMID: 19597183 2009
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| 30 | CD274
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| Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis.
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| Lee J, Zhuang Y, Wei X, Shang F, Wang J, Zhang Y, Liu X, Yang Y, Liu L, Zheng Q.
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| J Mol Cell Cardiol 46(2):169-76. Epub 2008 Nov 13.PMID: 19056397 2009
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| 31 | CD274, STAT3
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| Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
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| Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, Wang HY, Wysocka M, Cheng M, Ruggeri BA, Wasik MA.
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| Proc Natl Acad Sci U S A 105(52):20852-7. Epub 2008 Dec 16.PMID: 19088198 2008
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| 32 | CD274
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| Clinical significance of B7-H1 (PD-L1) expression in human acute leukemia.
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| Chen X, Liu S, Wang L, Zhang W, Ji Y, Ma X.
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| Cancer Biol Ther 7(5):622-7.PMID: 18756622 2008
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| 33 | PDCD1, PDCD1LG2, CD274
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| PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children.
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| Ni R, Ihara K, Miyako K, Kuromaru R, Inuo M, Kohno H, Hara T.
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| Hum Genet 121(2):223-32. Epub 2007 Jan 3. 2007
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| 34 | PDCD1, CD274 , PDCD1LG2
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| Association of PDCD1 with susceptibility to systemic lupus erythematosus: evidence of population-specific effects.
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| Ferreiros-Vidal I, Gomez-Reino JJ, Barros F, Carracedo A, Carreira P, Gonzalez-Escribano F, Liz M, Martin J, Ordi J, Vicario JL, Gonzalez A.
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| Arthritis Rheum 50(8):2590-7. 2004
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| 35 | CD274
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| B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis.
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| Mazanet MM, Hughes CC.
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| J Immunol 169(7):3581-8.PMID: 12244148 2002
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| 36 | CD274
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| Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
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| Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ,Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V,Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T.
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| J Exp Med 192(7):1027-34. 2000
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| 37 | CD274
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| B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
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| Dong H, Zhu G, Tamada K, Chen L.
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| Nat Med 5(12):1365-9. 1999
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