Citations for
Inhibition of the CCL5/CCR5 Axis against the Progression of Gastric Cancer.
Aldinucci D, Casagrande N.
Int J Mol Sci. May 16;19(5):1477. doi: 10.3390/ijms19051477 2018
CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells.
Singh SK, Mishra MK, Eltoum IA, Bae S, Lillard JW Jr, Singh R.
Sci Rep. Jan 22;8(1):1323. doi: 10.1038/s41598-018-19643-0 2018
Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Liang WG, Triandafillou CG, Huang TY, Zulueta MM, Banerjee S, Dinner AR, Hung SC, Tang WJ.
Proc Natl Acad Sci U S A 113(18):5000-5. doi: 10.1073/pnas.1523981113. Epub 2016 Apr 18. 2016
The Fli-1 transcription factor regulates the expression of CCL5/RANTES.
Lennard Richard ML, Sato S, Suzuki E, Williams S, Nowling TK, Zhang XK.
J Immunol 193(6):2661-8. doi: 10.4049/jimmunol.1302779. Epub 2014 Aug 6. 2014
5CCL5, IL15, IL15RA, NFKB1
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA.
J Immunol 188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23. 2012
6CCL5, KLF13
Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
Kim DS, Zhang W, Millman SE, Hwang BJ, Kwon SJ, Clayberger C, Pagano M, Krensky AM.
Blood 120(8):1658-67. doi: 10.1182/blood-2012-03-415968. Epub 2012 Jul 13. 2012
The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis.
Chan O, Burke JD, Gao DF, Fish EN.
J Biol Chem 287(35):29406-16. doi: 10.1074/jbc.M112.348946. Epub 2012 Jul 10. 2012
8CCL5, GLI2, IL6
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.
Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME.
J Biol Chem 286(24):21524-34. Epub 2011 Mar 18. 2011
A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection.
Crawford A, Angelosanto JM, Nadwodny KL, Blackburn SD, Wherry EJ.
PLoS Pathog 7(7):e1002098. Epub 2011 Jul 21. 2011
CCL5 (RANTES) gene polymorphisms in pulmonary tuberculosis patients of south India.
Selvaraj P, Alagarasu K, Singh B, Afsal K.
Int J Immunogenet 38(5):397-402. doi: 10.1111/j.1744-313X.2011.01021.x. Epub 2011 Jun 27. 2011
11CCL5, CCR7
Significantly increased CCL5/RANTES and CCR7 mRNA levels in localized scleroderma.
Gambichler T, Skrygan M, Labanski AA, Kolios AG, Altmeyer P, Kreuter A.
Regul Pept 170(1-3):4-6. Epub 2011 May 25. 2011
Polymorphisms in the RANTES gene increase susceptibility to active tuberculosis in Tunisia.
Ben-Selma W, Harizi H, Bougmiza I, Ben Kahla I, Letaief M, Boukadida J.
DNA Cell Biol 30(10):789-800. Epub 2011 Apr 21. 2011
Polymorphism in the promoter of the CCL5 gene (CCL5G-403A) in a cohort of North Indian children with Kawasaki disease. A preliminary study.
Chaudhuri K, Singh Ahluwalia T, Singh S, Binepal G, Khullar M.
Clin Exp Rheumatol 29(1 Suppl 64):S126-30. Epub 2011 May 11. 2011
14CCL5, IL13
Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line.
Zhang H, Yang H, Ma W, He S.
Cytokine 53(2):231-8. Epub 2010 Nov 11. 2011
Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity.
Elsawa SF, Novak AJ, Ziesmer SC, Almada LL, Hodge LS, Grote DM, Witzig TE, Fernandez-Zapico ME, Ansell SM.
Blood 118(20):5540-9. doi: 10.1182/blood-2011-04-351742. Epub 2011 Sep 14. 2011
16CCL2, CCL3, CCL4, CCL5
Adiponectin stimulates release of CCL2, -3, -4 and -5 while the surface abundance of CCR2 and -5 is simultaneously reduced in primary human monocytes.
Neumeier M, Bauer S, Brühl H, Eisinger K, Kopp A, Abke S, Walter R, Schäffler A, Buechler C.
Cytokine 56(3):573-80. doi: 10.1016/j.cyto.2011.08.017. Epub 2011 Sep 3. Erratum in: Cytokine. 2013 Jun;62(3):453. 2011
17CCL5, CCR5
Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy.
Pettigrew KA, McKnight AJ, Patterson CC, Kilner J, Sadlier DM, Maxwell AP.
J Hum Genet 55(4):248-51. Epub 2010 Mar 5. 2010
Effect of CC chemokine ligand 5 and CC chemokine receptor 5 genes polymorphisms on the risk and clinicopathological development of oral cancer.
Weng CJ, Chien MH, Lin CW, Chung TT, Zavras AI, Tsai CM, Chen MK, Yang SF.
Oral Oncol 46(10):767-72. Epub 2010 Aug 21. 2010
CCL5 promotes macrophage recruitment and survival in human adipose tissue.
Keophiphath M, Rouault C, Divoux A, Clément K, Lacasa D.
Arterioscler Thromb Vasc Biol 30(1):39-45. Epub 2009 Nov 5. 2010
CCL5 participates in early protection against Mycobacterium tuberculosis.
Vesosky B, Rottinghaus EK, Stromberg P, Turner J, Beamer G.
J Leukoc Biol 87(6):1153-65. Epub 2010 Apr 6. 2010
Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice.
Berres ML, Koenen RR, Rueland A, Zaldivar MM, Heinrichs D, Sahin H, Schmitz P, Streetz KL, Berg T, Gassler N, Weiskirchen R, Proudfoot A, Weber C, Trautwein C, Wasmuth HE.
J Clin Invest 120(11):4129-40. doi: 10.1172/JCI41732. Epub 2010 Oct 18. 2010
Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion.
Pinilla S, Alt E, Abdul Khalek FJ, Jotzu C, Muehlberg F, Beckmann C, Song YH.
Cancer Lett 284(1):80-5. Epub 2009 May 7. 2009
Expression of CC chemokine ligand 5 in patients with rheumatoid arthritis and its correlation with disease activity and medication.
Yang MH, Wu FX, Xie CM, Qing YF, Wang GR, Guo XL, Tang Z, Zhou JG, Yuan GH.
Chin Med Sci J 24(1):50-4. 2009
24CCL5, CCR5
CCL5/CCR5 axis promotes the motility of human oral cancer cells.
Chuang JY, Yang WH, Chen HT, Huang CY, Tan TW, Lin YT, Hsu CJ, Fong YC, Tang CH.
J Cell Physiol 220(2):418-26. 2009
Functional SNPs of the CCL5 gene and non-emphysematous phenotype in patients with COPD.
Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M; the Hokkaido COPD Cohort Study Group.
Eur Respir J ur Respir J. 2008 Apr 2. [Epub ahead of print] 2008
26PRPF4, CCL5, KLF13
Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.
Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM.
J Immunol 178(11):7081-7. 2007
27CCR5, CCL5
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.
Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ.
Nat Med 11(11):1180-7. Epub 2005 Oct 2. 2005
Modulating influence on HIV/AIDS by interacting RANTES gene variants.
An P, Nelson GW, Wang L, Donfield S, Goedert JJ, Phair J, Vlahov D, Buchbinder S, Farrar WL, Modi W, O'Brien SJ, Winkler CA.
Proc Natl Acad Sci U S A 99(15):10002-7. 2002
29CCL5, KLK13
A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.
Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM.
J Clin Invest 110(1):119-26. 2002
Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes.
Locati M, Deuschle U, Massardi ML, Martinez FO, Sironi M, Sozzani S, Bartfai T, Mantovani A.
J Immunol 168(7):3557-62. 2002
Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.
Liu H, et al.
Proc Natl Acad Sci U S A 96(8):4581-5. 1999
32CCL3, CCL4, CCL4L1, CCL5, CCL7, CCL11, CCL13, CCL20, CXCL12
Chemokines--chemotactic cytokines that mediate inflammation.
Luster AD.
N Engl J Med 338(7):436-45. Review. No abstract available. 1998
Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12.
Donlon TA, et al.
Genomics 6 : 548-553. 1990
Localization of a T cell-specific cDNA, p228, to 17q11-q21.
Donlon TA, et al.
(HGM10) Cytogenet Cell Genet 51 : 992. 1989
A human T cell-specific molecule is a member of a new gene family.
Schall TJ, et al.
J Immunol 141 : 1018-1025. 1988