| 1 | CCL2, GOLGA8B, IBTK, RAB26, SLC29A4, VEGFB
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| Negative correlation between endoglin levels and coronary atherosclerosis.
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| Chen H, Wang Y, Sun B, Bao X, Tang Y, Huang F, Zhu S, Xu J.
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| Lipids Health Dis Oct 3;20(1):127. doi: 10.1186/s12944-021-01545-2. 2021
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| 2 | CCL2, TERF1
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| Age intrinsic loss of telomere protection via TRF1 reduction in endothelial cells.
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| Hohensinner PJ, Kaun C, Buchberger E, Ebenbauer B, Demyanets S, Huk I, Eppel W, Maurer G, Huber K, Wojta J.
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| Biochim Biophys Acta 1863(2):360-7. doi: 10.1016/j.bbamcr.2015.11.034. Epub 2015 Dec 1.
2016
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| 3 | CCL2, F3, OLR1, TICAM1, TLR2
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| TRIF is a regulator of TLR2-induced foam cell formation.
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| Huang B, Park DW, Baek SH.
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| Mol Med Rep 14(4):3329-35. doi: 10.3892/mmr.2016.5647. Epub 2016 Aug 19.
2016
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| 4 | CCL2, FLI1
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| Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation.
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| Lennard Richard ML, Nowling TK, Brandon D, Watson DK, Zhang XK.
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| Mol Immunol 63(2):566-73. doi: 10.1016/j.molimm.2014.07.013. Epub 2014 Aug 6.
2015
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| 5 | CCL14, CCL2, CCL3
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| Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma.
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| Li Y, Zheng Y, Li T, Wang Q, Qian J, Lu Y, Zhang M, Bi E, Yang M, Reu F, Yi Q, Cai Z.
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| Oncotarget 6(27):24218-29.
2015
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| 6 | CCL2
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| Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans.
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| Patsouris D, Cao JJ, Vial G, Bravard A, Lefai E, Durand A, Durand C, Chauvin MA, Laugerette F, Debard C, Michalski MC, Laville M, Vidal H, Rieusset J.
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| PLoS One 9(10):e110653. doi: 10.1371/journal.pone.0110653. eCollection 2014.
2014
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| 7 | CCL2
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| The chemokine (C-C motif) ligand 2 in neuroinflammation and neurodegeneration.
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| Madrigal JL, Caso JR.
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| Adv Exp Med Biol 824:209-19. doi: 10.1007/978-3-319-07320-0_15. Review.
2014
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| 8 | CCL2, FASLG
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| Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm.
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| Wang Q, Ren J, Morgan S, Liu Z, Dou C, Liu B.
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| PLoS One 9(3):e92053. doi: 10.1371/journal.pone.0092053. eCollection 2014.
2014
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| 9 | CCL2
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| CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2.
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| Kalderén C, Stadler C, Forsgren M, Kvastad L, Johansson E, Sydow-Bäckman M, Svensson Gelius S.
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| Int Immunopharmacol 20(1):66-73. doi: 10.1016/j.intimp.2014.02.020. Epub 2014 Feb 26.
2014
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| 10 | CCL2, NR1D1
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| A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
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| Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
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| J Immunol 192(1):407-17. doi: 10.4049/jimmunol.1301982.
2014
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| 11 | CCL2, CCL3
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| Serum CCL2 and CCL3 as potential biomarkers for the diagnosis of oral squamous cell carcinoma.
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| Ding L, Li B, Zhao Y, Fu YF, Hu EL, Hu QG, Ni YH, Hou YY.
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| Tumour Biol 35(10):10539-46. doi: 10.1007/s13277-014-2306-1. Epub 2014 Jul 25.
2014
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| 12 | CCL2, OLR1
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| Ox-LDL promotes migration and adhesion of bone marrow-derived mesenchymal stem cells via regulation of MCP-1 expression.
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| Zhang F, Wang C, Wang H, Lu M, Li Y, Feng H, Lin J, Yuan Z, Wang X.
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| Mediators Inflamm 2013:691023. doi: 10.1155/2013/691023. Epub 2013 Jul 17.
2013
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| 13 | CCL2, TWIST1
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| Twist1 induces CCL2 and recruits macrophages to promote angiogenesis.
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| Low-Marchelli JM, Ardi VC, Vizcarra EA, van Rooijen N, Quigley JP, Yang J.
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| Cancer Res 73(2):662-71. doi: 10.1158/0008-5472.CAN-12-0653.
2013
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| 14 | CCL2
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| Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.
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| Arendt LM, McCready J, Keller PJ, Baker DD, Naber SP, Seewaldt V, Kuperwasser C.
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| Cancer Res 73(19):6080-93. doi: 10.1158/0008-5472.CAN-13-0926. Epub 2013 Aug 19.
2013
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| 15 | BCL6, CCL2, ZXDC
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| The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression.
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| Ramsey JE, Fontes JD.
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| Mol Immunol 56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14.
2013
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| 16 | CCL2, CCR2
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| Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases.
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| Bose S, Cho J.
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| Arch Pharm Res 36(9):1039-50. doi: 10.1007/s12272-013-0161-z. Epub 2013 Jun 15. Review.
2013
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| 17 | CCL2, LPA, OLR1
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| MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma.
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| Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI.
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| J Lipid Res 54(7):1877-83. doi: 10.1194/jlr.M036343. Epub 2013 May 10.
2013
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| 18 | CCL2, NFKBIZ
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| IκBζ is a transcriptional key regulator of CCL2/MCP-1.
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| Hildebrand DG, Alexander E, Hörber S, Lehle S, Obermayer K, Münck NA, Rothfuss O, Frick JS, Morimatsu M, Schmitz I, Roth J, Ehrchen JM, Essmann F, Schulze-Osthoff K.
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| J Immunol 190(9):4812-20. doi: 10.4049/jimmunol.1300089. Epub 2013 Apr 1.
2013
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| 19 | CCL2
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| Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone.
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| Tamasi JA, Vasilov A, Shimizu E, Benton N, Johnson J, Bitel CL, Morrison N, Partridge NC.
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| J Bone Miner Res 28(9):1975-86. doi: 10.1002/jbmr.1933.
2013
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| 20 | CCL2
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| MCP-1 expression is specifically regulated during activation of skeletal repair and remodeling.
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| Wu AC, Morrison NA, Kelly WL, Forwood MR.
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| Calcif Tissue Int 92(6):566-75. doi: 10.1007/s00223-013-9718-6. Epub 2013 Mar 5.
2013
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| 21 | CCL2, CCL3
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| Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury.
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| Kiguchi N, Kobayashi Y, Saika F, Kishioka S.
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| Cytokine 64(3):666-72. doi: 10.1016/j.cyto.2013.09.019. Epub 2013 Oct 14.
2013
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| 22 | CCL2, CCR2
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| MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes.
|
| Hodge DL, Reynolds D, Cerbán FM, Correa SG, Baez NS, Young HA, Rodriguez-Galan MC.
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| Eur J Immunol 42(10):2644-54. doi: 10.1002/eji.201242408. Epub 2012 Aug 15.
2012
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| 23 | CCL2, CCR2
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| Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain.
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| Zhang ZJ, Dong YL, Lu Y, Cao S, Zhao ZQ, Gao YJ.
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| J Neuroinflammation 9:136. doi: 10.1186/1742-2094-9-136.
2012
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| 24 | CCL2, CCR2
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| CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.
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| Volpe S, Cameroni E, Moepps B, Thelen S, Apuzzo T, Thelen M.
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| PLoS One 7(5):e37208. doi: 10.1371/journal.pone.0037208. Epub 2012 May 17.
2012
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| 25 | CCL2, TP53
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| p53 is an important regulator of CCL2 gene expression.
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| Tang X, Asano M, O'Reilly A, Farquhar A, Yang Y, Amar S.
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| Curr Mol Med 12(8):929-43.
2012
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| 26 | ACKR2, CCL2, CCR2
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| CCL2 binding is CCR2 independent in primary adult human astrocytes.
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| Fouillet A, Mawson J, Suliman O, Sharrack B, Romero IA, Woodroofe MN.
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| Brain Res 1437:115-26. doi: 10.1016/j.brainres.2011.11.049. Epub 2011 Dec 4.
2012
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| 27 | CCL2, PIK3CG
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| Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration.
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| Fougerat A, Smirnova NF, Gayral S, Malet N, Hirsch E, Wymann MP, Perret B, Martinez LO, Douillon M, Laffargue M.
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| Br J Pharmacol 166(5):1643-53. doi: 10.1111/j.1476-5381.2012.01866.x.
2012
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| 28 | CCL2, HDAC2, HDAC3, MS4A2
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| Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.
|
| Kim Y, Kim K, Park D, Lee E, Lee H, Lee YS, Choe J, Jeoung D.
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| J Biol Chem 287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7.
2012
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| 29 | CCL2, EDN1, IL6
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| Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
|
| Simonson MS, Ismail-Beigi F.
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| J Biol Chem 286(13):11003-8. Epub 2010 Dec 17.
2011
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| 30 | CCL2, CCR2
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| CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury.
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| Van Steenwinckel J, Reaux-Le Goazigo A, Pommier B, Mauborgne A, Dansereau MA, Kitabgi P, Sarret P, Pohl M, Mélik Parsadaniantz S.
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| J Neurosci 31(15):5865-75.
2011
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| 31 | CCL2
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| CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.
|
| Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, Kaiser EA, Snyder LA, Pollard JW.
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| Nature 475(7355):222-5. doi: 10.1038/nature10138.
2011
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| 32 | CCL2, F3
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| Tissue factor regulates microvessel formation and stabilization by induction of chemokine (C-C motif) ligand 2 expression.
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| Arderiu G, Peña E, Aledo R, Juan-Babot O, Badimon L.
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| Arterioscler Thromb Vasc Biol 31(11):2607-15. doi: 10.1161/ATVBAHA.111.233536.
2011
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| 33 | CCL2, CCL3, CCL4, CCL5
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| Adiponectin stimulates release of CCL2, -3, -4 and -5 while the surface abundance of CCR2 and -5 is simultaneously reduced in primary human monocytes.
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| Neumeier M, Bauer S, Brühl H, Eisinger K, Kopp A, Abke S, Walter R, Schäffler A, Buechler C.
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| Cytokine 56(3):573-80. doi: 10.1016/j.cyto.2011.08.017. Epub 2011 Sep 3. Erratum in: Cytokine. 2013 Jun;62(3):453.
2011
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| 34 | CCL2, ZC3H12A
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| MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP.
|
| Younce CW, Kolattukudy PE.
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| Biochem J 426(1):43-53.PMID: 19925454 2010
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| 35 | CCL2, CMTX1
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| Attenuation of MCP-1/CCL2 expression ameliorates neuropathy in a mouse model for Charcot-Marie-Tooth 1X.
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| Groh J, Heinl K, Kohl B, Wessig C, Greeske J, Fischer S, Martini R.
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| Hum Mol Genet 19(18):3530-43. Epub 2010 Jun 30.PMID: 20591826 2010
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| 36 | CCL2, RAC1
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| Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation.
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| Tanaka T, Terada M, Ariyoshi K, Morimoto K.
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| Biochem Biophys Res Commun 399(4):677-82. Epub 2010 Aug 5.PMID: 20691665 2010
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| 37 | CCL2, CCR2
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| The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases.
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| Conductier G, Blondeau N, Guyon A, Nahon JL, Rovère C.
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| J Neuroimmunol 224(1-2):93-100. Review.
2010
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| 38 | CCL2
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| Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy.
|
| Ogimoto A, Okayama H, Nagai T, Ohtsuka T, Suzuki J, Inoue K, Nishimura K, Shigematsu Y, Tabara Y, Kohara K, Miki T, Higaki J.
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| J Cardiol 54(1):66-70. Epub 2009 May 13.
2009
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| 39 | CCL2
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| MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner.
|
| Miyamoto K, Ninomiya K, Sonoda KH, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egashira K, Suda T, Toyama Y, Miyamoto T.
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| Biochem Biophys Res Commun 383(3):373-7. Epub 2009 Apr 11.
2009
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| 40 | CCL2, CXCL10
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| Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and -9: implications for chemotaxis.
|
| Denney H, Clench MR, Woodroofe MN.
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| Biochem Biophys Res Commun 382(2):341-7. Epub 2009 Mar 10.PMID: 19281798 2009
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| 41 | CCL2, CCR2
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| Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone.
|
| Lu Y, Chen Q, Corey E, Xie W, Fan J, Mizokami A, Zhang J.
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| Clin Exp Metastasis 26(2):161-9. Epub 2008 Nov 11.
2009
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| 42 | CCL2,TGFB1
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| MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration.
|
| Ma J, Wang Q, Fei T, Han JD, Chen YG.
|
| Blood 109(3):987-94. Epub 2006 Oct 10. 2007
|
| 43 | CCL2,CCR2,NUP85
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| A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart.
|
| Satoh M, Akatsu T, Ishkawa Y, Minami Y, Nakamura M.
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| J Card Fail 13(2):114-9. 2007
|
| 44 | CCL2
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| The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6.
|
| Liu X, Das AM, Seideman J, Griswold D, Afuh CN, Kobayashi T, Abe S, Fang Q, Hashimoto M, Kim H, Wang X, Shen L, Kawasaki S, Rennard SI.
|
| Am J Respir Cell Mol Biol 37(1):121-8. Epub 2007 Mar 22.
2007
|
| 45 | CCL2,CCR2
|
| Monocyte chemoattractant protein (MCP-1) is expressed in human cardiac cells and is differentially regulated by inflammatory mediators and hypoxia.
|
| Hohensinner PJ, Kaun C, Rychli K, Ben-Tal Cohen E, Kastl SP, Demyanets S, Pfaffenberger S, Speidl WS, Rega G, Ullrich R, Maurer G, Huber K, Wojta J.
|
| FEBS Lett 580(14):3532-8. Epub 2006 May 24. 2006
|
| 46 | CCL2,CCR2
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| The expression of monocyte chemoattractant protein-1 and C-C chemokine receptor 2 in post-kidney transplant patients and the influence of simvastatin treatment.
|
| Wang J, Zou H, Li Q, Wang Y, Xu Q.
|
| Clin Chim Acta 373(1-2):44-8. Epub 2006 May 12. 2006
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| 47 | CCL2
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| Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion.
|
| Lu Y, Cai Z, Galson DL, Xiao G, Liu Y, George DE, Melhem MF, Yao Z, Zhang J.
|
| Prostate 66(12):1311-8. 2006
|
| 48 | CCL2
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| A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.
|
| Flores-Villanueva PO, Ruiz-Morales JA, Song CH, Flores LM, Jo EK, Montano M, Barnes PF, Selman M, Granados J.
|
| J Exp Med 202(12):1649-58. Epub 2005 Dec 13. 2005
|
| 49 | CCL2
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| Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.
|
| Henkel JS, Engelhardt JI, Siklos L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH.
|
| Ann Neurol 55(2):221-35. 2004
|
| 50 | CCL2
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| MCP-1 promoter polymorphism in Spanish patients with rheumatoid arthritis.
|
| Gonzalez-Escribano MF, Torres B, Aguilar F, Rodriguez R, Garcia A, Valenzuela A, Nunez-Roldan A.
|
| Hum Immunol 64(7):741-4. 2003
|
| 51 | CCL2
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| A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease.
|
| Muhlbauer M, Bosserhoff AK, Hartmann A, Thasler WE, Weiss TS, Herfarth H, Lock G, Scholmerich J, Hellerbrand C.
|
| Gastroenterology 125(4):1085-93. 2003
|
| 52 | CCL2
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| Upregulation of monocyte chemoattractant protein 1 and effects of transforming growth factor-beta 1 in Peyronie's disease.
|
| Lin CS, Lin G, Wang Z, Maddah SA, Lue TF.
|
| Biochem Biophys Res Commun 295(4):1014-9. 2002
|
| 53 | CCL2
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| A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression.
|
| Rovin BH, et al.
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| Biochem Biophys Res Commun 259(2):344-8. 1999
|
| 54 | CCL2
|
| Monocyte chemoattractant protein 1 (MCP-1) gene expression in dilated cardiomyopathy.
|
| Lehmann MH, Kuhnert H, Muller S, Sigusch HH.
|
| Cytokine 10 : 739-746. 1998
|
| 55 | CCR2, JAK2, CCL2
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| The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
|
| Mellado M, Rodriguez-Frade JM, Aragay A, del Real G, Martin AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martinez-A C.
|
| J Immunol 161(2):805-13. 1998
|
| 56 | CCL2, CCL8
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| Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.
|
| Proost P, Struyf S, Couvreur M, Lenaerts JP, Conings R, Menten P, Verhaert P, Wuyts A, Van Damme J.
|
| J Immunol 160(8):4034-41.
1998
|
| 57 | CCL2
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| Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12 : evolutionary relatedness of cytokines clustered at the same locus.
|
| Rollins BJ, et al.
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| Genomics 10 : 489-492. 1991
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| 58 | CCL2
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| Localization of monocyte chemotactic protein-1 gene (SCYA2) to human chromosome 17q11.2-q21.1.
|
| Mehrabian M, et al.
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| Genomics 9 : 200-203. 1991
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| 59 | CCL1, CCL2
|
| Structure of human monocyte chemotactic protein gene and its regulation by TPA.
|
| Shyy YJ, et al.
|
| Biochem Biophys Res Commun 169 : 346-351. 1990
|