Citations for
1CCDC88A, PEHO
CCDC88A mutations cause PEHO-like syndrome in humans and mouse.
Nahorski MS, Asai M, Wakeling E, Parker A, Asai N, Canham N, Holder SE, Chen YC, Dyer J, Brady AF, Takahashi M, Woods CG.
Brain 139(Pt 4):1036-44. doi: 10.1093/brain/aww014. Epub 2016 Feb 25. 2016
2CCDC88A
Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.
Leyme A, Marivin A, Perez-Gutierrez L, Nguyen LT, Garcia-Marcos M.
J Cell Biol 210(7):1165-84. doi: 10.1083/jcb.201506041. Epub 2015 Sep 21. 2015
3CCDC88A, CDK5
Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.
Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P.
Proc Natl Acad Sci U S A 112(35):E4874-83. doi: 10.1073/pnas.1514157112. Epub 2015 Aug 18. 2015
4CCDC88A, GNAI3, PARD3
Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Gαi3 signaling.
Sasaki K, Kakuwa T, Akimoto K, Koga H, Ohno S.
J Cell Sci 128(13):2244-58. doi: 10.1242/jcs.160879. Epub 2015 May 14. 2015
5CCDC88A, CDH5, RRAS
Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.
Ichimiya H, Maeda K, Enomoto A, Weng L, Takahashi M, Murohara T.
Biochem Biophys Res Commun 461(2):260-7. doi: 10.1016/j.bbrc.2015.04.012. Epub 2015 Apr 11. 2015
6AKT1, CCDC88A
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.
Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, Ichihara S, Furukawa K, Maeda K, Murohara T, Takahashi M.
Cancer Res 75(5):813-23. doi: 10.1158/0008-5472.CAN-14-1317. 2015
7CCDC88A
Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration.
Omori K, Asai M, Kuga D, Ushida K, Izuchi T, Mii S, Enomoto A, Asai N, Nagino M, Takahashi M.
Biochem Biophys Res Commun 458(4):934-40. doi: 10.1016/j.bbrc.2015.02.065. Epub 2015 Feb 20. 2015
8CCDC88A
GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin.
Wang H, Misaki T, Taupin V, Eguchi A, Ghosh P, Farquhar MG.
J Am Soc Nephrol 26(2):314-27. doi: 10.1681/ASN.2013090985. Epub 2014 Jul 10. 2015
9CCDC88A
The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells.
Hartung A, Ordelheide AM, Staiger H, Melzer M, Häring HU, Lammers R.
Biochim Biophys Acta 1833(12):2803-11. doi: 10.1016/j.bbamcr.2013.07.012. Epub 2013 Jul 23. 2013
10CCDC88A
Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina.
Ito T, Komeima K, Yasuma T, Enomoto A, Asai N, Asai M, Iwase S, Takahashi M, Terasaki H.
Am J Pathol 182(2):586-96. doi: 10.1016/j.ajpath.2012.10.012. Epub 2012 Nov 27. 2013
11CCDC88A
Girdin maintains the stemness of glioblastoma stem cells.
Natsume A, Kato T, Kinjo S, Enomoto A, Toda H, Shimato S, Ohka F, Motomura K, Kondo Y, Miyata T, Takahashi M, Wakabayashi T.
Oncogene 31(22):2715-24. doi: 10.1038/onc.2011.466. Epub 2011 Oct 24. 2012
12CCDC88A
Girdin locates in centrosome and midbody and plays an important role in cell division.
Mao JZ, Jiang P, Cui SP, Ren YL, Zhao J, Yin XH, Enomoto A, Liu HJ, Hou L, Takahashi M, Zhang B.
Cancer Sci 103(10):1780-7. doi: 10.1111/j.1349-7006.2012.02378.x. Epub 2012 Aug 1. 2012
13CCDC88A
Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.
Wang Y, Kaneko N, Asai N, Enomoto A, Isotani-Sakakibara M, Kato T, Asai M, Murakumo Y, Ota H, Hikita T, Namba T, Kuroda K, Kaibuchi K, Ming GL, Song H, Sawamoto K, Takahashi M.
J Neurosci 31(22):8109-22. 2011
14CCDC88A
Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.
Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P.
Sci Signal 4(192):ra64. 2011
15CCDC88A
The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.
Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T.
Circ Res 108(10):1170-9. Epub 2011 Mar 17. 2011
16CCDC88A
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.
Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P.
FASEB J 25(2):590-9. Epub 2010 Oct 25. 2011
17CCDC88A, NUCB1, NUCB2
G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs.
Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG.
J Biol Chem 286(32):28138-49. Epub 2011 Jun 8. 2011
18CCDC88A
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.
Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG.
J Biol Chem 285(17):12765-77. Epub 2010 Feb 15. 2010
19CCDC88A
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.
Garcia-Marcos M, Ghosh P, Farquhar MG.
Proc Natl Acad Sci U S A 106(9):3178-83. Epub 2009 Feb 11. 2009
20CCDC88A
An actin-binding protein Girdin regulates the motility of breast cancer cells.
Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, Sato T, Asai N, Murakumo Y, Takahashi M.
Cancer Res 68(5):1310-8. 2008
21CCDC88A
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.
Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, Costantini F, Murohara T, Takahashi M.
Nat Cell Biol 10(3):329-37. Epub 2008 Feb 10. 2008
22CCDC88A, GNAI3
Activation of Galphai3 triggers cell migration via regulation of GIV.
Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG.
J Cell Biol 182(2):381-93. 2008
23CCDC88A
Akt/PKB regulates actin organization and cell motility via Girdin/APE.
Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, Murakumo Y, Usukura J, Kaibuchi K, Takahashi M.
Dev Cell 9(3):389-402. 2005
24CCDC88A, CCDC88B
A novel hook-related protein family and the characterization of hook-related protein 1.
Simpson F, Martin S, Evans TM, Kerr M, James DE, Parton RG, Teasdale RD, Wicking C.
Traffic 6(6):442-58. 2005
25CCDC88A
Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles.
Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG.
J Biol Chem 280(23):22012-20. Epub 2005 Mar 4. 2005