Citations for
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes.
Roach RJ, Garavís M, González C, Jameson GB, Filichev VV, Hale TK.
Nucleic Acids Res 48(2):682-693. doi: 10.1093/nar/gkz1138. 2020
2CBX5, SUV39H1
HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival.
Lai X, Deng Z, Guo H, Zhu X, Tu W.
Biochem Biophys Res Commun 490(2):415-422. doi: 10.1016/j.bbrc.2017.06.056. Epub 2017 Jun 13. 2017
3CBX1, CBX3, CBX5, SUV39H1
An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions.
Raurell-Vila H, Bosch-Presegue L, Gonzalez J, Kane-Goldsmith N, Casal C, Brown JP, Marazuela-Duque A, Singh PB, Serrano L, Vaquero A.
Epigenetics 12(2):166-175. doi: 10.1080/15592294.2016.1278096. Epub 2017 Jan 6. 2017
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.
Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H, Busch-Nentwich EM, Bartke T.
Nucleic Acids Res ucleic Acids Res. 2016 Oct 24. pii: gkw979. [Epub ahead of print] 2016
5CBX1, CBX5, WDR76
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.
Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G, Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L, Washburn MP.
PLoS One 11(6):e0155492. doi: 10.1371/journal.pone.0155492. eCollection 2016. 2016
Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.
Cheng W, Tian L, Wang B, Qi Y, Huang W, Li H, Chen YJ.
Oncotarget 7(30):48107-48119. doi: 10.18632/oncotarget.10371. 2016
Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box.
Moriyama T, Sangel P, Yamaguchi H, Obuse C, Miyamoto Y, Oka M, Yoneda Y.
Biochem Biophys Res Commun 462(3):201-7. doi: 10.1016/j.bbrc.2015.04.108. Epub 2015 May 7. 2015
RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.
Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z, Sun FL.
Mol Cell Biol 35(2):406-16. doi: 10.1128/MCB.01044-14. Epub 2014 Nov 10. 2015
Heterochromatin Protein 1 Alpha (HP1α: CBX5) is a Key Regulator in Differentiation of Endothelial Progenitor Cells to Endothelial Cells.
Maeng YS, Kwon JY, Kim EK, Kwon YG.
Stem Cells 33(5):1512-22. doi: 10.1002/stem.1954. 2015
Beyond the histone tale: HP1α deregulation in breast cancer epigenetics.
Vad-Nielsen J, Nielsen AL.
Cancer Biol Ther 16(2):189-200. doi: 10.1080/15384047.2014.1001277. Review. 2015
Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells.
Hinde E, Cardarelli F, Gratton E.
Sci Rep 5:12001. doi: 10.1038/srep12001. 2015
The spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division.
Chu L, Huo Y, Liu X, Yao P, Thomas K, Jiang H, Zhu T, Zhang G, Chaudhry M, Adams G, Thompson W, Dou Z, Jin C, He P, Yao X.
J Biol Chem 289(38):26249-62. doi: 10.1074/jbc.M114.581504. Epub 2014 Aug 7. 2014
Biochemical and structural properties of heterochromatin protein 1: understanding its role in chromatin assembly.
Nishibuchi G, Nakayama J.
J Biochem 156(1):11-20. doi: 10.1093/jb/mvu032. Epub 2014 May 13. Review. 2014
Phosphorylation-dephosphorylation cycle of HP1α governs accurate mitotic progression.
Chakraborty A, Prasanth SG.
Cell Cycle 13(11):1663-70. doi: 10.4161/cc.29065. Epub 2014 Apr 30. 2014
Human heterochromatin protein 1α promotes nucleosome associations that drive chromatin condensation.
Azzaz AM, Vitalini MW, Thomas AS, Price JP, Blacketer MJ, Cryderman DE, Zirbel LN, Woodcock CL, Elcock AH, Wallrath LL, Shogren-Knaak MA.
J Biol Chem 289(10):6850-61. doi: 10.1074/jbc.M113.512137. Epub 2014 Jan 10. 2014
Differential contribution of HP1 proteins to DNA end resection and homology-directed repair.
Soria G, Almouzni G.
Cell Cycle 12(3):422-9. doi: 10.4161/cc.23215. Epub 2012 Feb 1. 2013
Hinge and chromoshadow of HP1α participate in recognition of K9 methylated histone H3 in nucleosomes.
Mishima Y, Watanabe M, Kawakami T, Jayasinghe CD, Otani J, Kikugawa Y, Shirakawa M, Kimura H, Nishimura O, Aimoto S, Tajima S, Suetake I.
J Mol Biol 425(1):54-70. doi: 10.1016/j.jmb.2012.10.018. Epub 2012 Nov 6. 2013
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition.
Bawa-Khalfe T, Lu LS, Zuo Y, Huang C, Dere R, Lin FM, Yeh ET.
Proc Natl Acad Sci U S A 109(43):17466-71. doi: 10.1073/pnas.1209378109. Epub 2012 Oct 8. 2012
19CBX5, CXCR4, KLF11, SUV39H1
Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells.
Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R.
J Biol Chem 287(16):12723-35. doi: 10.1074/jbc.M112.351395. Epub 2012 Feb 28. 2012
ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1.
Lee SW, Cho YS, Na JM, Park UH, Kang M, Kim EJ, Um SJ.
J Biol Chem 285(1):18-29. Epub 2009 Oct 31.PMID: 19880879 2010
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.
Nozawa RS, Nagao K, Masuda HT, Iwasaki O, Hirota T, Nozaki N, Kimura H, Obuse C.
Nat Cell Biol 12(7):719-27. Epub 2010 Jun 20.PMID: 20562864 2010
22CBX5, ORC1, ORC2, ORC3
Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization.
Prasanth SG, Shen Z, Prasanth KV, Stillman B.
Proc Natl Acad Sci U S A 107(34):15093-8. Epub 2010 Aug 5.PMID: 20689044 2010
23CBX1, CBX3, CBX5
Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).
Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S.
J Biol Chem 285(41):31337-47. Epub 2010 Aug 1. 2010
24CBX5, NSL1
Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes.
Kiyomitsu T, Iwasaki O, Obuse C, Yanagida M.
J Cell Biol 188(6):791-807. Epub 2010 Mar 15. 2010
The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours.
Souza PP, Völkel P, Trinel D, Vandamme J, Rosnoblet C, Héliot L, Angrand PO.
BMC Cell Biol 10:41. 2009
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.
Loyola A, Tagami H, Bonaldi T, Roche D, Quivy JP, Imhof A, Nakatani Y, Dent SY, Almouzni G.
EMBO Rep 10(7):769-75. Epub 2009 Jun 5.PMID: 19498464 2009
Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications.
LeRoy G, Weston JT, Zee BM, Young NL, Plazas-Mayorca MD, Garcia BA.
Mol Cell Proteomics 8(11):2432-42. Epub 2009 Jun 30.PMID: 19567367 2009
Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.
Ameyar-Zazoua M, Souidi M, Fritsch L, Robin P, Thomas A, Hamiche A, Percipalle P, Ait-Si-Ali S, Harel-Bellan A.
J Biol Chem 284(41):27974-9. Epub 2009 Jul 17.PMID: 19617346 2009
29CBX5, YY1
The role of YY1 in reduced HP1alpha gene expression in invasive human breast cancer cells.
Lieberthal JG, Kaminsky M, Parkhurst CN, Tanese N.
Breast Cancer Res 11(3):R42. Epub 2009 Jun 30.PMID: 19566924 2009
30CBX1, CBX2, CBX3, CBX4, CBX5, CBX6, CBX7, CBX8
Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.
Vincenz C, Kerppola TK.
Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2008 Oct 16. [Epub ahead of print] 2008
31CBX1, CBX3, CBX5
Regulation of an inducible promoter by an HP1beta-HP1gamma switch.
Mateescu B, Bourachot B, Rachez C, Ogryzko V, Muchardt C.
EMBO Rep 9(3):267-72. Epub 2008 Feb 1.PMID: 18239689 2008
TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1.
Brancorsini S, Davidson I, Sassone-Corsi P.
Cell Cycle 7(10):1415-22. Epub 2008 Mar 3.PMID: 18418073 2008
Functional cooperation between HP1 and DNMT1 mediates gene silencing.
Smallwood A, Estčve PO, Pradhan S, Carey M.
Genes Dev 21(10):1169-78. Epub 2007 Apr 30.PMID: 17470536 2007
34CBX1, CBX3, CBX5
Pericentromeric heterochromatin domains are maintained without accumulation of HP1.
Mateos-Langerak J, Brink MC, Luijsterburg MS, van der Kraan I, van Driel R, Verschure PJ.
Mol Biol Cell 18(4):1464-71. Epub 2007 Feb 21.PMID: 17314413 2007
35CBX1, CBX3, CBX5, H3F3A
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation.
Fischle W, Tseng BS, Dormann HL, Ueberheide BM, Garcia BA, Shabanowitz J, Hunt DF, Funabiki H, Allis CD.
Nature 438(7071):1116-22. Epub 2005 Oct 12. 2005
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin.
Hirota T, Lipp JJ, Toh BH, Peters JM.
Nature 438(7071):1176-80. Epub 2005 Oct 12. 2005
37CBX1, CBX3, CBX5
Gene regulation by human orthologs of Drosophila heterochromatin protein 1.
Hwang KK, Worman HJ.
Biochem Biophys Res Commun 293(4):1217-22. 2002
38CBX3, CBX5
Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.
Ye Q, Worman HJ.
J Biol Chem 271(25):14653-6. 1996