| 1 | CBLB
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| NF-κB downregulates Cbl-b through binding and suppressing Cbl-b promoter in T cell activation.
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| Liu Y, Li Y, Zhang L, Li M, Li C, Xue C, Huang X, Zhou P.
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| J Immunol 194(8):3778-83. doi: 10.4049/jimmunol.1402104. Epub 2015 Mar 11.
2015
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| 2 | CBLB, ORMDL3, STAT6
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| E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation.
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| Yang WX, Jin R, Jiang CM, Wang XH, Shu J, Li L, Zhu LH, Zhuang LL, Gao C, Zhou GP.
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| FEBS Lett 589(15):1975-80. doi: 10.1016/j.febslet.2015.06.015. Epub 2015 Jun 22.
2015
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| 3 | CBLB
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| Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes.
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| Veselits M, Tanaka A, Lipkowitz S, O'Neill S, Sciammas R, Finnegan A, Zhang J, Clark MR.
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| PLoS One 9(3):e89792. doi: 10.1371/journal.pone.0089792. eCollection 2014.
2014
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| 4 | CBL, CBLB, SIRT2
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| Cbl regulates the activity of SIRT2.
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| Choi YH, Kim H, Han Y, Jin YH, Lee KY.
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| Biochem Biophys Res Commun 453(3):557-62. doi: 10.1016/j.bbrc.2014.09.125. Epub 2014 Oct 5.
2014
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| 5 | CBLB, PTK2B
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| Cbl-b accelerates trypsin-induced cell detachment through ubiquitination and degradation of proline-rich tyrosine kinase 2.
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| Fan Y, Qu X, Ma Y, Qu J, Liu Y, Hu X.
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| Tumour Biol 35(11):11129-35. doi: 10.1007/s13277-014-2296-z. Epub 2014 Aug 7.
2014
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| 6 | CBLB, DDR2
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| Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability.
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| Yu J, Zhao H, Zhang Y, Liu YC, Yao L, Li X, Su J.
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| FEBS Lett 588(9):1509-14. doi: 10.1016/j.febslet.2014.03.003. Epub 2014 Mar 12.
2014
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| 7 | CBLB, SMAD7
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| Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
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| Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang CM, Viola A, Pfeifhofer-Obermair C, Baier G.
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| J Mol Cell Biol 5(6):358-68. doi: 10.1093/jmcb/mjt017. Epub 2013 May 24.
2013
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| 8 | CBLB
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| T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.
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| Qiao G, Zhao Y, Li Z, Tang PQ, Langdon WY, Yang T, Zhang J.
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| J Immunol 191(2):632-9. doi: 10.4049/jimmunol.1202068. Epub 2013 Jun 7.
2013
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| 9 | CBLB, CLEC4G
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| Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets.
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| Zhao D, Zhang M, Wang M, Liu B, Wang X, Yang J, He F, Tang L.
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| Immunobiology 218(4):602-8. doi: 10.1016/j.imbio.2012.07.017. Epub 2012 Jul 23.
2013
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| 10 | CBLB, PTEN
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| E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.
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| Guo H, Qiao G, Ying H, Li Z, Zhao Y, Liang Y, Yang L, Lipkowitz S, Penninger JM, Langdon WY, Zhang J.
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| Cell Rep 1(5):472-82.
2012
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| 11 | CBLB
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| Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions.
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| Paolino M, Thien CB, Gruber T, Hinterleitner R, Baier G, Langdon WY, Penninger JM.
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| J Immunol 186(4):2138-47. doi: 10.4049/jimmunol.1003390. Epub 2011 Jan 19.
2011
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| 12 | CBLB
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| Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population.
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| Corrado L, Bergamaschi L, Barizzone N, Fasano ME, Guerini FR, Salvetti M, Galimberti D, Benedetti MD, Leone M, D'Alfonso S.
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| J Med Genet 48(3):210-1. doi: 10.1136/jmg.2010.081380. Epub 2010 Oct 30.
2011
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| 13 | CBLB
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| Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines.
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| Salingcarnboriboon RA, Pavasant P, Noda M.
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| J Cell Physiol 224(3):743-7. doi: 10.1002/jcp.22176.
2010
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| 14 | CBLB
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| The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells.
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| St Rose MC, Qui HZ, Bandyopadhyay S, Mihalyo MA, Hagymasi AT, Clark RB, Adler AJ.
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| J Immunol 183(8):4975-83. doi: 10.4049/jimmunol.0901243.
2009
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| 15 | CBL, CBLB
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| Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.
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| Nakajima A, Sanjay A, Chiusaroli R, Adapala NS, Neff L, Itzsteink C, Horne WC, Baron R.
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| J Bone Miner Res 24(7):1162-72. doi: 10.1359/jbmr.090205.
2009
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| 16 | CBLB
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| Identification and functional analysis of CBLB mutations in type 1 diabetes.
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| Yokoi N, Fujiwara Y, Wang HY, Kitao M, Hayashi C, Someya T, Kanamori M, Oiso Y, Tajima N, Yamada Y, Seino Y, Ikegami H, Seino S.
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| Biochem Biophys Res Commun 368(1):37-42. Epub 2008 Jan 15. 2008
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| 17 | CBLB
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| E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury.
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| Bachmaier K, Toya S, Gao X, Triantafillou T, Garrean S, Park GY, Frey RS, Vogel S, Minshall R, Christman JW, Tiruppathi C, Malik AB.
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| Nat Med 13(8):920-6. Epub 2007 Jul 8. 2007
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| 18 | CBL, CBLB, CBLC
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| Comparative genomic organization of the cbl genes.
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| Nau MM, Lipkowitz S.
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| Gene 308:103-13. 2003
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| 19 | CBLB, CD28
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| Cbl-b regulates the CD28 dependence of T-cell activation.
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| Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, Jang IK, Gutkind JS, Shevach E, Gu H.
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| Nature 403(6766):216-20 2000
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| 20 | CBLB
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| Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
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| Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, Penninger JM.
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| Nature 403(6766):211-6 2000
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| 21 | CBLB
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| Cloning and characterization of cbl-b : a SH3 binding protein with homology to the c-cbl proto-oncogene.
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| Keane MM, et al.
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| Oncogene 10 : 2367-2377. 1995
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