| 1 | CAST, PLCS
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| Loss-of-Function Mutations in CAST Cause Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis, and Knuckle Pads.
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| Lin Z, Zhao J, Nitoiu D, Scott CA, Plagnol V, Smith FJ, Wilson NJ, Cole C, Schwartz ME, McLean WH, Wang H, Feng C, Duo L, Zhou EY, Ren Y, Dai L, Chen Y, Zhang J, Xu X, O'Toole EA, Kelsell DP, Yang Y.
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| Am J Hum Genet 96(3):440-7. doi: 10.1016/j.ajhg.2014.12.026. Epub 2015 Feb 12.
2015
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| 2 | CAST
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| Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial Cells.
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| Miyazaki T, Taketomi Y, Saito Y, Hosono T, Lei XF, Kim-Kaneyama JR, Arata S, Takahashi H, Murakami M, Miyazaki A.
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| Circ Res irc Res. 2015 Feb 3. pii: CIRCRESAHA.114.305363. [Epub ahead of print]
2015
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| 3 | CAST
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| Loss of calpastatin leads to activation of calpain in human lens epithelial cells.
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| Nakajima T, Shearer TR, Azuma M.
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| Invest Ophthalmol Vis Sci 55(8):5278-83. doi: 10.1167/iovs.14-14778.
2014
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| 4 | CAST
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| Differential regulation of the calpain-calpastatin complex by the L-domain of calpastatin.
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| De Tullio R, Averna M, Pedrazzi M, Sparatore B, Salamino F, Pontremoli S, Melloni E.
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| Biochim Biophys Acta 1843(11):2583-91. doi: 10.1016/j.bbamcr.2014.07.002. Epub 2014 Jul 12.
2014
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| 5 | CAPN1, CAST
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| Altered expression of calcineurin, calpain, calpastatin and HMWCaMBP in cardiac cells following ischemia and reperfusion.
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| Parameswaran S, Sharma RK.
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| Biochem Biophys Res Commun 443(2):604-9. doi: 10.1016/j.bbrc.2013.12.019. Epub 2013 Dec 11.
2014
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| 6 | CAPN1, CAST
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| The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.
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| Raimbourg Q, Perez J, Vandermeersch S, Prignon A, Hanouna G, Haymann JP, Baud L, Letavernier E.
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| PLoS One 8(4):e60469. doi: 10.1371/journal.pone.0060469. Epub 2013 Apr 2.
2013
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| 7 | CAST
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| An association between the calpastatin (CAST) gene and keratoconus.
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| Li X, Bykhovskaya Y, Tang YG, Picornell Y, Haritunians T, Aldave AJ, Szczotka-Flynn L, Iyengar SK, Rotter JI, Taylor KD, Rabinowitz YS.
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| Cornea 32(5):696-701. doi: 10.1097/ICO.0b013e3182821c1c.
2013
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| 8 | ATXN3, CAPN1, CAPN2, CAST
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| Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
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| Hübener J, Weber JJ, Richter C, Honold L, Weiss A, Murad F, Breuer P, Wüllner U, Bellstedt P, Paquet-Durand F, Takano J, Saido TC, Riess O, Nguyen HP.
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| Hum Mol Genet 22(3):508-18. doi: 10.1093/hmg/dds449. Epub 2012 Oct 24.
2013
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| 9 | CAST
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| Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury.
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| Ma M, Shofer FS, Neumar RW.
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| J Neurotrauma 29(16):2555-63. doi: 10.1089/neu.2012.2473. Epub 2012 Aug 29.
2012
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| 10 | CAST, NOS1
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| Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia.
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| Samengo G, Avik A, Fedor B, Whittaker D, Myung KH, Wehling-Henricks M, Tidball JG.
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| Aging Cell 11(6):1036-45. doi: 10.1111/acel.12003. Epub 2012 Oct 4.
2012
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| 11 | CAST, SELENOK
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| Selenoprotein K Is a Novel Target of m-Calpain, and Cleavage Is Regulated by Toll-like Receptor-induced Calpastatin in Macrophages.
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| Huang Z, Hoffmann FW, Norton RL, Hashimoto AC, Hoffmann PR.
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| J Biol Chem 286(40):34830-8. Epub 2011 Aug 17. 2011
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| 12 | CAST
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| Calpastatin domain L is a partial agonist of the calmodulin-binding site for channel activation in Cav1.2 Ca2+ channels.
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| Minobe E, Asmara H, Saud ZA, Kameyama M.
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| J Biol Chem Biol Chem. 2011 Sep 21. [Epub ahead of print]
2011
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| 13 | CAST
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| Characterization of the expression profiles of calpastatin (CAST) gene in chicken.
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| Zhang ZR, Jiang XS, Du HR, Zhu Q, Li XC, Yang CW, Liu YP.
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| Mol Biol Rep ol Biol Rep. 2011 Jun 3. [Epub ahead of print]
2011
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| 14 | CAST
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| Calpastatin is associated with lymphovascular invasion in breast cancer.
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| Storr SJ, Mohammed RA, Woolston CM, Green AR, Parr T, Spiteri I, Caldas C, Ball GR, Ellis IO, Martin SG.
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| Breast 20(5):413-8. Epub 2011 May 4.
2011
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| 15 | CAST, CDK5
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| Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
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| Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga S.
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| J Neurochem 117(3):504-15. doi: 10.1111/j.1471-4159.2011.07222.x. Epub 2011 Mar 15. 2011
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| 16 | CAST, PIN1
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| Calpastatin is regulated by protein never in mitosis gene A interacting-1 (PIN1) in endothelial cells.
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| Liu T, Schneider RA, Hoyt DG.
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| Biochem Biophys Res Commun 414(3):581-6. Epub 2011 Oct 1.
2011
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| 17 | CAPN1, CAPN2, CAST
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| Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
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| Salehin D, Fromberg I, Haugk C, Dohmen B, Georg T, Bohle RM, Bauerschlag D, Thill M, Friedrich M.
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| Eur J Gynaecol Oncol 32(6):628-35.
2011
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| 18 | CAST
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| Photoreceptor rescue and toxicity induced by different calpain inhibitors.
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| Paquet-Durand F, Sanges D, McCall J, Silva J, van Veen T, Marigo V, Ekström P.
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| J Neurochem 115(4):930-40. doi: 10.1111/j.1471-4159.2010.06983.x. Epub 2010 Sep 28.
2010
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| 19 | CAST
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| Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer.
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| Salehin D, Fromberg I, Haugk C, Dohmen B, Georg T, Bohle RM, Bauerschlag D, Maass N, Friedrich M.
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| Anticancer Res 30(7):2837-43.
2010
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| 20 | CAST
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| Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
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| Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.
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| J Biol Chem 285(36):27737-44. Epub 2010 Jul 1.
2010
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| 21 | CAST
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| Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration.
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| Mizukoshi S, Nakazawa M, Sato K, Ozaki T, Metoki T, Ishiguro S.
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| Exp Eye Res 91(3):353-61. Epub 2010 Jun 12.
2010
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| 22 | CAST
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| SNPs in CAST are associated with Parkinson disease: a confirmation study.
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| Allen AS, Satten GA.
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| Am J Med Genet B Neuropsychiatr Genet 153B(4):973-9.
2010
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| 23 | CAST
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| Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis.
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| Stifanese R, Averna M, De Tullio R, Pedrazzi M, Beccaria F, Salamino F, Milanese M, Bonanno G, Pontremoli S, Melloni E.
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| J Biol Chem 285(1):631-43. Epub 2009 Oct 30.
2010
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| 24 | CAPN1, CAST
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| Calpain 1 and Calpastatin expression is developmentally regulated in rat brain.
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| Li Y, Bondada V, Joshi A, Geddes JW.
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| Exp Neurol 220(2):316-9. Epub 2009 Sep 12.
2009
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| 25 | CAST, IGF1
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| IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death.
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| Arroba AI, Wallace D, Mackey A, de la Rosa EJ, Cotter TG.
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| Eur J Neurosci 30(6):975-86. Epub 2009 Sep 1.
2009
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| 26 | CAST
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| A novel calpastatin-based inhibitor improves postischemic neurological recovery.
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| Anagli J, Han Y, Stewart L, Yang D, Movsisyan A, Abounit K, Seyfried D.
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| Biochem Biophys Res Commun 385(1):94-9. Epub 2009 May 5.
2009
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| 27 | CAST
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| A novel haplotype-sharing approach for genome-wide case-control association studies implicates the calpastatin gene in Parkinson's disease.
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| Allen AS, Satten GA.
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| Genet Epidemiol 33(8):657-67.
2009
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| 28 | CAST
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| Regulation of calpain activity by c-Myc through calpastatin and promotion of transformation in c-Myc-negative cells by calpastatin suppression.
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| Niapour M, Yu Y, Berger SA.
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| J Biol Chem 283(31):21371-81. Epub 2008 Jun 10.
2008
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| 29 | CACNA1C, CAST
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| Calpastatin binds to a calmodulin-binding site of cardiac Cav1.2 Ca2+ channels.
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| Saud ZA, Minobe E, Wang WY, Han DY, Horiuchi M, Hao LY, Kameyama M.
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| Biochem Biophys Res Commun 364(2):372-7. Epub 2007 Oct 15.
2007
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| 30 | CAST, ERC1, PCLO
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| Localization of the active zone proteins CAST, ELKS, and Piccolo at neuromuscular junctions.
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| Tokoro T, Higa S, Deguchi-Tawarada M, Inoue E, Kitajima I, Ohtsuka T.
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| Neuroreport 18(4):313-6.
2007
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| 31 | CAPN1, CAPN2, CAST
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| Expression and immunolocalization of the calpain-calpastatin system in the human oocyte.
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| Ben-Aharon I, Ben-Yosef D, Amit A, Shalgi R.
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| Fertil Steril 83(6):1807-13.
2005
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| 32 | CAST
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| Four promoters direct expression of the calpastatin gene.
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| Raynaud P, Jayat-Vignoles C, Laforêt MP, Levéziel H, Amarger V.
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| Arch Biochem Biophys 437(1):69-77.
2005
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| 33 | CAST
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| Regulation of calpain and calpastatin in differentiating myoblasts: mRNA levels, protein synthesis and stability.
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| Barnoy S, Supino-Rosin L, Kosower NS.
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| Biochem J 351 Pt 2:413-20. 2000
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| 34 | ADAMTS3, AKAP6, ALMS1, ANKRD28, AREL1, ARHGEF10, ARHGEF11, ARHGEF17, ARNT2, BAZ2A, CABIN1, CAST, CHD9, CIC, CLEC16A, CLOCK, CTNND1, DCLK1, DDX46, DIDO1, DNAH9, DNM3, DOCK3, DYNC1H1, ECM29, ENTPD4, EPB41L1, EZH1, FRMPD4, GCC2, HECW1, HERC2, HISPPD1, HUWE1, IGSF1, KAT6B, KHNYN, KIAA0319, KIAA0355, KIAA0379, KIF3B, KMT2B, LBA1, MADD, MAST4, MCF2L, MDN1, MTMR3, MYO6, N4BP3, NACAD, NRCAM, PCDH9, PCDHGA8, PCDHGC3, PDZD2, PER2, PFAS, PLEKHM1, PLXNB2, PRORP, PRUNE2, PTPRN2, RAPGEF2, RIMBP2, RIMS1, RIPOR2, RUSC2, SALL2, SEC16A, SEMA3C, SEMA3E, SETD1A, SFRS14, SNPH, SPECC1L, SPTBN2, SR140, SRCAP, SRRM2, SYNJ2, TECPR2, TLN2, TRIM66, TTC37, UBR2, WNK1, XPO6, ZBTB39, ZBTB5, ZFYVE16, ZFYVE26, ZMYM3, ZNF518A, ZNF609, ZNF629, ZNF646
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| Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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| Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
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| DNA Res 4(2):141-50. 1997
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| 35 | CAST
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| Molecular diversity in amino-terminal domains of human calpastatin by exon skipping.
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| Lee WJ, et al.
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| J Biol Chem 267 : 8437-8442. 1992
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| 36 | CAST
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| Assignment of the human calpastatin gene (CAST) to chromosome 5 at region q15-q21.
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| Inazawa J, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1898. 1991
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| 37 | CAST
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| Assignment of the human calpastatin gene (CAST) to chromosome 5 at region q14-q22.
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| Inazawa J, et al.
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| Cytogenet Cell Genet 54 : 156-158. 1990
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