Citations for
1CASP3, CASP8
Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants.
Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD, Joseph B, Brkanac Z.
PLoS One 12(10):e0185777. doi: 10.1371/journal.pone.0185777. eCollection 2017. 2017
2CASP3, MTRNR2L1
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR.
Invest Ophthalmol Vis Sci 57(3):1238-53. doi: 10.1167/iovs.15-17053. 2016
3CASP3, CASP4
Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress.
Morishima N, Nakanishi K.
Genes Cells 21(7):798-806. doi: 10.1111/gtc.12384. Epub 2016 Jun 14. 2016
4BIRC5, BIRC7, CASP3
Expression of livin, survivin and caspase-3 in prostatic cancer and their clinical significance.
Gu J, Ren L, Wang X, Qu C, Zhang Y.
Int J Clin Exp Pathol 8(11):14034-9. eCollection 2015. 2015
5CASP3, FANCD2
FANCD2 is a target for caspase 3 during DNA damage-induced apoptosis.
Sakai W, Sugasawa K.
FEBS Lett 588(20):3778-85. doi: 10.1016/j.febslet.2014.08.027. Epub 2014 Aug 28. 2014
6CASP3, MET
Novel Death Defying Domain in Met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes.
Ma J, Zou C, Guo L, Seneviratne DS, Tan X, Kwon YK, An J, Bowser R, DeFrances MC, Zarnegar R.
Hepatology 59(5):2010-21. doi: 10.1002/hep.26769. Epub 2014 Apr 1. 2014
7CASP3
Caspase-3 modulates regenerative response after stroke.
Fan W, Dai Y, Xu H, Zhu X, Cai P, Wang L, Sun C, Hu C, Zheng P, Zhao BQ.
Stem Cells 32(2):473-86. doi: 10.1002/stem.1503. 2014
8CASP3, PRTN3
Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation.
Loison F, Zhu H, Karatepe K, Kasorn A, Liu P, Ye K, Zhou J, Cao S, Gong H, Jenne DE, Remold-O'Donnell E, Xu Y, Luo HR.
J Clin Invest 124(10):4445-58. doi: 10.1172/JCI76246. Epub 2014 Sep 2. 2014
9CASP3, CASP9, MAPK14, ROBO2, SLIT1
Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization.
Campbell DS, Okamoto H.
J Cell Biol 203(4):657-72. doi: 10.1083/jcb.201303072. 2013
10CASP3
Paracrine control of tissue regeneration and cell proliferation by Caspase-3.
Boland K, Flanagan L, Prehn JH.
Cell Death Dis 4:e725. doi: 10.1038/cddis.2013.250. Review. 2013
11CASP3, CASP7, CASP9
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH.
BMC Cell Biol 14:32. doi: 10.1186/1471-2121-14-32. 2013
12CASP3
Active caspase-3 is stored within secretory compartments of viable mast cells.
Garcia-Faroldi G, Melo FR, Rönnberg E, Grujic M, Pejler G.
J Immunol 191(3):1445-52. doi: 10.4049/jimmunol.1300216. Epub 2013 Jul 1. 2013
13CASP3, NEK5
Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity.
Shimizu K, Sawasaki T.
FEBS Lett 587(14):2219-25. doi: 10.1016/j.febslet.2013.05.049. Epub 2013 May 31. 2013
14CASP3
Caspase-3 is involved in the signalling in erythroid differentiation by targeting late progenitors.
Boehm D, Mazurier C, Giarratana MC, Darghouth D, Faussat AM, Harmand L, Douay L.
PLoS One 8(5):e62303. doi: 10.1371/journal.pone.0062303. Print 2013. 2013
15CASP3, ROCK1
Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles.
Böing AN, Stap J, Hau CM, Afink GB, Ris-Stalpers C, Reits EA, Sturk A, van Noorden CJ, Nieuwland R.
Biochim Biophys Acta 1833(8):1844-52. doi: 10.1016/j.bbamcr.2013.03.013. Epub 2013 Mar 24. 2013
16CASP3, CCND1, MMP9, NUMBL, TRAF6
Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell.
Yingjie L, Jian T, Changhai Y, Jingbo L.
Tumour Biol 34(5):2773-80. doi: 10.1007/s13277-013-0835-7. Epub 2013 May 17. 2013
17CASP3, GLRX3
Caspase-3-mediated cleavage of PICOT in apoptosis.
Yun N, Kim C, Cha H, Park WJ, Shibayama H, Park IS, Oh YJ.
Biochem Biophys Res Commun 432(3):533-8. doi: 10.1016/j.bbrc.2013.02.017. Epub 2013 Feb 13. 2013
18CASP3
Caspase-3 protects stressed organs against cell death.
Khalil H, Peltzer N, Walicki J, Yang JY, Dubuis G, Gardiol N, Held W, Bigliardi P, Marsland B, Liaudet L, Widmann C.
Mol Cell Biol 32(22):4523-33. doi: 10.1128/MCB.00774-12. Epub 2012 Sep 4. 2012
19CASP3, TRIB3
Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3.
Shimizu K, Takahama S, Endo Y, Sawasaki T.
PLoS One 7(8):e42721. doi: 10.1371/journal.pone.0042721. Epub 2012 Aug 9. 2012
20CASP3
Caspase-3 in the central nervous system: beyond apoptosis.
D'Amelio M, Sheng M, Cecconi F.
Trends Neurosci 35(11):700-9. doi: 10.1016/j.tins.2012.06.004. Epub 2012 Jul 14. 2012
21ANP32B, CASP3
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) contributes to retinoic acid-induced differentiation of leukemic cells.
Yu Y, Shen SM, Zhang FF, Wu ZX, Han B, Wang LS.
Biochem Biophys Res Commun 423(4):721-5. doi: 10.1016/j.bbrc.2012.06.025. Epub 2012 Jun 13. 2012
22CASP3, PAWR
Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation.
Chaudhry P, Singh M, Parent S, Asselin E.
Mol Cell Biol 32(4):826-39. doi: 10.1128/MCB.06321-11. Epub 2011 Dec 19. 2012
23CASP3, LPPR1, MAP1LC3A, SLC30A4
Dynamic Pattern of Gene Expression of ZnT-4, Caspase-3, LC3, and PRG-3 in Rat Cerebral Cortex Following Flurothyl-Induced Recurrent Neonatal Seizures.
Ni H, Feng X, Xiao ZJ, Tao LY, Jin MF.
Biol Trace Elem Res iol Trace Elem Res. 2011 Feb 1. [Epub ahead of print] 2011
24CASP3, CASP9
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3.
Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW.
Structure 19(8):1084-96. 2011
25CASP3, DIABLO
Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death.
Hui KK, Kanungo AK, Elia AJ, Henderson JT.
Cell Death Differ 18(11):1780-90. doi: 10.1038/cdd.2011.50. Epub 2011 May 20. 2011
26ATCAY, CASP3, CASP7
Cayman ataxia-related protein is a presynapse-specific caspase-3 substrate.
Itoh M, Li S, Ohta K, Yamada A, Hayakawa-Yano Y, Ueda M, Hida Y, Suzuki Y, Ohta E, Mizuno A, Banno Y, Nakagawa T.
Neurochem Res 36(7):1304-13. doi: 10.1007/s11064-011-0430-5. Epub 2011 Mar 3. 2011
27CASP3, HIF1A, NFKB1, TGM2
Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells.
Jang GY, Jeon JH, Cho SY, Shin DM, Kim CW, Jeong EM, Bae HC, Kim TW, Lee SH, Choi Y, Lee DS, Park SC, Kim IG.
Oncogene 29(3):356-67. Epub 2009 Oct 19. 2010
28CASP3
Common variants in CASP3 confer susceptibility to Kawasaki disease.
Onouchi Y, Ozaki K, Buns JC, Shimizu C, Hamada H, Honda T, Terai M, Honda A, Takeuchi T, Shibuta S, Suenaga T, Suzuki H, Higashi K, Yasukawa K, Suzuki Y, Sasago K, Kemmotsu Y, Takatsuki S, Saji T, Yoshikawa T, Nagai T, Hamamoto K, Kishi F, Ouchi K, Sato Y, Newburger JW, Baker AL, Shulman ST, Rowley AH, Yashiro M, Nakamura Y, Wakui K, Fukushima Y, Fujino A, Tsunoda T, Kawasaki T, Hata A, Nakamura Y, Tanaka T.
Hum Mol Genet 19(14):2898-906. Epub 2010 Apr 27.PMID: 20423928 2010
29CASP3, CASP7
Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.
Nakatsumi H, Yonehara S.
J Biol Chem 285(33):25418-25. Epub 2010 Jun 21. 2010
30CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9
Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
Kim YR, Kim KM, Yoo NJ, Lee SH.
Hum Pathol 40(6):868-71. Epub 2009 Mar 9. 2009
31BIRC2, BIRC3, CASP3, CASP7
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB.
J Biol Chem 284(19):12772-82. Epub 2009 Mar 3. 2009
32CASP3
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.
Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC.
Biochem J 424(3):335-45.PMID: 19788411 2009
33CASP3
Caspase-3 is activated and rapidly released from human umbilical vein endothelial cells in response to lipopolysaccharide.
Shioiri T, Muroi M, Hatao F, Nishida M, Ogawa T, Mimura Y, Seto Y, Kaminishi M, Tanamoto K.
Biochim Biophys Acta 1792(10):1011-8. Epub 2009 Jun 25.PMID: 19559790 2009
34CASP3, CASP7
Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity.
Demon D, Van Damme P, Vanden Berghe T, Deceuninck A, Van Durme J, Verspurten J, Helsens K, Impens F, Wejda M, Schymkowitz J, Rousseau F, Madder A, Vandekerckhove J, Declercq W, Gevaert K, Vandenabeele P.
Mol Cell Proteomics 8(12):2700-14. Epub 2009 Sep 16.PMID: 19759058 2009
35CASP3, DSG2
The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery.
Cirillo N, Lanza M, De Rosa A, Cammarota M, La Gatta A, Gombos F, Lanza A.
J Cell Biochem 103(2):598-606.PMID: 17559062 2008
36CASP3
Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk.
Jang JS, Kim KM, Choi JE, Cha SI, Kim CH, Lee WK, Kam S, Jung TH, Park JY.
Mol Carcinog 47(5):383-90.PMID: 18058802 2008
37CASP3, CASP7
Executioner caspase-3 and caspase-7 are functionally distinct proteases.
Walsh JG, Cullen SP, Sheridan C, Lüthi AU, Gerner C, Martin SJ.
Proc Natl Acad Sci U S A 105(35):12815-9. Epub 2008 Aug 22.PMID: 18723680 2008
38HSPA1A, HSPA4, GATA1, CASP3
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
Ribeil JA, Zermati Y, Vandekerckhove J, Cathelin S, Kersual J, Dussiot M, Coulon S, Moura IC, Zeuner A, Kirkegaard-Sorensen T, Varet B, Solary E, Garrido C, Hermine O.
Nature 445(7123):102-5. Epub 2006 Dec 10. 2007
39CASP3, GLRX, TNF
Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death.
Sykes MC, Mowbray AL, Jo H.
Circ Res 100(2):152-4. 2007
40CASP3, CASP8, CASP12
Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells.
Neekhra A, Luthra S, Chwa M, Seigel G, Gramajo AL, Kuppermann BD, Kenney MC.
Invest Ophthalmol Vis Sci 48(3):1362-7. 2007
41RNF2, CASP3, CASP9
Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9.
Wong CK, Chen Z, So KL, Li D, Li P.
Biochim Biophys Acta 1773(6):844-52. Epub 2007 Feb 22. 2007
42CASP3, PTPN12
Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.
Halle M, Liu YC, Hardy S, Theberge JF, Blanchetot C, Bourdeau A, Meng TC, Tremblay ML.
Mol Cell Biol 27(3):1172-90. Epub 2006 Nov 27. 2007
43CASP3, CASP9, XIAP
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9.
Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS.
Biochem J 405(1):11-9. 2007
44ROCK1, CASP3
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.
Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ.
Proc Natl Acad Sci U S A 103(39):14495-500. Epub 2006 Sep 18. 2006
45CASP3, CASP8, CASP12
Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.
Luthra S, Fardin B, Dong J, Hertzog D, Kamjoo S, Gebremariam S, Butani V, Narayanan R, Mungcal JK, Kuppermann BD, Kenney MC.
Invest Ophthalmol Vis Sci 47(12):5569-75. 2006
46CASP3
Somatic mutations of CASP3 gene in human cancers.
Soung YH, Lee JW, Kim SY, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH.
Hum Genet 115(2):112-5. Epub 2004 May 04. 2004
47CASP3, GORASP1, GORASP2
Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis.
Lane JD, Lucocq J, Pryde J, Barr FA, Woodman PG, Allan VJ, Lowe M.
J Cell Biol 156(3):495-509. Epub 2002 Jan 28. 2002
48CASP3, XIAP
Structural basis for the inhibition of caspase-3 by XIAP.
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS.
Cell 104(5):791-800. 2001
49CASP1, CASP3
Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
Winter RN, Kramer A, Borkowski A, Kyprianou N.
Cancer Res 61(3):1227-32. 2001
50CASP3
Molecular cloning and characterization of a novel caspase-3 variant that attenuates apoptosis induced by proteasome inhibition.
Huang Y, Shin NH, Sun Y, Wang KK.
Biochem Biophys Res Commun 283(4):762-9. 2001
51CASP3
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.
Hartmann A, Hunot S, Michel PP, Muriel MP, Vyas S, Faucheux BA, Mouatt-Prigent A, Turmel H, Srinivasan A, Ruberg M, Evan GI, Agid Y, Hirsch EC.
Proc Natl Acad Sci U S A 97(6):2875-80. 2000
52CASP3
Heavy membrane-associated caspase 3: identification, isolation, and characterization.
Krebs JF, Srinivasan A, Wong AM, Tomaselli KJ, Fritz LC, Wu JC.
Biochemistry 39(51):16056-63. 2000
53CASP3, CDKN1A
Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.
Park JA, Kim KW, Kim SI, Lee SK.
Eur J Biochem 257(1):242-8. 1998
54CASP3
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo.
Zheng TS, Schlosser SF, Dao T, Hingorani R, Crispe IN, Boyer JL, Flavell RA.
Proc Natl Acad Sci U S A 95(23):13618-23. 1998
55CASP3, SPTAN1
Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis.
Janicke RU, Ng P, Sprengart ML, Porter AG.
J Biol Chem 273(25):15540-5. 1998
56AR, CASP3, SBMA
Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.
Kobayashi Y, Miwa S, Merry DE, Kume A, Mei L, Doyu M, Sobue G.
Biochem Biophys Res Commun 252(1):145-50. 1998
57CASP1, CASP3
Role of caspases 1 and 3 and Bcl-2-related molecules in endothelial cell apoptosis associated with thrombotic microangiopathies.
Mitra D, Kim J, MacLow C, Karsan A, Laurence J.
Am J Hematol 59(4):279-87. 1998
58CASP3, CASP6
Localization of the cell death genes CPP32 and Mch-2 to human chromosome 4q.
Nasir J, Theilmann JL, Chopra V, Jones AM, Walker D, Rasper DM, Vaillancourt JP, Hewitt JE, Nicholson DW, Hayden MR.
Mamm Genome 8(1):56-9. 1997
59CASP1, CASP2, CASP3, CASP4, CASP6, CASP7
Caspases: intracellular signaling by proteolysis.
Salvesen GS, Dixit VM.
Cell 91(4):443-6. 1997
60CASP3, GSN
Caspase-3-generated fragment of gelsolin : effector of morphological change in apoptosis.
Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT.
Science 278(5336):294-8. 1997
61CASP3, CASP6, CASP7
Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3.
Bullrich F, Fernandes-Alnemri T, Litwack G, Alnemri ES, Croce CM.
Genomics 36(2):362-5. 1996
62CASP1, CASP2, CASP3, CASP6, CASP7
Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis.
Tiso N, Pallavicini A, Muraro T, Zimbello R, Apolloni E, Valle G, Lanfranchi G, Danieli GA.
Biochem Biophys Res Commun 225(3):983-9. 1996
63CASP3, CASP4, CASP5, FAS
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis.
Enari M, Talanian RV, Wong WW, Nagata S.
Nature 380(6576):723-6. 1996
64CASP3
Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
Cell 81(5):801-9. 1995
65CASP7, CASP3
Mch3, a novel human apoptotic cysteine protease highly related to CPP32.
Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, et al.
Cancer Res 55(24):6045-52. 1995
66PARP1, CASP3
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.
Nature 376(6535):37-43. 1995
67CASP3
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
Fernandes-Alnemri T, Litwack G, Alnemri ES.
J Biol Chem 269(49):30761-4. 1994