1 | CASP3, CASP8
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| Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants.
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| Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD, Joseph B, Brkanac Z.
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| PLoS One 12(10):e0185777. doi: 10.1371/journal.pone.0185777. eCollection 2017.
2017
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2 | CASP3, MTRNR2L1
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| The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
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| Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR.
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| Invest Ophthalmol Vis Sci 57(3):1238-53. doi: 10.1167/iovs.15-17053.
2016
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3 | CASP3, CASP4
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| Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress.
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| Morishima N, Nakanishi K.
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| Genes Cells 21(7):798-806. doi: 10.1111/gtc.12384. Epub 2016 Jun 14.
2016
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4 | BIRC5, BIRC7, CASP3
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| Expression of livin, survivin and caspase-3 in prostatic cancer and their clinical significance.
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| Gu J, Ren L, Wang X, Qu C, Zhang Y.
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| Int J Clin Exp Pathol 8(11):14034-9. eCollection 2015.
2015
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5 | CASP3, FANCD2
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| FANCD2 is a target for caspase 3 during DNA damage-induced apoptosis.
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| Sakai W, Sugasawa K.
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| FEBS Lett 588(20):3778-85. doi: 10.1016/j.febslet.2014.08.027. Epub 2014 Aug 28.
2014
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6 | CASP3, MET
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| Novel Death Defying Domain in Met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes.
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| Ma J, Zou C, Guo L, Seneviratne DS, Tan X, Kwon YK, An J, Bowser R, DeFrances MC, Zarnegar R.
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| Hepatology 59(5):2010-21. doi: 10.1002/hep.26769. Epub 2014 Apr 1.
2014
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7 | CASP3
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| Caspase-3 modulates regenerative response after stroke.
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| Fan W, Dai Y, Xu H, Zhu X, Cai P, Wang L, Sun C, Hu C, Zheng P, Zhao BQ.
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| Stem Cells 32(2):473-86. doi: 10.1002/stem.1503.
2014
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8 | CASP3, PRTN3
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| Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation.
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| Loison F, Zhu H, Karatepe K, Kasorn A, Liu P, Ye K, Zhou J, Cao S, Gong H, Jenne DE, Remold-O'Donnell E, Xu Y, Luo HR.
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| J Clin Invest 124(10):4445-58. doi: 10.1172/JCI76246. Epub 2014 Sep 2.
2014
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9 | CASP3, CASP9, MAPK14, ROBO2, SLIT1
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| Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization.
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| Campbell DS, Okamoto H.
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| J Cell Biol 203(4):657-72. doi: 10.1083/jcb.201303072.
2013
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10 | CASP3
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| Paracrine control of tissue regeneration and cell proliferation by Caspase-3.
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| Boland K, Flanagan L, Prehn JH.
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| Cell Death Dis 4:e725. doi: 10.1038/cddis.2013.250. Review.
2013
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11 | CASP3, CASP7, CASP9
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| Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
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| Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH.
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| BMC Cell Biol 14:32. doi: 10.1186/1471-2121-14-32.
2013
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12 | CASP3
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| Active caspase-3 is stored within secretory compartments of viable mast cells.
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| Garcia-Faroldi G, Melo FR, Rönnberg E, Grujic M, Pejler G.
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| J Immunol 191(3):1445-52. doi: 10.4049/jimmunol.1300216. Epub 2013 Jul 1.
2013
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13 | CASP3, NEK5
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| Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity.
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| Shimizu K, Sawasaki T.
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| FEBS Lett 587(14):2219-25. doi: 10.1016/j.febslet.2013.05.049. Epub 2013 May 31.
2013
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14 | CASP3
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| Caspase-3 is involved in the signalling in erythroid differentiation by targeting late progenitors.
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| Boehm D, Mazurier C, Giarratana MC, Darghouth D, Faussat AM, Harmand L, Douay L.
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| PLoS One 8(5):e62303. doi: 10.1371/journal.pone.0062303. Print 2013.
2013
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15 | CASP3, ROCK1
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| Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles.
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| Böing AN, Stap J, Hau CM, Afink GB, Ris-Stalpers C, Reits EA, Sturk A, van Noorden CJ, Nieuwland R.
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| Biochim Biophys Acta 1833(8):1844-52. doi: 10.1016/j.bbamcr.2013.03.013. Epub 2013 Mar 24.
2013
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16 | CASP3, CCND1, MMP9, NUMBL, TRAF6
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| Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell.
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| Yingjie L, Jian T, Changhai Y, Jingbo L.
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| Tumour Biol 34(5):2773-80. doi: 10.1007/s13277-013-0835-7. Epub 2013 May 17.
2013
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17 | CASP3, GLRX3
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| Caspase-3-mediated cleavage of PICOT in apoptosis.
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| Yun N, Kim C, Cha H, Park WJ, Shibayama H, Park IS, Oh YJ.
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| Biochem Biophys Res Commun 432(3):533-8. doi: 10.1016/j.bbrc.2013.02.017. Epub 2013 Feb 13.
2013
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18 | CASP3
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| Caspase-3 protects stressed organs against cell death.
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| Khalil H, Peltzer N, Walicki J, Yang JY, Dubuis G, Gardiol N, Held W, Bigliardi P, Marsland B, Liaudet L, Widmann C.
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| Mol Cell Biol 32(22):4523-33. doi: 10.1128/MCB.00774-12. Epub 2012 Sep 4.
2012
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19 | CASP3, TRIB3
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| Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3.
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| Shimizu K, Takahama S, Endo Y, Sawasaki T.
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| PLoS One 7(8):e42721. doi: 10.1371/journal.pone.0042721. Epub 2012 Aug 9.
2012
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20 | CASP3
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| Caspase-3 in the central nervous system: beyond apoptosis.
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| D'Amelio M, Sheng M, Cecconi F.
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| Trends Neurosci 35(11):700-9. doi: 10.1016/j.tins.2012.06.004. Epub 2012 Jul 14.
2012
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21 | ANP32B, CASP3
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| Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) contributes to retinoic acid-induced differentiation of leukemic cells.
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| Yu Y, Shen SM, Zhang FF, Wu ZX, Han B, Wang LS.
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| Biochem Biophys Res Commun 423(4):721-5. doi: 10.1016/j.bbrc.2012.06.025. Epub 2012 Jun 13.
2012
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22 | CASP3, PAWR
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| Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation.
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| Chaudhry P, Singh M, Parent S, Asselin E.
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| Mol Cell Biol 32(4):826-39. doi: 10.1128/MCB.06321-11. Epub 2011 Dec 19.
2012
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23 | CASP3, LPPR1, MAP1LC3A, SLC30A4
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| Dynamic Pattern of Gene Expression of ZnT-4, Caspase-3, LC3, and PRG-3 in Rat Cerebral Cortex Following Flurothyl-Induced Recurrent Neonatal Seizures.
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| Ni H, Feng X, Xiao ZJ, Tao LY, Jin MF.
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| Biol Trace Elem Res iol Trace Elem Res. 2011 Feb 1. [Epub ahead of print]
2011
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24 | CASP3, CASP9
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| The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3.
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| Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW.
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| Structure 19(8):1084-96.
2011
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25 | CASP3, DIABLO
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| Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death.
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| Hui KK, Kanungo AK, Elia AJ, Henderson JT.
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| Cell Death Differ 18(11):1780-90. doi: 10.1038/cdd.2011.50. Epub 2011 May 20. 2011
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26 | ATCAY, CASP3, CASP7
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| Cayman ataxia-related protein is a presynapse-specific caspase-3 substrate.
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| Itoh M, Li S, Ohta K, Yamada A, Hayakawa-Yano Y, Ueda M, Hida Y, Suzuki Y, Ohta E, Mizuno A, Banno Y, Nakagawa T.
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| Neurochem Res 36(7):1304-13. doi: 10.1007/s11064-011-0430-5. Epub 2011 Mar 3.
2011
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27 | CASP3, HIF1A, NFKB1, TGM2
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| Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells.
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| Jang GY, Jeon JH, Cho SY, Shin DM, Kim CW, Jeong EM, Bae HC, Kim TW, Lee SH, Choi Y, Lee DS, Park SC, Kim IG.
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| Oncogene 29(3):356-67. Epub 2009 Oct 19.
2010
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28 | CASP3
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| Common variants in CASP3 confer susceptibility to Kawasaki disease.
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| Onouchi Y, Ozaki K, Buns JC, Shimizu C, Hamada H, Honda T, Terai M, Honda A, Takeuchi T, Shibuta S, Suenaga T, Suzuki H, Higashi K, Yasukawa K, Suzuki Y, Sasago K, Kemmotsu Y, Takatsuki S, Saji T, Yoshikawa T, Nagai T, Hamamoto K, Kishi F, Ouchi K, Sato Y, Newburger JW, Baker AL, Shulman ST, Rowley AH, Yashiro M, Nakamura Y, Wakui K, Fukushima Y, Fujino A, Tsunoda T, Kawasaki T, Hata A, Nakamura Y, Tanaka T.
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| Hum Mol Genet 19(14):2898-906. Epub 2010 Apr 27.PMID: 20423928 2010
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29 | CASP3, CASP7
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| Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.
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| Nakatsumi H, Yonehara S.
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| J Biol Chem 285(33):25418-25. Epub 2010 Jun 21.
2010
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30 | CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9
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| Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
|
| Kim YR, Kim KM, Yoo NJ, Lee SH.
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| Hum Pathol 40(6):868-71. Epub 2009 Mar 9.
2009
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31 | BIRC2, BIRC3, CASP3, CASP7
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| The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
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| Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB.
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| J Biol Chem 284(19):12772-82. Epub 2009 Mar 3. 2009
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32 | CASP3
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| A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.
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| Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC.
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| Biochem J 424(3):335-45.PMID: 19788411 2009
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33 | CASP3
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| Caspase-3 is activated and rapidly released from human umbilical vein endothelial cells in response to lipopolysaccharide.
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| Shioiri T, Muroi M, Hatao F, Nishida M, Ogawa T, Mimura Y, Seto Y, Kaminishi M, Tanamoto K.
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| Biochim Biophys Acta 1792(10):1011-8. Epub 2009 Jun 25.PMID: 19559790 2009
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34 | CASP3, CASP7
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| Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity.
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| Demon D, Van Damme P, Vanden Berghe T, Deceuninck A, Van Durme J, Verspurten J, Helsens K, Impens F, Wejda M, Schymkowitz J, Rousseau F, Madder A, Vandekerckhove J, Declercq W, Gevaert K, Vandenabeele P.
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| Mol Cell Proteomics 8(12):2700-14. Epub 2009 Sep 16.PMID: 19759058 2009
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35 | CASP3, DSG2
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| The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery.
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| Cirillo N, Lanza M, De Rosa A, Cammarota M, La Gatta A, Gombos F, Lanza A.
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| J Cell Biochem 103(2):598-606.PMID: 17559062 2008
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36 | CASP3
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| Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk.
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| Jang JS, Kim KM, Choi JE, Cha SI, Kim CH, Lee WK, Kam S, Jung TH, Park JY.
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| Mol Carcinog 47(5):383-90.PMID: 18058802 2008
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37 | CASP3, CASP7
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| Executioner caspase-3 and caspase-7 are functionally distinct proteases.
|
| Walsh JG, Cullen SP, Sheridan C, Lüthi AU, Gerner C, Martin SJ.
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| Proc Natl Acad Sci U S A 105(35):12815-9. Epub 2008 Aug 22.PMID: 18723680 2008
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38 | HSPA1A, HSPA4, GATA1, CASP3
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| Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
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| Ribeil JA, Zermati Y, Vandekerckhove J, Cathelin S, Kersual J, Dussiot M, Coulon S, Moura IC, Zeuner A, Kirkegaard-Sorensen T, Varet B, Solary E, Garrido C, Hermine O.
|
| Nature 445(7123):102-5. Epub 2006 Dec 10. 2007
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39 | CASP3, GLRX, TNF
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| Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death.
|
| Sykes MC, Mowbray AL, Jo H.
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| Circ Res 100(2):152-4. 2007
|
40 | CASP3, CASP8, CASP12
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| Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells.
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| Neekhra A, Luthra S, Chwa M, Seigel G, Gramajo AL, Kuppermann BD, Kenney MC.
|
| Invest Ophthalmol Vis Sci 48(3):1362-7. 2007
|
41 | RNF2, CASP3, CASP9
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| Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9.
|
| Wong CK, Chen Z, So KL, Li D, Li P.
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| Biochim Biophys Acta 1773(6):844-52. Epub 2007 Feb 22. 2007
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42 | CASP3, PTPN12
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| Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.
|
| Halle M, Liu YC, Hardy S, Theberge JF, Blanchetot C, Bourdeau A, Meng TC, Tremblay ML.
|
| Mol Cell Biol 27(3):1172-90. Epub 2006 Nov 27. 2007
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43 | CASP3, CASP9, XIAP
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| Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9.
|
| Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS.
|
| Biochem J 405(1):11-9.
2007
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44 | ROCK1, CASP3
|
| Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.
|
| Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ.
|
| Proc Natl Acad Sci U S A 103(39):14495-500. Epub 2006 Sep 18. 2006
|
45 | CASP3, CASP8, CASP12
|
| Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.
|
| Luthra S, Fardin B, Dong J, Hertzog D, Kamjoo S, Gebremariam S, Butani V, Narayanan R, Mungcal JK, Kuppermann BD, Kenney MC.
|
| Invest Ophthalmol Vis Sci 47(12):5569-75. 2006
|
46 | CASP3
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| Somatic mutations of CASP3 gene in human cancers.
|
| Soung YH, Lee JW, Kim SY, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH.
|
| Hum Genet 115(2):112-5. Epub 2004 May 04. 2004
|
47 | CASP3, GORASP1, GORASP2
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| Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis.
|
| Lane JD, Lucocq J, Pryde J, Barr FA, Woodman PG, Allan VJ, Lowe M.
|
| J Cell Biol 156(3):495-509. Epub 2002 Jan 28. 2002
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48 | CASP3, XIAP
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| Structural basis for the inhibition of caspase-3 by XIAP.
|
| Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS.
|
| Cell 104(5):791-800. 2001
|
49 | CASP1, CASP3
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| Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
|
| Winter RN, Kramer A, Borkowski A, Kyprianou N.
|
| Cancer Res 61(3):1227-32. 2001
|
50 | CASP3
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| Molecular cloning and characterization of a novel caspase-3 variant that attenuates apoptosis induced by proteasome inhibition.
|
| Huang Y, Shin NH, Sun Y, Wang KK.
|
| Biochem Biophys Res Commun 283(4):762-9. 2001
|
51 | CASP3
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| Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.
|
| Hartmann A, Hunot S, Michel PP, Muriel MP, Vyas S, Faucheux BA, Mouatt-Prigent A, Turmel H, Srinivasan A, Ruberg M, Evan GI, Agid Y, Hirsch EC.
|
| Proc Natl Acad Sci U S A 97(6):2875-80. 2000
|
52 | CASP3
|
| Heavy membrane-associated caspase 3: identification, isolation, and characterization.
|
| Krebs JF, Srinivasan A, Wong AM, Tomaselli KJ, Fritz LC, Wu JC.
|
| Biochemistry 39(51):16056-63. 2000
|
53 | CASP3, CDKN1A
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| Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.
|
| Park JA, Kim KW, Kim SI, Lee SK.
|
| Eur J Biochem 257(1):242-8. 1998
|
54 | CASP3
|
| Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo.
|
| Zheng TS, Schlosser SF, Dao T, Hingorani R, Crispe IN, Boyer JL, Flavell RA.
|
| Proc Natl Acad Sci U S A 95(23):13618-23. 1998
|
55 | CASP3, SPTAN1
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| Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis.
|
| Janicke RU, Ng P, Sprengart ML, Porter AG.
|
| J Biol Chem 273(25):15540-5. 1998
|
56 | AR, CASP3, SBMA
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| Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.
|
| Kobayashi Y, Miwa S, Merry DE, Kume A, Mei L, Doyu M, Sobue G.
|
| Biochem Biophys Res Commun 252(1):145-50. 1998
|
57 | CASP1, CASP3
|
| Role of caspases 1 and 3 and Bcl-2-related molecules in endothelial cell apoptosis associated with thrombotic microangiopathies.
|
| Mitra D, Kim J, MacLow C, Karsan A, Laurence J.
|
| Am J Hematol 59(4):279-87. 1998
|
58 | CASP3, CASP6
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| Localization of the cell death genes CPP32 and Mch-2 to human chromosome 4q.
|
| Nasir J, Theilmann JL, Chopra V, Jones AM, Walker D, Rasper DM, Vaillancourt JP, Hewitt JE, Nicholson DW, Hayden MR.
|
| Mamm Genome 8(1):56-9. 1997
|
59 | CASP1, CASP2, CASP3, CASP4, CASP6, CASP7
|
| Caspases: intracellular signaling by proteolysis.
|
| Salvesen GS, Dixit VM.
|
| Cell 91(4):443-6. 1997
|
60 | CASP3, GSN
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| Caspase-3-generated fragment of gelsolin : effector of morphological change in apoptosis.
|
| Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT.
|
| Science 278(5336):294-8. 1997
|
61 | CASP3, CASP6, CASP7
|
| Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3.
|
| Bullrich F, Fernandes-Alnemri T, Litwack G, Alnemri ES, Croce CM.
|
| Genomics 36(2):362-5. 1996
|
62 | CASP1, CASP2, CASP3, CASP6, CASP7
|
| Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis.
|
| Tiso N, Pallavicini A, Muraro T, Zimbello R, Apolloni E, Valle G, Lanfranchi G, Danieli GA.
|
| Biochem Biophys Res Commun 225(3):983-9. 1996
|
63 | CASP3, CASP4, CASP5, FAS
|
| Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis.
|
| Enari M, Talanian RV, Wong WW, Nagata S.
|
| Nature 380(6576):723-6. 1996
|
64 | CASP3
|
| Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
|
| Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
|
| Cell 81(5):801-9. 1995
|
65 | CASP7, CASP3
|
| Mch3, a novel human apoptotic cysteine protease highly related to CPP32.
|
| Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, et al.
|
| Cancer Res 55(24):6045-52. 1995
|
66 | PARP1, CASP3
|
| Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
|
| Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.
|
| Nature 376(6535):37-43. 1995
|
67 | CASP3
|
| CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
|
| Fernandes-Alnemri T, Litwack G, Alnemri ES.
|
| J Biol Chem 269(49):30761-4. 1994
|