| 1 | BCL10, CARD9, MALT1, SYK
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| The SYK tyrosine kinase: a crucial player in diverse biological functions.
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| Mócsai A, Ruland J, Tybulewicz VL.
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| Nat Rev Immunol 10(6):387-402. Review. 2010
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| 2 | CARD9
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| CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.
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| Bi L, Gojestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X.
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| J Biol Chem 285(34):25969-77. Epub 2010 Jun 9.
2010
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| 3 | CARD9, DNMT3A, ERAP2, FUT2, PTGER4, TNFSF11
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| Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
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| Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M.
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| Nat Genet 42(12):1118-25.
2010
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| 4 | CANDF2, CANDF4, CARD9
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| A homozygous CARD9 mutation in a family with susceptibility to fungal infections.
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| Glocker EO, Hennigs A, Nabavi M, Schäffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, Jamal S, Manguiat A, Rezaei N, Amirzargar AA, Plebani A, Hannesschläger N, Gross O, Ruland J, Grimbacher B.
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| N Engl J Med 361(18):1727-35. 2009
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| 5 | CARD9, IL18RAP
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| Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.
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| Zhernakova A, Festen EM, Franke L, Trynka G, van Diemen CC, Monsuur AJ, Bevova M, Nijmeijer RM, van 't Slot R, Heijmans R, Boezen HM, van Heel DA, van Bodegraven AA, Stokkers PC, Wijmenga C, Crusius JB, Weersma RK.
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| Am J Hum Genet 82(5):1202-10. Epub 2008 Apr 24. 2008
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| 6 | CARD9
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| The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.
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| Hsu YM, Zhang Y, You Y, Wang D, Li H, Duramad O, Qin XF, Dong C, Lin X.
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| Nat Immunol 8(2):198-205. Epub 2006 Dec 24.
2007
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| 7 | CARD9
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| The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
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| Hara H, Ishihara C, Takeuchi A, Imanishi T, Xue L, Morris SW, Inui M, Takai T, Shibuya A, Saijo S, Iwakura Y, Ohno N, Koseki H, Yoshida H, Penninger JM, Saito T.
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| Nat Immunol 8(6):619-29. Epub 2007 May 7.
2007
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| 8 | CARD9
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| Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.
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| Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J.
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| Nature 442(7103):651-6. Epub 2006 Jul 12. 2006
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| 9 | CARD10, CARD11, CARD14, CARD9
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| Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
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| Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J.
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| J Biol Chem 276(24):21405-9. 2001
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| 10 | BCL10, CARD10, CARD11, NLRC4, CARD14, NOD1, NOD2, CARD9, RIPK2
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| Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation.
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| Guiet C, Vito P.
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| J Cell Biol 148(6):1131-40. 2000
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| 11 | CARD9
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| CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.
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| Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES.
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| J Biol Chem 275(52):41082-6. 2000
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