Citations for
1CAD, EIEE50
CAD mutations and uridine-responsive epileptic encephalopathy.
Koch J, Mayr JA, Alhaddad B, Rauscher C, Bierau J, Kovacs-Nagy R, Coene KL, Bader I, Holzhacker M, Prokisch H, Venselaar H, Wevers RA, Distelmaier F, Polster T, Leiz S, Betzler C, Strom TM, Sperl W, Meitinger T, Wortmann SB, Haack TB.
Brain 140(2):279-286. doi: 10.1093/brain/aww300. Epub 2016 Dec 21. 2017
2CAD
Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
Moreno-Morcillo M, Grande-García A, Ruiz-Ramos A, Del Caño-Ochoa F, Boskovic J, Ramón-Maiques S.
Structure 25(6):912-923.e5. doi: 10.1016/j.str.2017.04.012. Epub 2017 May 25. 2017
3CAD, EIEE50
Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors.
Ng BG, Wolfe LA, Ichikawa M, Markello T, He M, Tifft CJ, Gahl WA, Freeze HH.
Hum Mol Genet 24(11):3050-7. doi: 10.1093/hmg/ddv057. Epub 2015 Feb 12. 2015
4CAD, RHEB, RHEBL1
Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
Sato T, Akasu H, Shimono W, Matsu C, Fujiwara Y, Shibagaki Y, Heard JJ, Tamanoi F, Hattori S.
J Biol Chem 290(2):1096-105. doi: 10.1074/jbc.M114.592402. Epub 2014 Nov 24. 2015
5CAD
Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD.
Ruiz-Ramos A, Lallous N, Grande-García A, Ramón-Maiques S.
Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 12):1425-30. doi: 10.1107/S1744309113031114. Epub 2013 Nov 29. 2013
6CAD, MLST8
Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes.
Nakashima A, Kawanishi I, Eguchi S, Yu EH, Eguchi S, Oshiro N, Yoshino K, Kikkawa U, Yonezawa K.
J Biomed Sci 20:24. doi: 10.1186/1423-0127-20-24. 2013
7CAD
The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells.
Richmond AL, Kabi A, Homer CR, Marina-García N, Nickerson KP, Nesvizhskii AI, Sreekumar A, Chinnaiyan AM, Nuñez G, McDonald C.
Gastroenterology 142(7):1483-92.e6. Epub 2012 Feb 28. 2012
8CAD
Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence.
Morin A, Fritsch L, Mathieu JR, Gilbert C, Guarmit B, Firlej V, Gallou-Kabani C, Vieillefond A, Delongchamps NB, Cabon F.
FASEB J 26(1):460-7. Epub 2011 Oct 7. 2012
9CAD
Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD.
Lallous N, Grande-García A, Molina R, Ramón-Maiques S.
Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 11):1341-5. doi: 10.1107/S1744309112038857. Epub 2012 Oct 30. 2012
10ABL2, AKAP8, ANKRD13D, AP3D1, ARFGAP3, ARMCX6, ASUN, BAT2L, BCl2L13, BNIP3L, BPTF, BRD7, BZW1, BZW2, C12orf43, C19orf26, C1orf105, C2orf49, C6orf81, CA10, CAD, CARHSP1, CBX4, CCDC55, CCDC61, CCNK, CDC42BPB, CDC42EP3, CDC42EP4, CDS2, CENPN, CLK1, COPA, CSDA, CTPS2, DBN1, DCP1A, DECR2, DPF2, DPM1, EIF2AK1, EPB41L4A, EPN1, FAM91A1, FOSL2, FOXK1, GDF5OS, GFOD2, GIGYF2, GPATCH8, GTPBP1, HES7, HNRNPUL1, KIF1C, LPIN2, LRCH4, MAN2C1, MAST1, MED13, MED24, MED26, MINK1, MISP, MYO10, NKTR, OSBP, PAM, PCDH7, PEX14, PHF16, PHRF1, PLCB4, PLXNC1, POM121, POM121L2, PPHLN1, PRICKLE3, PRX, PUM2, RABGGTB, RBEL1, RIMS1, RIMS2, RPL14, RRP1B, RRP8, SAFB, SCAMP3, SCMH1, SCYL1, SENP6, SERBP1, SFRS13A, SFRS17A, SIPA1L1, SLC26A6, SLIRP, SLMAP, SNTA1, SORBS3, SPICE1, SSFA2, STAM, SUB1, TFIP11, TLN2, TMC6, TMEM104, TMEM106B, TMEM22, TOM1, UHRF1, UTP14A, WDR43, ZNF324, ZNF648
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M.
Cell. 127(3):635-48. 2006
11CAD, HIF1A
Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha.
Chen KF, Lai YY, Sun HS, Tsai SJ.
Nucleic Acids Res 33(16):5190-8. Print 2005. 2005
12CAD
Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD.
Sigoillot FD, Kotsis DH, Serre V, Sigoillot SM, Evans DR, Guy HI.
J Biol Chem 280(27):25611-20. Epub 2005 May 12. 2005
13CAD
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.
Chen S, Bigner SH, Modrich P.
Proc Natl Acad Sci U S A 98(24):13802-7. 2001
14CAD
Regulation of carbamoyl phosphate synthetase by MAP kinase.
Graves LM, Guy HI, Kozlowski P, Huang M, Lazarowski E, Pope RM, Collins MA, Dahlstrand EN, Earp HS 3rd, Evans DR.
Nature 403(6767):328-32 2000
15APAF1, CAD, AIFM1
Apoptosis. A cellular poison cupboard.
Earnshaw WC.
Nature 397 : 387-389. 1999
16ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
c-Myc target genes involved in cell growth, apoptosis, and metabolism.
Dang CV.
Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
17CAD
Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M.
Biochem Biophys Res Commun 219(1):249-55. 1996
18CAD
Organization and nucleotide sequence of the 3' end of the human CAD gene.
Davidson JN, Rao GN, Niswander L, Andreano C, Tamer C, Chen KC.
DNA Cell Biol 9(9):667-76. 1990
19CAD
Mapping of the gene encoding the multifunctional protein carrying out the first three steps of pyrimidine biosynthesis to human chromosome 2.
Chen KC, et al.
Hum Genet 82 : 40-44. 1989
20CAD
Transcriptional regulation of the human CAD gene during myeloid differentiation.
Rao GN, Buford ES, Davidson JN.
Mol Cell Biol 7(5):1961-6. 1987