Citations for
1CAB39
Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.
Jiang L, Yan Q, Fang S, Liu M, Li Y, Yuan YF, Li Y, Zhu Y, Qi J, Yang X, Kwong DLW, Guan XY.
Hepatology Nov;66(5):1529-1545. doi: 10.1002/hep.29312. Epub 2017 Sep 29. Erratum in: Hepatology. 2020 Oct;72(4):1501. 2017
2CAB39, OSR1, STK39
A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters. 2014 PMID:
Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, Delpire E.
J Biol Chem. Jun 20;289(25):17680-8. doi: 10.1074/jbc.M113.540518. Epub 2014 May 8. 2014
3CAB39, MST3, STK26
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR.
EMBO J 30(9):1730-41. Epub 2011 Mar 18. 2011
4CAB39, STK11
MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.
Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE.
Mol Cell 37(5):620-32.PMID: 20227367 2010
5CAB39, STK11
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM.
Science 326(5960):1707-11. Epub 2009 Nov 5. 2009
6CAB39, STK11, STK26, STRADA
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.
Dev Cell 16(4):551-62.PMID: 19386264 2009
7CAB39, STK11, STRADA
Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24.PMID: 17921699 2007
8CAB39, STK11, STRADA
Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.
Neumann D, Suter M, Tuerk R, Riek U, Wallimann T.
Mol Biotechnol 36(3):220-31.PMID: 17873408 2007
9PJS1, STK11, SMARCA4, LYK5, CAB39
Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Naatsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Makela TP, Launonen V.
Br J Cancer 92(6):1126-9. 2005
10CAB39
Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.
Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM.
Nat Struct Mol Biol 11(2):193-200. Epub 2004 Jan 18.PMID: 14730349 2004
11CAB39, STK11
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR.
EMBO J 22(19):5102-14. 2003