1 | CAB39
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| Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.
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| Jiang L, Yan Q, Fang S, Liu M, Li Y, Yuan YF, Li Y, Zhu Y, Qi J, Yang X, Kwong DLW, Guan XY.
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| Hepatology Nov;66(5):1529-1545. doi: 10.1002/hep.29312. Epub 2017 Sep 29. Erratum in: Hepatology. 2020 Oct;72(4):1501. 2017
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2 | CAB39, OSR1, STK39
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| A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters. 2014 PMID:
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| Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, Delpire E.
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| J Biol Chem. Jun 20;289(25):17680-8. doi: 10.1074/jbc.M113.540518. Epub 2014 May 8. 2014
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3 | CAB39, MST3, STK26
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| MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
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| Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR.
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| EMBO J 30(9):1730-41. Epub 2011 Mar 18. 2011
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4 | CAB39, STK11
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| MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.
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| Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE.
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| Mol Cell 37(5):620-32.PMID: 20227367 2010
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5 | CAB39, STK11
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| Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
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| Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM.
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| Science 326(5960):1707-11. Epub 2009 Nov 5.
2009
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6 | CAB39, STK11, STK26, STRADA
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| Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
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| ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.
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| Dev Cell 16(4):551-62.PMID: 19386264 2009
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7 | CAB39, STK11, STRADA
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| Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
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| Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
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| Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24.PMID: 17921699 2007
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8 | CAB39, STK11, STRADA
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| Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.
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| Neumann D, Suter M, Tuerk R, Riek U, Wallimann T.
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| Mol Biotechnol 36(3):220-31.PMID: 17873408 2007
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9 | PJS1, STK11, SMARCA4, LYK5, CAB39
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| Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
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| Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Naatsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Makela TP, Launonen V.
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| Br J Cancer 92(6):1126-9. 2005
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10 | CAB39
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| Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.
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| Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM.
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| Nat Struct Mol Biol 11(2):193-200. Epub 2004 Jan 18.PMID: 14730349 2004
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11 | CAB39, STK11
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| MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
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| Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR.
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| EMBO J 22(19):5102-14. 2003
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