| 1 | C3
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| Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk.
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| King RJ, Schuett K, Tiede C, Jankowski V, John V, Trehan A, Simmons K, Ponnambalam S, Storey RF, Fishwick CWG, McPherson MJ, Tomlinson DC, Ajjan RA.
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| Haematologica un 1;106(6):1616-1623. doi: 10.3324/haematol.2019.239558 2021
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| 2 | C3
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| Complement C3 deficiency ameliorates aging related changes in the kidney.
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| Wu X, Lin L, Cui J, Chen Y, Yang L, Wan J.
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| Life Sci. Nov 1;260:118370. doi: 10.1016/j.lfs.2020.118370. Epub 2020 Aug 31. 2020
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| 3 | C3
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| Complement Components, C3 and C4, and the Metabolic Syndrome
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| Copenhaver M, Yu CY, Hoffman RP.
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| Curr Diabetes Rev. 15(1):44-48. doi: 10.2174/1573399814666180417122030 2019
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| 4 | ATG16L1, C3
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| Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation.
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| King BC, Kulak K, Krus U, Rosberg R, Golec E, Wozniak K, Gomez MF, Zhang E, O'Connell DJ, Renström E, Blom AM
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| Cell Metab. Jan 8;29(1):202-210.e6. doi: 10.1016/j.cmet.2018.09.009. Epub 2018 Oct 4. 2019
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| 5 | C3
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| Complement C3 Affects Rac1 Activity in the Developing Brain.
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| Gorelik A, Sapir T, Ben-Reuven L, Reiner O.
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| Front Mol Neurosci. May 7;11:150. doi: 10.3389/fnmol.2018.00150. 2018
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| 6 | C3, CFH, CFHR1
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| Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions
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| Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM.
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| PLoS One. Nov 4;11(11):e0166200. doi: 10.1371/journal.pone.0166200 2016
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| 7 | C3
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| Complement inhibition in C3 glomerulopathy
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| Nester CM, Smith RJ.
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| Semin Immunol. Jun;28(3):241-9. doi: 10.1016/j.smim.2016.06.002. Epub 2016 Jul 9. 2016
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| 8 | C3, GRIN1
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| Neuroprotective effects of C3 exoenzyme in excitotoxic retinopathy. 2014 PMID:
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| Wang Y, Wang Y, Yang Q, Guo L, Yin Y, Fan N, Zhou X, Cai SP, Kaufman PL, Liu X.
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| Exp Eye Res. Aug;125:128-34. doi: 10.1016/j.exer.2014.05.018. Epub 2014 Jun 11. 2014
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| 9 | C3
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| Complement C3: an emerging risk factor in cardiometabolic disease.
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| Hertle E, van Greevenbroek MM, Stehouwer CD.
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| Diabetologia. Apr;55(4):881-4. doi: 10.1007/s00125-012-2462-z. Epub 2012 Jan 27 2012
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| 10 | APOE, ARMD1, ARMD2, ARMD3, ARMD7, ARMD8, ARMDA, ARMDC, ARMS2, C2, C3, CFB, CFH, HTRA1
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| Multilocus analysis of age-related macular degeneration.
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| Bergeron-Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, Allikmets R, Dean M.
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| Eur J Hum Genet ur J Hum Genet. 2009 Mar 4. [Epub ahead of print] 2009
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| 11 | C3
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| C3 R102G polymorphism increases risk of age-related macular degeneration.
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| Spencer KL, Olson LM, Anderson BM, Schnetz-Boutaud N, Scott WK, Gallins P, Agarwal A, Postel EA, Pericak-Vance MA, Haines JL.
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| Hum Mol Genet 17(12):1821-4. Epub 2008 Mar 6. 2008
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| 12 | C3
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| Variation in complement factor 3 is associated with risk of age-related macular degeneration.
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| Maller JB, Fagerness JA, Reynolds RC, Neale BM, Daly MJ, Seddon JM.
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| Nat Genet 39(10):1200-1. Epub 2007 Sep 2. 2007
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| 13 | C3, C3D
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| Molecular analysis of a novel hereditary C3 deficiency with systemic lupus erythematosus.
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| Tsukamoto H, Horiuchi T, Kokuba H, Nagae S, Nishizaka H, Sawabe T, Harashima S, Himeji D, Koyama T, Otsuka J, Mitoma H, Kimoto Y, Hashimura C, Kitano E, Kitamura H, Furue M, Harada M.
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| Biochem Biophys Res Commun 330(1):298-304. 2005
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| 14 | C3
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| Inherited human complement C3 deficiency.
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| Singer L, et al.
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| J Biol Chem 269 : 28494-28499. 1994
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| 15 | C3
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| EcoRI polymorphism in the human third complement component (C3) gene.
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| Botto M, et al.
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| Nucleic Acids Res 18 : 2833. 1990
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| 16 | C3
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| Genomic organization of human complement component C3.
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| Fong KY, Botto M, Walport MJ, So AK.
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| Genomics 7(4):579-86. 1990
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| 17 | FUT1, C3
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| New linkage data on chromosome 19 with particular reference to the H (FUT1) locus.
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| Ball SP, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 956. 1989
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| 18 | LDLR, C3, APOC2, LW, BCAM , FUT2
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| The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man.
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| Lewis M, et al.
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| Ann Hum Genet 52 : 137-144. 1988
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| 19 | LW, C3
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| The LW:C3 recombination fraction in female meioses.
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| Lewis M, et al.
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| Ann Hum Genet 51 : 201-203. 1987
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| 20 | APOC1, APOC2, APOE, C3, LDLR, PEPD, GPI
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| Regional mapping of human chromosome 19 : Organisation of genes for plasma lipid transport (APOC1,-C2, and -E and LDLR) and the genes C3, PEPD, and GPI.
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| Lusis AJ, et al.
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| Proc Natl Acad Sci U S A 83 : 3929-3933. 1986
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| 21 | C3, LPCN
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| Linkage relationships of the insulin receptor gene with the complement component 3, LDL receptor, apolipoprotein C2 and myotonic dystrophy loci on chromosome 19.
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| Shaw DJ, et al.
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| Hum Genet 74 : 267-269. 1986
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| 22 | C3
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| Human complement component C3: cDNA coding sequence and derived primary structure.
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| De Bruijn MHL, et al.
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| Proc Natl Acad Sci U S A 82 : 708-712. 1985
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| 23 | C3, LW
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| Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
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| Sistonen P.
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| Ann Hum Genet 48 : 239-242. 1984
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| 24 | C3, PEPD, GPI, APOE
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| Mapping studies with peptidase D (PEPD).
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| Ball S, et al.
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| (HGM7) Cytogenet Cell Genet 37 : 411-412. 1984
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| 25 | C3, FUT2, LE, PEPD, BCAM
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| Genetics and linkage relationships of the C3 polymorphism: discovery of C3-Se linkage and assignment of LES-C3-DM-Se-PEPD-Lu synteny to chromosome 19.
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| Eiberg H, et al.
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| Clin Genet 24 : 159-170. 1983
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| 26 | C3
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| Assignment of the gene for the third component of human complement (C3) to chromosome 19 using human-mouse somatic cell hybrids.
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| Whitehead AS, et al.
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| Cytogenet Cell Genet 32 : 326-327. 1982
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| 27 | C3
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| Assignment of a structural gene for the third component of human complement to chromosome 19.
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| Whitehead AS, et al.
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| Proc Natl Acad Sci U S A 79 : 5021-5025. 1982
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| 28 | C3, LDLR
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| Probable linkage between essential familial hypercholesterolemia and third complement component (C3).
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| Elston RC, et al.
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| Cytogenet Cell Genet 16 : 294-297. 1976
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