| 1 | C1GALT1C1, TIMD4
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| Incomplete clearance of apoptotic cells by core 1-derived O-glycan-deficient resident peritoneal macrophages.
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| Wakui H, Fuseya S, Suzuki R, Shimbo M, Okada R, Hamada M, Kuno A, Hagiwara K, Sato T, Narimatsu H, Kudo T, Takahashi S.
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| Biochem Biophys Res Commun 495(2):2017-2023. doi: 10.1016/j.bbrc.2017.12.066. Epub 2017 Dec 13.
2018
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| 2 | C1GALT1C1
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| Biochemical characterization of functional domains of the chaperone Cosmc.
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| Hanes MS, Moremen KW, Cummings RD.
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| PLoS One 12(6):e0180242. doi: 10.1371/journal.pone.0180242. eCollection 2017.
2017
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| 3 | C1GALT1, C1GALT1C1, TGFB1
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| TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc.
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| Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J, Chen Q.
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| Mol Med Rep 15(2):969-974. doi: 10.3892/mmr.2016.6084. Epub 2016 Dec 29.
2017
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| 4 | C1GALT1C1
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| Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk.
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| Kudelka MR, Hinrichs BH, Darby T, Moreno CS, Nishio H, Cutler CE, Wang J, Wu H, Zeng J, Wang Y, Ju T, Stowell SR, Nusrat A, Jones RM, Neish AS, Cummings RD.
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| Proc Natl Acad Sci U S A 113(51):14787-14792. doi: 10.1073/pnas.1612158114. Epub 2016 Dec 7.
2016
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| 5 | C1GALT1, C1GALT1C1
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| Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation.
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| Zeng J, Mi R, Wang Y, Li Y, Lin L, Yao B, Song L, van Die I, Chapman AB, Cummings RD, Jin P, Ju T.
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| J Biol Chem 290(31):19018-33. doi: 10.1074/jbc.M115.654244. Epub 2015 Jun 10.
2015
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| 6 | C1GALT1C1
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| COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer.
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| Hofmann BT, Schlüter L, Lange P, Mercanoglu B, Ewald F, Fölster A, Picksak AS, Harder S, El Gammal AT, Grupp K, Güngör C, Drenckhan A, Schlüter H, Wagener C, Izbicki JR, Jücker M, Bockhorn M, Wolters-Eisfeld G.
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| Mol Cancer 14:109. doi: 10.1186/s12943-015-0386-1.
2015
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| 7 | C1GALT1C1
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| DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy.
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| Sun Q, Zhang J, Zhou N, Liu X, Shen Y.
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| PLoS One 10(2):e0112305. doi: 10.1371/journal.pone.0112305. eCollection 2015.
2015
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| 8 | C1GALT1, C1GALT1C1
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| Identification of a novel protein binding motif within the T-synthase for the molecular chaperone Cosmc.
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| Aryal RP, Ju T, Cummings RD.
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| J Biol Chem 289(17):11630-41. doi: 10.1074/jbc.M114.555870. Epub 2014 Mar 10.
2014
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| 9 | C1GALT1C1, KDR
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| COSMC is overexpressed in proliferating infantile hemangioma and enhances endothelial cell growth via VEGFR2.
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| Lee J Jr, Chen CH, Chen YH, Huang MJ, Huang J, Hung JS, Chen MT, Huang MC.
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| PLoS One 8(2):e56211. doi: 10.1371/journal.pone.0056211. Epub 2013 Feb 12.
2013
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| 10 | C1GALT1, C1GALT1C1
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| Tight complex formation between Cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociation.
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| Aryal RP, Ju T, Cummings RD.
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| J Biol Chem 287(19):15317-29. doi: 10.1074/jbc.M111.312587. Epub 2012 Mar 13.
2012
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| 11 | C1GALT1, C1GALT1C1
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| The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum.
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| Sun Q, Ju T, Cummings RD.
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| J Biol Chem 286(13):11529-42. doi: 10.1074/jbc.M110.173591. Epub 2011 Jan 24.
2011
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| 12 | C1GALT1, C1GALT1C1
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| The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase.
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| Aryal RP, Ju T, Cummings RD.
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| J Biol Chem 285(4):2456-62. Epub 2009 Nov 18.PMID: 19923218 2010
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| 13 | C1GALT1C1
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| The role of C1GALT1C1 in lipopolysaccharide-induced IgA1 aberrant O-glycosylation in IgA nephropathy.
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| Xie LS, Qin W, Fan JM, Huang J, Xie XS, Li Z.
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| Clin Invest Med 33(1):E5-13.PMID: 20144270 2010
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| 14 | C1GALT1C1
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| Cosmc is an essential chaperone for correct protein O-glycosylation.
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| Wang Y, Ju T, Ding X, Xia B, Wang W, Xia L, He M, Cummings RD.
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| Proc Natl Acad Sci U S A 107(20):9228-33. Epub 2010 May 3.PMID: 20439703 2010
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| 15 | C1GALT1C1
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| No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients.
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| Malycha F, Eggermann T, Hristov M, Schena FP, Mertens PR, Zerres K, Floege J, Eitner F.
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| Nephrol Dial Transplant 24(1):321-4. Epub 2008 Oct 7.PMID: 18840896 2009
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| 16 | C1GALT1C1
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| Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc.
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| Ju T, Aryal RP, Stowell CJ, Cummings RD.
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| J Cell Biol 182(3):531-42.PMID: 18695044 2008
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| 17 | C1GALT1C1
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| Immunocytochemical analysis for intracellular dynamics of C1GalT associated with molecular chaperone, Cosmc.
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| Narimatsu Y, Ikehara Y, Iwasaki H, Nonomura C, Sato T, Nakanishi H, Narimatsu H.
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| Biochem Biophys Res Commun 366(1):199-205. Epub 2007 Dec 3.PMID: 18061573 2008
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| 18 | C1GALT1C1
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| New mutations in C1GALT1C1 in individuals with Tn positive phenotype.
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| Crew VK, Singleton BK, Green C, Parsons SF, Daniels G, Anstee DJ.
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| Br J Haematol 142(4):657-67. Epub 2008 Jun 5.PMID: 18537974 2008
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| 19 | C1GALT1, C1GALT1C1
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| Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy.
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| Li GS, Zhang H, Lv JC, Shen Y, Wang HY.
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| Kidney Int 71(5):448-53. Epub 2007 Jan 17. 2007
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| 20 | C1GALT1C1
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| A mutant chaperone converts a wild-type protein into a tumor-specific antigen.
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| Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, Schreiber H.
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| Science 314(5797):304-8. 2006
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| 21 | C1GALT1C1
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| Protein glycosylation: chaperone mutation in Tn syndrome.
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| Ju T, Cummings RD.
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| Nature 437(7063):1252. 2005
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| 22 | C1GALT1C1
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| Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan.
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| Kudo T, Iwai T, Kubota T, Iwasaki H, Takayma Y, Hiruma T, Inaba N, ZhangY, Gotoh M, Togayachi A, Narimatsu H.
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| J Biol Chem 277(49):47724-31. Epub 2002 Oct 01. 2002
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| 23 | C1GALT1C1
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| A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.
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| Ju T, Cummings RD.
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| Proc Natl Acad Sci U S A 99(26):16613-8. Epub 2002 Dec 03. 2002
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| 24 | C1GALT1, C1GALT1C1
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| Cloning and expression of human core 1 beta1,3-galactosyltransferase.
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| Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM.
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| J Biol Chem 277(1):178-86. Epub 2001 Oct 24. 2002
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| 25 | B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GALT6, B3GNT2, B3GNT4, B3GNT5, C1GALT1, C1GALT1C1
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| Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.
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| Amado M, Almeida R, Schwientek T, Clausen H.
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| Biochim Biophys Acta 1473(1):35-53. Review. 1999
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