Citations for
1BTG2
Inhibitory effects of B‑cell translocation gene 2 on skin cancer cells via the Wnt/β‑catenin signaling pathway.
Gao SS, Yang XH, Wang M.
Mol Med Rep 14(4):3464-8. doi: 10.3892/mmr.2016.5596. 2016
2BTG2
Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA.
Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
Sci Rep 6:28592. doi: 10.1038/srep28592. 2016
3BTG2, TP53
Shifting p53-induced senescence to cell death by TIS21(/BTG2/Pc3) gene through posttranslational modification of p53 protein.
Choi OR, Ryu MS, Lim IK.
Cell Signal 28(9):1172-85. doi: 10.1016/j.cellsig.2016.05.014. 2016
4BTG1, BTG2
Tumor suppressors BTG1 and BTG2 regulate early mouse B-cell development.
Tijchon E, van Emst L, Yuniati L, van Ingen Schenau D, Havinga J, Rouault JP, Hoogerbrugge PM, van Leeuwen FN, Scheijen B.
Haematologica 101(7):e272-6. doi: 10.3324/haematol.2015.139675. No abstract available. 2016
5BTG2, CNOT7, CNOT8, PABPC1
BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation.
Stupfler B, Birck C, Séraphin B, Mauxion F.
Nat Commun 7:10811. doi: 10.1038/ncomms10811. 2016
6BTG2, STAT3
B cell translocation gene 2 (Btg2) is regulated by Stat3 signaling and inhibits adipocyte differentiation.
Kim S, Hong JW, Park KW.
Mol Cell Biochem 413(1-2):145-53. doi: 10.1007/s11010-015-2648-z. 2016
7BTG1, BTG2
Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.
Tijchon E, van Ingen Schenau D, van Opzeeland F, Tirone F, Hoogerbrugge PM, Van Leeuwen FN, Scheijen B.
PLoS One 10(7):e0131481. doi: 10.1371/journal.pone.0131481. 2015
8BTG2, HAMP, YY1
B-cell translocation gene 2 promotes hepatic hepcidin production via induction of Yin Yang 1.
Lee SE, Hwang SL, Jang WG, Chang HW, Kim YD.
Biochem Biophys Res Commun 460(4):996-1001. doi: 10.1016/j.bbrc.2015.03.140. 2015
9BTG2
Neurogenesis of the spiral ganglion cells in the cochlea requires the transcriptional cofactor TIS21.
Yamada T, Minoda R, Miwa T, Ise M, Takeda H, Yumoto E.
Neurosci Lett 584:265-9. doi: 10.1016/j.neulet.2014.10.001. 2015
10BTG2, CYR61, SCD, ZFP36
Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy.
Planck T, Shahida B, Sjögren M, Groop L, Hallengren B, Lantz M.
Thyroid 24(7):1156-61. doi: 10.1089/thy.2013.0654. 2014
11BTG2
B-cell translocation gene 2 regulates hepatic glucose homeostasis via induction of orphan nuclear receptor Nur77 in diabetic mouse model.
Kim YD, Kim SG, Hwang SL, Choi HS, Bae JH, Song DK, Im SS.
Diabetes 63(6):1870-80. doi: 10.2337/db13-1368. 2014
12BTG2
B-cell translocation gene 2 regulates hepatic glucose homeostasis via induction of orphan nuclear receptor Nur77 in diabetic mouse model.
Kim YD, Kim SG, Hwang SL, Choi HS, Bae JH, Song DK, Im SS.
Diabetes 63(6):1870-80. doi: 10.2337/db13-1368. 2014
13BTG2, CRP
C-reactive protein induces G2/M phase cell cycle arrest and apoptosis in monocytes through the upregulation of B-cell translocation gene 2 expression.
Kim Y, Ryu J, Ryu MS, Lim S, Han KO, Lim IK, Han KH.
FEBS Lett 588(4):625-31. doi: 10.1016/j.febslet.2014.01.008. 2014
14BTG2, IL6, sTAT3
TIS21(/BTG2/PC3) inhibits interleukin-6 expression via downregulation of STAT3 pathway.
Quy LN, Choi YW, Kim YH, Chwae YJ, Park TJ, Lim IK.
Cell Signal 25(12):2391-9. doi: 10.1016/j.cellsig.2013.07.024. 2013
15BTG2, GCG, PDX1
B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic β-cells.
Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD.
Exp Mol Med 45:e25. doi: 10.1038/emm.2013.47. 2013
16BTG2, NFE2L2
B-cell translocation gene 2 (BTG2) stimulates cellular antioxidant defenses through the antioxidant transcription factor NFE2L2 in human mammary epithelial cells.
Karve TM, Rosen EM.
J Biol Chem 287(37):31503-14. doi: 10.1074/jbc.M112.367433. 2012
17BTG2
B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB.
Hwang SL, Kwon O, Lee SJ, Roh SS, Kim YD, Choi JH.
Biochem Biophys Res Commun 427(4):801-5. doi: 10.1016/j.bbrc.2012.09.146. 2012
18BTG1, BTG2, BTG3, BTG4, CNOT7, CNOT8, TOB1, TOB2
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
Doidge R, Mittal S, Aslam A, Winkler GS.
PLoS One. ;7(12):e51331. doi: 10.1371/journal.pone.0051331. Epub 2012 Dec 7 2012
19AR, BTG2
BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity.
Hu XD, Meng QH, Xu JY, Jiao Y, Ge CM, Jacob A, Wang P, Rosen EM, Fan S.
Biochem Biophys Res Commun 404(4):903-9. Epub 2010 Dec 21. 2011
20BTG1, BTG2, BTG3, BTG4, CNOT7, CNOT8, TOB1, TOB2
The mammalian anti-proliferative BTG/Tob protein family.
Winkler GS.
J Cell Physiol 222(1):66-72. Review.PMID: 19746446 2010
21BTG2, BTG3, BTG4
Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer.
Dong W, Tu S, Xie J, Sun P, Wu Y, Wang L.
Biochem Biophys Res Commun 387(1):132-8. Epub 2009 Jul 1.PMID: 19576178 2009
22BTG2
B-cell translocation gene 2 is over-expressed in peri-infarct neurons after ischaemic stroke.
Slevin M, Sanfeliu C, Turu MM, Grau-Olivares M, Ferrer I, Boluda S, Marti-Fabregas J, Kumar S, Kumar P, Krupinski J.
Pathobiology 76(3):129-35. Epub 2009 May 19.PMID: 19468252 2009
23BTG1, BTG2, TOB2
BTG/TOB factors impact deadenylases.
Mauxion F, Chen CY, Séraphin B, Shyu AB.
Trends Biochem Sci 34(12):640-7. Epub 2009 Oct 12. Review.PMID: 19828319 2009
24BTG2
Impact of BTG2 expression on proliferation and invasion of gastric cancer cells in vitro.
Zhang L, Huang H, Wu K, Wang M, Wu B.
Mol Biol Rep ol Biol Rep. 2009 Sep 2. [Epub ahead of print]PMID: 19728149 2009
25BTG2, CNOT8
The BTG2 protein is a general activator of mRNA deadenylation.
Mauxion F, Faux C, SŽraphin B.
EMBO J 27(7):1039-48. Epub 2008 Mar 13. 2008
26BTG2, CNOT7, CNOT8
Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity.
Yang X, Morita M, Wang H, Suzuki T, Yang W, Luo Y, Zhao C, Yu Y, Bartlam M, Yamamoto T, Rao Z.
Nucleic Acids Res 36(21):6872-81. Epub 2008 Oct 30. 2008
27BTG1, BTG2
Btg1 and Btg2 gene expression during early chick development.
Kamaid A, Giráldez F.
Dev Dyn 237(8):2158-69.PMID: 18651656 2008
28BTG1, BTG2
Role for Btg1 and Btg2 in growth arrest of WEHI-231 cells through arginine methylation following membrane immunoglobulin engagement.
Hata K, Nishijima K, Mizuguchi J.
Exp Cell Res 313(11):2356-66. Epub 2007 Mar 30.PMID: 17466295 2007
29BTG1, BTG2, BTG3, BTG4, TOB1, TOB2
Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.
Sasajima H, Nakagawa K, Yokosawa H.
Eur J Biochem 269(14):3596-604.PMID: 12135500 2002
30BTG3, BTG2
In search of a function for the TIS21/PC3/BTG1/TOB family.
Matsuda S, Rouault J, Magaud J, Berthet C.
FEBS Lett 497(2-3):67-72. Review. 2001
31BTG2
Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division.
Iacopetti P, et al.
Proc Natl Acad Sci U S A 96(8):4639-44. 1999
32BTG2
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway.
Rouault JP, et al.
Nat Genet 14 : 482-486. 1996