Citations for
1BRD4, SERTAD4
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.
Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MP, Haldar SM, Lin CY, McKinsey TA.
Circ Res irc Res. 2019 Aug 14. doi: 10.1161/CIRCRESAHA.119.315125. [Epub ahead of print] 2019
2BRD4, TMPRSS2
BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer.
Li X, Baek G, Ramanand SG, Sharp A, Gao Y, Yuan W, Welti J, Rodrigues DN, Dolling D, Figueiredo I, Sumanasuriya S, Crespo M, Aslam A, Li R, Yin Y, Mukherjee B, Kanchwala M, Hughes AM, Halsey WS, Chiang CM, Xing C, Raj GV, Burma S, de Bono J, Mani RS.
Cell Rep 22(3):796-808. doi: 10.1016/j.celrep.2017.12.078. 2018
3BRD2, BRD4
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, Walsh MJ, Xiong H, Zeng L, Zhou MM.
Mol Cell 65(6):1068-1080.e5. doi: 10.1016/j.molcel.2016.12.022. Epub 2017 Mar 3. 2017
4BRD4
Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer.
Gao X, Wu X, Zhang X, Hua W, Zhang Y, Maimaiti Y, Gao Z, Zhang Y.
Biochem Biophys Res Commun iochem Biophys Res Commun. 2015 Dec 17. pii: S0006-291X(15)31013-5. doi: 10.1016/j.bbrc.2015.12.008. [Epub ahead of print] 2015
5BRD4
BRD4 is a novel therapeutic target for liver fibrosis.
Ding N, Hah N, Yu RT, Sherman MH, Benner C, Leblanc M, He M, Liddle C, Downes M, Evans RM.
Proc Natl Acad Sci U S A 112(51):15713-8. doi: 10.1073/pnas.1522163112. Epub 2015 Dec 7. 2015
6BRD4, WHSC1L1
NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.
Shen C, Ipsaro JJ, Shi J, Milazzo JP, Wang E, Roe JS, Suzuki Y, Pappin DJ, Joshua-Tor L, Vakoc CR.
Mol Cell 60(6):847-59. doi: 10.1016/j.molcel.2015.10.033. Epub 2015 Nov 25. 2015
7BRD4
BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway.
Wang YH, Sui XM, Sui YN, Zhu QW, Yan K, Wang LS, Wang F, Zhou JH.
Oncol Lett 10(4):2227-2232. Epub 2015 Aug 4. 2015
8BRD4
Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression.
Li GQ, Guo WZ, Zhang Y, Seng JJ, Zhang HP, Ma XX, Zhang G, Li J, Yan B, Tang HW, Li SS, Wang LD, Zhang SJ.
Oncotarget ncotarget. 2015 Nov 12. doi: 10.18632/oncotarget.6275. [Epub ahead of print] 2015
9BRD4
Characterization of BRD4 during mammalian postmeiotic sperm development.
Bryant JM, Donahue G, Wang X, Meyer-Ficca M, Luense LJ, Weller AH, Bartolomei MS, Blobel GA, Meyer RG, Garcia BA, Berger SL.
Mol Cell Biol 35(8):1433-48. doi: 10.1128/MCB.01328-14. Epub 2015 Feb 17. 2015
10BRD4
BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.
Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K.
Nat Struct Mol Biol 21(12):1047-57. doi: 10.1038/nsmb.2912. Epub 2014 Nov 10. 2014
11BRD4
Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.
Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW.
Cell Rep 8(6):1919-29. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18. 2014
12BRD4
Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription.
Nagarajan S, Hossan T, Alawi M, Najafova Z, Indenbirken D, Bedi U, Taipaleenmäki H, Ben-Batalla I, Scheller M, Loges S, Knapp S, Hesse E, Chiang CM, Grundhoff A, Johnsen SA.
Cell Rep 8(2):460-9. doi: 10.1016/j.celrep.2014.06.016. Epub 2014 Jul 10. 2014
13BRD4
Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining.
Stanlie A, Yousif AS, Akiyama H, Honjo T, Begum NA.
Mol Cell 55(1):97-110. doi: 10.1016/j.molcel.2014.05.018. Epub 2014 Jun 19. 2014
14BRD4
Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.
Itzen F, Greifenberg AK, Bösken CA, Geyer M.
Nucleic Acids Res 42(12):7577-90. doi: 10.1093/nar/gku449. Epub 2014 May 23. 2014
15BRD4, HMOX1
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.
Hussong M, Börno ST, Kerick M, Wunderlich A, Franz A, Sültmann H, Timmermann B, Lehrach H, Hirsch-Kauffmann M, Schweiger MR.
Cell Death Dis 5:e1195. doi: 10.1038/cddis.2014.157. 2014
16BRD4
Role of BRD4 in hematopoietic differentiation of embryonic stem cells.
Rodriguez RM, Suarez-Alvarez B, Salvanés R, Huidobro C, Torańo EG, Garcia-Perez JL, Lopez-Larrea C, Fernandez AF, Bueno C, Menendez P, Fraga MF.
Epigenetics 9(4):566-78. doi: 10.4161/epi.27711. Epub 2014 Jan 20. 2014
17BRD4
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.
Nature 498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2. 2013
18BRD4
BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes.
Patel MC, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, Heightman TD, Tamura T, Ozato K.
Mol Cell Biol 33(12):2497-507. doi: 10.1128/MCB.01180-12. Epub 2013 Apr 15. 2013
19BRD4, CDK9, JMJD6
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.
Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, Aggarwal A, Rosenfeld MG.
Cell 155(7):1581-1595. doi: 10.1016/j.cell.2013.10.056. 2013
20BRD4, NUT
NUT rearrangement is uncommon in human thymic epithelial tumors.
Petrini P, French CA, Rajan A, Cameron MJ, Jaffe ES, Zucali PA, Xie J, Wang Y, Giaccone G.
J Thorac Oncol 7(4):744-50. 2012
21BRD4, POLR2A
Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells.
Zhang W, Prakash C, Sum C, Gong Y, Li Y, Kwok JJ, Thiessen N, Pettersson S, Jones SJ, Knapp S, Yang H, Chin KC.
J Biol Chem 287(51):43137-55. doi: 10.1074/jbc.M112.413047. Epub 2012 Oct 19. 2012
22BRD4, CDK9
BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.
Devaiah BN, Lewis BA, Cherman N, Hewitt MC, Albrecht BK, Robey PG, Ozato K, Sims RJ 3rd, Singer DS.
Proc Natl Acad Sci U S A 109(18):6927-32. doi: 10.1073/pnas.1120422109. Epub 2012 Apr 16. 2012
23BRD2, BRD3, BRD4, BRDT
Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains.
Chung CW, Coste H, White JH, Mirguet O, Wilde J, Gosmini RL, Delves C, Magny SM, Woodward R, Hughes SA, Boursier EV, Flynn H, Bouillot AM, Bamborough P, Brusq JM, Gellibert FJ, Jones EJ, Riou AM, Homes P, Martin SL, Uings IJ, Toum J, Clément CA, Boullay AB, Grimley RL, Blandel FM, Prinjha RK, Lee K, Kirilovsky J, Nicodeme E.
J Med Chem 54(11):3827-3838. Epub 2011 May 13. 2011
24ATAD5, BRD4, CHD4, GLTSCR1, WHSC1L1
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Rahman S, Sowa ME, Ottinger M, Smith JA, Shi Y, Harper JW, Howley PM.
Mol Cell Biol 31(13):2641-52. Epub 2011 May 9. 2011
25BRD4, KAT2A, KAT5, NUT
Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma.
Yan J, Diaz J, Jiao J, Wang R, You J.
J Biol Chem 286(31):27663-75. Epub 2011 Jun 7. 2011
26BRD4
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR.
Nature 478(7370):524-8. doi: 10.1038/nature10334. 2011
27BRD4
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T.
Nature 478(7370):529-33. doi: 10.1038/nature10509. 2011
28BRD2, BRD3, BRD4, BRDT
Selective inhibition of BET bromodomains.
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE.
Nature 468(7327):1067-73. Epub 2010 Sep 24. 2010
29BRD2, BRD3, BRD4, BRDT
Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2.
Umehara T, Nakamura Y, Wakamori M, Ozato K, Yokoyama S, Padmanabhan B.
FEBS Lett 584(18):3901-8. Epub 2010 Aug 13. 2010
30BRD4, CDK9, RELA
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.
Huang B, Yang XD, Zhou MM, Ozato K, Chen LF.
Mol Cell Biol 29(5):1375-87. Epub 2008 Dec 22. 2009
31AURKB, BRD4
Regulation of aurora B expression by the bromodomain protein Brd4.
You J, Li Q, Wu C, Kim J, Ottinger M, Howley PM.
Mol Cell Biol 29(18):5094-103. Epub 2009 Jul 13. 2009
32BRD4
Brd4 regulation of papillomavirus protein E2 stability.
Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM.
J Virol 83(17):8683-92. Epub 2009 Jun 24. 2009
33BRD4
Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4.
Gagnon D, Joubert S, Sénéchal H, Fradet-Turcotte A, Torre S, Archambault J.
J Virol 83(9):4127-39. Epub 2009 Feb 11. 2009
34BRD4, CDK9
Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.
Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, Kashanchi F, Pise-Masison CA, Brady JN.
J Virol 83(2):1036-44. Epub 2008 Oct 29. 2009
35BRD4, NUT
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC.
Oncogene 27(15):2237-42. Epub 2007 Oct 15. 2008
36BRD4, CCNT1
Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression.
Yang Z, He N, Zhou Q.
Mol Cell Biol 28(3):967-76. Epub 2007 Nov 26. 2008
37BRD4
Bromodomain 4 activation predicts breast cancer survival.
Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, Lee MP, Ozato K, Hunter KW.
Proc Natl Acad Sci U S A 105(17):6380-5. Epub 2008 Apr 21. 2008
38BRD4, NUT
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC.
Oncogene 27(15):2237-42. Epub 2007 Oct 15. 2008
39BRD2, BRD3, BRD4, BRDT
Bromodomain testis-specific protein is expressed in mouse oocyte and evolves faster than its ubiquitously expressed paralogs BRD2, -3, and -4.
Paillisson A, Levasseur A, Gouret P, Callebaut I, Bontoux M, Pontarotti P, Monget P.
Genomics 89(2):215-23. Epub 2006 Oct 16. 2007
40BRD4
Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies.
Micci F, Panagopoulos I, Tjřnnfjord GE, Kolstad A, Delabie J, Beiske K, Heim S.
Virchows Arch 450(5):559-65. Epub 2007 Apr 4. 2007
41BRD4, NUT
BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.
French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA.
Cancer Res 63(2):304-7. 2003
42BRD4
A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.
Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K.
Mol Cell Biol 22(18):6509-20. 2002
43BRD4
BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19).
French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA.
Am J Pathol 159(6):1987-92. 2001
44BRD4
A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition.
Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K.
Mol Cell Biol 20(17):6537-49. 2000