| 1 | BRD2, EJM3
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| Subtle Brain Developmental Abnormalities in the Pathogenesis of Juvenile Myoclonic Epilepsy.
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| Gilsoul M, Grisar T, Delgado-Escueta AV, de Nijs L, Lakaye B.
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| Front Cell Neurosci 13:433. doi: 10.3389/fncel.2019.00433. eCollection 2019. Review.
2019
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| 2 | BRD2, EJM3
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| DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians.
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| Pathak S, Miller J, Morris EC, Stewart WCL, Greenberg DA.
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| Epilepsia 59(5):1011-1019. doi: 10.1111/epi.14058. Epub 2018 Apr 2.
2018
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| 3 | BRD2, ZMYND8
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| Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair.
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| Gursoy-Yuzugullu O, Carman C, Price BD.
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| Sci Rep 7(1):12921. doi: 10.1038/s41598-017-13036-5.
2017
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| 4 | BRD2, CTCF
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| The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.
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| Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins JE, Blobel GA.
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| Mol Cell 66(1):102-116.e7. doi: 10.1016/j.molcel.2017.02.027.
2017
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| 5 | BRD2, BRD4
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| Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
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| Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, Walsh MJ, Xiong H, Zeng L, Zhou MM.
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| Mol Cell 65(6):1068-1080.e5. doi: 10.1016/j.molcel.2016.12.022. Epub 2017 Mar 3.
2017
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| 6 | BRD2, H2AZ1
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| H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs.
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| Surface LE, Fields PA, Subramanian V, Behmer R, Udeshi N, Peach SE, Carr SA, Jaffe JD, Boyer LA.
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| Cell Rep 14(5):1142-1155. doi: 10.1016/j.celrep.2015.12.100. Epub 2016 Jan 21.
2016
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| 7 | BRD2
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| DNA methylation regulates bromodomain-containing protein 2 expression during adipocyte differentiation.
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| Sun R, Wu Y, Wang Y, Zang K, Wei H, Wang F, Yu M.
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| Mol Cell Biochem 402(1-2):23-31. doi: 10.1007/s11010-014-2310-1. Epub 2015 Jan 10.
2015
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| 8 | BRD2, PTN
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| Pleiotrophin antagonizes Brd2 during neuronal differentiation.
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| Garcia-Gutierrez P, Juarez-Vicente F, Wolgemuth DJ, Garcia-Dominguez M.
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| J Cell Sci 127(Pt 11):2554-64. doi: 10.1242/jcs.147462. Epub 2014 Apr 2.
2014
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| 9 | BRD2
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| The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.
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| Belkina AC, Blanton WP, Nikolajczyk BS, Denis GV.
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| J Leukoc Biol 95(3):451-60. doi: 10.1189/jlb.1112588. Epub 2013 Dec 6.
2014
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| 10 | BRD2
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| The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.
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| Hnilicová J, Hozeifi S, Stejskalová E, Dušková E, Poser I, Humpolíčková J, Hof M, Staněk D.
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| Mol Biol Cell 24(22):3557-68. doi: 10.1091/mbc.E13-06-0303. Epub 2013 Sep 18.
2013
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| 11 | BRD2, BRD3, BRD4, BRDT
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| PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.
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| Picaud S, Da Costa D, Thanasopoulou A, Filippakopoulos P, Fish PV, Philpott M, Fedorov O, Brennan P, Bunnage ME, Owen DR, Bradner JE, Taniere P, O'Sullivan B, Müller S, Schwaller J, Stankovic T, Knapp S.
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| Cancer Res. Jun 1;73(11):3336-46. doi: 10.1158/0008-5472.CAN-12-3292. Epub 2013 Apr 10 2013
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| 12 | BRD2
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| Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells.
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| Tsume M, Kimura-Yoshida C, Mochida K, Shibukawa Y, Amazaki S, Wada Y, Hiramatsu R, Shimokawa K, Matsuo I.
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| Biochem Biophys Res Commun 425(4):762-8. doi: 10.1016/j.bbrc.2012.07.149. Epub 2012 Aug 2.
2012
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| 13 | BRD2
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| Expression of BET genes in testis of men with different spermatogenic impairments.
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| Barda S, Paz G, Yogev L, Yavetz H, Lehavi O, Hauser R, Botchan A, Breitbart H, Kleiman SE.
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| Fertil Steril 97(1):46-52.e5. doi: 10.1016/j.fertnstert.2011.10.010. Epub 2011 Oct 28.
2012
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| 14 | BRD2, BRD3, BRD4, BRDT
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| Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains.
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| Chung CW, Coste H, White JH, Mirguet O, Wilde J, Gosmini RL, Delves C, Magny SM, Woodward R, Hughes SA, Boursier EV, Flynn H, Bouillot AM, Bamborough P, Brusq JM, Gellibert FJ, Jones EJ, Riou AM, Homes P, Martin SL, Uings IJ, Toum J, Clément CA, Boullay AB, Grimley RL, Blandel FM, Prinjha RK, Lee K, Kirilovsky J, Nicodeme E.
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| J Med Chem 54(11):3827-3838. Epub 2011 May 13.
2011
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| 15 | BRD2, EJM3
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| The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels.
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| Shang E, Cui Q, Wang X, Beseler C, Greenberg DA, Wolgemuth DJ.
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| J Cell Biochem 112(10):2784-93. doi: 10.1002/jcb.23192.
2011
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| 16 | BRD2, BRD3, BRD4, BRDT
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| Selective inhibition of BET bromodomains.
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| Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE.
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| Nature 468(7327):1067-73. Epub 2010 Sep 24.
2010
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| 17 | BRD2, BRD3, BRD4, BRDT
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| Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2.
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| Umehara T, Nakamura Y, Wakamori M, Ozato K, Yokoyama S, Padmanabhan B.
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| FEBS Lett 584(18):3901-8. Epub 2010 Aug 13.
2010
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| 18 | BRD2
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| Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain.
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| Umehara T, Nakamura Y, Jang MK, Nakano K, Tanaka A, Ozato K, Padmanabhan B, Yokoyama S.
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| J Biol Chem 285(10):7610-8. Epub 2010 Jan 4.
2010
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| 19 | BRD2
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| Brd2 disruption in mice causes severe obesity without Type 2 diabetes.
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| Wang F, Liu H, Blanton WP, Belkina A, Lebrasseur NK, Denis GV.
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| Biochem J 425(1):71-83.
2009
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| 20 | BRD2
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| The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis.
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| Gyuris A, Donovan DJ, Seymour KA, Lovasco LA, Smilowitz NR, Halperin AL, Klysik JE, Freiman RN.
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| Biochim Biophys Acta 1789(5):413-21. Epub 2009 Apr 10.
2009
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| 21 | BRD2
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| Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.
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| Shang E, Wang X, Wen D, Greenberg DA, Wolgemuth DJ.
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| Dev Dyn 238(4):908-17.
2009
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| 22 | BRD2, BRD3
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| The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription.
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| LeRoy G, Rickards B, Flint SJ.
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| Mol Cell 30(1):51-60.
2008
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| 23 | BRD2, BRD3, BRD4, BRDT
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| Bromodomain testis-specific protein is expressed in mouse oocyte and evolves faster than its ubiquitously expressed paralogs BRD2, -3, and -4.
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| Paillisson A, Levasseur A, Gouret P, Callebaut I, Bontoux M, Pontarotti P, Monget P.
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| Genomics 89(2):215-23. Epub 2006 Oct 16. 2007
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| 24 | BRD2
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| A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy.
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| Cavalleri GL, Walley NM, Soranzo N, Mulley J, Doherty CP, Kapoor A, Depondt C, Lynch JM, Scheffer IE, Heils A, Gehrmann A, Kinirons P, Gandhi S, Satishchandra P, Wood NW, Anand A, Sander T, Berkovic SF, Delanty N, Goldstein DB, Sisodiya SM.
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| Epilepsia 48(4):706-12.
2007
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| 25 | BRD2
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| Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation.
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| Peng J, Dong W, Chen L, Zou T, Qi Y, Liu Y.
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| Mol Cell Biochem 294(1-2):45-54. Epub 2006 Nov 17.
2007
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| 26 | BRD2, BRD7
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| BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis.
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| Zhou M, Xu XJ, Zhou HD, Liu HY, He JJ, Li XL, Peng C, Xiong W, Fan SQ, Lu JH, Ouyang J, Shen SR, Xiang B, Li GY.
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| Mol Cell Biochem 292(1-2):205-12. Epub 2006 Jun 20.
2006
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| 27 | ENFL1, CHRNA4, BRD2, ME2, LGI1, EPT, EFHC1, EJM1, BFNIS, SCN2A
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| Sacred disease secrets revealed: the genetics of human epilepsy.
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| Turnbull J, Lohi H, Kearney JA, Rouleau GA, Delgado-Escueta AV, Meisler MH, Cossette P, Minassian BA.
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| Hum Mol Genet 14(17):2491-500. Epub 2005 Jul 27. 2005
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| 28 | BRD2, EJM1
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| BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy.
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| Pal DK, Evgrafov OV, Tabares P, Zhang F, Durner M, Greenberg DA.
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| Am J Hum Genet 73(2):261-70. Epub 2003 Jun 25. 2003
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| 29 | BRD2
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| Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.
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| Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ.
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| Mol Endocrinol 16(8):1727-37. 2002
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| 30 | BRD2
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| Identification and cloning of an 85-kDa protein homologous to RING3 that is upregulated in proliferating endothelial cells.
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| BelAiba RS, Baril P, Chebloune Y, Tabone E, Boukerche H.
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| Eur J Biochem 268(16):4398-407. 2001
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| 31 | BRD2
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| Nucleotide sequence of the Ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells.
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| Taniguchi Y, et al.
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| Genomics 51 : 114-123. 1998
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| 32 | BRD2, BRD3
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| Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene.
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| Thorpe KL, Gorman P, Thomas C, Sheer D, Trowsdale J, Beck S.
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| Gene 200(1-2):177-83. 1997
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| 33 | BRD2
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| A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator.
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| Denis GV, et al.
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| Genes Dev 10 : 261-271. 1996
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| 34 | BRD2, BRD3, NLRP1
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| Phylogeny and structure of the RING3 gene.
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| Thorpe KL, Abdulla S, Kaufman J, Trowsdale J, Beck S.
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| Immunogenetics 44(5):391-6. No abstract available. 1996
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| 35 | BRD2
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| A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC.
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| Beck S, et al.
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| DNA Seq 2 : 203-210. 1992
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| 36 | BRD2
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| The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins.
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| Haynes SR, Dollard C, Winston F, Beck S, Trowsdale J, Dawid IB.
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| Nucleic Acids Res 20(10):2603. No abstract available. 1992
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| 37 | RING1, D6S112E, BRD2, TAP1
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| New genes in the class II region of the human major histocompatibility complex.
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| Hanson IM, et al.
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| Genomics 10 : 417-424. 1991
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| 38 | BRD2, HLA-DOA
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| Orientation of HLA-DNA gene and identification of a CpG island-associated gene adjacent to DNA in human major histocompatibility complex class II region.
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| Okamoto N, Ando A, Kawai J, Yoshiwara T, Tsuji K, Inoko H.
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| Hum Immunol 32(3):221-8. 1991
|