1 | BNIP3, BNIP3L, FUNDC1, PINK1
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| Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.
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| Wei H, Liu L, Chen Q.
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| Biochim Biophys Acta 1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1. Review.
2015
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2 | BNIP3, BNIP3L
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| Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.
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| Ney PA.
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| Biochim Biophys Acta 1853(10 Pt B):2775-83. doi: 10.1016/j.bbamcr.2015.02.022. Epub 2015 Mar 6. Review.
2015
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3 | BNIP3, BNIP3L
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| BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory.
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| O'Sullivan TE, Johnson LR, Kang HH, Sun JC.
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| Immunity 43(2):331-42. doi: 10.1016/j.immuni.2015.07.012. Epub 2015 Aug 4.
2015
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4 | BNIP3
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| BNIP3 is degraded by ULK1-dependent autophagy via MTORC1 and AMPK.
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| Park CW, Hong SM, Kim ES, Kwon JH, Kim KT, Nam HG, Choi KY.
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| Autophagy 9(3). [Epub ahead of print]
2013
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5 | BNIP3, BNIP3L, C14orf1, CLN8, GABARAPL2, STX8, VAPA
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| Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.
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| Passantino R, Cascio C, Deidda I, Galizzi G, Russo D, Spedale G, Guarneri P.
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| Biochim Biophys Acta 1833(3):529-40. doi: 10.1016/j.bbamcr.2012.10.030. Epub 2012 Nov 8. 2013
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6 | BNIP3, BNIP3L
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| A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription.
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| Chen Y, Decker KF, Zheng D, Matkovich SJ, Jia L, Dorn GW 2nd.
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| J Biol Chem 288(22):15455-65. doi: 10.1074/jbc.M113.452342. Epub 2013 Apr 19.
2013
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7 | BNIP3, BNIP3L, SPATA18
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| BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria.
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| Nakamura Y, Kitamura N, Shinogi D, Yoshida M, Goda O, Murai R, Kamino H, Arakawa H.
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| PLoS One 7(1):e30767. doi: 10.1371/journal.pone.0030767. Epub 2012 Jan 26.
2012
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8 | AIFM1, BNIP3
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| Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
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| Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S.
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| J Cell Biol 198(1):103-14. doi: 10.1083/jcb.201111063. Epub 2012 Jul 2.
2012
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9 | BNIP3
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| Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy.
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| Hanna RA, Quinsay MN, Orogo AM, Giang K, Rikka S, Gustafsson ÅB.
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| J Biol Chem 287(23):19094-104. doi: 10.1074/jbc.M111.322933. Epub 2012 Apr 13.
2012
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10 | AIFM1, BNIP3
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| Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
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| Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S.
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| J Cell Biol 198(1):103-14. doi: 10.1083/jcb.201111063. Epub 2012 Jul 2. Erratum in: J Cell Biol. 2013 Apr 1;201(1):165.
2012
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11 | BNIP3
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| BNip3 regulates mitochondrial function and lipid metabolism in the liver.
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| Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, Hart J, Dorn GW 2nd, Brady MJ, Macleod KF.
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| Mol Cell Biol 32(13):2570-84. doi: 10.1128/MCB.00167-12. Epub 2012 Apr 30.
2012
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12 | BNIP3
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| Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover.
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| Rikka S, Quinsay MN, Thomas RL, Kubli DA, Zhang X, Murphy AN, Gustafsson ÅB.
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| Cell Death Differ 18(4):721-31. Epub 2010 Nov 19.
2011
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13 | BNIP3
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| Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes.
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| Lee Y, Lee HY, Hanna RA, Gustafsson ÅB.
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| Am J Physiol Heart Circ Physiol 301(5):H1924-31. doi: 10.1152/ajpheart.00368.2011. Epub 2011 Sep 2.
2011
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14 | BNIP3
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| p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death.
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| Feng X, Liu X, Zhang W, Xiao W.
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| EMBO J 30(16):3397-415. doi: 10.1038/emboj.2011.248.
2011
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15 | BNIP3
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| VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells.
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| Jurasz P, Yurkova N, Kirshenbaum L, Stewart DJ.
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| Angiogenesis 14(2):199-207. doi: 10.1007/s10456-011-9204-6. Epub 2011 Feb 13.
2011
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16 | BNIP3
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| Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium.
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| Gustafsson AB.
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| Pediatr Cardiol 32(3):267-74. doi: 10.1007/s00246-010-9876-5. Epub 2011 Jan 6. Review.
2011
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17 | BNIP3, HRAS
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| H-ras up-regulates expression of BNIP3.
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| Kalas W, Swiderek E, Rapak A, Kopij M, Rak J, Strzadala L.
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| Anticancer Res 31(9):2869-75.
2011
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18 | BNIP3, OPA1
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| The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms.
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| Landes T, Emorine LJ, Courilleau D, Rojo M, Belenguer P, Arnauné-Pelloquin L.
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| EMBO Rep 11(6):459-65. Epub 2010 Apr 30.
2010
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19 | BNIP3
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| Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies.
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| Azad MB, Gibson SB.
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| Ann N Y Acad Sci 1210:8-16. doi: 10.1111/j.1749-6632.2010.05778.x.
2010
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20 | BNIP3, PDK1
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| Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: role of Bnip3 and Pdk1.
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| Jian B, Wang D, Chen D, Voss J, Chaudry I, Raju R.
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| Shock 34(2):169-75. doi: 10.1097/SHK.0b013e3181cffe7d.
2010
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21 | BNIP3
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| Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism.
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| Quinsay MN, Lee Y, Rikka S, Sayen MR, Molkentin JD, Gottlieb RA, Gustafsson AB.
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| J Mol Cell Cardiol 48(6):1146-56. doi: 10.1016/j.yjmcc.2009.12.004. Epub 2009 Dec 16.
2010
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22 | BNIP3, BNIP3L
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| Role of BNIP3 and NIX in cell death, autophagy, and mitophagy.
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| Zhang J, Ney PA.
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| Cell Death Differ 16(7):939-46. Epub 2009 Feb 20.
2009
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23 | BNIP3
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| BNIP3 (Bcl-2 19 kDa interacting protein) acts as transcriptional repressor of apoptosis-inducing factor expression preventing cell death in human malignant gliomas.
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| Burton TR, Eisenstat DD, Gibson SB.
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| J Neurosci 29(13):4189-99.
2009
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24 | BNIP3, BNIP3L
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| Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
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| Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J, Mazure NM.
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| Mol Cell Biol 29(10):2570-81. Epub 2009 Mar 9. 2009
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25 | BNIP3, TYMP
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| Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3.
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| Ikeda R, Tajitsu Y, Iwashita K, Che XF, Yoshida K, Ushiyama M, Furukawa T, Komatsu M, Yamaguchi T, Shibayama Y, Yamamoto M, Zhao HY, Arima J, Takeda Y, Akiyama S, Yamada K.
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| Biochem Biophys Res Commun 370(2):220-4. Epub 2008 Mar 24.
2008
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26 | BNIP3, ACAA2
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| Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines.
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| Cao W, Liu N, Tang S, Bao L, Shen L, Yuan H, Zhao X, Lu H.
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| Biochim Biophys Acta 1780(6):873-80. Epub 2008 Mar 6. 2008
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27 | BCL2L1, BNIP3
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| Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.
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| Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.
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| J Biol Chem 283(39):26499-508. Epub 2008 Jul 16.
2008
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28 | BNIP3
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| Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.
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| Shaida N, Launchbury R, Boddy JL, Jones C, Campo L, Turley H, Kanga S, Banham AH, Malone PR, Harris AL, Fox SB.
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| Prostate 68(3):336-43.
2008
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29 | BNIP3
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| Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3.
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| Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E, Israels SJ, Gibson SB.
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| Autophagy 4(2):195-204. Epub 2007 Nov 8.
2008
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30 | BNIP3, BNIP3L
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| BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions.
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| Chinnadurai G, Vijayalingam S, Gibson SB.
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| Oncogene 27 Suppl 1:S114-27.
2008
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31 | BNIP3, E2F1
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| The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes.
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| Yurkova N, Shaw J, Blackie K, Weidman D, Jayas R, Flynn B, Kirshenbaum LA.
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| Circ Res 102(4):472-9. Epub 2007 Dec 20.PMID: 18096822 2008
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32 | BNIP3
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| Mutational and expressional analysis of BNIP3, a pro-apoptotic Bcl-2 member, in gastric carcinomas.
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| Lee SH, Jeong EG, Yoo NJ, Lee SH.
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| APMIS 115(11):1274-80.
2007
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33 | BAK1, BAX, BNIP3
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| Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak.
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| Kubli DA, Ycaza JE, Gustafsson AB.
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| Biochem J 405(3):407-15.
2007
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34 | BNIP3, FOXO3, MAP1LC3
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| FoxO3 controls autophagy in skeletal muscle in vivo.
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| Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M.
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| Cell Metab 6(6):458-71.PMID: 18054315 2007
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35 | BNIP3
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| Upregulation of BNIP3 promotes apoptosis of lung cancer cells that were induced by p53.
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| Yan J, Yun H, Yang Y, Jing B, Feng C, Song-bin F.
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| Biochem Biophys Res Commun 346(2):501-7.
2006
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36 | BNIP3
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| Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.
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| Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, Issa JP, Hinoda Y, Tokino T, Imai K.
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| Br J Cancer 92(6):1165-72. 2005
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37 | BNIP3
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| Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis.
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| Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, Giese NA, Friess H.
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| Oncogene 24(27):4421-32. 2005
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38 | BNIP3
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| Nitric oxide induces BNIP3 expression that causes cell death in macrophages.
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| Yook YH, Kang KH, Maeng O, Kim TR, Lee JO, Kang KI, Kim YS, Paik SG, Lee H.
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| Biochem Biophys Res Commun 321(2):298-305. 2004
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39 | BNIP3
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| BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.
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| Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA, Gibson SB.
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| Oncogene 22(30):4734-44. 2003
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40 | BNIP3
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| Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3.
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| Kubasiak LA, Hernandez OM, Bishopric NH, Webster KA.
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| Proc Natl Acad Sci U S A 99(20):12825-30. Epub 2002 Sep 11.
2002
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41 | BNIP3
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| Hypoxia induces the expression of the pro-apoptotic gene BNIP3.
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| Guo K, Searfoss G, Krolikowski D, Pagnoni M, Franks C, Clark K, Yu KT, Jaye M, Ivashchenko Y.
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| Cell Death Differ 8(4):367-76. 2001
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42 | BCL2, BNIP3
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| BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites.
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| Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH.
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| J Biol Chem 275(2):1439-48. 2000
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43 | BNIP3, BNIP3L
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| Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.
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| Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L, Dubik D, Greenberg A.
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| J Biol Chem 274(1):7-10. 1999
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44 | BNIP3
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| Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence.
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| Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G.
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| J Biol Chem 273(20):12415-21. 1998
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45 | BNIP3
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| The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.
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| Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley RC, Saxena S, Gietz RD, Greenberg AH.
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| J Exp Med 186(12):1975-83. 1997
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