| 1 | BMPR2, SMYD2
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| The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling.
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| Gao S, Wang Z, Wang W, Hu X, Chen P, Li J, Feng X, Wong J, Du JX.
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| J Biol Chem 292(30):12702-12712. doi: 10.1074/jbc.M117.776278. Epub 2017 Jun 6.
2017
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| 2 | BMPR2, PPH1
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| Diffusion capacity and BMPR2 mutations in pulmonary arterial hypertension.
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| Trip P, Girerd B, Bogaard HJ, de Man FS, Boonstra A, Garcia G, Humbert M, Montani D, Vonk-Noordegraaf A.
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| Eur Respir J ur Respir J. 2013 Sep 13. [Epub ahead of print] No abstract available.
2013
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| 3 | ACVR2A, BMPR2
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| Endoglin-Mediated Suppression of Prostate Cancer Invasion Is Regulated by Activin and Bone Morphogenetic Protein Type II Receptors.
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| Breen MJ, Moran DM, Liu W, Huang X, Vary CP, Bergan RC.
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| PLoS One 8(8):e72407. doi: 10.1371/journal.pone.0072407.
2013
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| 4 | BMPR2
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| BMPR2 is required for postimplantation uterine function and pregnancy maintenance.
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| Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM.
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| J Clin Invest 123(6):2539-50. doi: 10.1172/JCI65710. Epub 2013 May 8.
2013
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| 5 | BMPR2, PPH1
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| BMPR2 mutations influence phenotype more obviously in male patients with pulmonary arterial hypertension.
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| Liu D, Wu WH, Mao YM, Yuan P, Zhang R, Ju FL, Jing ZC.
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| Circ Cardiovasc Genet 5(5):511-8. doi: 10.1161/CIRCGENETICS.111.962209. Epub 2012 Aug 25.
2012
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| 6 | BMPR2, PPH1
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| Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension.
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| Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J.
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| Am J Physiol Lung Cell Mol Physiol 302(5):L474-84. doi: 10.1152/ajplung.00202.2011. Epub 2011 Dec 16.
2012
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| 7 | BMPR2
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| Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators.
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| Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL.
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| Proc Natl Acad Sci U S A 109(8):2814-9. doi: 10.1073/pnas.1101139108. Epub 2011 May 16.
2012
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| 8 | BMPR1A, BMPR2, PLXNA2
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| PlexinA2 mediates osteoblast differentiation via regulation of Runx2.
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| Oh JE, Kim HJ, Kim WS, Lee ZH, Ryoo HM, Hwang SJ, Lee Y, Kim HH.
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| J Bone Miner Res 27(3):552-62. doi: 10.1002/jbmr.1471.
2012
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| 9 | BMPR2, NIPA1
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| NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis.
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| Blauw HM, van Rheenen W, Koppers M, Van Damme P, Waibel S, Lemmens R, van Vught PW, Meyer T, Schulte C, Gasser T, Cuppen E, Pasterkamp RJ, Robberecht W, Ludolph AC, Veldink JH, van den Berg LH.
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| Hum Mol Genet 21(11):2497-502. doi: 10.1093/hmg/dds064. Epub 2012 Feb 28.
2012
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| 10 | BMPR2
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| Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation.
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| Gangopahyay A, Oran M, Bauer EM, Wertz JW, Comhair SA, Erzurum SC, Bauer PM.
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| J Biol Chem 286(38):33134-40. doi: 10.1074/jbc.M111.274100. Epub 2011 Aug 1.
2011
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| 11 | BMPR2, PPH1
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| Physiologic and molecular consequences of endothelial Bmpr2 mutation.
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| Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J.
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| Respir Res 12:84. doi: 10.1186/1465-9921-12-84.
2011
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| 12 | BMPR2
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| BMPR-II is dispensable for formation of the limb skeleton.
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| Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V.
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| Genesis 49(9):719-24. doi: 10.1002/dvg.20761. Epub 2011 Aug 19.
2011
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| 13 | BMPR2, PPHI
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| A Novel BMPR2 Mutation Associated with Pulmonary Arterial Hypertension in an Octogenarian.
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| Johri S, Dunnington GH, Vnencak-Jones CL.
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| Lung ung. 2010 May 23. [Epub ahead of print]PMID: 20496075 2010
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| 14 | BMPR2
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| Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials.
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| Jurasz P, Courtman D, Babaie S, Stewart DJ.
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| Pharmacol Ther 126(1):1-8. Epub 2010 Feb 1.PMID: 20117135 2010
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| 15 | BMPR2, ITCH
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| Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
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| Durrington HJ, Upton PD, Hoer S, Boname J, Dunmore BJ, Yang J, Crilley TK, Butler LM, Blackbourn DJ, Nash GB, Lehner PJ, Morrell NW.
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| J Biol Chem 285(48):37641-9. Epub 2010 Sep 24.
2010
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| 16 | ACVRL1, BMPR2, GDF2
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| Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells.
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| Upton PD, Davies RJ, Trembath RC, Morrell NW.
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| J Biol Chem 284(23):15794-804. Epub 2009 Apr 14.
2009
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| 17 | BMPR2, PPH1
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| Novel promoter and exon mutations of the BMPR2 gene in Chinese patients with pulmonary arterial hypertension.
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| Wang H, Li W, Zhang W, Sun K, Song X, Gao S, Zhang C, Hui R, Hu H.
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| Eur J Hum Genet 17(8):1063-9. Epub 2009 Feb 18.PMID: 19223935 2009
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| 18 | BMPR2
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| Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension.
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| Johnson JA, Vnencak-Jones CL, Cogan JD, Loyd JE, West J.
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| BMC Med Genet 10:58.PMID: 19531247 2009
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| 19 | BMP1, BMP6, BMP7, BMPR2
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| Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines.
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| Bock O, Höftmann J, Theophile K, Hussein K, Wiese B, Schlué J, Kreipe H.
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| Am J Pathol 172(4):951-60. Epub 2008 Mar 18.
2008
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| 20 | BMPR2, CAV1
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| Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells.
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| Wertz JW, Bauer PM.
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| Biochem Biophys Res Commun 375(4):557-61. Epub 2008 Aug 24.PMID: 18725205 2008
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| 21 | BMPR2, TNC
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| Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension.
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| Ihida-Stansbury K, McKean DM, Lane KB, Loyd JE, Wheeler LA, Morrell NW, Jones PL.
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| Am J Physiol Lung Cell Mol Physiol 291(4):L694-702. Epub 2006 Jun 16. 2006
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| 22 | BMPR2, PPH1
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| BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension.
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| Sankelo M, Flanagan JA, Machado R, Harrison R, Rudarakanchana N, Morrell N, Dixon M, Halme M, Puolijoki H, Kere J, Elomaa O, Kupari M, Raisanen-Sokolowski A, Trembath RC, Laitinen T.
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| Hum Mutat 26(2):119-24. 2005
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| 23 | BMP2, BMPR2
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| The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.
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| Nohe A, Hassel S, Ehrlich M, Neubauer F, Sebald W, Henis YI, Knaus P.
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| J Biol Chem 277(7):5330-8. 2002
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| 24 | BMP2, BMP4, BMP7, BMPR1A, BMPR1B, BMPR2, GREM1
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| Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues.
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| Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF.
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| Mol Vis 8:241-50. 2002
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| 25 | BMPR2
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| BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension.
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| Machado RD, Pauciulo MW, Thomson JR, Lane KB, Morgan NV, Wheeler L, Phillips JA 3rd, Newman J, Williams D, Galie N, Manes A, McNeil K, Yacoub M, Mikhail G, Rogers P, Corris P, Humbert M, Donnai D, Martensson G, Tranebjaerg L, Loyd JE, Trembath RC, Nichols WC.
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| Am J Hum Genet 68(1):92-102. 2001
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| 26 | BMPR2, PPH1
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| Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred.
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| Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA 3rd, Loyd JE.
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| N Engl J Med 345(5):319-24. 2001
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| 27 | BMPR2
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| Genetic clues to the cause of primary pulmonary hypertension.
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| Loscalzo J.
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| N Engl J Med 345(5):367-71. No abstract available. 2001
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| 28 | ABI2, AOX1, BMPR2, CASP10, CASP8, CD28, CFLAR, CLK1, CTLA4, DAZAP2, MAGI2, ORC2, PPH1, PSMA2, SATB2, SUMO1, TRAK2
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| A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension.
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| Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC.
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| Genomics 68(2):220-8. 2000
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| 29 | BMPR2, PPH1
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| Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family.
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| Thomson JR, Machado RD, Pauciulo MW, Morgan NV, Humbert M, Elliott GC, Ward K, Yacoub M, Mikhail G, Rogers P, Newman J, Wheeler L, Higenbottam T, Gibbs JS, Egan J, Crozier A, Peacock A, Allcock R, Corris P, Loyd JE, Trembath RC, Nichols WC.
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| J Med Genet 37(10):741-5. 2000
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| 30 | BMPR2, PPH1
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| Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.
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| Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, Kalachikov S, Cayanis E, Fischer SG, Barst RJ, Hodge SE, Knowles JA.
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| Am J Hum Genet 67(3):737-44. 2000
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| 31 | BMPR2, BMPR1APS1
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| Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.
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| Astrom AK, et al.
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| Mamm Genome 10(3):299-302. 1999
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| 32 | BMP1, BMP15, BMP2, BMP3, GDF10, BMP4, BMP5, BMP6, BMP7, BMPR1A, BMPR1APS1, BMPR1B, BMPR2, GDF1, GDF2, GDF3, GDF5, MSTN, GDF9
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| Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.
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| Constam DB, Robertson EJ.
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| J Cell Biol 144(1):139-49. 1999
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| 33 | BMPR2
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| Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors.
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| Nohno T, Ishikawa T, Saito T, Hosokawa K, Noji S, Wolsing DH, Rosenbaum JS.
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| J Biol Chem 270(38):22522-6. 1995
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| 34 | BMPR2
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| Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
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| Liu F, Ventura F, Doody J, Massague J.
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| Mol Cell Biol 15(7):3479-86. 1995
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| 35 | BMPR2
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| Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor.
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| Kawabata M, Chytil A, Moses HL.
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| J Biol Chem 270(10):5625-30. 1995
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| 36 | BMPR2
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| Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
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| Rosenzweig BL, Imamura T, Okadome T, Cox GN, Yamashita H, ten Dijke P, Heldin CH, Miyazono K.
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| Proc Natl Acad Sci U S A 92(17):7632-6. 1995
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