Citations for
1BMP2, SSSCH
Monoallelic BMP2 Variants Predicted to Result in Haploinsufficiency Cause Craniofacial, Skeletal, and Cardiac Features Overlapping Those of 20p12 Deletions.
Tan TY, Gonzaga-Jauregui C, Bhoj EJ, Strauss KA, Brigatti K, Puffenberger E, Li D, Xie L, Das N, Skubas I, Deckelbaum RA, Hughes V, Brydges S, Hatsell S, Siao CJ, Dominguez MG, Economides A, Overton JD, Mayne V, Simm PJ, Jones BO, Eggers S, Le Guyader G, Pelluard F, Haack TB, Sturm M, Riess A, Waldmueller S, Hofbeck M, Steindl K, Joset P, Rauch A, Hakonarson H, Baker NL, Farlie PG.
Am J Hum Genet 101(6):985-994. doi: 10.1016/j.ajhg.2017.10.006. Epub 2017 Nov 30. 2017
2BMP2, GATA4, LMO3
GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells.
Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantzi H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS.
Gene 627:491-499. doi: 10.1016/j.gene.2017.06.051. Epub 2017 Jun 29. 2017
3BMP2, NEO1
Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex.
Huang Z, Sun D, Hu JX, Tang FL, Lee DH, Wang Y, Hu G, Zhu XJ, Zhou J, Mei L, Xiong WC.
J Neurosci 36(21):5833-49. doi: 10.1523/JNEUROSCI.4487-15.2016. 2016
4BMP2, HFE2, NEO1
Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.
Zhao N, Maxson JE, Zhang RH, Wahedi M, Enns CA, Zhang AS.
J Biol Chem 291(23):12322-35. doi: 10.1074/jbc.M116.721191. Epub 2016 Apr 12. 2016
5BMP2, GREM1
Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
Church RH, Krishnakumar A, Urbanek A, Geschwindner S, Meneely J, Bianchi A, Basta B, Monaghan S, Elliot C, Strömstedt M, Ferguson N, Martin F, Brazil DP.
Biochem J 466(1):55-68. doi: 10.1042/BJ20140771. 2015
6BMP2, CALU, MGP
CALU polymorphism A29809G affects calumenin availability involving vascular calcification.
Jover E, Marín F, Quintana M, Pérez-Andreu J, Hurtado JA, Rodríguez C, Martínez-González J, González-Conejero R, Valdés M, Hernández-Romero D.
J Mol Cell Cardiol 82:218-27. doi: 10.1016/j.yjmcc.2015.03.015. Epub 2015 Mar 28. 2015
7BMP2, ID3
The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes.
Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch KS, Dumit VI, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C.
EMBO J 34(22):2804-19. doi: 10.15252/embj.201591118. Epub 2015 Oct 5. 2015
8BMP2, BMP7
Bmp 2 and bmp 7 induce odonto- and osteogenesis of human tooth germ stem cells.
Taşlı PN, Aydın S, Yalvaç ME, Sahin F.
Appl Biochem Biotechnol 172(6):3016-25. doi: 10.1007/s12010-013-0706-0. Epub 2014 Jan 30. 2014
9BMP2, FBLN1, SP7
Fibulin-1 is required for bone formation and Bmp-2-mediated induction of Osterix.
Cooley MA, Harikrishnan K, Oppel JA, Miler SF, Barth JL, Haycraft CJ, Reddy SV, Scott Argraves W.
Bone 69:30-8. doi: 10.1016/j.bone.2014.07.038. Epub 2014 Sep 6. 2014
10BMP2, DEL20P12, PLCB1, TMX4, WPW2
Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome.
Mills KI, Anderson J, Levy PT, Cole FS, Silva JN, Kulkarni S, Shinawi M.
Am J Med Genet A 161(1):137-44. doi: 10.1002/ajmg.a.35701. Epub 2012 Dec 13. 2013
11BMP2, DKK1, SOST
High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells.
Kim HK, Oxendine I, Kamiya N.
Bone 54(1):141-50. doi: 10.1016/j.bone.2013.01.031. Epub 2013 Jan 27. 2013
12BMP2
Folding and dimerization kinetics of bone morphogenetic protein-2, a member of the transforming growth factor-β family.
Vallejo LF, Rinas U.
FEBS J 280(1):83-92. doi: 10.1111/febs.12051. Epub 2012 Nov 22. 2013
13BMP2
Chondrocyte BMP2 signaling plays an essential role in bone fracture healing.
Mi M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D.
Gene 512(2):211-8. doi: 10.1016/j.gene.2012.09.130. Epub 2012 Oct 27. 2013
14BMP2
Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts.
Zhang R, Oyajobi BO, Harris SE, Chen D, Tsao C, Deng HW, Zhao M.
Bone 52(1):145-56. doi: 10.1016/j.bone.2012.09.029. Epub 2012 Sep 29. 2013
15BMP2, NPY1R
Regulation of neuropeptide Y Y1 receptor expression by bone morphogenetic protein 2 in C2C12 myoblasts.
Kurebayashi N, Sato M, Fujisawa T, Fukushima K, Tamura M.
Biochem Biophys Res Commun 439(4):506-10. doi: 10.1016/j.bbrc.2013.09.014. Epub 2013 Sep 8. 2013
16BMP2, CDKN1A
Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenance.
Porlan E, Morante-Redolat JM, Marqués-Torrejón MÁ, Andreu-Agulló C, Carneiro C, Gómez-Ibarlucea E, Soto A, Vidal A, Ferrón SR, Farińas I.
Nat Neurosci 16(11):1567-75. doi: 10.1038/nn.3545. Epub 2013 Oct 6. 2013
17BMP2, DEL20P12
Cleft palate in a multigenerational family with a microdeletion of 20p12.3 involving BMP2.
Williams ES, Uhas KA, Bunke BP, Garber KB, Martin CL.
Am J Med Genet A 158A(10):2616-20. doi: 10.1002/ajmg.a.35594. Epub 2012 Sep 10. 2012
18BBS9, BMP2
A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9.
Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA.
Nat Genet 44(12):1360-4. doi: 10.1038/ng.2463. Epub 2012 Nov 18. 2012
19ATF6, BGLAP, BMP2, RUNX2
BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription.
Jang WG, Kim EJ, Kim DK, Ryoo HM, Lee KB, Kim SH, Choi HS, Koh JT.
J Biol Chem 287(2):905-15. doi: 10.1074/jbc.M111.253187. Epub 2011 Nov 18. 2012
20BMP2, GATA6
GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation.
Rong L, Liu J, Qi Y, Graham AM, Parmacek MS, Li S.
Mol Biol Cell 23(18):3754-63. doi: 10.1091/mbc.E12-04-0313. Epub 2012 Aug 1. 2012
21BMP2, GREM1, GREM2
BMP2 differentially regulates the expression of Gremlin1 and Gremlin2, the negative regulators of BMP function, during osteoblast differentiation.
Suzuki D, Yamada A, Aizawa R, Funato S, Matsumoto T, Suzuki W, Takami M, Miyamoto Y, Suzawa T, Yamamoto M, Baba K, Kamijo R.
Calcif Tissue Int 91(1):88-96. doi: 10.1007/s00223-012-9614-5. Epub 2012 May 29. 2012
22BMP2
Mutation of a cleavage site adjacent to the mature domain leads to increase in secreted mature BMP-2 with reduced activity.
Zhou AJ, Zhu Z, Clokie CM, Peel SA.
Growth Factors 30(4):267-75. doi: 10.3109/08977194.2012.686497. Epub 2012 May 14. 2012
23BMP2, BMP4
Expression of BMP-2 and BMP-4 proteins by type-1 and type-2 astrocytes induced from neural stem cells under different differentiation conditions.
Hu JG, Zhang YX, Qi Q, Wang R, Shen L, Zhang C, Xi J, Zhou JS, Lu HZ.
Acta Neurobiol Exp (Wars) 72(1):95-101. 2012
24BMP2, NOG
BMP2 induces osteoblast apoptosis in a maturation state and noggin-dependent manner.
Hyzy SL, Olivares-Navarrete R, Schwartz Z, Boyan BD.
J Cell Biochem 113(10):3236-45. doi: 10.1002/jcb.24201. 2012
25BMP2, S1PR1
Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.
Sato C, Iwasaki T, Kitano S, Tsunemi S, Sano H.
Biochem Biophys Res Commun 423(1):200-5. doi: 10.1016/j.bbrc.2012.05.130. Epub 2012 May 31. 2012
26BMP2, DDIT3, EIF2AK3, PARM1
PARM-1 promotes cardiomyogenic differentiation through regulating the BMP/Smad signaling pathway.
Nakanishi N, Takahashi T, Ogata T, Adachi A, Imoto-Tsubakimoto H, Ueyama T, Matsubara H.
Biochem Biophys Res Commun 428(4):500-5. doi: 10.1016/j.bbrc.2012.10.078. Epub 2012 Nov 1. 2012
27BMP2, DUP20P
A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family.
Su P, Ding H, Huang D, Zhou Y, Huang W, Zhong L, Vyse TJ, Wang Y.
J Med Genet 48(5):312-6. Epub 2011 Feb 26. 2011
28BMP2
An autonomous BMP2 regulatory element in mesenchymal cells.
Kruithof BP, Fritz DT, Liu Y, Garsetti DE, Frank DB, Pregizer SK, Gaussin V, Mortlock DP, Rogers MB.
J Cell Biochem 112(2):666-74. doi: 10.1002/jcb.22975. 2011
29BMP2, BMP4, NEO1
Neogenin, a receptor for bone morphogenetic proteins.
Hagihara M, Endo M, Hata K, Higuchi C, Takaoka K, Yoshikawa H, Yamashita T.
J Biol Chem 286(7):5157-65. Epub 2010 Dec 13. 2011
30BMP2, COMP
Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
Du Y, Wang Y, Wang L, Liu B, Tian Q, Liu CJ, Zhang T, Xu Q, Zhu Y, Ake O, Qi Y, Tang C, Kong W, Wang X.
Circ Res 108(8):917-28. Epub 2011 Feb 24. 2011
31BMP2, DLX5, PRKACA
Protein kinase A phosphorylates and regulates the osteogenic activity of Dlx5.
Han Y, Jin YH, Yum J, Jeong HM, Choi JK, Yeo CY, Lee KY.
Biochem Biophys Res Commun 407(3):461-5. Epub 2011 Mar 22. 2011
32BMP2, DEL20P12
Microdeletion 20p12.3 involving BMP2 contributes to syndromic forms of cleft palate.
Sahoo T, Theisen A, Sanchez-Lara PA, Marble M, Schweitzer DN, Torchia BS, Lamb AN, Bejjani BA, Shaffer LG, Lacassie Y.
Am J Med Genet A 155A(7):1646-53. doi: 10.1002/ajmg.a.34063. Epub 2011 Jun 10. 2011
33BMP2, RUNX2
Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification.
Liberman M, Johnson RC, Handy DE, Loscalzo J, Leopold JA.
Biochem Biophys Res Commun 413(3):436-41. Epub 2011 Aug 30. 2011
34BMP2
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.
Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D.
J Cell Sci 124(Pt 20):3428-40. doi: 10.1242/jcs.083659. Epub 2011 Oct 7. 2011
35BMP2
Repressive BMP2 gene regulatory elements near the BMP2 promoter.
Jiang S, Chandler RL, Fritz DT, Mortlock DP, Rogers MB.
Biochem Biophys Res Commun 392(2):124-8. Epub 2010 Jan 12. 2010
36BMP2
BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.
Kang MH, Kim JS, Seo JE, Oh SC, Yoo YA.
Exp Cell Res 316(1):24-37. Epub 2009 Oct 14. 2010
37BMP2, NELL1
The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration.
Aghaloo T, Cowan CM, Zhang X, Freymiller E, Soo C, Wu B, Ting K, Zhang Z.
J Oral Maxillofac Surg 68(2):300-8.PMID: 20116699 2010
38BMP2, BMP4, DPYSL2
The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development.
Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H, Xu Z.
J Biol Chem 285(50):39039-50. Epub 2010 Oct 6. 2010
39BMP2, BMP6
BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells.
Valera E, Isaacs MJ, Kawakami Y, Izpisúa Belmonte JC, Choe S.
PLoS One 5(6):e11167. 2010
40BMP2, BMP4, GDF11, MSTN, TGFB1, WFIKKN1, WFIKKN2
WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity.
Szláma G, Kondás K, Trexler M, Patthy L.
FEBS J 277(24):5040-50. doi: 10.1111/j.1742-4658.2010.07909.x. Epub 2010 Nov 5. 2010
41BMP2, PDZRN3
PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling.
Honda T, Yamamoto H, Ishii A, Inui M.
Mol Biol Cell 21(18):3269-77. doi: 10.1091/mbc.E10-02-0117. Epub 2010 Jul 28. 2010
42BMP2, DEL20P12, JAG1, WPW2
20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits.
Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L.
J Med Genet 46(3):168-75. Epub 2008 Sep 23. 2009
43BMP2, LXN
Latexin is involved in bone morphogenetic protein-2-induced chondrocyte differentiation.
Kadouchi I, Sakamoto K, Tangjiao L, Murakami T, Kobayashi E, Hoshino Y, Yamaguchi A.
Biochem Biophys Res Commun 378(3):600-4. Epub 2008 Dec 4. 2009
44BMP2, BMP4
Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis.
Nakanishi S, Sskamoto K, Yoshitake H, Kino K, Amagasa T, Yamaguchi A.
Biochem Biophys Res Commun 379(4):914-9. Epub 2009 Jan 10. 2009
45BMP2, GLI2
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.
Zhao M, Ko SY, Liu JH, Chen D, Zhang J, Wang B, Harris SE, Oyajobi BO, Mundy GR.
Mol Cell Biol 29(5):1291-305. Epub 2008 Dec 22. 2009
46BMP2, DUP20P
Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2.
Dathe K, Kjaer KW, Brehm A, Meinecke P, Nürnberg P, Neto JC, Brunoni D, Tommerup N, Ott CE, Klopocki E, Seemann P, Mundlos S.
Am J Hum Genet 84(4):483-92. Epub 2009 Mar 26. 2009
47BMP2, SOX9
Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene.
Pan Q, Wu Y, Lin T, Yao H, Yang Z, Gao G, Song E, Shen H.
Biochem Biophys Res Commun 379(2):356-61. Epub 2008 Dec 25. 2009
48SP7, DLX5, BMP2
BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38.
Ulsamer A, Ortu–o MJ, Ruiz S, Susperregui AR, Osses N, Rosa JL, Ventura F.
J Biol Chem 283(7):3816-26. Epub 2007 Dec 3. 2008
49BMP2, PLAP1
PLAP-1/asporin inhibits activation of BMP receptor via its leucine-rich repeat motif.
Tomoeda M, Yamada S, Shirai H, Ozawa Y, Yanagita M, Murakami S.
Biochem Biophys Res Commun 371(2):191-6. Epub 2008 Apr 11. 2008
50DSPP, BMP2
Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling.
Chen S, Gluhak-Heinrich J, Martinez M, Li T, Wu Y, Chuang HH, Chen L, Dong J, Gay I, MacDougall M.
J Biol Chem 283(28):19359-70. Epub 2008 Apr 18. 2008
51BMP2, BMP4, BMP6, SOST, WNT10B
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.
Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ.
Proc Natl Acad Sci U S A 105(52):20764-9. Epub 2008 Dec 15. 2008
52BMP2, DEL20P12, JAG1, WPW2
A 8.26Mb deletion in 6q16 and a 4.95Mb deletion in 20p12 including JAG1 and BMP2 in a patient with Alagille syndrome and Wolff-Parkinson-White syndrome.
Le Gloan L, Pichon O, Isidor B, Boceno M, Rival JM, David A, Le Caignec C.
Eur J Med Genet 51(6):651-7. Epub 2008 Aug 15.PMID: 18775522 2008
53SP1, BMP2
Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors.
Xu J, Rogers MB.
Gene 392(1-2):221-9. Epub 2007 Jan 20. 2007
54HFE2, BMP2, BMP4
Common Variants in the BMP2, BMP4, and HJV Genes of the Hepcidin Regulation Pathway Modulate HFE Hemochromatosis Penetrance.
Milet J, Dehais V, Bourgain C, Jouanolle AM, Mosser A, Perrin M, Morcet J, Brissot P, David V, Deugnier Y, Mosser J.
Am J Hum Genet 81(4):799-807. Epub 2007 Aug 31. 2007
55BMP1, BMP2, BMP4
Bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4.
Jasuja R, Ge G, Voss NG, Lyman-Gingerich J, Branam AM, Pelegri FJ, Greenspan DS.
J Biol Chem 282(12):9053-62. Epub 2007 Jan 25. 2007
56BMP2, BMP6, CDKN1C
BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.
Gosselet FP, Magnaldo T, Culerrier RM, Sarasin A, Ehrhart JC.
Cell Signal 19(4):731-9. Epub 2006 Oct 4. 2007
57BMP2
BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines.
Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A.
J Cell Physiol 211(3):728-35. 2007
58BMP2, MEF2A
Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility.
Wang YX, Qian LX, Liu D, Yao LL, Jiang Q, Yu Z, Gui YH, Zhong TP, Song HY.
Cardiovasc Res 74(2):290-303. Epub 2007 Feb 12. 2007
59BMP2
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.
Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, Rosen V.
Nat Genet 38(12):1424-9. Epub 2006 Nov 12. 2006
60BMP2
Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.
Langenfeld EM, Kong Y, Langenfeld J.
Oncogene 25(5):685-92. 2006
61PKIG, BMP2
Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation.
Zhao L, Yang S, Zhou GQ, Yang J, Ji D, Sabatakos G, Zhu T.
Int J Biochem Cell Biol 38(12):2064-73. Epub 2006 Jun 7. 2006
62GLI2, BMP2
The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.
Zhao M, Qiao M, Harris SE, Chen D, Oyajobi BO, Mundy GR.
Mol Cell Biol 26(16):6197-208. 2006
63BMP2, KCNA10, KCNA2, KCNA5, KCNA7, KCNAB1, KCNC3, KCNC4, KCNF1, KCNG2, KCNG3, KCNS1, KCNS3, KCNV2
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX.
Am J Physiol Lung Cell Mol Physiol 291(5):L993-1004. Epub 2006 Jun 30. 2006
64BMP2, BMPR1B
Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells.
Hay E, Lemonnier J, Fromigue O, Guenou H, Marie PJ.
J Biol Chem 279(3):1650-8. Epub 2003 Oct 23. 2004
65BMP2
Regulation of Notch signaling genes during BMP2-induced differentiation of osteoblast precursor cells.
de Jong DS, Steegenga WT, Hendriks JM, van Zoelen EJ, Olijve W, Dechering KJ.
Biochem Biophys Res Commun 320(1):100-7. 2004
66BMP2, PTEN
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
Waite KA, Eng C.
Hum Mol Genet 12(6):679-84. 2003
67BMP2
Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells.
Marrony S, Bassilana F, Seuwen K, Keller H.
Bone 33(3):426-33. 2003
68BMP2, BMPR2
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.
Nohe A, Hassel S, Ehrlich M, Neubauer F, Sebald W, Henis YI, Knaus P.
J Biol Chem 277(7):5330-8. 2002
69BMP2, BMP4, BMP5, BMP7, NOG
Bone morphogenetic proteins with some comments on fibrodysplasia ossificans progressiva and NOGGIN.
Cohen MM Jr.
Am J Med Genet 109(2):87-92. No abstract available. 2002
70BMP2, BMP4, BMP7, BMPR1A, BMPR1B, BMPR2, GREM1
Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues.
Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF.
Mol Vis 8:241-50. 2002
71BMP2, AKT1
Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.
Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, Choudhury GG.
J Biol Chem 277(36):33361-8. Epub 2002 Jun 25. Erratum in: J Biol Chem. 2003 May 2;278(18):16452. 2002
72BMP2, GDF2
BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1.
Majumdar MK, Wang E, Morris EA.
J Cell Physiol 189(3):275-84. 2001
73BMP2, DLX2
Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2.
Xu SC, Harris MA, Rubenstein JL, Mundy GR, Harris SE.
DNA Cell Biol 20(6):359-65. 2001
74BMP2
Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation.
Ghosh-Choudhury N, Woodruff K, Qi W, Celeste A, Abboud SL, Ghosh Choudhury G.
Biochem Biophys Res Commun 272(3):705-11. 2000
75BMP2
The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2.
Ju W, Hoffmann A, Verschueren K, Tylzanowski P, Kaps C, Gross G, Huylebroeck D.
J Bone Miner Res 15(10):1889-99. 2000
76BMP2
Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3.
Kawamura C, Kizaki M, Yamato K, Uchida H, Fukuchi Y, Hattori Y, Koseki T, Nishihara T, Ikeda Y.
Blood 96(6):2005-11. 2000
77BMP2
Cloning and functional characterization of the 5'-flanking region of the human bone morphogenetic protein-2 gene.
Sugiura T.
Biochem J 338 ( Pt 2):433-40. 1999
78BMP2, IHH, SOX9
The transcription factor Sox9 is involved in BMP-2 signaling.
Zehentner BK, Dony C, Burtscher H.
J Bone Miner Res 14(10):1734-41 1999
79BMP1, BMP15, BMP2, BMP3, GDF10, BMP4, BMP5, BMP6, BMP7, BMPR1A, BMPR1APS1, BMPR1B, BMPR2, GDF1, GDF2, GDF3, GDF5, MSTN, GDF9
Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.
Constam DB, Robertson EJ.
J Cell Biol 144(1):139-49. 1999
80BMP2, EP300, LIF, SMAD1, STAT3
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T.
Science 284(5413):479-82. 1999
81PAX3, BMP2, BMP4
The importance of timing differentiation during limb muscle development.
Amthor H, et al.
Curr Biol 8(11):642-52. 1998
82ALGS, BMP2, JAG1, PLCB4, SNAP25
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83BMP2, FGF4, SHH
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84GHRH, PYGB, BMP2
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85BMP2
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86BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7
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87BMP1, BMP2, BMP3
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