| 1 | BMI1, RNF144A, ZDHHC18, ZDHHC23
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| DHHC protein family targets different subsets of glioma stem cells in specific niches
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| Chen X, Hu L, Yang H, Ma H, Ye K, Zhao C, Zhao Z, Dai H, Wang H, Fang Z.
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| J Exp Clin Cancer Res. Jan 18;38(1):25. doi: 10.1186/s13046-019-1033-2. 2019
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| 2 | BMI1, PCGF2
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| Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium.
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| Goldstein BJ, Choi R, Goss GM.
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| Laryngoscope Investig Otolaryngol 3(5):337-344. doi: 10.1002/lio2.180. eCollection 2018 Oct.
2018
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| 3 | BMI1, CXXC4
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| BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX. 2018
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| Yu F, Zhou C, Zeng H, Liu Y, Li S.
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| Biochem Biophys Res Commun. 5;496(2):468-474. doi: 10.1016/j.bbrc.2018.01.063. Epub 2018 Jan 12. 2018
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| 4 | BMI1, EPHA7
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| The putative tumor suppressor gene EphA7 is a novel BMI-1 target.
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| Prost G, Braun S, Hertwig F, Winkler M, Jagemann L, Nolbrant S, Leefa IV, Offen N, Miharada K, Lang S, Artner I, Nuber UA.
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| Oncotarget 7(36):58203-58217. doi: 10.18632/oncotarget.11279.
2016
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| 5 | BMI1, FSCN1
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| Significance of BMI1 and FSCN1 expression in colorectal cancer
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| Alajez NM.
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| Saudi J Gastroenterol Jul-Aug;22(4):288-93. doi: 10.4103/1319-3767.187602. 2016
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| 6 | BMI1, KAT6A
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| MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.
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| Sheikh BN, Downer NL, Phipson B, Vanyai HK, Kueh AJ, McCarthy DJ, Smyth GK, Thomas T, Voss AK.
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| Proc Natl Acad Sci U S A 112(17):5437-42. doi: 10.1073/pnas.1422872112. Epub 2015 Apr 14.
2015
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| 7 | BMI1
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| Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.
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| López-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A, Espinosa L.
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| Development 142(1):41-50. doi: 10.1242/dev.107714. Epub 2014 Dec 5.
2015
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| 8 | BMI1, SIN3B
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| Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation.
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| DiMauro T, Cantor DJ, Bainor AJ, David G.
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| Oncogene 34(30):4011-7. doi: 10.1038/onc.2014.322. Epub 2014 Sep 29.
2015
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| 9 | BMI1
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| Bmi-1 regulates the migration and invasion of glioma cells through p16.
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| Liang J, Wang P, Xie S, Wang W, Zhou X, Hu J, Shi Q, Zhang X, Yu R.
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| Cell Biol Int 39(3):283-90. doi: 10.1002/cbin.10390. Epub 2014 Oct 8.
2015
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| 10 | BMI1, CCNE1, CDKN1A
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| p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells.
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| Deng W, Zhou Y, Tiwari AF, Su H, Yang J, Zhu D, Lau VM, Hau PM, Yip YL, Cheung AL, Guan XY, Tsao SW.
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| Int J Cancer 136(6):1361-70. doi: 10.1002/ijc.29114. Epub 2014 Aug 7.
2015
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| 11 | BMI1, NANOG
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| Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis.
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| Xie X, Piao L, Cavey GS, Old M, Teknos TN, Mapp AK, Pan Q.
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| Oncogene 33(16):2040-52. doi: 10.1038/onc.2013.173. Epub 2013 May 27.
2014
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| 12 | BMI1
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| Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy.
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| Di Foggia V, Zhang X, Licastro D, Gerli MF, Phadke R, Muntoni F, Mourikis P, Tajbakhsh S, Ellis M, Greaves LC, Taylor RW, Cossu G, Robson LG, Marino S.
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| J Exp Med 211(13):2617-33. doi: 10.1084/jem.20140317. Epub 2014 Dec 1.
2014
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| 13 | BMI1, UBAP2L
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| UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
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| Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G.
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| Blood 124(15):2362-9. doi: 10.1182/blood-2014-01-548651. Epub 2014 Sep 2.
2014
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| 14 | BMI1
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| Bmi-1 regulates epithelial-to-mesenchymal transition to promote migration and invasion of breast cancer cells.
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| Li H, Song F, Chen X, Li Y, Fan J, Wu X.
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| Int J Clin Exp Pathol 7(6):3057-64. eCollection 2014.
2014
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| 15 | BMI1
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| The role of BMI1 as a biomarker of cancer stem cells in head and neck cancer: a review.
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| Allegra E, Trapasso S, Pisani D, Puzzo L.
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| Oncology 86(4):199-205. doi: 10.1159/000358598. Epub 2014 Apr 30. Review.
2014
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| 16 | BMI1, ZMYM3
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| BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression.
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| Shen H, Chen Z, Ding X, Qi X, Cen J, Wang Y, Yao L, Chen Y.
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| J Cell Mol Med 18(6):1004-17. doi: 10.1111/jcmm.12246. Epub 2014 Feb 27.
2014
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| 17 | BMI1
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| BMI1, the polycomb-group gene, is recurrently targeted by genomic rearrangements in progressive B-cell leukemia/lymphoma.
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| Rouhigharabaei L, Ferreiro JF, Put N, Michaux L, Tousseyn T, Lefebvre C, Gardiner A, De Kelver W, Demuynck H, Verschuere J, Théate I, Vicente C, Vandenberghe P, Cools J, Wlodarska I.
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| Genes Chromosomes Cancer 52(10):928-44. doi: 10.1002/gcc.22088. Epub 2013 Jul 19.
2013
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| 18 | BMI1
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| BMI-1 activation is crucial in hTERT-induced epithelial-mesenchymal transition of oral epithelial cells.
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| Qiao B, Chen Z, Hu F, Tao Q, Lam AK.
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| Exp Mol Pathol 95(1):57-61. doi: 10.1016/j.yexmp.2013.05.004. Epub 2013 May 24.
2013
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| 19 | BMI1
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| Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.
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| Zencak D, Schouwey K, Chen D, Ekström P, Tanger E, Bremner R, van Lohuizen M, Arsenijevic Y.
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| Proc Natl Acad Sci U S A 110(7):E593-601. doi: 10.1073/pnas.1108297110. Epub 2013 Jan 28.
2013
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| 20 | BMI1
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| A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway.
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| Cho JH, Dimri M, Dimri GP.
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| J Biol Chem 288(5):3406-18. doi: 10.1074/jbc.M112.422931. Epub 2012 Dec 13.
2013
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| 21 | BMI1
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| Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation.
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| Calao M, Sekyere EO, Cui HJ, Cheung BB, Thomas WD, Keating J, Chen JB, Raif A, Jankowski K, Davies NP, Bekkum MV, Chen B, Tan O, Ellis T, Norris MD, Haber M, Kim ES, Shohet JM, Trahair TN, Liu T, Wainwright BJ, Ding HF, Marshall GM.
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| Oncogene 32(31):3616-26. doi: 10.1038/onc.2012.368. Epub 2012 Aug 20.
2013
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| 22 | BMI1, CHMP1A, PCH8
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| CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.
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| Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA.
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| Nat Genet 44(11):1260-4. doi: 10.1038/ng.2425. Epub 2012 Sep 30.
2012
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| 23 | BMI1, CCNE1, FBXW7
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| Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.
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| Mao L, Ding J, Perdue A, Yang L, Zha Y, Ren M, Huang S, Cui H, Ding HF.
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| Oncogene 31(33):3785-95. doi: 10.1038/onc.2011.536. Epub 2011 Nov 28.
2012
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| 24 | BMI1, GATA6
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| Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
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| Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I, Hiiragi T, Chazaud C, Azuara V.
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| Genes Dev 26(13):1445-58. doi: 10.1101/gad.188193.112. Epub 2012 Jun 19.
2012
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| 25 | BMI1
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| Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
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| Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.
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| PLoS One 7(5):e36209. doi: 10.1371/journal.pone.0036209. Epub 2012 May 11.
2012
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| 26 | BMI1, IKZF1
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| Bmi1 is critical to prevent Ikaros-mediated lymphoid priming in hematopoietic stem cells.
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| Arranz L, Herrera-Merchan A, Ligos JM, de Molina A, Dominguez O, Gonzalez S.
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| Cell Cycle 11(1):65-78. doi: 10.4161/cc.11.1.18097. Epub 2012 Jan 1.
2012
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| 27 | BMI1, PCGF2
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| Regulation of hematopoietic stem cells using protein transduction domain-fused Polycomb.
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| Kajiume T, Sera Y, Kawahara Y, Matsumoto M, Fukazawa T, Imura T, Yuge L, Kobayashi M.
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| Exp Hematol 40(9):751-760.e1. doi: 10.1016/j.exphem.2012.05.005. Epub 2012 May 24.
2012
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| 28 | BMI1, BTRC
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| βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.
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| Sahasrabuddhe AA, Dimri M, Bommi PV, Dimri GP.
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| Cell Cycle 10(8):1322-30. Epub 2011 Apr 15.
2011
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| 29 | BMI1, RNF2, UBE2D3
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| Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
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| Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG.
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| EMBO J 30(16):3285-97. doi: 10.1038/emboj.2011.243.
2011
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| 30 | BMI1
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| BMI1 as a novel target for drug discovery in cancer.
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| Cao L, Bombard J, Cintron K, Sheedy J, Weetall ML, Davis TW.
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| J Cell Biochem 112(10):2729-41. doi: 10.1002/jcb.23234. Review.
2011
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| 31 | BMI1, SOX2
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| Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.
|
| Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A.
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| Mol Cell Biol 31(22):4593-608. doi: 10.1128/MCB.05798-11. Epub 2011 Sep 19.
2011
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| 32 | BMI1, CADM1, KIF1B, MYCN
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| Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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| Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T.
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| Oncogene 29(18):2681-90. Epub 2010 Mar 1.PMID: 20190806 2010
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| 33 | BMI1
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| Bmi-1 gene is upregulated in early-stage hepatocellular carcinoma and correlates with ATP-binding cassette transporter B1 expression.
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| Effendi K, Mori T, Komuta M, Masugi Y, Du W, Sakamoto M.
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| Cancer Sci 101(3):666-72. Epub 2009 Nov 11.
2010
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| 34 | BMI1, PCGF2
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| BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.
|
| Zhang XW, Sheng YP, Li Q, Qin W, Lu YW, Cheng YF, Liu BY, Zhang FC, Li J, Dimri GP, Guo WJ.
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| Mol Cancer 9:40.
2010
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| 35 | BMI1
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| Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.
|
| Häyry V, Mäkinen LK, Atula T, Sariola H, Mäkitie A, Leivo I, Keski-Säntti H, Lundin J, Haglund C, Hagström J.
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| Br J Cancer 102(5):892-7. Epub 2010 Feb 9.
2010
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| 36 | BMI1
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| Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway.
|
| Li J, Gong LY, Song LB, Jiang LL, Liu LP, Wu J, Yuan J, Cai JC, He M, Wang L, Zeng M, Cheng SY, Li M.
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| Am J Pathol 176(2):699-709. Epub 2009 Dec 24.
2010
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| 37 | BMI1, CDKN2A, RNF2
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| Identification and characterization of Bmi-1-responding element within the human p16 promoter.
|
| Meng S, Luo M, Sun H, Yu X, Shen M, Zhang Q, Zhou R, Ju X, Tao W, Liu D, Deng H, Lu Z.
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| J Biol Chem 285(43):33219-29. Epub 2010 Jun 15. 2010
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| 38 | BMI1, TWIST1
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| Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition.
|
| Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ.
|
| Nat Cell Biol 12(10):982-92. Epub 2010 Sep 5.
2010
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| 39 | BMI1, FOXG1
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| Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.
|
| Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos JT, Lemischka IR, Studer L, Temple S.
|
| Genes Dev 23(5):561-74. 2009
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| 40 | BMI1
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| Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.
|
| Zhang J, Sarge KD.
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| FEBS Lett 583(6):960-4. Epub 2009 Feb 20.
2009
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| 41 | BMI1
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| Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis.
|
| Sangiorgi E, Capecchi MR.
|
| Proc Natl Acad Sci U S A 106(17):7101-6. Epub 2009 Apr 16.
2009
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| 42 | BMI1
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| Bmi1 regulates mitochondrial function and the DNA damage response pathway.
|
| Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T.
|
| Nature 459(7245):387-92. Epub 2009 Apr 29.
2009
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| 43 | BMI1
|
| Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
|
| Dovey JS, Zacharek SJ, Kim CF, Lees JA.
|
| Proc Natl Acad Sci U S A 105(33):11857-62. Epub 2008 Aug 12.
2008
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| 44 | BMI1, DMAP1
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| Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing.
|
| Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M, Tajima S, Koseki H, Tsuda H, Takasaki Y, Nakauchi H, Iwama A.
|
| Biochem Biophys Res Commun 353(4):992-8. Epub 2006 Dec 29. 2007
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| 45 | BMI1,SALL4
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| Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.
|
| Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y.
|
| Proc Natl Acad Sci U S A 104(25):10494-9. Epub 2007 Jun 8. 2007
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| 46 | BMI1
|
| Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.
|
| Heffner M, Fearon DT.
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| Proc Natl Acad Sci U S A 104(33):13414-9. Epub 2007 Aug 8.
2007
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| 47 | BMI1, MEL18
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| Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells.
|
| Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP.
|
| Cancer Res 67(11):5083-9.
2007
|
| 48 | BMI1, MYC, PCGF2
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| Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins.
|
| Guo WJ, Datta S, Band V, Dimri GP.
|
| Mol Biol Cell 18(2):536-46. Epub 2006 Dec 6.
2007
|
| 49 | BMI1
|
| Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis.
|
| Sasaki M, Ikeda H, Sato Y, Nakanuma Y.
|
| Am J Pathol 169(3):831-45. 2006
|
| 50 | E4F1, BMI1
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| E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
|
| Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G.
|
| Genes Dev 20(15):2110-20. 2006
|
| 51 | BMI1, RING1
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| Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
|
| Cao R, Tsukada Y, Zhang Y.
|
| Mol Cell 20(6):845-54.
2005
|
| 52 | BMI1
|
| Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.
|
| Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, Van Lohuizen M, Marino S.
|
| Nature 428(6980):337-41. 2004
|
| 53 | BMI1
|
| The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.
|
| Kim JH, Yoon SY, Kim CN, Joo JH, Moon SK, Choe IS, Choe YK, Kim JW.
|
| Cancer Lett 203(2):217-24. 2004
|
| 54 | BMI1
|
| Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
|
| Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF.
|
| Nature 423(6937):302-5. 2003
|
| 55 | BMI1
|
| BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.
|
| Bea S, Tort F, Pinyol M, Puig X, Hernandez L, Hernandez S, Fernandez PL, van Lohuizen M, Colomer D, Campo E.
|
| Cancer Res 61(6):2409-12. 2001
|
| 56 | BMI1
|
| The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression.
|
| Vonlanthen S, Heighway J, Altermatt HJ, Gugger M, Kappeler A, Borner MM, van Lohuizen M, Betticher DC.
|
| Br J Cancer 84(10):1372-6. 2001
|
| 57 | BMI1, CBX8
|
| HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.
|
| Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS.
|
| J Biol Chem 275(37):28785-92. 2000
|
| 58 | BMI1, PHC1, PHC2
|
| Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
|
| Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP.
|
| Mol Cell Biol 17(4):2326-35. 1997
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| 59 | BMI1
|
| Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.
|
| Alkema MJ, van der Lugt NM, Bobeldijk RC, Berns A, van Lohuizen M.
|
| Nature 374(6524):724-7. 1995
|
| 60 | BMI1
|
| Characterization and chromosomal localization of the human proto-oncogene BMI-1.
|
| Alkema MJ, et al.
|
| Hum Mol Genet 2 : 1597-1603. 1993
|