Citations for
1BMI1, RNF144A, ZDHHC18, ZDHHC23
DHHC protein family targets different subsets of glioma stem cells in specific niches
Chen X, Hu L, Yang H, Ma H, Ye K, Zhao C, Zhao Z, Dai H, Wang H, Fang Z.
J Exp Clin Cancer Res. Jan 18;38(1):25. doi: 10.1186/s13046-019-1033-2. 2019
2BMI1, PCGF2
Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium.
Goldstein BJ, Choi R, Goss GM.
Laryngoscope Investig Otolaryngol 3(5):337-344. doi: 10.1002/lio2.180. eCollection 2018 Oct. 2018
3BMI1, EPHA7
The putative tumor suppressor gene EphA7 is a novel BMI-1 target.
Prost G, Braun S, Hertwig F, Winkler M, Jagemann L, Nolbrant S, Leefa IV, Offen N, Miharada K, Lang S, Artner I, Nuber UA.
Oncotarget 7(36):58203-58217. doi: 10.18632/oncotarget.11279. 2016
4BMI1, FSCN1
Significance of BMI1 and FSCN1 expression in colorectal cancer
Alajez NM.
Saudi J Gastroenterol Jul-Aug;22(4):288-93. doi: 10.4103/1319-3767.187602. 2016
5BMI1, KAT6A
MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.
Sheikh BN, Downer NL, Phipson B, Vanyai HK, Kueh AJ, McCarthy DJ, Smyth GK, Thomas T, Voss AK.
Proc Natl Acad Sci U S A 112(17):5437-42. doi: 10.1073/pnas.1422872112. Epub 2015 Apr 14. 2015
6BMI1
Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.
López-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A, Espinosa L.
Development 142(1):41-50. doi: 10.1242/dev.107714. Epub 2014 Dec 5. 2015
7BMI1, SIN3B
Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation.
DiMauro T, Cantor DJ, Bainor AJ, David G.
Oncogene 34(30):4011-7. doi: 10.1038/onc.2014.322. Epub 2014 Sep 29. 2015
8BMI1
Bmi-1 regulates the migration and invasion of glioma cells through p16.
Liang J, Wang P, Xie S, Wang W, Zhou X, Hu J, Shi Q, Zhang X, Yu R.
Cell Biol Int 39(3):283-90. doi: 10.1002/cbin.10390. Epub 2014 Oct 8. 2015
9BMI1, CCNE1, CDKN1A
p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells.
Deng W, Zhou Y, Tiwari AF, Su H, Yang J, Zhu D, Lau VM, Hau PM, Yip YL, Cheung AL, Guan XY, Tsao SW.
Int J Cancer 136(6):1361-70. doi: 10.1002/ijc.29114. Epub 2014 Aug 7. 2015
10BMI1, NANOG
Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis.
Xie X, Piao L, Cavey GS, Old M, Teknos TN, Mapp AK, Pan Q.
Oncogene 33(16):2040-52. doi: 10.1038/onc.2013.173. Epub 2013 May 27. 2014
11BMI1
Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy.
Di Foggia V, Zhang X, Licastro D, Gerli MF, Phadke R, Muntoni F, Mourikis P, Tajbakhsh S, Ellis M, Greaves LC, Taylor RW, Cossu G, Robson LG, Marino S.
J Exp Med 211(13):2617-33. doi: 10.1084/jem.20140317. Epub 2014 Dec 1. 2014
12BMI1, UBAP2L
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G.
Blood 124(15):2362-9. doi: 10.1182/blood-2014-01-548651. Epub 2014 Sep 2. 2014
13BMI1
Bmi-1 regulates epithelial-to-mesenchymal transition to promote migration and invasion of breast cancer cells.
Li H, Song F, Chen X, Li Y, Fan J, Wu X.
Int J Clin Exp Pathol 7(6):3057-64. eCollection 2014. 2014
14BMI1
The role of BMI1 as a biomarker of cancer stem cells in head and neck cancer: a review.
Allegra E, Trapasso S, Pisani D, Puzzo L.
Oncology 86(4):199-205. doi: 10.1159/000358598. Epub 2014 Apr 30. Review. 2014
15BMI1, ZMYM3
BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression.
Shen H, Chen Z, Ding X, Qi X, Cen J, Wang Y, Yao L, Chen Y.
J Cell Mol Med 18(6):1004-17. doi: 10.1111/jcmm.12246. Epub 2014 Feb 27. 2014
16BMI1
BMI1, the polycomb-group gene, is recurrently targeted by genomic rearrangements in progressive B-cell leukemia/lymphoma.
Rouhigharabaei L, Ferreiro JF, Put N, Michaux L, Tousseyn T, Lefebvre C, Gardiner A, De Kelver W, Demuynck H, Verschuere J, Théate I, Vicente C, Vandenberghe P, Cools J, Wlodarska I.
Genes Chromosomes Cancer 52(10):928-44. doi: 10.1002/gcc.22088. Epub 2013 Jul 19. 2013
17BMI1
BMI-1 activation is crucial in hTERT-induced epithelial-mesenchymal transition of oral epithelial cells.
Qiao B, Chen Z, Hu F, Tao Q, Lam AK.
Exp Mol Pathol 95(1):57-61. doi: 10.1016/j.yexmp.2013.05.004. Epub 2013 May 24. 2013
18BMI1
Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.
Zencak D, Schouwey K, Chen D, Ekström P, Tanger E, Bremner R, van Lohuizen M, Arsenijevic Y.
Proc Natl Acad Sci U S A 110(7):E593-601. doi: 10.1073/pnas.1108297110. Epub 2013 Jan 28. 2013
19BMI1
A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway.
Cho JH, Dimri M, Dimri GP.
J Biol Chem 288(5):3406-18. doi: 10.1074/jbc.M112.422931. Epub 2012 Dec 13. 2013
20BMI1
Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation.
Calao M, Sekyere EO, Cui HJ, Cheung BB, Thomas WD, Keating J, Chen JB, Raif A, Jankowski K, Davies NP, Bekkum MV, Chen B, Tan O, Ellis T, Norris MD, Haber M, Kim ES, Shohet JM, Trahair TN, Liu T, Wainwright BJ, Ding HF, Marshall GM.
Oncogene 32(31):3616-26. doi: 10.1038/onc.2012.368. Epub 2012 Aug 20. 2013
21BMI1, CHMP1A, PCH8
CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.
Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA.
Nat Genet 44(11):1260-4. doi: 10.1038/ng.2425. Epub 2012 Sep 30. 2012
22BMI1, CCNE1, FBXW7
Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.
Mao L, Ding J, Perdue A, Yang L, Zha Y, Ren M, Huang S, Cui H, Ding HF.
Oncogene 31(33):3785-95. doi: 10.1038/onc.2011.536. Epub 2011 Nov 28. 2012
23BMI1, GATA6
Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I, Hiiragi T, Chazaud C, Azuara V.
Genes Dev 26(13):1445-58. doi: 10.1101/gad.188193.112. Epub 2012 Jun 19. 2012
24BMI1
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.
PLoS One 7(5):e36209. doi: 10.1371/journal.pone.0036209. Epub 2012 May 11. 2012
25BMI1, IKZF1
Bmi1 is critical to prevent Ikaros-mediated lymphoid priming in hematopoietic stem cells.
Arranz L, Herrera-Merchan A, Ligos JM, de Molina A, Dominguez O, Gonzalez S.
Cell Cycle 11(1):65-78. doi: 10.4161/cc.11.1.18097. Epub 2012 Jan 1. 2012
26BMI1, PCGF2
Regulation of hematopoietic stem cells using protein transduction domain-fused Polycomb.
Kajiume T, Sera Y, Kawahara Y, Matsumoto M, Fukazawa T, Imura T, Yuge L, Kobayashi M.
Exp Hematol 40(9):751-760.e1. doi: 10.1016/j.exphem.2012.05.005. Epub 2012 May 24. 2012
27BMI1, BTRC
βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.
Sahasrabuddhe AA, Dimri M, Bommi PV, Dimri GP.
Cell Cycle 10(8):1322-30. Epub 2011 Apr 15. 2011
28BMI1, RNF2, UBE2D3
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG.
EMBO J 30(16):3285-97. doi: 10.1038/emboj.2011.243. 2011
29BMI1
BMI1 as a novel target for drug discovery in cancer.
Cao L, Bombard J, Cintron K, Sheedy J, Weetall ML, Davis TW.
J Cell Biochem 112(10):2729-41. doi: 10.1002/jcb.23234. Review. 2011
30BMI1, SOX2
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.
Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A.
Mol Cell Biol 31(22):4593-608. doi: 10.1128/MCB.05798-11. Epub 2011 Sep 19. 2011
31BMI1, CADM1, KIF1B, MYCN
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T.
Oncogene 29(18):2681-90. Epub 2010 Mar 1.PMID: 20190806 2010
32BMI1
Bmi-1 gene is upregulated in early-stage hepatocellular carcinoma and correlates with ATP-binding cassette transporter B1 expression.
Effendi K, Mori T, Komuta M, Masugi Y, Du W, Sakamoto M.
Cancer Sci 101(3):666-72. Epub 2009 Nov 11. 2010
33BMI1, PCGF2
BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.
Zhang XW, Sheng YP, Li Q, Qin W, Lu YW, Cheng YF, Liu BY, Zhang FC, Li J, Dimri GP, Guo WJ.
Mol Cancer 9:40. 2010
34BMI1
Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.
Häyry V, Mäkinen LK, Atula T, Sariola H, Mäkitie A, Leivo I, Keski-Säntti H, Lundin J, Haglund C, Hagström J.
Br J Cancer 102(5):892-7. Epub 2010 Feb 9. 2010
35BMI1
Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway.
Li J, Gong LY, Song LB, Jiang LL, Liu LP, Wu J, Yuan J, Cai JC, He M, Wang L, Zeng M, Cheng SY, Li M.
Am J Pathol 176(2):699-709. Epub 2009 Dec 24. 2010
36BMI1, CDKN2A, RNF2
Identification and characterization of Bmi-1-responding element within the human p16 promoter.
Meng S, Luo M, Sun H, Yu X, Shen M, Zhang Q, Zhou R, Ju X, Tao W, Liu D, Deng H, Lu Z.
J Biol Chem 285(43):33219-29. Epub 2010 Jun 15. 2010
37BMI1, TWIST1
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition.
Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ.
Nat Cell Biol 12(10):982-92. Epub 2010 Sep 5. 2010
38BMI1, FOXG1
Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.
Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos JT, Lemischka IR, Studer L, Temple S.
Genes Dev 23(5):561-74. 2009
39BMI1
Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.
Zhang J, Sarge KD.
FEBS Lett 583(6):960-4. Epub 2009 Feb 20. 2009
40BMI1
Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis.
Sangiorgi E, Capecchi MR.
Proc Natl Acad Sci U S A 106(17):7101-6. Epub 2009 Apr 16. 2009
41BMI1
Bmi1 regulates mitochondrial function and the DNA damage response pathway.
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T.
Nature 459(7245):387-92. Epub 2009 Apr 29. 2009
42BMI1
Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Dovey JS, Zacharek SJ, Kim CF, Lees JA.
Proc Natl Acad Sci U S A 105(33):11857-62. Epub 2008 Aug 12. 2008
43BMI1, DMAP1
Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing.
Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M, Tajima S, Koseki H, Tsuda H, Takasaki Y, Nakauchi H, Iwama A.
Biochem Biophys Res Commun 353(4):992-8. Epub 2006 Dec 29. 2007
44BMI1,SALL4
Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.
Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y.
Proc Natl Acad Sci U S A 104(25):10494-9. Epub 2007 Jun 8. 2007
45BMI1
Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.
Heffner M, Fearon DT.
Proc Natl Acad Sci U S A 104(33):13414-9. Epub 2007 Aug 8. 2007
46BMI1, MEL18
Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells.
Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP.
Cancer Res 67(11):5083-9. 2007
47BMI1, MYC, PCGF2
Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins.
Guo WJ, Datta S, Band V, Dimri GP.
Mol Biol Cell 18(2):536-46. Epub 2006 Dec 6. 2007
48BMI1
Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis.
Sasaki M, Ikeda H, Sato Y, Nakanuma Y.
Am J Pathol 169(3):831-45. 2006
49E4F1, BMI1
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G.
Genes Dev 20(15):2110-20. 2006
50BMI1, RING1
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
Cao R, Tsukada Y, Zhang Y.
Mol Cell 20(6):845-54. 2005
51BMI1
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.
Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, Van Lohuizen M, Marino S.
Nature 428(6980):337-41. 2004
52BMI1
The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.
Kim JH, Yoon SY, Kim CN, Joo JH, Moon SK, Choe IS, Choe YK, Kim JW.
Cancer Lett 203(2):217-24. 2004
53BMI1
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF.
Nature 423(6937):302-5. 2003
54BMI1
BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.
Bea S, Tort F, Pinyol M, Puig X, Hernandez L, Hernandez S, Fernandez PL, van Lohuizen M, Colomer D, Campo E.
Cancer Res 61(6):2409-12. 2001
55BMI1
The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression.
Vonlanthen S, Heighway J, Altermatt HJ, Gugger M, Kappeler A, Borner MM, van Lohuizen M, Betticher DC.
Br J Cancer 84(10):1372-6. 2001
56BMI1, CBX8
HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.
Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS.
J Biol Chem 275(37):28785-92. 2000
57BMI1, PHC1, PHC2
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP.
Mol Cell Biol 17(4):2326-35. 1997
58BMI1
Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.
Alkema MJ, van der Lugt NM, Bobeldijk RC, Berns A, van Lohuizen M.
Nature 374(6524):724-7. 1995
59BMI1
Characterization and chromosomal localization of the human proto-oncogene BMI-1.
Alkema MJ, et al.
Hum Mol Genet 2 : 1597-1603. 1993