| 1 | BLM, EXO5, RPA1
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| EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart
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| Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, Tainer JA.
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| Mol Cell. Jul 15;81(14):2989-3006.e9. doi: 10.1016/j.molcel.2021.05.027. Epub 2021 Jun 30. 2021
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| 2 | AKT1S1, BLM
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| Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells.
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| Chen K, Xu H, Zhao J.
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| Oxid Med Cell Longev 2019:3685817. doi: 10.1155/2019/3685817. eCollection 2019.
2019
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| 3 | BLM, RMI1, RMI2, TOP3A
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| Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.
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| Martin CA, Sarlós K, Logan CV, Thakur RS, Parry DA, Bizard AH, Leitch A, Cleal L, Ali NS, Al-Owain MA, Allen W, Altmüller J, Aza-Carmona M, Barakat BAY, Barraza-García J, Begtrup A, Bogliolo M, Cho MT, Cruz-Rojo J, Dhahrabi HAM, Elcioglu NH; GOSgene, Gorman GS, Jobling R, Kesterton I, Kishita Y, Kohda M, Le Quesne Stabej P, Malallah AJ, Nürnberg P, Ohtake A, Okazaki Y, Pujol R, Ramirez MJ, Revah-Politi A, Shimura M, Stevens P, Taylor RW, Turner L, Williams H, Wilson C, Yigit G, Zahavich L, Alkuraya FS, Surralles J, Iglesais A, Murayama K, Wollnik B, Dattani M, Heath KE, Hickson ID, Jackson AP.
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| Am J Hum Genet 103(2):221-231. doi: 10.1016/j.ajhg.2018.07.001. Epub 2018 Jul 26. Erratum in: Am J Hum Genet. 2018 Sep 6;103(3):456.
2018
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| 4 | BLM, RMI1, RMI2, TOP3A
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| Knockdown of RMI1 impairs DNA repair under DNA replication stress.
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| Xu C, Fang L, Kong Y, Xiao C, Yang M, Du LQ, Liu Q.
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| Biochem Biophys Res Commun 494(1-2):158-164. doi: 10.1016/j.bbrc.2017.10.062. Epub 2017 Oct 14.
2017
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| 5 | BLM, WRN
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| Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.
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| de Renty C, Ellis NA.
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| Ageing Res Rev 33:36-51. doi: 10.1016/j.arr.2016.05.010. Epub 2016 May 26. Review.
2017
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| 6 | BLM, FANCM
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| Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks.
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| Ling C, Huang J, Yan Z, Li Y, Ohzeki M, Ishiai M, Xu D, Takata M, Seidman M, Wang W.
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| Cell Discov 2:16047. doi: 10.1038/celldisc.2016.47. eCollection 2016.
2016
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| 7 | BLM, DNA2, WRN
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| Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.
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| Pinto C, Kasaciunaite K, Seidel R, Cejka P.
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| Elife 5. pii: e18574. doi: 10.7554/eLife.18574.
2016
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| 8 | BLM, PARP1, RECQL, RECQL4, RECQL5, WRN
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| RecQ helicases and PARP1 team up in maintaining genome integrity.
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| Veith S, Mangerich A.
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| Ageing Res Rev 23(Pt A):12-28. doi: 10.1016/j.arr.2014.12.006. Epub 2014 Dec 30. Review.
2015
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| 9 | BLM, RMI1, RMI2, TOP3A
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| Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.
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| Daley JM, Chiba T, Xue X, Niu H, Sung P.
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| Nucleic Acids Res 42(17):11083-91. doi: 10.1093/nar/gku803. Epub 2014 Sep 8.
2014
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| 10 | BLM, DNA2, RMI1, RMI2, WRN
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| DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.
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| Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.
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| J Biol Chem 289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.
2014
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| 11 | BLM
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| Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM.
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| Owen N, Hejna J, Rennie S, Mitchell A, Hanlon Newell A, Ziaie N, Moses RE, Olson SB.
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| Cytogenet Genome Res 144(4):255-63. doi: 10.1159/000375247. Epub 2015 Feb 28.
2014
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| 12 | BLM, BLMS
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| A novel frameshift mutation in BLM gene associated with high sister chromatid exchanges (SCE) in heterozygous family members.
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| Ben Salah G, Hadj Salem I, Masmoudi A, Kallabi F, Turki H, Fakhfakh F, Ayadi H, Kamoun H.
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| Mol Biol Rep 41(11):7373-80. doi: 10.1007/s11033-014-3624-5. Epub 2014 Aug 17.
2014
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| 13 | BLM, BRCA1, RAD50
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| Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells.
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| Acharya S, Kaul Z, Gocha AS, Martinez AR, Harris J, Parvin JD, Groden J.
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| PLoS One 9(8):e103819. doi: 10.1371/journal.pone.0103819. eCollection 2014.
2014
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| 14 | BLM, DNA2, WRN
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| DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.
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| Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.
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| J Biol Chem 289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.
2014
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| 15 | BLM, TOPBP1
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| TopBP1 controls BLM protein level to maintain genome stability.
|
| Wang J, Chen J, Gong Z.
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| Mol Cell 52(5):667-78. doi: 10.1016/j.molcel.2013.10.012. Epub 2013 Nov 14.
2013
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| 16 | BLM, UIMC1
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| Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination.
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| Tikoo S, Madhavan V, Hussain M, Miller ES, Arora P, Zlatanou A, Modi P, Townsend K, Stewart GS, Sengupta S.
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| EMBO J 32(12):1778-92. doi: 10.1038/emboj.2013.117. Epub 2013 May 24.
2013
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| 17 | BLM, RAD51, SPIDR
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| Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.
|
| Wan L, Han J, Liu T, Dong S, Xie F, Chen H, Huang J.
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| Proc Natl Acad Sci U S A 110(26):10646-51. doi: 10.1073/pnas.1220921110. Epub 2013 Mar 18.
2013
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| 18 | BLM
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| On BLM helicase in recombination-mediated telomere maintenance.
|
| Rezazadeh S.
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| Mol Biol Rep 40(4):3049-64. doi: 10.1007/s11033-012-2379-0. Epub 2012 Dec 26.
2013
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| 19 | BLM, RMI1, RMI2, TOP3A
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| Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis.
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| Pradhan A, Singh TR, Ali AM, Wahengbam K, Meetei AR.
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| J Biol Chem 288(47):33500-8. doi: 10.1074/jbc.M113.470823. Epub 2013 Oct 9.
2013
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| 20 | BLM, ERCC6L, TOP2A
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| Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphase.
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| Rouzeau S, Cordelières FP, Buhagiar-Labarchède G, Hurbain I, Onclercq-Delic R, Gemble S, Magnaghi-Jaulin L, Jaulin C, Amor-Guéret M.
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| PLoS One 7(4):e33905. Epub 2012 Apr 26.
2012
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| 21 | BLM, FANCM
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| Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome.
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| Hoadley KA, Xue Y, Ling C, Takata M, Wang W, Keck JL.
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| Proc Natl Acad Sci U S A 109(12):4437-42. doi: 10.1073/pnas.1117279109. Epub 2012 Mar 5.
2012
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| 22 | BLM, RECQL4
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| The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.
|
| Singh DK, Popuri V, Kulikowicz T, Shevelev I, Ghosh AK, Ramamoorthy M, Rossi ML, Janscak P, Croteau DL, Bohr VA.
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| Nucleic Acids Res 40(14):6632-48. doi: 10.1093/nar/gks349. Epub 2012 Apr 28.
2012
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| 23 | BLM, RMI1, RMI2, TOP3A
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| RMI1 promotes DNA replication fork progression and recovery from replication fork stress.
|
| Yang J, O'Donnell L, Durocher D, Brown GW.
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| Mol Cell Biol 32(15):3054-64. doi: 10.1128/MCB.00255-12. Epub 2012 May 29.
2012
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| 24 | BLM, BLMS
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| Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.
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| Mirzaei H, Schmidt KH.
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| Proc Natl Acad Sci U S A 109(47):19357-62. doi: 10.1073/pnas.1210304109. Epub 2012 Nov 5.
2012
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| 25 | BLM, BLMS
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| Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.
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| Mirzaei H, Schmidt KH.
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| Proc Natl Acad Sci U S A 109(47):19357-62. doi: 10.1073/pnas.1210304109. Epub 2012 Nov 5.
2012
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| 26 | BLM, DNA2, EXO1, NBN
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| BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
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| Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, Modrich P, Kowalczykowski SC.
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| Genes Dev 25(4):350-62.
2011
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| 27 | BLM, BRIP1
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| Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.
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| Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM Jr.
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| EMBO J 30(4):692-705. Epub 2011 Jan 14.
2011
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| 28 | BLM, WRN
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| The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.
|
| Machwe A, Karale R, Xu X, Liu Y, Orren DK.
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| Biochemistry 50(32):6774-88. Epub 2011 Jul 21.
2011
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| 29 | BLM, ERCC6L
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| PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.
|
| Ke Y, Huh JW, Warrington R, Li B, Wu N, Leng M, Zhang J, Ball HL, Li B, Yu H.
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| EMBO J 30(16):3309-21. doi: 10.1038/emboj.2011.226.
2011
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| 30 | BLM
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| Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA.
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| Gyimesi M, Sarlós K, Kovács M.
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| Nucleic Acids Res 38(13):4404-14. Epub 2010 Mar 8.
2010
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| 31 | BLM, INSL6
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| Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication.
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| Xu D, Muniandy P, Leo E, Yin J, Thangavel S, Shen X, Ii M, Agama K, Guo R, Fox D 3rd, Meetei AR, Wilson L, Nguyen H, Weng NP, Brill SJ, Li L, Vindigni A, Pommier Y, Seidman M, Wang W.
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| EMBO J 29(18):3140-55. Epub 2010 Aug 13. 2010
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| 32 | BLM
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| Structure and function of the regulatory HRDC domain from human Bloom syndrome protein.
|
| Kim YM, Choi BS.
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| Nucleic Acids Res 38(21):7764-77. Epub 2010 Jul 17.
2010
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| 33 | BLM, RMI1, TOP3A
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| Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.
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| Yang J, Bachrati CZ, Ou J, Hickson ID, Brown GW.
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| J Biol Chem 285(28):21426-36. doi: 10.1074/jbc.M110.123216. Epub 2010 May 5. 2010
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| 34 | BLM, RMI1, RMI2, TOP3A
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| Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha.
|
| Mönnich M, Hess I, Wiest W, Bachrati C, Hickson ID, Schorpp M, Boehm T.
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| Eur J Immunol 40(9):2379-84. doi: 10.1002/eji.201040634.
2010
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| 35 | BLM, BLMS, FANCD2
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| The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities.
|
| Naim V, Rosselli F.
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| Nat Cell Biol 11(6):761-8. Epub 2009 May 24. 2009
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| 36 | BLM
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| Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
|
| Bugreev DV, Mazina OM, Mazin AV.
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| J Biol Chem 284(39):26349-59. Epub 2009 Jul 24.
2009
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| 37 | BLM, BLMS
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| Loss of Bloom syndrome protein destabilizes human gene cluster architecture.
|
| Killen MW, Stults DM, Adachi N, Hanakahi L, Pierce AJ.
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| Hum Mol Genet 18(18):3417-28. Epub 2009 Jun 19.PMID: 19542097 2009
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| 38 | BLM, RMI1, TOP3A
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| Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
|
| Broberg K, Huynh E, Schläwicke Engström K, Björk J, Albin M, Ingvar C, Olsson H, Höglund M.
|
| BMC Cancer 9:140. doi: 10.1186/1471-2407-9-140.
2009
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| 39 | BLM, RTS, IKBKG, PRO1, WRN1, WRN2
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| NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?
|
| Salminen A, Suuronen T, Huuskonen J, Kaarniranta K.
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| Biochem Biophys Res Commun 367(4):715-8. Epub 2008 Jan 15. Review. 2008
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| 40 | BLM, RECQL
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| The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities.
|
| Popuri V, Bachrati CZ, Muzzolini L, Mosedale G, Costantini S, Giacomini E, Hickson ID, Vindigni A.
|
| J Biol Chem 283(26):17766-76. Epub 2008 Apr 30. 2008
|
| 41 | BLM, POLD4
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| The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
|
| Selak N, Bachrati CZ, Shevelev I, Dietschy T, van Loon B, Jacob A, Hübscher U, Hoheisel JD, Hickson ID, Stagljar I.
|
| Nucleic Acids Res 36(16):5166-79. Epub 2008 Aug 5.
2008
|
| 42 | BLM, EXO1
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| Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.
|
| Nimonkar AV, Ozsoy AZ, Genschel J, Modrich P, Kowalczykowski SC.
|
| Proc Natl Acad Sci U S A 105(44):16906-11. Epub 2008 Oct 29.
2008
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| 43 | BLM, RMI1, RMI2, TOP3A
|
| RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
|
| Xu D, Guo R, Sobeck A, Bachrati CZ, Yang J, Enomoto T, Brown GW, Hoatlin ME, Hickson ID, Wang W.
|
| Genes Dev 22(20):2843-55.
2008
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| 44 | BLM, RMI1, RMI2, TOP3A
|
| BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
|
| Singh TR, Ali AM, Busygina V, Raynard S, Fan Q, Du CH, Andreassen PR, Sung P, Meetei AR.
|
| Genes Dev 22(20):2856-68. 2008
|
| 45 | BLM, BLMS
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| Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry.
|
| German J, Sanz MM, Ciocci S, Ye TZ, Ellis NA.
|
| Hum Mutat 28(8):743-53. 2007
|
| 46 | BLM, BLMS
|
| Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein.
|
| Guo RB, Rigolet P, Ren H, Zhang B, Zhang XD, Dou SX, Wang PY, Amor-Gueret M, Xi XG.
|
| Nucleic Acids Res 35(18):6297-310. Epub 2007 Sep 18. 2007
|
| 47 | BLM, BLMS
|
| BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
|
| Chan KL, North PS, Hickson ID.
|
| EMBO J 26(14):3397-409. Epub 2007 Jun 28. 2007
|
| 48 | BGS, BLM, RAPADILINO, RECQL4, WRN
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| The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress.
|
| Dietschy T, Shevelev I, Stagljar I.
|
| Cell Mol Life Sci 64(7-8):796-802. Review.
2007
|
| 49 | BLM, RMI1, TOP3A
|
| Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.
|
| Bussen W, Raynard S, Busygina V, Singh AK, Sung P.
|
| J Biol Chem 282(43):31484-92. Epub 2007 Aug 28.
2007
|
| 50 | BLM, XRCC3
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| Functional interactions between BLM and XRCC3 in the cell.
|
| Otsuki M, Seki M, Inoue E, Yoshimura A, Kato G, Yamanouchi S, Kawabe Y, Tada S, Shinohara A, Komura J, Ono T, Takeda S, Ishii Y, Enomoto T.
|
| J Cell Biol 179(1):53-63.PMID: 17923529 2007
|
| 51 | BLM
|
| Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.
|
| Bugreev DV, Yu X, Egelman EH, Mazin AV.
|
| Genes Dev 21(23):3085-94. Epub 2007 Nov 14.PMID: 18003860 2007
|
| 52 | BLM, FBXO18
|
| Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse.
|
| Kohzaki M, Hatanaka A, Sonoda E, Yamazoe M, Kikuchi K, Vu Trung N, Szüts D, Sale JE, Shinagawa H, Watanabe M, Takeda S.
|
| Mol Cell Biol ol Cell Biol. 2007 2007
|
| 53 | BLM, BLMS, WRN
|
| The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.
|
| Machwe A, Xiao L, Groden J, Orren DK.
|
| Biochemistry 45(47):13939-46. 2006
|
| 54 | BLM
|
| MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability.
|
| Leng M, Chan DW, Luo H, Zhu C, Qin J, Wang Y.
|
| Proc Natl Acad Sci U S A 103(31):11485-90. Epub 2006 Jul 24. 2006
|
| 55 | RMI1, TOP3A, BLM
|
| A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.
|
| Raynard S, Bussen W, Sung P.
|
| J Biol Chem 281(20):13861-4. Epub 2006 Apr 4. 2006
|
| 56 | BLM, TOP3A
|
| Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.
|
| Seki M, Nakagawa T, Seki T, Kato G, Tada S, Takahashi Y, Yoshimura A, Kobayashi T, Aoki A, Otsuki M, Habermann FA, Tanabe H, Ishii Y, Enomoto T.
|
| Mol Cell Biol 26(16):6299-307. 2006
|
| 57 | BLM, SUMO1, SUMO2, SUMO3, SUMO4
|
| Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
|
| Eladad S, Ye TZ, Hu P, Leversha M, Beresten S, Matunis MJ, Ellis NA.
|
| Hum Mol Genet 14(10):1351-65. Epub 2005 Apr 13. 2005
|
| 58 | RMI1, TOP3A, BLM
|
| BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.
|
| Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W.
|
| EMBO J 24(7):1465-76. Epub 2005 Mar 17. 2005
|
| 59 | BLM
|
| The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.
|
| Cheok CF, Wu L, Garcia PL, Janscak P, Hickson ID.
|
| Nucleic Acids Res 33(12):3932-41. Print 2005. 2005
|
| 60 | WRN, RPA1, BLM
|
| Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
|
| Doherty KM, Sommers JA, Gray MD, Lee JW, von Kobbe C, Thoma NH, Kureekattil RP, Kenny MK, Brosh RM Jr.
|
| J Biol Chem 280(33):29494-505. Epub 2005 Jun 17. 2005
|
| 61 | BLM,POT1,WRN
|
| POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
|
| Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA.
|
| J Biol Chem 280(37):32069-80. Epub 2005 Jul 18. 2005
|
| 62 | TRF1, TERF2, BLM
|
| Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.
|
| Lillard-Wetherell K, Machwe A, Langland GT, Combs KA, Behbehani GK, Schonberg SA, German J, Turchi JJ, Orren DK, Groden J.
|
| Hum Mol Genet 13(17):1919-32. Epub 2004 Jun 30. 2004
|
| 63 | BLM
|
| Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.
|
| Davies SL, North PS, Dart A, Lakin ND, Hickson ID.
|
| Mol Cell Biol 24(3):1279-91. 2004
|
| 64 | BLM
|
| The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
|
| Wu L, Hickson ID.
|
| Nature 426(6968):870-4. 2003
|
| 65 | BLM, MSH6
|
| The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.
|
| Pedrazzi G, Bachrati CZ, Selak N, Studer I, Petkovic M, Hickson ID, Jiricny J, Stagljar I.
|
| Biol Chem 384(8):1155-64. 2003
|
| 66 | BLM, RAD51D
|
| Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
|
| Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID.
|
| J Biol Chem 278(48):48357-66. Epub 2003 Sep 15. 2003
|
| 67 | BLM, BLMS
|
| BLM heterozygosity and the risk of colorectal cancer.
|
| Gruber SB, Ellis NA, Rennert G, Offit K, Scott KK, Almog R, Kolachana P, Bonner JD, Kirchhoff T, Tomsho LP, Nafa K, Pierce H, Low M, Satagopan J, Rennert H, Huang H, Greenson JK, Groden J, Rapaport B, Shia J, Johnson S, Gregersen PK, Harris CC, Boyd J.
|
| Science 297(5589):2013. No abstract available. 2002
|
| 68 | BLM, MRE11A, NBS1, RAD50, WRN, NBN
|
| Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
|
| Franchitto A, Pichierri P.
|
| Hum Mol Genet 11(20):2447-53. 2002
|
| 69 | WRN, BLM
|
| Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.
|
| von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, Brosh RM Jr, Hickson ID, Bohr VA.
|
| J Biol Chem 277(24):22035-44. Epub 2002 Mar 27. 2002
|
| 70 | TERF2, BLM, WRN
|
| Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
|
| Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA.
|
| J Biol Chem 277(43):41110-9. Epub 2002 Aug 13. 2002
|
| 71 | BLM
|
| Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.
|
| Hu P, Beresten SF, van Brabant AJ, Ye TZ, Pandolfi PP, Johnson FB, Guarente L, Ellis NA.
|
| Hum Mol Genet 10(12):1287-98. 2001
|
| 72 | BLM, WRN
|
| The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.
|
| Mohaghegh P, Karow JK, Brosh Jr RM Jr, Bohr VA, Hickson ID.
|
| Nucleic Acids Res 29(13):2843-9. 2001
|
| 73 | BLM
|
| Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.
|
| Pedrazzi G, Perrera C, Blaser H, Kuster P, Marra G, Davies SL, Ryu GH, Freire R, Hickson ID, Jiricny J, Stagljar I.
|
| Nucleic Acids Res 29(21):4378-86. 2001
|
| 74 | BLM
|
| Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.
|
| Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J.
|
| J Biol Chem 276(15):12068-75. 2001
|
| 75 | BLM
|
| Nuclear structure in normal and Bloom syndrome cells.
|
| Yankiwski V, Marciniak RA, Guarente L, Neff NF.
|
| Proc Natl Acad Sci U S A 97(10):5214-9. 2000
|
| 76 | BLM
|
| The Bloom's syndrome gene product promotes branch migration of holliday junctions.
|
| Karow JK, Constantinou A, Li JL, West SC, Hickson ID.
|
| Proc Natl Acad Sci U S A 97(12):6504-8. 2000
|
| 77 | BLM, TOP3A
|
| The Bloom's syndrome gene product interacts with topoisomerase III.
|
| Wu L, Davies SL, North PS, Goulaouic H, Riou JF, Turley H, Gatter KC, Hickson ID.
|
| J Biol Chem 275(13):9636-44. 2000
|
| 78 | BLM
|
| BLM, the Bloom's syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins.
|
| Sanz MM, Proytcheva M, Ellis NA, Holloman WK, German J.
|
| Cytogenet Cell Genet 91(1-4):217-23. 2000
|
| 79 | BLM, RPA1, RPA2, RPA3
|
| Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes.
|
| Walpita D, et al.
|
| Proc Natl Acad Sci U S A 96(10):5622-7. 1999
|
| 80 | BLM, BLMS
|
| The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in Non-Jewish Americans of Spanish ancestry.
|
| Ellis NA, Ciocci S, Proytcheva M, Lennon D, Groden J, German J.
|
| Am J Hum Genet 63 : 1685-1693. 1998
|
| 81 | BLM, RECQL4, RECQL5, WRN
|
| Cloning of two new human helicase genes of the RecQ family : biological significance of multiple species in higher eukaryotes.
|
| Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A.
|
| Genomics 54 : 443-452. 1998
|
| 82 | BLM, BLMS
|
| Point mutations causing Bloom's syndrome abolish ATPase and DNA helicase activities of the BLM protein.
|
| Bahr A, De Graeve F, Kedinger C, Chatton B.
|
| Oncogene 17 : 2565-2571. 1998
|
| 83 | ATM, ATR, BLM, MLH1, RAD51, RPA1, RPA2, RPA3
|
| Changes in protein composition of meiotic nodules during mammalian meiosis.
|
| Plug AW, et al.
|
| J Cell Sci 111 ( Pt 4):413-23. 1998
|
| 84 | BLM, BLMS
|
| Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
|
| Foucault F, Vaury C, Barakat A, Thibout D, Planchon P, Jaulin C, Praz F, Amor-Gueret M.
|
| Hum Mol Genet 6(9):1427-34. 1997
|
| 85 | BLM
|
| BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal.
|
| Kaneko H, Orii KO, Matsui E, Shimozawa N, Fukao T, Matsumoto T, Shimamoto A, Furuichi Y, Hayakawa S, Kasahara K, Kondo N.
|
| Biochem Biophys Res Commun 240(2):348-53. 1997
|
| 86 | BLM
|
| The Bloom's syndrome gene product is a 3'-5' DNA helicase.
|
| Karow JK, Chakraverty RK, Hickson ID.
|
| J Biol Chem 272(49):30611-4. 1997
|
| 87 | BLM, BLMS
|
| Bloom's syndrome. XIX. Cytogenetic and population evidence for genetic heterogeneity.
|
| German J, et al.
|
| Clin Genet 49 : 223-231. 1996
|
| 88 | BLM
|
| Physical mapping of the Bloom syndrome region by the identification of YAC and P1 clones from human chromosome 15 band q26.1.
|
| Straughen J, et al.
|
| Genomics 35 : 118-128. 1996
|
| 89 | BLM
|
| Large deletions at the HPRT locus associated with the mutator phenotype in a Bloom's syndrome lymphoblastoid cell line.
|
| Tachibana A, et al.
|
| Mol Carcinog 17 : 41-47. 1996
|
| 90 | BLM, WRN
|
| Human homologues of yeast helicase.
|
| Lu J, et al.
|
| Nature 383 : 678-679. 1996
|
| 91 | BLM, BLMS
|
| Somatic intragenic recombination within the mutated locus BLM can correct the high sister-chromatid exchange phenotype of Bloom syndrome cells.
|
| Ellis NA, et al.
|
| Am J Hum Genet 57 : 1019-1027. 1995
|
| 92 | BLM
|
| The Bloom's syndrome gene product is homologous to RecQ helicases.
|
| Ellis NA, et al.
|
| Cell 83 : 655-666. 1995
|
| 93 | BLM, BLMS
|
| Bloom syndrome : an analysis of consanguineous families assigns the locus mutated to chromosome band 15q26.1.
|
| German J, et al.
|
| Proc Natl Acad Sci U S A 91 : 6669-6673. 1994
|
| 94 | BLM, BLMS
|
| Linkage disequilibrium between the FES, D15S127, and BLM loci in Ashkenazi Jews with Bloom syndrome.
|
| Ellis NA, et al.
|
| Am J Hum Genet 55 : 453-460. 1994
|
| 95 | BLM, BLMS
|
| Bloom syndrome and maternal uniparental disomy for chromosome 15.
|
| Woodage T, et al.
|
| Am J Hum Genet 55 : 74-80. 1994
|
| 96 | BLM
|
| DNA double-strand break repair : genetic determinants of flanking crossing-over.
|
| Kusano K, et al.
|
| Proc Natl Acad Sci U S A 91 : 1173-1177. 1994
|
| 97 | BLM, BLMS
|
| Elevated sister chromatid exchange phenotype of Bloom syndrome cells is complemented by human chromosome 15.
|
| McDaniel LD, et al.
|
| Proc Natl Acad Sci U S A 89 : 7968-7972. 1992
|
| 98 | BLM
|
| Homozygosity mapping of the Bloom's syndrome locus.
|
| Ellis NA, et al.
|
| Am J Hum Genet 51 : A187. 1992
|