| 1 | BIRC2, BIRC3, NAIP
|
| Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.
|
| Morón-Calvente V, Romero-Pinedo S, Toribio-Castelló S, Plaza-Díaz J, Abadía-Molina AC, Rojas-Barros DI, Beug ST, LaCasse EC, MacKenzie A, Korneluk R, Abadía-Molina F.
|
| PLoS One 13(3):e0193643. doi: 10.1371/journal.pone.0193643. eCollection 2018.
2018
|
| 2 | BIRC3, PACS2, TNFSF10, bIRC2
|
| Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
|
| Guicciardi ME, Werneburg NW, Bronk SF, Franke A, Yagita H, Thomas G, Gores GJ.
|
| PLoS One 9(3):e92124. doi: 10.1371/journal.pone.0092124. eCollection 2014.
2014
|
| 3 | BIRC3, NFKB1, TNFSF12
|
| TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.
|
| Enwere EK, Holbrook J, Lejmi-Mrad R, Vineham J, Timusk K, Sivaraj B, Isaac M, Uehling D, Al-awar R, LaCasse E, Korneluk RG.
|
| Sci Signal 5(246):ra75. doi: 10.1126/scisignal.2003086.
2012
|
| 4 | BIRC2, BIRC3, RIPK3, RIPK4
|
| cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
|
| Bertrand MJ, Lippens S, Staes A, Gilbert B, Roelandt R, De Medts J, Gevaert K, Declercq W, Vandenabeele P.
|
| PLoS One 6(9):e22356. Epub 2011 Sep 12. 2011
|
| 5 | BIRC2, BIRC3, TRAF2
|
| Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.
|
| Labbé K, McIntire CR, Doiron K, Leblanc PM, Saleh M.
|
| Immunity 35(6):897-907.
2011
|
| 6 | BIRC2, BIRC3
|
| Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
|
| Dueber EC, Schoeffler AJ, Lingel A, Elliott JM, Fedorova AV, Giannetti AM, Zobel K, Maurer B, Varfolomeev E, Wu P, Wallweber HJ, Hymowitz SG, Deshayes K, Vucic D, Fairbrother WJ.
|
| Science 334(6054):376-80.
2011
|
| 7 | BIRC2, BIRC3, USP19
|
| The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
|
| Mei Y, Hahn AA, Hu S, Yang X.
|
| J Biol Chem 286(41):35380-7. Epub 2011 Aug 17.
2011
|
| 8 | BIRC2, BIRC3, XIAP
|
| Inhibitor of apoptosis proteins as novel targets in inflammatory processes.
|
| Mayer BA, Rehberg M, Erhardt A, Wolf A, Reichel CA, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar AM, Fürst R.
|
| Arterioscler Thromb Vasc Biol 31(10):2240-50. Epub 2011 Aug 4.
2011
|
| 9 | BIRC2, BIRC3
|
| cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production.
|
| Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P, Bertrand MJ.
|
| Cell Death Differ 18(4):656-65. Epub 2010 Nov 5.
2011
|
| 10 | BIRC2, BIRC3, VGLL4, XIAP
|
| A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration.
|
| Jin HS, Park HS, Shin JH, Kim DH, Jun SH, Lee CJ, Lee TH.
|
| Biochem Biophys Res Commun 412(3):454-9. Epub 2011 Aug 4.
2011
|
| 11 | BIRC3
|
| Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma.
|
| Rossi D, Deaglio S, Dominguez-Sola D, Rasi S, Vaisitti T, Agostinelli C, Spina V, Bruscaggin A, Monti S, Cerri M, Cresta S, Fangazio M, Arcaini L, Lucioni M, Marasca R, Thieblemont C, Capello D, Facchetti F, Kwee I, Pileri SA, Foà R, Bertoni F, Dalla-Favera R, Pasqualucci L, Gaidano G.
|
| Blood 118(18):4930-4. doi: 10.1182/blood-2011-06-359166. Epub 2011 Aug 31.
2011
|
| 12 | BIRC3, ZFP36
|
| Tristetraprolin controls the stability of cIAP2 mRNA through binding to the 3'UTR of cIAP2 mRNA.
|
| Kim CW, Kim HK, Vo MT, Lee HH, Kim HJ, Min YJ, Cho WJ, Park JW.
|
| Biochem Biophys Res Commun 400(1):46-52. Epub 2010 Aug 4.
2010
|
| 13 | BIRC2, BIRC3
|
| Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
|
| Zheng C, Kabaleeswaran V, Wang Y, Cheng G, Wu H.
|
| Mol Cell 38(1):101-13.
2010
|
| 14 | BIIRC2, BIRC3, XIAP
|
| cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.
|
| Jin HS, Lee DH, Kim DH, Chung JH, Lee SJ, Lee TH.
|
| Cancer Res 69(5):1782-91. Epub 2009 Feb 17. 2009
|
| 15 | BIRC2, BIRC3
|
| Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).
|
| Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D.
|
| Biochem J 417(1):149-60.
2009
|
| 16 | BIRC3, MALT1
|
| TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaB.
|
| Garrison JB, Samuel T, Reed JC.
|
| Oncogene 28(13):1584-93. Epub 2009 Feb 23.
2009
|
| 17 | BIRC2, BIRC3, CASP3, CASP7
|
| The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
|
| Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB.
|
| J Biol Chem 284(19):12772-82. Epub 2009 Mar 3. 2009
|
| 18 | BIRC2, BIRC3, XIAP
|
| cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.
|
| Jin HS, Lee DH, Kim DH, Chung JH, Lee SJ, Lee TH.
|
| Cancer Res 69(5):1782-91. Epub 2009 Feb 17.
2009
|
| 19 | BIRC3, UBE2D1, UBE2D2, UBE2D3
|
| Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment.
|
| Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL.
|
| J Biol Chem 283(46):31633-40. Epub 2008 Sep 10. 2008
|
| 20 | BIRC2, BIRC3
|
| cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.
|
| Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA.
|
| Mol Cell 30(6):689-700.
2008
|
| 21 | BIRC3
|
| Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.
|
| Conte D, Holcik M, Lefebvre CA, Lacasse E, Picketts DJ, Wright KE, Korneluk RG.
|
| Mol Cell Biol 26(2):699-708. 2006
|
| 22 | BIRC3
|
| Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest.
|
| Jin HS, Lee TH.
|
| Biochem J 399(2):335-42.
2006
|
| 23 | BIRC2, BIRC3, XAF1, XIAP
|
| Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XIAP-associated factor 1.
|
| Perrelet D, Perrin FE, Liston P, Korneluk RG, MacKenzie A, Ferrer-Alcon M, Kato AC.
|
| J Neurosci 24(15):3777-85. 2004
|
| 24 | MALT1, BIRC3, DIABLO, MALTLY
|
| Antiapoptotic function of apoptosis inhibitor 2-MALT1 fusion protein involved in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphoma.
|
| Hosokawa Y, Suzuki H, Suzuki Y, Takahashi R, Seto M.
|
| Cancer Res 64(10):3452-7. 2004
|
| 25 | BIRC2, BIRC3
|
| A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.
|
| Dai Z, Zhu WG, Morrison CD, Brena RM, Smiraglia DJ, Raval A, Wu YZ, Rush LJ, Ross P, Molina JR, Otterson GA, Plass C.
|
| Hum Mol Genet 12(7):791-801. 2003
|
| 26 | BIRC3
|
| Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia.
|
| Dong Z, Nishiyama J, Yi X, Venkatachalam MA, Denton M, Gu S, Li S, Qiang M.
|
| Biochem J 364(Pt 2):413-21. 2002
|
| 27 | BIRC3
|
| Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma.
|
| Gordon GJ, Appasani K, Parcells JP, Mukhopadhyay NK, Jaklitsch MT, Richards WG, Sugarbaker DJ, Bueno R.
|
| Carcinogenesis 23(6):1017-24. 2002
|
| 28 | BIRC3, MALT1, MALTLY
|
| The API2/MALT1 fusion product may lead to germinal center B cell lymphomas by suppression of apoptosis.
|
| Stoffel A, Le Beau MM.
|
| Hum Hered 51(1-2):1-7. 2001
|
| 29 | BIRC3, MALT1, MALTLY
|
| Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.
|
| Baens M, Steyls A, Dierlamm J, De Wolf-Peeters C, Marynen P.
|
| Genes Chromosomes Cancer 29(4):281-91. 2000
|
| 30 | BIRC3, MKKS
|
| Phenotypic overlap of McKusick-kaufman syndrome with bardet-biedl syndrome: A literature review
|
| Slavotinek AM, Biesecker LG.
|
| Am J Med Genet 95(3):208-15. 2000
|
| 31 | BIRC3, MALT1, MALTLY
|
| Heterogeneity of the API2-MALT1 gene rearrangement in MALT-type lymphoma.
|
| Kalla J, Stilgenbauer S, Schaffner C, Wolf S, Ott G, Greiner A, Rosenwald A, Dohner H, Muller-Hermelink HK, Lichter P.
|
| Leukemia 14(11):1967-74. 2000
|
| 32 | BIRC2, BIRC3
|
| Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.
|
| Young SS, et al.
|
| Mamm Genome 10(1):44-8. 1999
|
| 33 | BIRC3, MALT1, MALTLY
|
| The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin's lymphomas of the mucosa-associated lymphoid tissue (MALT-) type.
|
| Ott G, Katzenberger T, Greiner A, Kalla J, Rosenwald A, Heinrich U, Ott MM, Muller-Hermelink HK.
|
| Cancer Res 57(18):3944-8. 1997
|
| 34 | BIRC2, BIRC3, CD47, NAIP, XIAP
|
| Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.
|
| Liston P, et al.
|
| Nature 379 : 349-353. 1996
|
| 35 | BIRC2, BIRC3, XIAP
|
| Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization.
|
| Rajcan-Separovic E, et al.
|
| Genomics 37 : 404-406. 1996
|
| 36 | BIRC2, BIRC3, XIAP
|
| ITA, a vertebrate homologue of IAP that is expressed in T lymphocytes.
|
| Digby MR, et al.
|
| DNA Cell Biol 15 : 981-988. 1996
|