| 1 | ASB11, BIK, CUL5
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| BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
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| Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY, Hung MC, Chen RH.
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| J Cell Biol. Sep 2;218(9):3002-3018. doi: 10.1083/jcb.201901156. Epub 2019 Aug 6 2019
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| 2 | BIK
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| BIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines.
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| Borst A, Haferkamp S, Grimm J, Rösch M, Zhu G, Guo S, Li C, Gao T, Meierjohann S, Schrama D, Houben R.
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| Cancer Lett. Sep 28;404:70-78. doi: 10.1016/j.canlet.2017.07.005. Epub 2017 Jul 15 2017
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| 3 | BIK, SQSTM1
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| Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
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| Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S.
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| Mol Cell Biol 34(18):3435-49. doi: 10.1128/MCB.01383-13. Epub 2014 Jul 7.
2014
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| 4 | BIK, TUT1
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| Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKIα and PKCδ signaling.
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| Li W, Laishram RS, Ji Z, Barlow CA, Tian B, Anderson RA.
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| Mol Cell 45(1):25-37. doi: 10.1016/j.molcel.2011.11.017. 2012
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| 5 | BIK
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| BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients.
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| López-Muñoz E, Hernández-Zarco A, García-Hernández N, Alvarado-Cabrero I, Zarco-Espinosa G, Salamanca-Gómez F, Arenas-Aranda D.
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| Clin Transl Oncol. Aug;14(8):586-91. doi: 10.1007/s12094-012-0845-8. Epub 2012 Jul 11 2012
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| 6 | BIK, HSPA5, PMAIP1
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| Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).
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| Zhou H, Zhang Y, Fu Y, Chan L, Lee AS.
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| J Biol Chem 286(29):25687-96. Epub 2011 May 26.
2011
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| 7 | BIK
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| BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma.
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| Bodet L, Ménoret E, Descamps G, Pellat-Deceunynck C, Bataille R, Le Gouill S, Moreau P, Amiot M, Gomez-Bougie P.
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| Br J Cancer 103(12):1808-14. Epub 2010 Nov 9.
2010
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| 8 | BIK
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| BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes.
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| Chinnadurai G, Vijayalingam S, Rashmi R.
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| Oncogene 27 Suppl 1:S20-9.
2008
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| 9 | BIK, RHBDD1
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| A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis.
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| Wang Y, Guan X, Fok KL, Li S, Zhang X, Miao S, Zong S, Koide SS, Chan HC, Wang L.
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| Cell Mol Life Sci 65(23):3822-9. doi: 10.1007/s00018-008-8452-0.
2008
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| 10 | BIK,CASP12
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| Apoptosis induced by BIK was decreased with RNA interference of caspase-12.
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| Zhao X, Sun Y, Yu H, Ye L, Zhang L, Lu J, Yuan Y, Qian G, Ge S.
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| Biochem Biophys Res Commun 359(4):896-901. Epub 2007 Jun 4. 2007
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| 11 | BIK
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| Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells.
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| Real PJ, Sanz C, Gutierrez O, Pipaon C, Zubiaga AM, Fernandez-Luna JL.
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| FEBS Lett 580(25):5905-9. Epub 2006 Oct 2. 2006
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| 12 | BIK
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| Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein.
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| Hur J, Bell DW, Dean KL, Coser KR, Hilario PC, Okimoto RA, Tobey EM, Smith SL, Isselbacher KJ, Shioda T.
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| Cancer Res 66(20):10153-61. 2006
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| 13 | BIK
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| Mutations of the BIK gene in human peripheral B-cell lymphomas.
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| Arena V, Martini M, Luongo M, Capelli A, Larocca LM.
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| Genes Chromosomes Cancer 38(1):91-6. 2003
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| 14 | TSG22A, BIK
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| Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.
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| Castells A, Ino Y, Louis DN, Ramesh V, Gusella JF, Rustgi AK.
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| Gastroenterology 117(4):831-7. 1999
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| 15 | BIK
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| Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K.
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| Han J, Sabbatini P, White E.
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| Mol Cell Biol 16(10):5857-64. 1996
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| 16 | BAK1, BIK
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| A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.
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| Chittenden T, et al.
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| EMBO J 14 : 5589-5596. 1995
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| 17 | BIK
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| Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.
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| Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ, et al.
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| Oncogene 11(9):1921-8. 1995
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