Citations for
1ALPP, BGLAP, RBM3
Short-term moderate hypothermia stimulates alkaline phosphatase activity and osteocalcin expression in osteoblasts by upregulating Runx2 and osterix in vitro.
Aisha MD, Nor-Ashikin MN, Sharaniza AB, Nawawi HM, Kapitonova MY, Froemming GR.
Exp Cell Res 326(1):46-56. doi: 10.1016/j.yexcr.2014.06.003. Epub 2014 Jun 11. 2014
2BGLAP, GPRC6A
Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a.
Wei J, Hanna T, Suda N, Karsenty G, Ducy P.
Diabetes 63(3):1021-31. doi: 10.2337/db13-0887. Epub 2013 Sep 5. 2014
3BGLAP, BMP4
Rho-kinase limits BMP-4-stimulated osteocalcin synthesis in osteoblasts: regulation of the p38 MAP kinase pathway.
Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kuroyanagi G, Yamamoto N, Mizutani J, Kozawa O, Otsuka T.
Life Sci 96(1-2):18-25. doi: 10.1016/j.lfs.2013.12.017. Epub 2013 Dec 22. 2014
4BGLAP
Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice.
Mizokami A, Yasutake Y, Gao J, Matsuda M, Takahashi I, Takeuchi H, Hirata M.
PLoS One 8(2):e57375. doi: 10.1371/journal.pone.0057375. Epub 2013 Feb 20. 2013
5BGLAP
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.
Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, Lacombe J, Srinivas P, Chamouni A, Lugani F, Lejeune H, Kumar TR, Plotton I, Karsenty G.
J Clin Invest 123(6):2421-33. 2013
6BGLAP
In vivo determination of vitamin d function using transgenic mice carrying a human osteocalcin luciferase reporter gene.
Nakanishi T, Saito R, Taniguchi M, Oda H, Soma A, Yasunaga M, Yamane M, Sato K.
Biomed Res Int 2013:895706. doi: 10.1155/2013/895706. Epub 2013 Mar 27. 2013
7BGLAP
Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-κB signaling pathway.
Zhou B, Li H, Xu L, Zang W, Wu S, Sun H.
Endocrinology 154(3):1055-68. doi: 10.1210/en.2012-2144. Epub 2013 Feb 13. 2013
8BGLAP
The role of osteocalcin in human glucose metabolism: marker or mediator?
Booth SL, Centi A, Smith SR, Gundberg C.
Nat Rev Endocrinol 9(1):43-55. doi: 10.1038/nrendo.2012.201. Epub 2012 Nov 13. Review. 2013
9BGLAP
Osteocalcin: skeletal and extra-skeletal effects.
Neve A, Corrado A, Cantatore FP.
J Cell Physiol 228(6):1149-53. doi: 10.1002/jcp.24278. Review. 2013
10BGLAP, IBSP, KDM6B, RUNX2, SP7
Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.
Yang D, Okamura H, Nakashima Y, Haneji T.
J Biol Chem 288(47):33530-41. doi: 10.1074/jbc.M113.497040. Epub 2013 Oct 8. 2013
11BGLAP
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.
Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, Lacombe J, Srinivas P, Chamouni A, Lugani F, Lejeune H, Kumar TR, Plotton I, Karsenty G.
J Clin Invest 123(6):2421-33. 2013
12ATF4, BGLAP, IHH
Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.
Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X.
Development 139(3):601-11. doi: 10.1242/dev.069575. Epub 2011 Dec 21. 2012
13BGLAP
Conditional expression of human bone Gla protein in osteoblasts causes skeletal abnormality in mice.
Ikeda K, Tsukui T, Tanaka D, Maruyama Y, Horie-Inoue K, Inoue S.
Biochem Biophys Res Commun 424(1):164-9. doi: 10.1016/j.bbrc.2012.06.098. Epub 2012 Jun 23. 2012
14ATF6, BGLAP, BMP2, RUNX2
BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription.
Jang WG, Kim EJ, Kim DK, Ryoo HM, Lee KB, Kim SH, Choi HS, Koh JT.
J Biol Chem 287(2):905-15. doi: 10.1074/jbc.M111.253187. Epub 2011 Nov 18. 2012
15AGT, BGLAP
From skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4.
Yuen CY, Wong SL, Lau CW, Tsang SY, Xu A, Zhu Z, Ng CF, Yao X, Kong SK, Lee HK, Huang Y.
Circ Res 111(3):e55-66. doi: 10.1161/CIRCRESAHA.112.271361. Epub 2012 Jun 7. 2012
16BGLAP
Osteocalcin gene expression is regulated by wild-type p53.
Chen H, Hays E, Liboon J, Neely C, Kolman K, Chandar N.
Calcif Tissue Int 89(5):411-8. doi: 10.1007/s00223-011-9533-x. Epub 2011 Oct 1. 2011
17BGLAP, SP1, SP7
The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter.
Niger C, Lima F, Yoo DJ, Gupta RR, Buo AM, Hebert C, Stains JP.
Bone 49(4):683-92. doi: 10.1016/j.bone.2011.07.027. Epub 2011 Jul 28. 2011
18BGLAP, HSPB1
Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts.
Kato K, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Natsume H, Katagiri Y, Hirose Y, Mizutani J, Tokuda H, Kozawa O, Otsuka T.
Endocrinology 152(5):1872-82. doi: 10.1210/en.2010-1062. Epub 2011 Mar 22. 2011
19BGLAP, GRPC6A
GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo.
Pi M, Wu Y, Quarles LD.
J Bone Miner Res 26(7):1680-3. doi: 10.1002/jbmr.390. 2011
20BGLAP
Circulating osteocalcin is increased in early-stage diabetes.
Aoki A, Muneyuki T, Yoshida M, Munakata H, Ishikawa SE, Sugawara H, Kawakami M, Kakei M.
Diabetes Res Clin Pract 92(2):181-6. doi: 10.1016/j.diabres.2011.01.009. Epub 2011 Feb 2. 2011
21BGLAP
Evidence for osteocalcin production by adipose tissue and its role in human metabolism.
Foresta C, Strapazzon G, De Toni L, Gianesello L, Calcagno A, Pilon C, Plebani M, Vettor R.
J Clin Endocrinol Metab 95(7):3502-6. doi: 10.1210/jc.2009-2557. Epub 2010 Apr 21. 2010
22BGLAP
Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus.
Lumachi F, Camozzi V, Tombolan V, Luisetto G.
Ann N Y Acad Sci 1173 Suppl 1:E64-7. doi: 10.1111/j.1749-6632.2009.04955.x. 2009
23BGLAP
Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men.
Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellström D.
J Bone Miner Res 24(5):785-91. doi: 10.1359/jbmr.081234. Erratum in: J Bone Miner Res. 2010 Dec;25(12):2527. 2009
24ANKH,BGLAP,PTH
Contribution of the putative genetic factors and ANKH gene polymorphisms to variation of circulating calciotropic molecules, PTH and BGP.
Vistoropsky Y, Keter M, Malkin I, Trofimov S, Kobyliansky E, Livshits G.
Hum Mol Genet 16(10):1233-40. Epub 2007 Apr 2. 2007
25BGLAP
Nuclear orphan receptor Nurr1 directly transactivates the osteocalcin gene in osteoblasts.
Pirih FQ, Tang A, Ozkurt IC, Nervina JM, Tetradis S.
J Biol Chem 279(51):53167-74. Epub 2004 Oct 12. 2004
26BGLAP, SPARC, DSPP
Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth.
Papagerakis P, Berdal A, Mesbah M, Peuchmaur M, Malaval L, Nydegger J, Simmer J, Macdougall M.
Bone 30(2):377-85. 2002
27BGLAP, D1S3737
Osteocalcin: genetic and physical mapping of the human gene BGLAP and its potential role in postmenopausal osteoporosis.
Raymond MH, et al.
Genomics 60(2):210-7 1999
28BGLAP
A novel polymorphism in the promoter region for the human osteocalcin gene : the possibility of a correlation with bone mineral density in postmenopausal Japaneses women.
Dohi Y, et al.
J Bone Miner Res 13 : 1633-1639. 1998
29BGLAP
Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation.
Lian JB, et al.
J Cell Biochem Suppl 30-31:62-72. 1998
30BGLAP
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene.
Ducy P, Karsenty G.
Mol Cell Biol 15(4):1858-69. 1995
31BGLAP
Chromosomal localization of the human osteocalcin gene.
Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C.
Endocrinology 124 : 2648-2651. 1989
32BGLAP
Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.
Celeste AJ, Rosen V, Buecker JL, Kriz R, Wang EA, Wozney JM.
EMBO J 5 : 1885-1890. 1986
33BGLAP, NACA
128.
αNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression.
Jafarov T, Alexander JW, St-Arnaud R afarov T, Alexander JW, St-Arnaud R.