1 | BCL2L11, SPZ1
|
| SPZ1 promotes deregulation of Bim to boost apoptosis resistance in colorectal cancer.
|
| Liu XY, Zheng CB, Wang T, Xu J, Zhang M, Gou LS, Jin L, Qi X, Zeng X, Li H, Qiu S, Zhang P.
|
| Biosci Rep. Jan 31;134(2):155-167. doi: 10.1042/CS20190865 2020
|
2 | BCL2L11, PMAIP1, TAF6
|
| BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.
|
| Delannoy A, Wilhelm E, Eilebrecht S, Alvarado-Cuevas EM, Benecke AG, Bell B.
|
| Cell Death Dis. Jan 22;9(2):70. doi: 10.1038/s41419-017-0115-3 2018
|
3 | BCL2L11, IL4
|
| IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints.
|
| Granato A, Hayashi EA, Baptista BJ, Bellio M, Nobrega A.
|
| J Immunol 192(12):5761-75. doi: 10.4049/jimmunol.1300749. Epub 2014 May 16.
2014
|
4 | BAK1, BBC3, BCL2L11, PMAIP1
|
| Evaluation of the BH3-only protein Puma as a direct Bak activator.
|
| Dai H, Pang YP, Ramirez-Alvarado M, Kaufmann SH.
|
| J Biol Chem 289(1):89-99. doi: 10.1074/jbc.M113.505701. Epub 2013 Nov 21.
2014
|
5 | BCL2L11
|
| BCL2L11/BIM: a novel molecular link between autophagy and apoptosis.
|
| Luo S, Rubinsztein DC.
|
| Autophagy 9(1):104-5. doi: 10.4161/auto.22399. Epub 2012 Oct 12.
2013
|
6 | BBC3, BCL2L11, PMAIP1
|
| A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia.
|
| Zhang LN, Li JY, Xu W.
|
| Cancer Gene Ther 20(1):1-7. doi: 10.1038/cgt.2012.84. Epub 2012 Nov 23. Review.
2013
|
7 | BCL2L11, E2F1
|
| Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.
|
| Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, Seshadri A, Sun L, Aldaz CM, Tang DG, Chandra D.
|
| J Biol Chem 288(1):368-81. doi: 10.1074/jbc.M112.386102. Epub 2012 Nov 14.
2013
|
8 | AURKA, BCL2L11
|
| BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1.
|
| Moustafa-Kamal M, Gamache I, Lu Y, Li S, Teodoro JG.
|
| Cell Death Differ 20(10):1393-403. doi: 10.1038/cdd.2013.93. Epub 2013 Aug 2.
2013
|
9 | BAK1, BAX, BBC3, BCL2L11
|
| PUMA and BIM are required for oncogene inactivation-induced apoptosis.
|
| Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJ, Cheng EH.
|
| Sci Signal 6(268):ra20. doi: 10.1126/scisignal.2003483.
2013
|
10 | BBC3, BCL2L11
|
| The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
|
| Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.
|
| Immunity 37(3):451-62. doi: 10.1016/j.immuni.2012.05.030. Epub 2012 Sep 6.
2012
|
11 | BCL2L11
|
| Bim inhibits autophagy by recruiting Beclin 1 to microtubules.
|
| Luo S, Garcia-Arencibia M, Zhao R, Puri C, Toh PP, Sadiq O, Rubinsztein DC.
|
| Mol Cell 47(3):359-70. doi: 10.1016/j.molcel.2012.05.040. Epub 2012 Jun 27.
2012
|
12 | BCL2L11
|
| The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.
|
| Ruppert SM, Li W, Zhang G, Carlson AL, Limaye A, Durum SK, Khaled AR.
|
| Biochim Biophys Acta 1823(10):1877-93. doi: 10.1016/j.bbamcr.2012.06.017. Epub 2012 Jun 21.
2012
|
13 | BCL2L11, CDH2
|
| N-cadherin mediates neuronal cell survival through Bim down-regulation.
|
| Lelièvre EC, Plestant C, Boscher C, Wolff E, Mège RM, Birbes H.
|
| PLoS One 7(3):e33206. doi: 10.1371/journal.pone.0033206. Epub 2012 Mar 12.
2012
|
14 | BCL2L11
|
| Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.
|
| Clybouw C, Merino D, Nebl T, Masson F, Robati M, O'Reilly L, Hübner A, Davis RJ, Strasser A, Bouillet P.
|
| Cell Death Differ 19(6):1060-8. doi: 10.1038/cdd.2011.198. Epub 2012 Jan 13.
2012
|
15 | BCL2L11
|
| Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.
|
| Mérino D, Strasser A, Bouillet P.
|
| Oncogene 31(28):3392-6. doi: 10.1038/onc.2011.508. Epub 2011 Nov 14.
2012
|
16 | BCL2L11, PRKAR1A
|
| Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim.
|
| Moujalled D, Weston R, Anderton H, Ninnis R, Goel P, Coley A, Huang DC, Wu L, Strasser A, Puthalakath H.
|
| EMBO Rep 12(1):77-83. Epub 2010 Dec 10.
2011
|
17 | BCL2L11
|
| Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia.
|
| Wang S, Park S, Fei P, Sorenson CM.
|
| Dev Biol 349(2):296-309. Epub 2010 Nov 1.
2011
|
18 | BCL2L11, TRIM2
|
| Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
|
| Thompson S, Pearson AN, Ashley MD, Jessick V, Murphy BM, Gafken P, Henshall DC, Morris KT, Simon RP, Meller R.
|
| J Biol Chem 286(22):19331-9. Epub 2011 Apr 8.
2011
|
19 | BCL2L1, BCL2L11, TARDBP
|
| TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
|
| Suzuki H, Lee K, Matsuoka M.
|
| J Biol Chem 286(15):13171-83. Epub 2011 Feb 21.
2011
|
20 | BCL2L11, MCL1, PMAIP1
|
| Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.
|
| Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X.
|
| Cell Death Differ 18(5):864-73. Epub 2010 Nov 26.
2011
|
21 | BCL2L11, CCNB1, CDK1
|
| Cyclin B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis.
|
| Mac Fhearraigh S, Mc Gee MM.
|
| Cell Cycle 10(22):3886-96. Epub 2011 Nov 15. 2011
|
22 | BCL2L11, PMAIP1
|
| Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa.
|
| Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S, Eitz-Ferrer P, Grespi F, Ottina E, Villunger A, Häcker H, Häcker G.
|
| Cell Death Differ 18(11):1805-14. doi: 10.1038/cdd.2011.69. Epub 2011 Jun 10.
2011
|
23 | BCL2L11, EGFR, NOTCH3
|
| Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.
|
| Konishi J, Yi F, Chen X, Vo H, Carbone DP, Dang TP.
|
| Oncogene 29(4):589-96. Epub 2009 Nov 2.
2010
|
24 | BCL2L11, CAMLG
|
| CAML regulates Bim-dependent thymocyte death.
|
| Edgar CE, Lindquist LD, McKean DL, Strasser A, Bram RJ.
|
| Cell Death Differ 17(10):1566-76. Epub 2010 Mar 19.
2010
|
25 | BAK1, BAX, BBC3, BCL2L11, BID
|
| BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
|
| Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.
|
| Science 330(6009):1390-3.
2010
|
26 | BCL2L11, BMF
|
| Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis.
|
| Whelan KA, Caldwell SA, Shahriari KS, Jackson SR, Franchetti LD, Johannes GJ, Reginato MJ.
|
| Mol Biol Cell 21(22):3829-37. Epub 2010 Sep 22.
2010
|
27 | BCL2L11, BMF
|
| Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.
|
| Hübner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ.
|
| Mol Cell Biol 30(1):98-105. Epub .
2010
|
28 | BCL2L11, GRB10
|
| Grb10 interacts with Bim L and inhibits apoptosis.
|
| Hu ZQ, Zhang JY, Ji CN, Xie Y, Chen JZ, Mao YM.
|
| Mol Biol Rep 37(7):3547-52. Epub 2010 Feb 20.
2010
|
29 | BCL2L11, IER3, MCL1
|
| IEX-1-induced cell death requires BIM and is modulated by MCL-1.
|
| Yoon S, Ha HJ, Kim YH, Won M, Park M, Ko JJ, Lee K, Bae J.
|
| Biochem Biophys Res Commun 382(2):400-4. Epub 2009 Mar 13.
2009
|
30 | BAX, BCL2L11, RACK1
|
| A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.
|
| Mamidipudi V, Cartwright CA.
|
| Oncogene 28(50):4421-33. Epub 2009 Sep 21.PMID: 19767770 2009
|
31 | BBC3, BCL2L11, HUS1, RAD9A
|
| Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.
|
| Meyerkord CL, Takahashi Y, Araya R, Takada N, Weiss RS, Wang HG.
|
| Oncogene 27(58):7248-59. Epub 2008 Sep 15.
2008
|
32 | BCL2L11
|
| Bim and Bmf in tissue homeostasis and malignant disease.
|
| Piñon JD, Labi V, Egle A, Villunger A.
|
| Oncogene 27 Suppl 1:S41-52. Review.
2008
|
33 | BCL2L11
|
| Critical role for BIM in T cell receptor restimulation-induced death.
|
| Snow AL, Oliveira JB, Zheng L, Dale JK, Fleisher TA, Lenardo MJ.
|
| Biol Direct 3:34.
2008
|
34 | BCL2L11, CISH, DYNLL1, RACK1
|
| RACK1 and CIS mediate the degradation of BimEL in cancer cells.
|
| Zhang W, Cheng GZ, Gong J, Hermanto U, Zong CS, Chan J, Cheng JQ, Wang LH.
|
| J Biol Chem 283(24):16416-26. Epub 2008 Apr 17.PMID: 18420585 2008
|
35 | BCL2L11, MAPK1, MAPK3
|
| ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.
|
| Ewings KE, Hadfield-Moorhouse K, Wiggins CM, Wickenden JA, Balmanno K, Gilley R, Degenhardt K, White E, Cook SJ.
|
| EMBO J 26(12):2856-67. Epub 2007 May 24. 2007
|
36 | BCL2L11
|
| The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis.
|
| Hetz C, Thielen P, Fisher J, Pasinelli P, Brown RH, Korsmeyer S, Glimcher L.
|
| Cell Death Differ 14(7):1386-9. Epub 2007 May 18. No abstract available. 2007
|
37 | BCL2L11
|
| Overexpression of BimSs3, the novel isoform of Bim, can trigger cell apoptosis by inducing cytochrome c release from mitochondria.
|
| Liu L, Chen J, Zhang J, Ji C, Zhang X, Gu S, Xie Y, Mao Y.
|
| Acta Biochim Pol 54(3):603-10. Epub 2007 Aug 24.PMID: 17717606 2007
|
38 | BCL2L11, PMAIP1
|
| FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells.
|
| Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ.
|
| Cell Death Differ 14(3):534-47. Epub 2006 Aug 4.PMID: 16888645 2007
|
39 | BCL2L11, BCL2L2
|
| Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.
|
| Yao M, Nguyen TV, Pike CJ.
|
| J Neurosci 27(6):1422-33.
2007
|
40 | BCL2L11,MAPK14
|
| p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells.
|
| Lu J, Quearry B, Harada H.
|
| FEBS Lett 580(14):3539-44. Epub 2006 May 19. 2006
|
41 | BCL2L11
|
| Structure of the human Bim gene and its transcriptional regulation in Baf-3, interleukin-3-dependent hematopoietic cells.
|
| Matsui H, Shinjyo T, Inaba T.
|
| Mol Biol Rep 32(2):79-85. 2005
|
42 | BCL2L11
|
| Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis.
|
| Chen JZ, Ji CN, Gu SH, Li JX, Zhao EP, Huang Y, Huang L, Ying K, Xie Y, Mao YM.
|
| Int J Biochem Cell Biol 36(8):1554-61. 2004
|
43 | BCL2L11
|
| Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.
|
| Marani M, Tenev T, Hancock D, Downward J, Lemoine NR.
|
| Mol Cell Biol 22(11):3577-89. 2002
|
44 | BCL2L11
|
| Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim.
|
| Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre HJ, Sutherland GR, Adams JM.
|
| Mamm Genome 12(2):163-8. 2001
|
45 | BCL2L11
|
| Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family.
|
| U M, Miyashita T, Shikama Y, Tadokoro K, Yamada M.
|
| FEBS Lett 509(1):135-41. 2001
|
46 | BCL2L11
|
| Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids.
|
| Murray S, Halford S, Ebenezer ND, Gregory-Evans CY, Bhattacharya SS.
|
| Cytogenet Cell Genet 92(3-4):353. No abstract available. 2001
|
47 | BCL2L11
|
| Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis.
|
| Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JA, Strasser A, Johnson EM.
|
| Neuron 29(3):615-28. 2001
|
48 | BCL2L11
|
| The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
|
| Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A.
|
| Mol Cell 3(3):287-96. 1999
|
49 | BCL2L11
|
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
|
| Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A.
|
| Science 286(5445):1735-8. 1999
|
50 | BCL2L11
|
| BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members.
|
| Hsu SY, Lin P, Hsueh AJ.
|
| Mol Endocrinol 12(9):1432-40. 1998
|
51 | BCL2L11
|
| Bim: a novel member of the Bcl-2 family that promotes apoptosis.
|
| O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC.
|
| EMBO J 17(2):384-95. 1998
|