Citations for
1BCL2L11, SPZ1
SPZ1 promotes deregulation of Bim to boost apoptosis resistance in colorectal cancer.
Liu XY, Zheng CB, Wang T, Xu J, Zhang M, Gou LS, Jin L, Qi X, Zeng X, Li H, Qiu S, Zhang P.
Biosci Rep. Jan 31;134(2):155-167. doi: 10.1042/CS20190865 2020
BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.
Delannoy A, Wilhelm E, Eilebrecht S, Alvarado-Cuevas EM, Benecke AG, Bell B.
Cell Death Dis. Jan 22;9(2):70. doi: 10.1038/s41419-017-0115-3 2018
3BCL2L11, IL4
IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints.
Granato A, Hayashi EA, Baptista BJ, Bellio M, Nobrega A.
J Immunol 192(12):5761-75. doi: 10.4049/jimmunol.1300749. Epub 2014 May 16. 2014
Evaluation of the BH3-only protein Puma as a direct Bak activator.
Dai H, Pang YP, Ramirez-Alvarado M, Kaufmann SH.
J Biol Chem 289(1):89-99. doi: 10.1074/jbc.M113.505701. Epub 2013 Nov 21. 2014
BCL2L11/BIM: a novel molecular link between autophagy and apoptosis.
Luo S, Rubinsztein DC.
Autophagy 9(1):104-5. doi: 10.4161/auto.22399. Epub 2012 Oct 12. 2013
A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia.
Zhang LN, Li JY, Xu W.
Cancer Gene Ther 20(1):1-7. doi: 10.1038/cgt.2012.84. Epub 2012 Nov 23. Review. 2013
7BCL2L11, E2F1
Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.
Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, Seshadri A, Sun L, Aldaz CM, Tang DG, Chandra D.
J Biol Chem 288(1):368-81. doi: 10.1074/jbc.M112.386102. Epub 2012 Nov 14. 2013
BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1.
Moustafa-Kamal M, Gamache I, Lu Y, Li S, Teodoro JG.
Cell Death Differ 20(10):1393-403. doi: 10.1038/cdd.2013.93. Epub 2013 Aug 2. 2013
PUMA and BIM are required for oncogene inactivation-induced apoptosis.
Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJ, Cheng EH.
Sci Signal 6(268):ra20. doi: 10.1126/scisignal.2003483. 2013
10BBC3, BCL2L11
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.
Immunity 37(3):451-62. doi: 10.1016/j.immuni.2012.05.030. Epub 2012 Sep 6. 2012
Bim inhibits autophagy by recruiting Beclin 1 to microtubules.
Luo S, Garcia-Arencibia M, Zhao R, Puri C, Toh PP, Sadiq O, Rubinsztein DC.
Mol Cell 47(3):359-70. doi: 10.1016/j.molcel.2012.05.040. Epub 2012 Jun 27. 2012
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.
Ruppert SM, Li W, Zhang G, Carlson AL, Limaye A, Durum SK, Khaled AR.
Biochim Biophys Acta 1823(10):1877-93. doi: 10.1016/j.bbamcr.2012.06.017. Epub 2012 Jun 21. 2012
13BCL2L11, CDH2
N-cadherin mediates neuronal cell survival through Bim down-regulation.
Lelièvre EC, Plestant C, Boscher C, Wolff E, Mège RM, Birbes H.
PLoS One 7(3):e33206. doi: 10.1371/journal.pone.0033206. Epub 2012 Mar 12. 2012
Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.
Clybouw C, Merino D, Nebl T, Masson F, Robati M, O'Reilly L, Hübner A, Davis RJ, Strasser A, Bouillet P.
Cell Death Differ 19(6):1060-8. doi: 10.1038/cdd.2011.198. Epub 2012 Jan 13. 2012
Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.
Mérino D, Strasser A, Bouillet P.
Oncogene 31(28):3392-6. doi: 10.1038/onc.2011.508. Epub 2011 Nov 14. 2012
Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim.
Moujalled D, Weston R, Anderton H, Ninnis R, Goel P, Coley A, Huang DC, Wu L, Strasser A, Puthalakath H.
EMBO Rep 12(1):77-83. Epub 2010 Dec 10. 2011
Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia.
Wang S, Park S, Fei P, Sorenson CM.
Dev Biol 349(2):296-309. Epub 2010 Nov 1. 2011
18BCL2L11, TRIM2
Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
Thompson S, Pearson AN, Ashley MD, Jessick V, Murphy BM, Gafken P, Henshall DC, Morris KT, Simon RP, Meller R.
J Biol Chem 286(22):19331-9. Epub 2011 Apr 8. 2011
TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
Suzuki H, Lee K, Matsuoka M.
J Biol Chem 286(15):13171-83. Epub 2011 Feb 21. 2011
Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.
Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X.
Cell Death Differ 18(5):864-73. Epub 2010 Nov 26. 2011
21BCL2L11, CCNB1, CDK1
Cyclin B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis.
Mac Fhearraigh S, Mc Gee MM.
Cell Cycle 10(22):3886-96. Epub 2011 Nov 15. 2011
Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa.
Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S, Eitz-Ferrer P, Grespi F, Ottina E, Villunger A, Häcker H, Häcker G.
Cell Death Differ 18(11):1805-14. doi: 10.1038/cdd.2011.69. Epub 2011 Jun 10. 2011
Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.
Konishi J, Yi F, Chen X, Vo H, Carbone DP, Dang TP.
Oncogene 29(4):589-96. Epub 2009 Nov 2. 2010
CAML regulates Bim-dependent thymocyte death.
Edgar CE, Lindquist LD, McKean DL, Strasser A, Bram RJ.
Cell Death Differ 17(10):1566-76. Epub 2010 Mar 19. 2010
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.
Science 330(6009):1390-3. 2010
26BCL2L11, BMF
Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis.
Whelan KA, Caldwell SA, Shahriari KS, Jackson SR, Franchetti LD, Johannes GJ, Reginato MJ.
Mol Biol Cell 21(22):3829-37. Epub 2010 Sep 22. 2010
27BCL2L11, BMF
Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.
Hübner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ.
Mol Cell Biol 30(1):98-105. Epub . 2010
28BCL2L11, GRB10
Grb10 interacts with Bim L and inhibits apoptosis.
Hu ZQ, Zhang JY, Ji CN, Xie Y, Chen JZ, Mao YM.
Mol Biol Rep 37(7):3547-52. Epub 2010 Feb 20. 2010
29BCL2L11, IER3, MCL1
IEX-1-induced cell death requires BIM and is modulated by MCL-1.
Yoon S, Ha HJ, Kim YH, Won M, Park M, Ko JJ, Lee K, Bae J.
Biochem Biophys Res Commun 382(2):400-4. Epub 2009 Mar 13. 2009
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.
Mamidipudi V, Cartwright CA.
Oncogene 28(50):4421-33. Epub 2009 Sep 21.PMID: 19767770 2009
31BBC3, BCL2L11, HUS1, RAD9A
Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.
Meyerkord CL, Takahashi Y, Araya R, Takada N, Weiss RS, Wang HG.
Oncogene 27(58):7248-59. Epub 2008 Sep 15. 2008
Bim and Bmf in tissue homeostasis and malignant disease.
Piñon JD, Labi V, Egle A, Villunger A.
Oncogene 27 Suppl 1:S41-52. Review. 2008
Critical role for BIM in T cell receptor restimulation-induced death.
Snow AL, Oliveira JB, Zheng L, Dale JK, Fleisher TA, Lenardo MJ.
Biol Direct 3:34. 2008
RACK1 and CIS mediate the degradation of BimEL in cancer cells.
Zhang W, Cheng GZ, Gong J, Hermanto U, Zong CS, Chan J, Cheng JQ, Wang LH.
J Biol Chem 283(24):16416-26. Epub 2008 Apr 17.PMID: 18420585 2008
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.
Ewings KE, Hadfield-Moorhouse K, Wiggins CM, Wickenden JA, Balmanno K, Gilley R, Degenhardt K, White E, Cook SJ.
EMBO J 26(12):2856-67. Epub 2007 May 24. 2007
The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis.
Hetz C, Thielen P, Fisher J, Pasinelli P, Brown RH, Korsmeyer S, Glimcher L.
Cell Death Differ 14(7):1386-9. Epub 2007 May 18. No abstract available. 2007
Overexpression of BimSs3, the novel isoform of Bim, can trigger cell apoptosis by inducing cytochrome c release from mitochondria.
Liu L, Chen J, Zhang J, Ji C, Zhang X, Gu S, Xie Y, Mao Y.
Acta Biochim Pol 54(3):603-10. Epub 2007 Aug 24.PMID: 17717606 2007
FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells.
Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ.
Cell Death Differ 14(3):534-47. Epub 2006 Aug 4.PMID: 16888645 2007
39BCL2L11, BCL2L2
Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.
Yao M, Nguyen TV, Pike CJ.
J Neurosci 27(6):1422-33. 2007
p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells.
Lu J, Quearry B, Harada H.
FEBS Lett 580(14):3539-44. Epub 2006 May 19. 2006
Structure of the human Bim gene and its transcriptional regulation in Baf-3, interleukin-3-dependent hematopoietic cells.
Matsui H, Shinjyo T, Inaba T.
Mol Biol Rep 32(2):79-85. 2005
Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis.
Chen JZ, Ji CN, Gu SH, Li JX, Zhao EP, Huang Y, Huang L, Ying K, Xie Y, Mao YM.
Int J Biochem Cell Biol 36(8):1554-61. 2004
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.
Marani M, Tenev T, Hancock D, Downward J, Lemoine NR.
Mol Cell Biol 22(11):3577-89. 2002
Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim.
Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre HJ, Sutherland GR, Adams JM.
Mamm Genome 12(2):163-8. 2001
Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family.
U M, Miyashita T, Shikama Y, Tadokoro K, Yamada M.
FEBS Lett 509(1):135-41. 2001
Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids.
Murray S, Halford S, Ebenezer ND, Gregory-Evans CY, Bhattacharya SS.
Cytogenet Cell Genet 92(3-4):353. No abstract available. 2001
Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis.
Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JA, Strasser A, Johnson EM.
Neuron 29(3):615-28. 2001
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A.
Mol Cell 3(3):287-96. 1999
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A.
Science 286(5445):1735-8. 1999
BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members.
Hsu SY, Lin P, Hsueh AJ.
Mol Endocrinol 12(9):1432-40. 1998
Bim: a novel member of the Bcl-2 family that promotes apoptosis.
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC.
EMBO J 17(2):384-95. 1998