Citations for
1BCL2L1, PRKN
Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.
Gong Y, Schumacher SE, Wu WH, Tang F, Beroukhim R, Chan TA.
Neoplasia 19(2):75-83. doi: 10.1016/j.neo.2016.12.006. Epub 2016 Dec 27. 2017
2BCL2, BCL2L1, MCL1, SUFU
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L.
Nat Cell Biol 19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25. 2017
3BCL2L1, DNM1L, PGAM5
Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury.
Yang C, Liu X, Yang F, Zhang W, Chen Z, Yan D, You Q, Wu X.
In Vitro Cell Dev Biol Anim 53(3):248-257. doi: 10.1007/s11626-016-0105-2. Epub 2016 Nov 4. 2017
4BCL2L1
Caspase-3-dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells.
Vardaki I, Sanchez C, Fonseca P, Olsson M, Chioureas D, Rassidakis G, Ullén A, Zhivotovsky B, Björkholm M, Panaretakis T.
Blood 128(23):2655-2665. Epub 2016 Oct 14. 2016
5BCL2L1
Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors.
Nakamura A, Swahari V, Plestant C, Smith I, McCoy E, Smith S, Moy SS, Anton ES, Deshmukh M.
J Neurosci 36(20):5448-61. doi: 10.1523/JNEUROSCI.4247-15.2016. 2016
6BCL2L1
Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL.
Yao Y, Nisan D, Fujimoto LM, Antignani A, Barnes A, Tjandra N, Youle RJ, Marassi FM.
Protein Expr Purif 122:56-63. doi: 10.1016/j.pep.2016.02.010. Epub 2016 Feb 23. 2016
7ATM, BCL2L1, PACS2
PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage.
Barroso-González J, Auclair S, Luan S, Thomas L, Atkins KM, Aslan JE, Thomas LL, Zhao J, Zhao Y, Thomas G.
Cell Death Differ 23(9):1448-57. doi: 10.1038/cdd.2016.23. Epub 2016 Mar 4. 2016
8BAX, BCL2L1
Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737.
Renault TT, Teijido O, Missire F, Ganesan YT, Velours G, Arokium H, Beaumatin F, Llanos R, Athané A, Camougrand N, Priault M, Antonsson B, Dejean LM, Manon S.
Int J Biochem Cell Biol 64:136-46. doi: 10.1016/j.biocel.2015.03.020. Epub 2015 Apr 8. 2015
9BCL2L1
Conformation of BCL-XL upon Membrane Integration.
Yao Y, Fujimoto LM, Hirshman N, Bobkov AA, Antignani A, Youle RJ, Marassi FM.
J Mol Biol 427(13):2262-70. doi: 10.1016/j.jmb.2015.02.019. Epub 2015 Feb 27. 2015
10BCL2L1, TNFRSF21
Bcl-xL is necessary for neurite outgrowth in hippocampal neurons.
Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA.
Antioxid Redox Signal 22(2):93-108. doi: 10.1089/ars.2013.5570. 2015
11BCL2L1
PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL.
Busca A, Saxena M, Iqbal S, Angel J, Kumar A.
J Leukoc Biol 96(6):1011-22. doi: 10.1189/jlb.1A0414-212R. Epub 2014 Sep 15. 2014
12BCL2L1, FUNDC1, PGAM5
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.
Wu H, Xue D, Chen G, Han Z, Huang L, Zhu C, Wang X, Jin H, Wang J, Zhu Y, Liu L, Chen Q.
Autophagy 10(10):1712-25. doi: 10.4161/auto.29568. Epub 2014 Jul 17. 2014
13BCL2L1, SYK
Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.
Wang WH, Childress MO, Geahlen RL.
Mol Cell Biol 34(20):3788-99. doi: 10.1128/MCB.00937-14. Epub 2014 Aug 4. 2014
14BCL2L1, CD1D
Bcl-xL regulates CD1d-mediated antigen presentation to NKT cells by altering CD1d trafficking through the endocytic pathway.
Subrahmanyam PB, Carey GB, Webb TJ.
J Immunol 193(5):2096-105. doi: 10.4049/jimmunol.1400155. Epub 2014 Jul 28. 2014
15BCL2L1, DDIT3
Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation.
Gaudette BT, Iwakoshi NN, Boise LH.
J Biol Chem 289(34):23629-40. doi: 10.1074/jbc.M114.569376. Epub 2014 Jul 14. 2014
16BCL2L1, TP53
The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Follis AV, Llambi F, Ou L, Baran K, Green DR, Kriwacki RW.
Nat Struct Mol Biol 21(6):535-43. doi: 10.1038/nsmb.2829. Epub 2014 May 11. 2014
17BCL2L1
Functions of BCL-X L at the Interface between Cell Death and Metabolism.
Michels J, Kepp O, Senovilla L, Lissa D, Castedo M, Kroemer G, Galluzzi L.
Int J Cell Biol 2013:705294. doi: 10.1155/2013/705294. Epub 2013 Feb 28. 2013
18ATXN3, BAX, BCL2L1, MJD
Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-XL and Bax.
Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z, Wang G.
Neuroscience 243:14-21. doi: 10.1016/j.neuroscience.2013.03.047. Epub 2013 Apr 2. 2013
19BCL2, BCL2L1, HSPA9
Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.
Saxena N, Katiyar SP, Liu Y, Grover A, Gao R, Sundar D, Kaul SC, Wadhwa R.
Biosci Rep 33(5). pii: e00073. doi: 10.1042/BSR20130034. 2013
20BCL2L1
Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.
Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.
Cell Death Differ 19(11):1856-69. doi: 10.1038/cdd.2012.88. Epub 2012 Jul 13. 2012
21BCL2L1
Co-regulation of survival of motor neuron and Bcl-xL expression: implications for neuroprotection in spinal muscular atrophy.
Anderton RS, Price LL, Turner BJ, Meloni BP, Mitrpant C, Mastaglia FL, Goh C, Wilton SD, Boulos S.
Neuroscience 220:228-36. doi: 10.1016/j.neuroscience.2012.06.042. Epub 2012 Jun 23. 2012
22BCL2L1
Identification of novel potent inhibitors against Bcl-xL anti-apoptotic protein using docking studies.
Shipra G, Gauri M, Chandra PM, Kishore SP.
Protein Pept Lett 19(12):1302-17. 2012
23BCL2L1, VDAC1
Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein.
Arbel N, Ben-Hail D, Shoshan-Barmatz V.
J Biol Chem 287(27):23152-61. doi: 10.1074/jbc.M112.345918. Epub 2012 May 15. 2012
24BCL2L1
Identification of a novel cis-element that regulates alternative splicing of Bcl-x pre-mRNA.
Lee J, Zhou J, Zheng X, Cho S, Moon H, Loh TJ, Jo K, Shen H.
Biochem Biophys Res Commun 420(2):467-72. doi: 10.1016/j.bbrc.2012.03.029. Epub 2012 Mar 13. 2012
25BCL2L1, MCL1
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT.
Blood 119(24):5850-8. doi: 10.1182/blood-2011-12-398834. Epub 2012 Feb 28. 2012
26BCL2L1
Developing and activated T cell survival depends on differential signaling pathways to regulate anti-apoptotic Bcl-x(L).
Wang R, Xie H, Huang Z, Shang W, Sun Z.
Clin Dev Immunol 2012:632837. doi: 10.1155/2012/632837. Epub 2011 Dec 26. Review. 2012
27BCL2L1
Amyloid fibrils formed by the programmed cell death regulator Bcl-xL.
Chenal A, Vendrely C, Vitrac H, Karst JC, Gonneaud A, Blanchet CE, Pichard S, Garcia E, Salin B, Catty P, Gillet D, Hussy N, Marquette C, Almunia C, Forge V.
J Mol Biol 415(3):584-99. doi: 10.1016/j.jmb.2011.11.024. Epub 2011 Nov 19. 2012
28BCL2L1, PMAIP1
The Bcl-2 proteins Noxa and Bcl-xL co-ordinately regulate oxidative stress-induced apoptosis.
Eno CO, Zhao G, Olberding KE, Li C.
Biochem J 444(1):69-78. doi: 10.1042/BJ20112023. 2012
29BCL2L1, TCERG1
TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.
Montes M, Cloutier A, Sánchez-Hernández N, Michelle L, Lemieux B, Blanchette M, Hernández-Munain C, Chabot B, Suńé C.
Mol Cell Biol 32(4):751-62. doi: 10.1128/MCB.06255-11. Epub 2011 Dec 12. 2012
30BCL2L1, BIRC5, CTNNB1, TBX5, YAP1, YES1
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo CJ, Goessling W, Hahn WC.
Cell 151(7):1457-73. doi: 10.1016/j.cell.2012.11.026. Epub 2012 Dec 13. Erratum in: Cell. 2013 Mar 28;153(1):267-70. 2012
31BAX, BCL2L1, MCL1
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.
Czabotar PE, Lee EF, Thompson GV, Wardak AZ, Fairlie WD, Colman PM.
J Biol Chem 286(9):7123-31. Epub 2011 Jan 3. 2011
32BCL2L1, BCL2L11, TARDBP
TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
Suzuki H, Lee K, Matsuoka M.
J Biol Chem 286(15):13171-83. Epub 2011 Feb 21. 2011
33BACH2, BCL2L1
A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1.
Türkmen S, Riehn M, Klopocki E, Molkentin M, Reinhardt R, Burmeister T.
Genes Chromosomes Cancer 50(6):389-96. doi: 10.1002/gcc.20863. Epub 2011 Mar 15. 2011
34BCL2L1, ROMO1
Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1.
Lee SB, Kim HJ, Shin J, Kang ST, Kang S, Yoo YD.
Oncol Rep 25(5):1337-42. doi: 10.3892/or.2011.1210. Epub 2011 Mar 8. 2011
35BCL2L1, HEBP2
Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.
Ambrosi E, Capaldi S, Bovi M, Saccomani G, Perduca M, Monaco HL.
Biochem J 438(2):291-301. 2011
36BCL2L1
Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL.
Ospina A, Lagunas-Martínez A, Pardo J, Carrodeguas JA.
FEBS Lett 585(19):2935-42. doi: 10.1016/j.febslet.2011.08.012. Epub 2011 Aug 16. 2011
37BCL2L1, HRK
Deficiency of pro-apoptotic Hrk attenuates programmed cell death in the developing murine nervous system but does not affect Bcl-x deficiency-induced neuron apoptosis.
Ghosh AP, Cape JD, Klocke BJ, Roth KA.
J Histochem Cytochem 59(11):976-83. doi: 10.1369/0022155411424311. 2011
38BCL2L1, PARK7
Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL.
Ren H, Fu K, Wang D, Mu C, Wang G.
J Biol Chem 286(40):35308-17. doi: 10.1074/jbc.M110.207134. Epub 2011 Aug 18. 2011
39BCL2L1, MCL1
Mcl-1 is essential for germinal center formation and B cell memory.
Vikstrom I, Carotta S, Lüthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM.
Science 330(6007):1095-9. Epub 2010 Oct 7. 2010
40BCL2L1, ROMO1
TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L).
Kim JJ, Lee SB, Park JK, Yoo YD.
Cell Death Differ 17(9):1420-34. Epub 2010 Mar 5. 2010
41BCL2L1, HEBP2
Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein.
Szigeti A, Hocsak E, Rapolti E, Racz B, Boronkai A, Pozsgai E, Debreceni B, Bognar Z, Bellyei S, Sumegi B, Gallyas F Jr.
J Biol Chem 285(3):2140-51. Epub 2009 Nov 9. 2010
42BCL2L1, PLK1
Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis.
Tamura Y, Simizu S, Muroi M, Takagi S, Kawatani M, Watanabe N, Osada H.
Oncogene 28(1):107-16. Epub 2008 Sep 29. 2009
43BCL2L1, BIRC5
Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression.
Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, Wu Y, Croft M, Song J.
J Immunol 182(11):6744-52.PMID: 19454669 2009
44BCL2L1, BNIP3
Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.
Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.
J Biol Chem 283(39):26499-508. Epub 2008 Jul 16. 2008
45BCL2L1
Distinct promoters mediate constitutive and inducible Bcl-XL expression in malignant lymphocytes.
Habens F, Lapham AS, Dallman CL, Pickering BM, Michels J, Marcusson EG, Johnson PW, Packham G.
Oncogene 26(13):1910-9. Epub 2006 Sep 18. 2007
46BCL2, BCL2L1, CASP1, CASP5, NLRP1
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Bruey JM, Bruey-Sedano N, Luciano F, Zhai D, Balpai R, Xu C, Kress CL, Bailly-Maitre B, Li X, Osterman A, Matsuzawa S, Terskikh AV, Faustin B, Reed JC.
Cell 129(1):45-56. 2007
47BCL2L1
Loss of BCL-XL in Rod Photoreceptors: Increased Susceptibility to Bright Light Stress.
Zheng L, Anderson RE, Agbaga MP, Rucker EB 3rd, Le YZ.
Invest Ophthalmol Vis Sci 47(12):5583-9. 2006
48BCL2L1
Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease.
Hartmann A, Mouatt-Prigent A, Vila M, Abbas N, Perier C, Faucheux BA, Vyas S, Hirsch EC.
Neurobiol Dis 10(1):28-32. 2002
49BCL2L1
Mutation of bcl-x gene in non-Hodgkin's lymphoma.
Yamaguchi H, Inokuchi K, Tarusawa M, Dan K.
Am J Hematol 69(1):74-6. 2002
50BCL2L1
Identification of a novel human BCL-X promoter and exon.
MacCarthy-Morrogh L, Wood L, Brimmell M, Johnson PW, Packham G.
Oncogene 19(48):5534-8. 2000
51BCL2, BCL2L1, BLK
Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
Hegde R, Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES.
J Biol Chem 273(14):7783-6. 1998