Citations for
1BCL2, SAV1, STK3
Mammalian Hippo kinase pathway is downregulated by BCL-2 via protein degradation.
Won GW, Park SH, Park J, Lee Y, Lee YH.
Biochem Biophys Res Commun. Apr 23;512(1):87-92. doi: 10.1016/j.bbrc.2019.03.015. Epub 2019 Mar 11 2019
2BCL2, BCL2L1, MCL1, SUFU
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L.
Nat Cell Biol 19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25. 2017
3BCL2, SEPTIN4, XIAP
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.
Edison N, Curtz Y, Paland N, Mamriev D, Chorubczyk N, Haviv-Reingewertz T, Kfir N, Morgenstern D, Kupervaser M, Kagan J, Kim HT, Larisch S.
Cell Rep 21(2):442-454. doi: 10.1016/j.celrep.2017.09.052. 2017
4BCL2, DACH1
Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion in pancreatic cancer.
Bu XN, Qiu C, Wang C, Jiang Z.
Oncol Rep 36(2):745-54. doi: 10.3892/or.2016.4843. 2016
5ANKRD1, BCL2
Cardiac ankyrin repeat protein attenuates cardiomyocyte apoptosis by upregulation of Bcl-2 expression.
Zhang N, Ye F, Zhu W, Hu D, Xiao C, Nan J, Su S, Wang Y, Liu M, Gao K, Hu X, Chen J, Yu H, Xie X, Wang J.
Biochim Biophys Acta 1863(12):3040-3049. doi: 10.1016/j.bbamcr.2016.09.024. Epub 2016 Oct 3. 2016
6BCL2, EXOC3, EXOC4, MCL1
Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.
Tanaka T, Kikuchi N, Goto K, Iino M.
Apoptosis 21(5):594-608. doi: 10.1007/s10495-016-1230-9. 2016
7BCL2, PINK1, PRKN
Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy.
Hollville E, Carroll RG, Cullen SP, Martin SJ.
Mol Cell 55(3):451-66. doi: 10.1016/j.molcel.2014.06.001. Epub 2014 Jul 3. 2014
8BCL2, GPR65
Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL Microenvironment.
Rosko AE, McColl KS, Zhong F, Ryder CB, Chang MJ, Sattar A, Caimi PF, Hill BT, Al-Harbi S, Almasan A, Distelhorst CW.
J Leuk (Los Angel) 2(5). pii: 160. 2014
9BCL2, FKBP8
Mitochondria: FKBP38 and mitochondrial degradation.
Shirane-Kitsuji M, Nakayama KI.
Int J Biochem Cell Biol 51:19-22. doi: 10.1016/j.biocel.2014.03.007. Epub 2014 Mar 20. Review. 2014
10BCL2, ZFP36L1
Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells.
Zekavati A, Nasir A, Alcaraz A, Aldrovandi M, Marsh P, Norton JD, Murphy JJ.
PLoS One. Jul 11;9(7):e102625. doi: 10.1371/journal.pone.0102625. eCollection 2014 2014
11BCL2, BECN1, SQSTM1
Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro.
Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH.
Acta Pharmacol Sin 34(5):651-6. doi: 10.1038/aps.2013.12. Epub 2013 Apr 8. 2013
12BCL2, RRM2
RRM2 regulates Bcl-2 in head and neck and lung cancers: a potential target for cancer therapy.
Rahman MA, Amin AR, Wang D, Koenig L, Nannapaneni S, Chen Z, Wang Z, Sica G, Deng X, Chen ZG, Shin DM.
Clin Cancer Res 19(13):3416-28. doi: 10.1158/1078-0432.CCR-13-0073. Epub 2013 May 29. 2013
13BCL2, GABARAP
Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.
Ma P, Schwarten M, Schneider L, Boeske A, Henke N, Lisak D, Weber S, Mohrlüder J, Stoldt M, Strodel B, Methner A, Hoffmann S, Weiergräber OH, Willbold D.
J Biol Chem 288(52):37204-15. doi: 10.1074/jbc.M113.528067. Epub 2013 Nov 15. 2013
14BCL2, FKBP8
Functional role of the flexible N-terminal extension of FKBP38 in catalysis.
Kang C, Ye H, Chia J, Choi BH, Dhe-Paganon S, Simon B, Schütz U, Sattler M, Yoon HS.
Sci Rep 3:2985. doi: 10.1038/srep02985. 2013
15BCL2, FKBP8
Selective escape of proteins from the mitochondria during mitophagy.
Saita S, Shirane M, Nakayama KI.
Nat Commun 4:1410. doi: 10.1038/ncomms2400. 2013
16BCL2, BCL2L1, HSPA9
Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.
Saxena N, Katiyar SP, Liu Y, Grover A, Gao R, Sundar D, Kaul SC, Wadhwa R.
Biosci Rep 33(5). pii: e00073. doi: 10.1042/BSR20130034. 2013
17BCL2, KEAP1, NFE2L2
Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
Niture SK, Jaiswal AK.
J Biol Chem 287(13):9873-86. doi: 10.1074/jbc.M111.312694. Epub 2012 Jan 24. 2012
18BCL2
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B.
Nature 481(7382):511-5. doi: 10.1038/nature10758. Erratum in: Nature. 2013 Nov 7:503(7474):146. 2012
19BCL2, FKBP8
The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.
Haupt K, Jahreis G, Linnert M, Maestre-Martínez M, Malesevic M, Pechstein A, Edlich F, Lücke C.
J Biol Chem 287(23):19665-73. doi: 10.1074/jbc.M111.317214. Epub 2012 Apr 20. 2012
20BCL2, BMP7, FGFR2, HOXC6, PDGFRA
HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression.
Moon SM, Kim SA, Yoon JH, Ahn SG.
J Biol Chem 287(42):35678-88. doi: 10.1074/jbc.M112.361675. Epub 2012 Aug 15. 2012
21BCL2
A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum.
Lian J, Wu X, He F, Karnak D, Tang W, Meng Y, Xiang D, Ji M, Lawrence TS, Xu L.
Cell Death Differ. 18(1):60-71. 2011
22ATF5, BCL2
BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner.
Dluzen D, Li G, Tacelosky D, Moreau M, Liu DX.
J Biol Chem 286(9):7705-13. Epub 2011 Jan 6. 2011
23BCL2, LGALS7
Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells.
Villeneuve C, Baricault L, Canelle L, Barboule N, Racca C, Monsarrat B, Magnaldo T, Larminat F.
Mol Biol Cell 22(7):999-1013. Epub 2011 Feb 2. 2011
24AMBRA1, BCL2
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.
Strappazzon F, Vietri-Rudan M, Campello S, Nazio F, Florenzano F, Fimia GM, Piacentini M, Levine B, Cecconi F.
EMBO J 30(7):1195-208. Epub 2011 Feb 25. 2011
25BCL2, BRCA1
Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes.
Laulier C, Barascu A, Guirouilh-Barbat J, Pennarun G, Le Chalony C, Chevalier F, Palierne G, Bertrand P, Verbavatz JM, Lopez BS.
Cancer Res 71(10):3590-602. Epub 2011 Mar 28. 2011
26BCL2, SATB1
The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR.
Gong F, Sun L, Wang Z, Shi J, Li W, Wang S, Han X, Sun Y.
Nucleic Acids Res 39(11):4640-52. Epub 2011 Feb 9. 2011
27BCL2
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy.
Kelly PN, Strasser A.
Cell Death Differ 18(9):1414-24. doi: 10.1038/cdd.2011.17. Epub 2011 Mar 18. Review. 2011
28ATG12, BCL2, MCL1
The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis.
Rubinstein AD, Eisenstein M, Ber Y, Bialik S, Kimchi A.
Mol Cell 44(5):698-709. doi: 10.1016/j.molcel.2011.10.014. 2011
29BCL2, FKBP8
FKBP38 protects Bcl-2 from caspase-dependent degradation.
Choi BH, Feng L, Yoon HS.
J Biol Chem 285(13):9770-9. Epub 2010 Feb 5. 2010
30BCL2, RORA
Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain.
Nguyen A, Rauch TA, Pfeifer GP, Hu VW.
FASEB J 24(8):3036-51. Epub 2010 Apr 7.PMID: 20375269 2010
31ALS1, BCL2, SOD1
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.
Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P.
Hum Mol Genet 19(15):2974-86. Epub 2010 May 11.PMID: 20460269 2010
32BCL2
The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression.
Shahid R, Bugaut A, Balasubramanian S.
Biochemistry 49(38):8300-6. 2010
33BCL2, PRKN
Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.
Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G.
J Biol Chem 285(49):38214-23. Epub 2010 Oct 2. 2010
34BCL2, MDM4, TP53
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta F, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F.
EMBO J 28(13):1926-39. Epub 2009 Jun 11. 2009
35BCL2, BCL6, PIAS2
BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma.
Saito M, Novak U, Piovan E, Basso K, Sumazin P, Schneider C, Crespo M, Shen Q, Bhagat G, Califano A, Chadburn A, Pasqualucci L, Dalla-Favera R.
Proc Natl Acad Sci U S A 106(27):11294-9. Epub 2009 Jun 23. 2009
36BAK1, BCL2
Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.
Dai H, Meng XW, Lee SH, Schneider PA, Kaufmann SH.
J Biol Chem 284(27):18311-22. Epub 2009 Apr 7.PMID: 19351886 2009
37BCL2, ELAVL1
Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.
Ishimaru D, Ramalingam S, Sengupta TK, Bandyopadhyay S, Dellis S, Tholanikunnel BG, Fernandes DJ, Spicer EK.
Mol Cancer Res 7(8):1354-66. Epub 2009 Aug 11.PMID: 19671677 2009
38BCL2, HNRNPL
hnRNP L binds to CA repeats in the 3'UTR of bcl-2 mRNA.
Lee DH, Lim MH, Youn DY, Jung SE, Ahn YS, Tsujimoto Y, Lee JH.
Biochem Biophys Res Commun 382(3):583-7. doi: 10.1016/j.bbrc.2009.03.069. Epub 2009 Mar 17. 2009
39BCL2, TP53BP2
Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.
Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Iosub A, Refaely H, Dines M, Bronner V, Bravman T, Shalev DE, Rüdiger S, Friedler A.
Proc Natl Acad Sci U S A 105(34):12277-82. Epub 2008 Aug 21. 2008
40BCL2
P53 and bcl-2 assessment in serous ovarian carcinoma.
Palmer JE, Sant Cassia LJ, Irwin CJ, Morris AG, Rollason TP.
Int J Gynecol Cancer 18(2):241-8. 2008
41BCL2, BECN1
The autophagy effector Beclin 1: a novel BH3-only protein.
Sinha S, Levine B.
Oncogene 27 Suppl 1:S137-48. Review. 2008
42BCL2, DLEC1, HOXA1, HOXA10, KL, NR3C1, SEZ6L, SFRP4, SFRP5, SMAD9, TWIST1
DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis.
Kang GH, Lee S, Cho NY, Gandamihardja T, Long TI, Weisenberger DJ, Campan M, Laird PW.
Lab Invest 88(2):161-70. Epub 2007 Dec 24. 2008
43BCL2, BCL3
BCL2 and BCL3 are recurrent translocation partners of the IGH locus.
Szymanowska N, Klapper W, Gesk S, Küppers R, Martín-Subero JI, Siebert R.
Cancer Genet Cytogenet 186(2):110-4.PMID: 18940474 2008
44BCL2, MKI67, TP53
Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix.
Looi ML, Dali AZ, Ali SA, Ngah WZ, Yusof YA.
Anal Quant Cytol Histol 30(2):63-70. 2008
45BCL2, BCL2L1, CASP1, CASP5, NLRP1
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Bruey JM, Bruey-Sedano N, Luciano F, Zhai D, Balpai R, Xu C, Kress CL, Bailly-Maitre B, Li X, Osterman A, Matsuzawa S, Terskikh AV, Faustin B, Reed JC.
Cell 129(1):45-56. 2007
46BCL2, ZBTB17
BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis.
Patel JH, McMahon SB.
J Biol Chem 282(1):5-13. Epub 2006 Nov 1. 2007
47BCL2
Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region.
Bredow S, Juri DE, Cardon K, Tesfaigzi Y.
Gene 404(1-2):110-6. Epub 2007 Sep 14. 2007
48AKT1, BCL2
BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer.
Mortenson MM, Galante JG, Gilad O, Schlieman MG, Virudachalam S, Kung HJ, Bold RJ.
J Cell Biochem 102(5):1171-9.PMID: 17960583 2007
49IL6, BCL2, ADCYAP1
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.
Ohtaki H, Nakamachi T, Dohi K, Aizawa Y, Takaki A, Hodoyama K, Yofu S, Hashimoto H, Shintani N, Baba A, Kopf M, Iwakura Y, Matsuda K, Arimura A, Shioda S.
Proc Natl Acad Sci U S A 103(19):7488-93. Epub 2006 May 1. 2006
50BCL2, GATA4
Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo.
Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, Liang Q.
FASEB J 20(6):800-2. Epub 2006 Feb 9. 2006
51MDC1A, BCL2
Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice.
Dominov JA, Kravetz AJ, Ardelt M, Kostek CA, Beermann ML, Miller JB.
Hum Mol Genet 14(8):1029-40. Epub 2005 Mar 9. 2005
52PSEN1, PSEN2, BCL2, FKBP8
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.
Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M.
Hum Mol Genet 14(13):1889-902. Epub 2005 May 19. 2005
53BCL2, BECN1
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B.
Cell 122(6):927-39. 2005
54BCL2
Bcl-2 as prognostic factor in head and neck squamous cell carcinoma.
Lo Muzio L, Falaschini S, Farina A, Rubini C, Pezzetti F, Campisi G, De Rosa G, Capogreco M, Carinci F.
Oncol Res 15(5):249-55. 2005
55BCL2
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC.
Mol Cell. 17(3):393-403. 2005
56BCL2
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.
Chen R, Valencia I, Zhong F, McColl KS, Roderick HL, Bootman MD, Berridge MJ, Conway SJ, Holmes AB, Mignery GA, Velez P, Distelhorst CW.
J Cell Biol 166(2):193-203. 2004
57BCL2, RIPK2
Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation.
Ruefli-Brasse AA, Lee WP, Hurst S, Dixit VM.
J Biol Chem 279(2):1570-4. Epub 2003 Nov 24. 2004
58BCL2
Nuclear partners of Bcl-2: Bax and PML.
Hoetelmans RW.
DNA Cell Biol. 23(6):351-4. 2004
59BCL2, BNIP2, BNIPL, GFER, MIF
BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L,Wan D, Gu J.
Biochem Biophys Res Commun 308(2):379-85. 2003
60BCL2
Deletion of the BH1 domain of Bcl-2 accelerates apoptosis by acting in a dominant negative fashion.
Kawatani M, Imoto M.
J Biol Chem 278(22):19732-42. Epub 2003 Mar 18. 2003
61BCL2
Expression of bcl-2 protein is associated with shorter survival in nonsmall cell lung carcinoma.
Huang CI, Neuberg D, Johnson BE, Wei JY, Christiani DC.
Cancer 98(1):135-43. 2003
62FKBP8, BCL2
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
Shirane M, Nakayama KI.
Nat Cell Biol 5(1):28-37. 2003
63BCL2, CDKN2A, MYC, RB1, TSG3B
Cytogenetics and molecular genetics of lung cancer.
Mitsuuchi Y, Testa JR.
Am J Med Genet 115(3):183-8. 2002
64BCL2, VEGFA
VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells.
Beierle EA, Strande LF, Chen MK.
J Pediatr Surg 37(3):467-71. 2002
65BCL2
Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells.
Fenton JA, Vaandrager JW, Aarts WM, Bende RJ, Heering K, van Dijk M, Morgan G, van Noesel CJ, Schuuring E, Kluin PM.
Blood 99(2):716-8. 2002
66BCL2, PIN1
Proteasomal degradation of human peptidyl prolyl isomerase pin1-pointing phospho Bcl2 toward dephosphorylation.
Basu A, Das M, Qanungo S, Fan XJ, DuBois G, Haldar S.
Neoplasia. 4(3):218-27 2002
67BCL2
Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a.
Song D, Sakamoto S, Taniguchi T.
Biochemistry. 41(3):929-34. 2002
68BCL2, RAD51
A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway.
Saintigny Y, Dumay A, Lambert S, Lopez BS.
EMBO J 20(10):2596-2607. 2001
69BCL2, CASP9, DIABLO
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
Adrain C, Creagh EM, Martin SJ.
EMBO J 20(23):6627-36. 2001
70BCL2, CCNA1, CCNB1, CCND1, CDKN1A, CDKN2A, MKI67, RB1
Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus.
Kanavaros P, Stefanaki K, Rontogianni D, Papalazarou D, Sgantzos M, Arvanitis D, Vamvouka C, Gorgoulis V, Siatitsas I, Agnantis NJ, Bai M.
Histol Histopathol 16(4):1005-12. 2001
71BCL2
Bcl-2 targets protein phosphatase 1 alpha to Bad.
Ayllón V, Cayla X, García A, Roncal F, Fernández R, Albar JP, Martínez C, Rebollo A.
J Immunol. 166(12):7345-52. 2001
72BCL2, BNIP3
BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites.
Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH.
J Biol Chem 275(2):1439-48. 2000
73BCL2, DCC
Chromosome 18 breakpoint in t(11;18)(q21;q21) translocation associated with MALT lymphoma is proximal to BCL2 and distal to DCC.
Stoffel A, et al.
Genes Chromosomes Cancer 24 : 156-159. 1999
74BCL2
Deletion of the loop region of bcl-2 completely blocks paclitaxel-induced apoptosis.
Srivastava RK, et al.
Proc Natl Acad Sci U S A 96(7):3775-80. 1999
75BCL2
Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade.
Liu YZ, et al.
Nucleic Acids Res 27(10):2086-2090. 1999
76BAK1, BAX, BCL2
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC.
Shimizu S, et al.
Nature 399(6735):483-7. 1999
77BCL2, BCLAF1, TSG6F
Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins.
Kasof GM, et al.
Mol Cell Biol 19(6):4390-404. 1999
78BCL2, BCL6, MYC
Concurrent chromosomal alterations at 3q27, 8q24 and 18q21 in B-cell lymphomas.
Au WY, et al.
Br J Haematol 105(2):437-40. 1999
79BIRC5, BAX, BCL2
Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.
Saitoh Y, et al.
Int J Oncol 15(1):137-41 1999
80BCL2, BCL6
Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities.
Skinnider BF, et al.
Hum Pathol 30(7):803-8 1999
81BCL2, BNIP3L
Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability.
Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y.
Oncogene 18(32):4523-9 1999
82BCL2
Bcl-2 oncogene (B cell lymphoma/leukemia-2) levels correlate with systemic lupus erythematosus disease activity.
Miret C, Font J, Molina R, Garcia-Carrasco M, Filella X, Ramos M, Cervera R, Ballesta A, Ingelmo M.
Anticancer Res 19(4B):3073-6. 1999
83BCL2, BNIP1
Novel BNIP1 variants and their interaction with BCL2 family members.
Zhang H, Heim J, Meyhack B.
FEBS Lett 448(1):23-7. 1999
84BCL2, PSEN1
Presenilin 1 protein directly interacts with Bcl-2.
Alberici A, Moratto D, Benussi L, Gasparini L, Ghidoni R, Gatta LB, Finazzi D, Frisoni GB, Trabucchi M, Growdon JH, Nitsch RM, Binetti G.
J Biol Chem. 274(43):30764-9. 1999
85BCL2
Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.
Rebollo A, Pérez-Sala D, Martínez-A C.
Oncogene. 18(35):4930-9. 1999
86BCL2
Focal adhesion kinase, paxillin, and bcl-2: analysis of expression, phosphorylation, and association during morphogenesis.
Sorenson CM, Sheibani N.
Dev Dyn. 215(4):371-82. 1999
87BCL2
Refinement of the BCL2/immunoglobulin heavy chain fusion gene in t(14;18)(q32;q21) by polymerase chain reaction amplification for long targets.
Akasaka T, Akasaka H, Yonetani N, Ohno H, Yamabe H, Fukuhara S, Okuma M.
Genes Chromosomes Cancer 21(1):17-29. 1998
88BCL2, BCL8, BRINP1, CDK4, GLI1, MDM2, MYC, REL
Chromosomal and gene amplification in diffuse large B-cell lymphoma.
Rao PH, et al.
Blood 92 : 234-240. 1998
89BAK1, BAX, BCL2, BCL2L2, BID, BNIP3L
The Bcl-2 protein family : arbiters of cell survival.
Adams JM, et al.
Science 281 : 1322-1326. 1998
90BAX, BCL2, CDK2
A link between cell cycle and cell death : Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.
Gil-Gomez G, Berns A, Brady HJ.
EMBO J 17 : 7209-7218. 1998
91BAK1, BAX, BCL2A1, BCL2, BID
BCL-2 family members in the development and degenerative pathologies of the nervous system.
Sadoul R.
Cell Death Differ 5 : 805-815. 1998
92BCL2
bcl-2 protein expression in endometrial carcinoma: the lack of correlation with p53.
Miturski R, et al.
Cancer Lett 133(1):63-9. 1998
93BCL2
Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase.
Srivastava RK, et al.
Mol Cell Biol 18(6):3509-17. 1998
94BCL2, BCL2L1, BLK
Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
Hegde R, Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES.
J Biol Chem 273(14):7783-6. 1998
95BCL2
The bcl-2 family member, bcl2al,maps to mouse chromosome 9 and human chromosome 15.
Lin EY, et al.
Mamm Genome 8 : 293-294. 1997
96BCL2
Detection of somatic mutations of the bcl-2 oncogene in B cell lymphomas with the t(14;18).
Pappa VI, et al.
Int J Oncol 11 : 481-488. 1997
97BCL2, SMN1
Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy.
Iwahashi H, et al.
Nature 390 : 413-417. 1997
98BCL2
harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).
Inohara N, Ding L, Chen S, Núńez G.
EMBO J. 16(7):1686-94. 1997
99BCAP31, BCL2
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.
Ng FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, Shore GC.
J Cell Biol. 139(2):327-38. 1997
100BCL2
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2.
Paumen MB, Ishida Y, Han H, Muramatsu M, Eguchi Y, Tsujimoto Y, Honjo T.
Biochem Biophys Res Commun. 231(3):523-5. 1997
101BCL2
Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.
Shibasaki F, Kondo E, Akagi T, McKeon F.
Nature. 386(6626):728-31. 1997
102BCL2, RUNX1, RUNX1T1
The AML1/ETO fusion protein activates transcription of BCL-2.
Klampfer L, et al.
Proc Natl Acad Sci U S A 93 : 14059-14064. 1996
103BCL2
The BCL2 major breakpoint region is a sequence- and cell-cycle-specific binding site of the Ku antigen.
DiCroce PA, et al.
Proc Natl Acad Sci U S A 92 : 10137-10141. 1995
104BCL2
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with bax.
Yin XM, et al.
Nature 369 : 321-323. 1994
105BCL2
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.
Hengartner MO, Horvitz HR.
Cell 76(4):665-76. 1994
106BCL2
A submicroscopic interstitial deletion of chromosome 14 frequently occurs adjacent to the t(14;18) translocation breakpoint in human follicular lymphoma.
Zelenetz AD, et al.
Genes Chromosomes Cancer 6 : 140-150. 1993
107BCL2
A frequent EcoRI polymorphism in the bcl-2 gene.
Ghia P, et al.
Hum Genet 91 : 513. 1993
108BCL2
t(11;18)(q21;q21) may delineate a spectrum of diffuse small B-cell lymphoma with extranodal involvement.
Leroux D, et al.
Genes Chromosomes Cancer 7 : 54-56. 1993
109BCL2
The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis.
Allsopp TE, et al.
Cell 73(2):295-307. 1993
110BCL2
Cytogenetic 2;18 and 18;22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl-2 and immunoglobulin light chain genes.
Tashiro S, et al.
Oncogene 7 : 573-577. 1992
111BCL2
t(14;18) and BCL-2 gene rearrangement in a B-chronic lymphocytic leukaemia.
Jonveaux P, et al.
Br J Haematol 81 : 620-621. 1992
112BCL2
Direct sequence analysis of the t(14;18) chromosomal translocation in Hodgkin's disease.
Gupta RK, et al.
Blood 79 : 2084-2088. 1992
113BCL2
Correlation between cytogenetic and molecular analysis of t(14;18) in follicular lymphomas.
Benitez J, et al.
Cancer Genet Cytogenet 59 : 68-72. 1992
114BCL2
Detection of residual disease in translocation (14;18) positive non-Hodgkin's lymphoma, using the polymerase chain reaction : a comparison with conventional staging methods.
Lambrechts AC, et al.
Leukemia 6 : 29-34. 1992
115BCL2, IGHJ@
Expression of the bcl-2 oncogene product and chromosomal translocation t(14;18) in Hodgkin's disease.
Lorenzen J, et al.
Hum Pathol 23 : 1205-1209. 1992
116BCL2
BCL2 oncogene translocation is mediated by a khi-like consensus.
Wyatt RT, et al.
J Exp Med 175 : 1575-1588. 1992
117BCL2
The bcl-2 gene translocation is undetectable in Hodgkin's disease by southern blot hybridization and polymerase chain reaction.
Athan E, et al.
Am J Pathol 141 : 193-201. 1992
118BCL2
Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients.
Aster JC, et al.
Am J Pathol 141 : 291-299. 1992
119BCL2, IGHJ@
t(11;18)(q21;q21.1) : a recurring translocation in lymphomas of mucosa-associated lymphoid tissue (MALT)?
Horsman D, et al.
Genes Chromosomes Cancer 4 : 183-187. 1992
120BCL2
Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.
Tanaka S, et al.
Blood 79 : 229-237. 1992
121BCL2
Structural alterations in the 5' region of the BCL2 gene in follicular lymphomas with BCL2-MBR or BCL2-MCR rearrangements.
Mikraki V, et al.
Genes Chromosomes Cancer 3 : 117-121. 1991
122BCL2
Frequency and structure of t(14;18) major breakpoint regions in non-Hodgkin's lymphomas typed according to the Kiel classification : analysis by direct DNA sequencing.
Kneba M, et al.
Cancer Res 51 : 3243-3250. 1991
123BCL2
t(18;22)(q21;q11) with rearrangement of BCL2 as a possible secondary change in a lymphocytic lymphoma.
Leroux D, et al.
Genes Chromosomes Cancer 3 : 205-209. 1991
124BCL2
Bcl-2/Jh rearrangements in benign lymphoid tissues with follicular hyperplasia.
Limpens J, et al.
Oncogene 6 : 2271-2276. 1991
125BCL2
Molecular monitoring of low grade non-Hodgkin's lymphoma by gene amplification.
Hickish TF, et al.
Br J Cancer 64 : 1161-1163. 1991
126BCL2
G to A polymorphism in the second exon of the BCL2 gene.
Tanaka S, et al.
Nucleic Acids Res 19 : 1964. 1991
127BCL2
t(2;18) and t(18;22) variant chromosomal translocations and bcl-2 gene rearrangements in human malignant lymphomas.
Larsen CJ, et al.
Nouv Rev Fr Hematol 32 : 401-403. 1990
128BCL2
Small G proteins are expressed ubiquitously in lymphoid cells and do not correspond to Bcl-2.
Monica K, et al.
Nature 346 : 189-191. 1990
129BCL2
Direct sequence analysis of the 14q+ and 18q- chromosome junctions in follicular lymphoma.
Cotter F, et al.
Blood 76 : 131-135. 1990
130BCL2
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
Hockenbery D, et al.
Nature 348(6299):334-6. 1990
131BCL2
The bcl-2 gene encodes a novel G protein.
Haldar S, et al.
Nature 342 : 195-198. 1989
132BCL2
Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas.
Ngan BY, et al.
Blood 73 : 1759-1762. 1989
133BCL2
Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.
Crescenzi M, et al.
Proc Natl Acad Sci U S A 85 : 4869-4873. 1988
134BCL2
Evolution of B-cell malignancy : pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.
Gauwerky CE, et al.
Proc Natl Acad Sci U S A 85 : 8548-8552. 1988
135BCL2
The bcl-2 gene is rearranged in many diffuse B-cell lymphomas.
Aisenberg AC, et al.
Blood 71 : 969-972. 1988
136BCL2
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.
Vaux DL, et al.
Nature 335(6189):440-2. 1988
137BCL2
Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas.
Weiss LM, et al.
N Engl J Med 317 : 1185-1189. 1987
138BCL2
Molecular analysis of mbcl-2 : Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma.
Negrini M, et al.
Cell 49 : 455-463. 1987
139BCL2
The gene located at chromosome 18 band q21 is rearranged in uncultured diffuse lymphomas as well as follicular lymphomas.
Lee MS, et al.
Blood 70 : 90-95. 1987
140BCL2
DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene.
Tsujimoto Y, et al.
Proc Natl Acad Sci U S A 84 : 1329-1331. 1987
141BCL2
Mechanism of the t(14;18) chromosomal translocation : structural analysis of both derivative 14 and 18 reciprocal partners.
Bakhshi A, et al.
Proc Natl Acad Sci U S A 84 : 2396-2400. 1987
142BCL2, YES1
C-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma cell line carrying a T(14;18) chromosomal translocation.
Ohno H, et al.
Int J Cancer 39 : 785-788. 1987
143BCL2, DCC
Malignant lymphoma of mucosa-associated lymphoid tissue.
Isaacson PG, et al.
Histopathology 11 : 445-462. 1987
144BCL2
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
Tsujimoto Y, et al.
Proc Natl Acad Sci U S A 83 : 5214-5218. 1986
145BCL2
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.
Cleary ML, et al.
J Exp Med 164 : 315-320. 1986
146BCL2
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.
Tsujimoto Y, et al.
Science 226 : 1097-1099. 1984