1 | BCL2, SAV1, STK3
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| Mammalian Hippo kinase pathway is downregulated by BCL-2 via protein degradation.
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| Won GW, Park SH, Park J, Lee Y, Lee YH.
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| Biochem Biophys Res Commun. Apr 23;512(1):87-92. doi: 10.1016/j.bbrc.2019.03.015. Epub 2019 Mar 11 2019
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2 | BCL2, BCL2L1, MCL1, SUFU
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| Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
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| Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L.
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| Nat Cell Biol 19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25.
2017
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3 | BCL2, SEPTIN4, XIAP
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| Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.
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| Edison N, Curtz Y, Paland N, Mamriev D, Chorubczyk N, Haviv-Reingewertz T, Kfir N, Morgenstern D, Kupervaser M, Kagan J, Kim HT, Larisch S.
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| Cell Rep 21(2):442-454. doi: 10.1016/j.celrep.2017.09.052.
2017
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4 | BCL2, DACH1
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| Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion in pancreatic cancer.
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| Bu XN, Qiu C, Wang C, Jiang Z.
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| Oncol Rep 36(2):745-54. doi: 10.3892/or.2016.4843.
2016
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5 | ANKRD1, BCL2
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| Cardiac ankyrin repeat protein attenuates cardiomyocyte apoptosis by upregulation of Bcl-2 expression.
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| Zhang N, Ye F, Zhu W, Hu D, Xiao C, Nan J, Su S, Wang Y, Liu M, Gao K, Hu X, Chen J, Yu H, Xie X, Wang J.
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| Biochim Biophys Acta 1863(12):3040-3049. doi: 10.1016/j.bbamcr.2016.09.024. Epub 2016 Oct 3.
2016
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6 | BCL2, EXOC3, EXOC4, MCL1
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| Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.
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| Tanaka T, Kikuchi N, Goto K, Iino M.
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| Apoptosis 21(5):594-608. doi: 10.1007/s10495-016-1230-9.
2016
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7 | BCL2, PINK1, PRKN
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| Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy.
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| Hollville E, Carroll RG, Cullen SP, Martin SJ.
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| Mol Cell 55(3):451-66. doi: 10.1016/j.molcel.2014.06.001. Epub 2014 Jul 3. 2014
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8 | BCL2, GPR65
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| Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL Microenvironment.
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| Rosko AE, McColl KS, Zhong F, Ryder CB, Chang MJ, Sattar A, Caimi PF, Hill BT, Al-Harbi S, Almasan A, Distelhorst CW.
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| J Leuk (Los Angel) 2(5). pii: 160.
2014
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9 | BCL2, FKBP8
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| Mitochondria: FKBP38 and mitochondrial degradation.
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| Shirane-Kitsuji M, Nakayama KI.
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| Int J Biochem Cell Biol 51:19-22. doi: 10.1016/j.biocel.2014.03.007. Epub 2014 Mar 20. Review.
2014
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10 | BCL2, ZFP36L1
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| Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells.
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| Zekavati A, Nasir A, Alcaraz A, Aldrovandi M, Marsh P, Norton JD, Murphy JJ.
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| PLoS One. Jul 11;9(7):e102625. doi: 10.1371/journal.pone.0102625. eCollection 2014 2014
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11 | BCL2, BECN1, SQSTM1
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| Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro.
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| Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH.
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| Acta Pharmacol Sin 34(5):651-6. doi: 10.1038/aps.2013.12. Epub 2013 Apr 8.
2013
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12 | BCL2, RRM2
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| RRM2 regulates Bcl-2 in head and neck and lung cancers: a potential target for cancer therapy.
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| Rahman MA, Amin AR, Wang D, Koenig L, Nannapaneni S, Chen Z, Wang Z, Sica G, Deng X, Chen ZG, Shin DM.
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| Clin Cancer Res 19(13):3416-28. doi: 10.1158/1078-0432.CCR-13-0073. Epub 2013 May 29.
2013
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13 | BCL2, GABARAP
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| Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.
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| Ma P, Schwarten M, Schneider L, Boeske A, Henke N, Lisak D, Weber S, Mohrlüder J, Stoldt M, Strodel B, Methner A, Hoffmann S, Weiergräber OH, Willbold D.
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| J Biol Chem 288(52):37204-15. doi: 10.1074/jbc.M113.528067. Epub 2013 Nov 15.
2013
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14 | BCL2, FKBP8
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| Functional role of the flexible N-terminal extension of FKBP38 in catalysis.
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| Kang C, Ye H, Chia J, Choi BH, Dhe-Paganon S, Simon B, Schütz U, Sattler M, Yoon HS.
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| Sci Rep 3:2985. doi: 10.1038/srep02985.
2013
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15 | BCL2, FKBP8
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| Selective escape of proteins from the mitochondria during mitophagy.
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| Saita S, Shirane M, Nakayama KI.
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| Nat Commun 4:1410. doi: 10.1038/ncomms2400.
2013
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16 | BCL2, BCL2L1, HSPA9
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| Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.
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| Saxena N, Katiyar SP, Liu Y, Grover A, Gao R, Sundar D, Kaul SC, Wadhwa R.
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| Biosci Rep 33(5). pii: e00073. doi: 10.1042/BSR20130034.
2013
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17 | BCL2, KEAP1, NFE2L2
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| Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
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| Niture SK, Jaiswal AK.
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| J Biol Chem 287(13):9873-86. doi: 10.1074/jbc.M111.312694. Epub 2012 Jan 24.
2012
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18 | BCL2
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| Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
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| He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B.
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| Nature 481(7382):511-5. doi: 10.1038/nature10758. Erratum in: Nature. 2013 Nov 7:503(7474):146.
2012
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19 | BCL2, FKBP8
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| The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.
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| Haupt K, Jahreis G, Linnert M, Maestre-Martínez M, Malesevic M, Pechstein A, Edlich F, Lücke C.
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| J Biol Chem 287(23):19665-73. doi: 10.1074/jbc.M111.317214. Epub 2012 Apr 20.
2012
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20 | BCL2, BMP7, FGFR2, HOXC6, PDGFRA
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| HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression.
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| Moon SM, Kim SA, Yoon JH, Ahn SG.
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| J Biol Chem 287(42):35678-88. doi: 10.1074/jbc.M112.361675. Epub 2012 Aug 15.
2012
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21 | BCL2, LGMD2C
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| Impact of single-nucleotide polymorphisms at the TP53-binding and responsive promoter region of BCL2 gene in modulating the phenotypic variability of LGMD2C patients.
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| Hadj Salem I, Kamoun F, Louhichi N, Trigui M, Triki C, Fakhfakh F.
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| Mol Biol Rep. Jul;39(7):7479-86. doi: 10.1007/s11033-012-1581-4. Epub 2012 Feb 25. 2012
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22 | BCL2
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| A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum.
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| Lian J, Wu X, He F, Karnak D, Tang W, Meng Y, Xiang D, Ji M, Lawrence TS, Xu L.
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| Cell Death Differ. 18(1):60-71. 2011
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23 | ATF5, BCL2
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| BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner.
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| Dluzen D, Li G, Tacelosky D, Moreau M, Liu DX.
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| J Biol Chem 286(9):7705-13. Epub 2011 Jan 6.
2011
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24 | BCL2, LGALS7
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| Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells.
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| Villeneuve C, Baricault L, Canelle L, Barboule N, Racca C, Monsarrat B, Magnaldo T, Larminat F.
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| Mol Biol Cell 22(7):999-1013. Epub 2011 Feb 2.
2011
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25 | AMBRA1, BCL2
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| Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.
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| Strappazzon F, Vietri-Rudan M, Campello S, Nazio F, Florenzano F, Fimia GM, Piacentini M, Levine B, Cecconi F.
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| EMBO J 30(7):1195-208. Epub 2011 Feb 25.
2011
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26 | BCL2, BRCA1
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| Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes.
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| Laulier C, Barascu A, Guirouilh-Barbat J, Pennarun G, Le Chalony C, Chevalier F, Palierne G, Bertrand P, Verbavatz JM, Lopez BS.
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| Cancer Res 71(10):3590-602. Epub 2011 Mar 28.
2011
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27 | BCL2, SATB1
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| The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR.
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| Gong F, Sun L, Wang Z, Shi J, Li W, Wang S, Han X, Sun Y.
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| Nucleic Acids Res 39(11):4640-52. Epub 2011 Feb 9.
2011
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28 | BCL2
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| The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy.
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| Kelly PN, Strasser A.
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| Cell Death Differ 18(9):1414-24. doi: 10.1038/cdd.2011.17. Epub 2011 Mar 18. Review.
2011
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29 | ATG12, BCL2, MCL1
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| The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis.
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| Rubinstein AD, Eisenstein M, Ber Y, Bialik S, Kimchi A.
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| Mol Cell 44(5):698-709. doi: 10.1016/j.molcel.2011.10.014.
2011
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30 | BCL2, FKBP8
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| FKBP38 protects Bcl-2 from caspase-dependent degradation.
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| Choi BH, Feng L, Yoon HS.
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| J Biol Chem 285(13):9770-9. Epub 2010 Feb 5.
2010
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31 | BCL2, RORA
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| Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain.
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| Nguyen A, Rauch TA, Pfeifer GP, Hu VW.
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| FASEB J 24(8):3036-51. Epub 2010 Apr 7.PMID: 20375269 2010
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32 | ALS1, BCL2, SOD1
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| ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.
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| Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P.
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| Hum Mol Genet 19(15):2974-86. Epub 2010 May 11.PMID: 20460269 2010
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33 | BCL2
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| The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression.
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| Shahid R, Bugaut A, Balasubramanian S.
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| Biochemistry 49(38):8300-6.
2010
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34 | BCL2, PRKN
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| Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.
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| Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G.
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| J Biol Chem 285(49):38214-23. Epub 2010 Oct 2. 2010
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35 | BCL2, MDM4, TP53
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| MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
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| Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta F, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F.
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| EMBO J 28(13):1926-39. Epub 2009 Jun 11.
2009
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36 | BCL2, BCL6, PIAS2
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| BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma.
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| Saito M, Novak U, Piovan E, Basso K, Sumazin P, Schneider C, Crespo M, Shen Q, Bhagat G, Califano A, Chadburn A, Pasqualucci L, Dalla-Favera R.
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| Proc Natl Acad Sci U S A 106(27):11294-9. Epub 2009 Jun 23.
2009
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37 | BAK1, BCL2
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| Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.
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| Dai H, Meng XW, Lee SH, Schneider PA, Kaufmann SH.
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| J Biol Chem 284(27):18311-22. Epub 2009 Apr 7.PMID: 19351886 2009
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38 | BCL2, ELAVL1
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| Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.
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| Ishimaru D, Ramalingam S, Sengupta TK, Bandyopadhyay S, Dellis S, Tholanikunnel BG, Fernandes DJ, Spicer EK.
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| Mol Cancer Res 7(8):1354-66. Epub 2009 Aug 11.PMID: 19671677 2009
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39 | BCL2, HNRNPL
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| hnRNP L binds to CA repeats in the 3'UTR of bcl-2 mRNA.
|
| Lee DH, Lim MH, Youn DY, Jung SE, Ahn YS, Tsujimoto Y, Lee JH.
|
| Biochem Biophys Res Commun 382(3):583-7. doi: 10.1016/j.bbrc.2009.03.069. Epub 2009 Mar 17.
2009
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40 | BCL2, TP53BP2
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| Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.
|
| Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Iosub A, Refaely H, Dines M, Bronner V, Bravman T, Shalev DE, Rüdiger S, Friedler A.
|
| Proc Natl Acad Sci U S A 105(34):12277-82. Epub 2008 Aug 21.
2008
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41 | BCL2
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| P53 and bcl-2 assessment in serous ovarian carcinoma.
|
| Palmer JE, Sant Cassia LJ, Irwin CJ, Morris AG, Rollason TP.
|
| Int J Gynecol Cancer 18(2):241-8. 2008
|
42 | BCL2, BECN1
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| The autophagy effector Beclin 1: a novel BH3-only protein.
|
| Sinha S, Levine B.
|
| Oncogene 27 Suppl 1:S137-48. Review.
2008
|
43 | BCL2, DLEC1, HOXA1, HOXA10, KL, NR3C1, SEZ6L, SFRP4, SFRP5, SMAD9, TWIST1
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| DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis.
|
| Kang GH, Lee S, Cho NY, Gandamihardja T, Long TI, Weisenberger DJ, Campan M, Laird PW.
|
| Lab Invest 88(2):161-70. Epub 2007 Dec 24.
2008
|
44 | BCL2, BCL3
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| BCL2 and BCL3 are recurrent translocation partners of the IGH locus.
|
| Szymanowska N, Klapper W, Gesk S, Küppers R, Martín-Subero JI, Siebert R.
|
| Cancer Genet Cytogenet 186(2):110-4.PMID: 18940474 2008
|
45 | BCL2, MKI67, TP53
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| Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix.
|
| Looi ML, Dali AZ, Ali SA, Ngah WZ, Yusof YA.
|
| Anal Quant Cytol Histol 30(2):63-70.
2008
|
46 | BCL2, BCL2L1, CASP1, CASP5, NLRP1
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| Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
|
| Bruey JM, Bruey-Sedano N, Luciano F, Zhai D, Balpai R, Xu C, Kress CL, Bailly-Maitre B, Li X, Osterman A, Matsuzawa S, Terskikh AV, Faustin B, Reed JC.
|
| Cell 129(1):45-56. 2007
|
47 | BCL2, ZBTB17
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| BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis.
|
| Patel JH, McMahon SB.
|
| J Biol Chem 282(1):5-13. Epub 2006 Nov 1. 2007
|
48 | BCL2
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| Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region.
|
| Bredow S, Juri DE, Cardon K, Tesfaigzi Y.
|
| Gene 404(1-2):110-6. Epub 2007 Sep 14. 2007
|
49 | AKT1, BCL2
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| BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer.
|
| Mortenson MM, Galante JG, Gilad O, Schlieman MG, Virudachalam S, Kung HJ, Bold RJ.
|
| J Cell Biochem 102(5):1171-9.PMID: 17960583 2007
|
50 | IL6, BCL2, ADCYAP1
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| Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.
|
| Ohtaki H, Nakamachi T, Dohi K, Aizawa Y, Takaki A, Hodoyama K, Yofu S, Hashimoto H, Shintani N, Baba A, Kopf M, Iwakura Y, Matsuda K, Arimura A, Shioda S.
|
| Proc Natl Acad Sci U S A 103(19):7488-93. Epub 2006 May 1. 2006
|
51 | BCL2, GATA4
|
| Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo.
|
| Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, Liang Q.
|
| FASEB J 20(6):800-2. Epub 2006 Feb 9. 2006
|
52 | MDC1A, BCL2
|
| Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice.
|
| Dominov JA, Kravetz AJ, Ardelt M, Kostek CA, Beermann ML, Miller JB.
|
| Hum Mol Genet 14(8):1029-40. Epub 2005 Mar 9. 2005
|
53 | PSEN1, PSEN2, BCL2, FKBP8
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| Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.
|
| Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M.
|
| Hum Mol Genet 14(13):1889-902. Epub 2005 May 19. 2005
|
54 | BCL2, BECN1
|
| Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
|
| Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B.
|
| Cell 122(6):927-39. 2005
|
55 | BCL2
|
| Bcl-2 as prognostic factor in head and neck squamous cell carcinoma.
|
| Lo Muzio L, Falaschini S, Farina A, Rubini C, Pezzetti F, Campisi G, De Rosa G, Capogreco M, Carinci F.
|
| Oncol Res 15(5):249-55. 2005
|
56 | BCL2
|
| Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
|
| Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC.
|
| Mol Cell. 17(3):393-403. 2005
|
57 | BCL2
|
| Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.
|
| Chen R, Valencia I, Zhong F, McColl KS, Roderick HL, Bootman MD, Berridge MJ, Conway SJ, Holmes AB, Mignery GA, Velez P, Distelhorst CW.
|
| J Cell Biol 166(2):193-203. 2004
|
58 | BCL2, RIPK2
|
| Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation.
|
| Ruefli-Brasse AA, Lee WP, Hurst S, Dixit VM.
|
| J Biol Chem 279(2):1570-4. Epub 2003 Nov 24. 2004
|
59 | BCL2
|
| Nuclear partners of Bcl-2: Bax and PML.
|
| Hoetelmans RW.
|
| DNA Cell Biol. 23(6):351-4. 2004
|
60 | BCL2, BNIP2, BNIPL, GFER, MIF
|
| BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
|
| Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L,Wan D, Gu J.
|
| Biochem Biophys Res Commun 308(2):379-85. 2003
|
61 | BCL2
|
| Deletion of the BH1 domain of Bcl-2 accelerates apoptosis by acting in a dominant negative fashion.
|
| Kawatani M, Imoto M.
|
| J Biol Chem 278(22):19732-42. Epub 2003 Mar 18. 2003
|
62 | BCL2
|
| Expression of bcl-2 protein is associated with shorter survival in nonsmall cell lung carcinoma.
|
| Huang CI, Neuberg D, Johnson BE, Wei JY, Christiani DC.
|
| Cancer 98(1):135-43. 2003
|
63 | FKBP8, BCL2
|
| Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
|
| Shirane M, Nakayama KI.
|
| Nat Cell Biol 5(1):28-37. 2003
|
64 | BCL2, CDKN2A, MYC, RB1, TSG3B
|
| Cytogenetics and molecular genetics of lung cancer.
|
| Mitsuuchi Y, Testa JR.
|
| Am J Med Genet 115(3):183-8. 2002
|
65 | BCL2, VEGFA
|
| VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells.
|
| Beierle EA, Strande LF, Chen MK.
|
| J Pediatr Surg 37(3):467-71. 2002
|
66 | BCL2
|
| Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells.
|
| Fenton JA, Vaandrager JW, Aarts WM, Bende RJ, Heering K, van Dijk M, Morgan G, van Noesel CJ, Schuuring E, Kluin PM.
|
| Blood 99(2):716-8. 2002
|
67 | BCL2, PIN1
|
| Proteasomal degradation of human peptidyl prolyl isomerase pin1-pointing phospho Bcl2 toward dephosphorylation.
|
| Basu A, Das M, Qanungo S, Fan XJ, DuBois G, Haldar S.
|
| Neoplasia. 4(3):218-27 2002
|
68 | BCL2
|
| Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a.
|
| Song D, Sakamoto S, Taniguchi T.
|
| Biochemistry. 41(3):929-34. 2002
|
69 | BCL2, RAD51
|
| A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway.
|
| Saintigny Y, Dumay A, Lambert S, Lopez BS.
|
| EMBO J 20(10):2596-2607. 2001
|
70 | BCL2, CASP9, DIABLO
|
| Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
|
| Adrain C, Creagh EM, Martin SJ.
|
| EMBO J 20(23):6627-36. 2001
|
71 | BCL2, CCNA1, CCNB1, CCND1, CDKN1A, CDKN2A, MKI67, RB1
|
| Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus.
|
| Kanavaros P, Stefanaki K, Rontogianni D, Papalazarou D, Sgantzos M, Arvanitis D, Vamvouka C, Gorgoulis V, Siatitsas I, Agnantis NJ, Bai M.
|
| Histol Histopathol 16(4):1005-12. 2001
|
72 | BCL2
|
| Bcl-2 targets protein phosphatase 1 alpha to Bad.
|
| Ayllón V, Cayla X, García A, Roncal F, Fernández R, Albar JP, Martínez C, Rebollo A.
|
| J Immunol. 166(12):7345-52. 2001
|
73 | BCL2, BNIP3
|
| BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites.
|
| Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH.
|
| J Biol Chem 275(2):1439-48. 2000
|
74 | BCL2, DCC
|
| Chromosome 18 breakpoint in t(11;18)(q21;q21) translocation associated with MALT lymphoma is proximal to BCL2 and distal to DCC.
|
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76 | BCL2
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77 | BAK1, BAX, BCL2
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78 | BCL2, BCLAF1, TSG6F
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79 | BCL2, BCL6, MYC
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80 | BIRC5, BAX, BCL2
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81 | BCL2, BCL6
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82 | BCL2, BNIP3L
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83 | BCL2
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84 | BCL2, BNIP1
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85 | BCL2, PSEN1
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86 | BCL2
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87 | BCL2
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88 | BCL2
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| Refinement of the BCL2/immunoglobulin heavy chain fusion gene in t(14;18)(q32;q21) by polymerase chain reaction amplification for long targets.
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89 | BCL2, BCL8, BRINP1, CDK4, GLI1, MDM2, MYC, REL
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90 | BAK1, BAX, BCL2, BCL2L2, BID, BNIP3L
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91 | BAX, BCL2, CDK2
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| A link between cell cycle and cell death : Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.
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92 | BAK1, BAX, BCL2A1, BCL2, BID
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| BCL-2 family members in the development and degenerative pathologies of the nervous system.
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93 | BCL2
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| bcl-2 protein expression in endometrial carcinoma: the lack of correlation with p53.
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94 | BCL2
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95 | BCL2, BCL2L1, BLK
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96 | BCL2
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97 | BCL2
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98 | BCL2, SMN1
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99 | BCL2
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100 | BCAP31, BCL2
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101 | BCL2
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102 | BCL2
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103 | BCL2, RUNX1, RUNX1T1
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104 | BCL2
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105 | BCL2
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106 | BCL2
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| C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.
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| Cell 76(4):665-76. 1994
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107 | BCL2
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| A submicroscopic interstitial deletion of chromosome 14 frequently occurs adjacent to the t(14;18) translocation breakpoint in human follicular lymphoma.
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108 | BCL2
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| A frequent EcoRI polymorphism in the bcl-2 gene.
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| Hum Genet 91 : 513. 1993
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109 | BCL2
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| t(11;18)(q21;q21) may delineate a spectrum of diffuse small B-cell lymphoma with extranodal involvement.
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110 | BCL2
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| Cell 73(2):295-307. 1993
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111 | BCL2
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112 | BCL2
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113 | BCL2
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114 | BCL2
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115 | BCL2
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116 | BCL2, IGHJ@
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117 | BCL2
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118 | BCL2
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| The bcl-2 gene translocation is undetectable in Hodgkin's disease by southern blot hybridization and polymerase chain reaction.
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119 | BCL2
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| Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients.
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120 | BCL2, IGHJ@
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121 | BCL2
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| Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.
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122 | BCL2
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123 | BCL2
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124 | BCL2
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| t(18;22)(q21;q11) with rearrangement of BCL2 as a possible secondary change in a lymphocytic lymphoma.
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125 | BCL2
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| Bcl-2/Jh rearrangements in benign lymphoid tissues with follicular hyperplasia.
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126 | BCL2
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127 | BCL2
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| G to A polymorphism in the second exon of the BCL2 gene.
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128 | BCL2
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| t(2;18) and t(18;22) variant chromosomal translocations and bcl-2 gene rearrangements in human malignant lymphomas.
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129 | BCL2
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| Small G proteins are expressed ubiquitously in lymphoid cells and do not correspond to Bcl-2.
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130 | BCL2
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| Direct sequence analysis of the 14q+ and 18q- chromosome junctions in follicular lymphoma.
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131 | BCL2
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| Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
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132 | BCL2
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133 | BCL2
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| Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas.
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134 | BCL2
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135 | BCL2
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136 | BCL2
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| The bcl-2 gene is rearranged in many diffuse B-cell lymphomas.
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137 | BCL2
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| Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.
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138 | BCL2
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139 | BCL2
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140 | BCL2
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| The gene located at chromosome 18 band q21 is rearranged in uncultured diffuse lymphomas as well as follicular lymphomas.
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141 | BCL2
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| DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene.
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142 | BCL2
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143 | BCL2, YES1
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| C-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma cell line carrying a T(14;18) chromosomal translocation.
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144 | BCL2, DCC
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| Malignant lymphoma of mucosa-associated lymphoid tissue.
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145 | BCL2
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| Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
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146 | BCL2
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| Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.
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147 | BCL2
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| Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.
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