Citations for
1BBC3
PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints.
Hong SS, Marotte H, Courbon G, Firestein GS, Boulanger P, Miossec P.
Nat Commun 8(1):146. doi: 10.1038/s41467-017-00142-1. 2017
2BBC3
Involvement of PUMA in pericyte migration induced by methamphetamine.
Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, Yao H.
Exp Cell Res 356(1):28-39. doi: 10.1016/j.yexcr.2017.04.007. Epub 2017 Apr 10. 2017
3BBC3, EZH2
EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis.
Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y.
Oncotarget 7(35):56338-56354. doi: 10.18632/oncotarget.10841. 2016
4BBC3, HMGB1
Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming.
Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y.
Am J Physiol Endocrinol Metab 310(11):E1016-26. doi: 10.1152/ajpendo.00441.2015. Epub 2016 Apr 26. 2016
5BBC3
p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.
Litwak SA, Loh K, Stanley WJ, Pappas EG, Wali JA, Selck C, Strasser A, Thomas HE, Gurzov EN.
Sci Rep 6:23802. doi: 10.1038/srep23802. 2016
6BBC3, MYSM1, TP53
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Belle JI, Petrov JC, Langlais D, Robert F, Cencic R, Shen S, Pelletier J, Gros P, Nijnik A.
Cell Death Differ 23(5):759-75. doi: 10.1038/cdd.2015.140. Epub 2016 Jan 15. 2016
7BBC3
Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells.
Ambroise G, Portier A, Roders N, Arnoult D, Vazquez A.
Oncotarget 6(35):38181-94. doi: 10.18632/oncotarget.5901. 2015
8BBC3, HSPA8
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H.
Autophagy 11(9):1623-35. doi: 10.1080/15548627.2015.1075688. 2015
9BBC3
PUMA-mediated mitochondrial apoptotic disruption by hypoxic postconditioning.
Li Y, Guo Q, Liu X, Wang C, Song D.
Apoptosis 20(8):1026-32. doi: 10.1007/s10495-015-1127-z. 2015
10BBC3, MCL1
Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress.
Delbridge AR, Opferman JT, Grabow S, Strasser A.
Blood 125(21):3273-80. doi: 10.1182/blood-2015-01-621250. Epub 2015 Apr 6. 2015
11BBC3
PUMA is invovled in ischemia/reperfusion-induced apoptosis of mouse cerebral astrocytes.
Chen H, Tian M, Jin L, Jia H, Jin Y.
Neuroscience 284:824-32. doi: 10.1016/j.neuroscience.2014.10.059. Epub 2014 Nov 5. 2015
12BAK1, BBC3, BCL2L11, PMAIP1
Evaluation of the BH3-only protein Puma as a direct Bak activator.
Dai H, Pang YP, Ramirez-Alvarado M, Kaufmann SH.
J Biol Chem 289(1):89-99. doi: 10.1074/jbc.M113.505701. Epub 2013 Nov 21. 2014
13BBC3
PUMA regulates germ cell loss and primordial follicle endowment in mice.
Myers M, Morgan FH, Liew SH, Zerafa N, Gamage TU, Sarraj M, Cook M, Kapic I, Sutherland A, Scott CL, Strasser A, Findlay JK, Kerr JB, Hutt KJ.
Reproduction 148(2):211-9. doi: 10.1530/REP-13-0666. Epub 2014 May 23. 2014
14BBC3
PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy.
Tan S, Wei X, Song M, Tao J, Yang Y, Khatoon S, Liu H, Jiang J, Wu B.
Cell Death Dis 5:e1128. doi: 10.1038/cddis.2014.95. 2014
15BBC3
PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy.
Tan S, Wei X, Song M, Tao J, Yang Y, Khatoon S, Liu H, Jiang J, Wu B.
Cell Death Dis 5:e1128. doi: 10.1038/cddis.2014.95. 2014
16BBC3, BCL2L11, PMAIP1
A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia.
Zhang LN, Li JY, Xu W.
Cancer Gene Ther 20(1):1-7. doi: 10.1038/cgt.2012.84. Epub 2012 Nov 23. Review. 2013
17BBC3, SOX4
Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA.
Jang SM, Kang EJ, Kim JW, Kim CH, An JH, Choi KH.
Biochem Biophys Res Commun 438(2):445-51. doi: 10.1016/j.bbrc.2013.07.099. Epub 2013 Jul 31. 2013
18BBC3
Puma, but not noxa is essential for oligodendroglial cell death.
Hagemeier K, Lürbke A, Hucke S, Albrecht S, Preisner A, Klassen E, Hoffmann E, Cui QL, Antel J J, Brück W, Klotz L, Kuhlmann T.
Glia 61(10):1712-23. doi: 10.1002/glia.22552. Epub 2013 Aug 6. 2013
19BAK1, BAX, BBC3, BCL2L11
PUMA and BIM are required for oncogene inactivation-induced apoptosis.
Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJ, Cheng EH.
Sci Signal 6(268):ra20. doi: 10.1126/scisignal.2003483. 2013
20BBC3, BCL2L11
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.
Immunity 37(3):451-62. doi: 10.1016/j.immuni.2012.05.030. Epub 2012 Sep 6. 2012
21BBC3, HRK, PMAIP1
ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.
Pike LR, Phadwal K, Simon AK, Harris AL.
Mol Biol Rep 39(12):10811-22. doi: 10.1007/s11033-012-1975-3. Epub 2012 Oct 23. 2012
22BBC3, LGR5, TLR4
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.
Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ.
J Biol Chem 287(44):37296-308. doi: 10.1074/jbc.M112.375881. Epub 2012 Sep 6. 2012
23BBC3, PMAIP1, TP53, TP63
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.
Kerr JB, Hutt KJ, Michalak EM, Cook M, Vandenberg CJ, Liew SH, Bouillet P, Mills A, Scott CL, Findlay JK, Strasser A.
Mol Cell 48(3):343-52. doi: 10.1016/j.molcel.2012.08.017. Epub 2012 Sep 20. 2012
24BBC3
Repression of Puma by scratch2 is required for neuronal survival during embryonic development.
Rodríguez-Aznar E, Nieto MA.
Cell Death Differ. 18(7):1196-207. 2011
25BBC3
Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer.
Roberts CG, Millar EK, O'Toole SA, McNeil CM, Lehrbach GM, Pinese M, Tobelmann P, McCloy RA, Musgrove EA, Sutherland RL, Butt AJ.
Oncogene 30(28):3186-97. doi: 10.1038/onc.2011.36. Epub 2011 Mar 7. 2011
26BBC3, PMAIP1
Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1.
Nakajima W, Tanaka N.
Biochem Biophys Res Commun 413(4):643-8. doi: 10.1016/j.bbrc.2011.09.036. Epub 2011 Sep 14. 2011
27BBC3
Regulation of memory B-cell survival by the BH3-only protein Puma.
Clybouw C, Fischer S, Auffredou MT, Hugues P, Alexia C, Bouillet P, Raphael M, Leca G, Strasser A, Tarlinton DM, Vazquez A.
Blood 118(15):4120-8. doi: 10.1182/blood-2011-04-347096. Epub 2011 Aug 25. 2011
28BBC3, TP53
Puma is required for p53-induced depletion of adult stem cells.
Liu D, Ou L, Clemenson GD Jr, Chao C, Lutske ME, Zambetti GP, Gage FH, Xu Y.
Nat Cell Biol 12(10):993-8. Epub 2010 Sep 5. 2010
29ATF4, BBC3, DDIT3
Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.
Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP.
J Neurosci. 30(50):16938-48. 2010
30BAK1, BAX, BBC3, BCL2L11, BID
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.
Science 330(6009):1390-3. 2010
31BBC3
Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members.
Gallenne T, Gautier F, Oliver L, Hervouet E, Noël B, Hickman JA, Geneste O, Cartron PF, Vallette FM, Manon S, Juin P.
J Cell Biol 185(2):279-90. 2009
32BBC3, PMAIP1
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.
Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL.
Cell Death Differ 16(5):684-96. Epub 2009 Jan 16. 2009
33BBC3
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis.
Cazanave SC, Mott JL, Elmi NA, Bronk SF, Werneburg NW, Akazawa Y, Kahraman A, Garrison SP, Zambetti GP, Charlton MR, Gores GJ.
J Biol Chem 284(39):26591-602. Epub 2009 Jul 28. 2009
34BBC3, BCL2L11, HUS1, RAD9A
Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.
Meyerkord CL, Takahashi Y, Araya R, Takada N, Weiss RS, Wang HG.
Oncogene 27(58):7248-59. Epub 2008 Sep 15. 2008
35BBC3
Sp1 and p73 activate PUMA following serum starvation.
Ming L, Sakaida T, Yue W, Jha A, Zhang L, Yu J.
Carcinogenesis 29(10):1878-84. Epub 2008 Jun 25. 2008
36BBC3
Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells.
Wang X, Wang J, Lin S, Geng Y, Wang J, Jiang B.
J Exp Clin Cancer Res 27:44. 2008
37BBC3
Expressional and mutational analysis of pro-apoptotic Bcl-2 member PUMA in hepatocellular carcinomas.
Ahn CH, Jeong EG, Kim SS, Lee JW, Lee SH, Kim SH, Kim MS, Yoo NJ, Lee SH.
Dig Dis Sci 53(5):1395-9. Epub 2007 Oct 13. 2008
38BBC3, DIABLO
SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events.
Yu J, Wang P, Ming L, Wood MA, Zhang L.
Oncogene 26(29):4189-98. Epub 2007 Jan 22. 2007
39BBC3
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR.
Science 309(5741):1732-5. 2005
40BAX, BBC3
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.
Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, Meflah K, Vallette FM, Juin P.
Mol Cell. 16(5):807-18. 2004
41BBC3
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L.
Proc Natl Acad Sci U S A 100(4):1931-6. 2003
42BBC3
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.
Villunger A, Michalak EM, Coultas L, Müllauer F, Böck G, Ausserlechner MJ, Adams JM, Strasser A.
Science. 302(5647):1036-8 2003
43BBC3
PUMA induces the rapid apoptosis of colorectal cancer cells.
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B.
Mol Cell 7(3):673-82. 2001
44BBC3
PUMA, a novel proapoptotic gene, is induced by p53.
Nakano K, Vousden KH.
Mol Cell 7(3):683-94. 2001