1 | BBC3
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| PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints.
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| Hong SS, Marotte H, Courbon G, Firestein GS, Boulanger P, Miossec P.
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| Nat Commun 8(1):146. doi: 10.1038/s41467-017-00142-1.
2017
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2 | BBC3
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| Involvement of PUMA in pericyte migration induced by methamphetamine.
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| Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, Yao H.
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| Exp Cell Res 356(1):28-39. doi: 10.1016/j.yexcr.2017.04.007. Epub 2017 Apr 10.
2017
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3 | BBC3, EZH2
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| EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis.
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| Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y.
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| Oncotarget 7(35):56338-56354. doi: 10.18632/oncotarget.10841.
2016
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4 | BBC3, HMGB1
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| Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming.
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| Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y.
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| Am J Physiol Endocrinol Metab 310(11):E1016-26. doi: 10.1152/ajpendo.00441.2015. Epub 2016 Apr 26.
2016
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5 | BBC3
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| p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.
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| Litwak SA, Loh K, Stanley WJ, Pappas EG, Wali JA, Selck C, Strasser A, Thomas HE, Gurzov EN.
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| Sci Rep 6:23802. doi: 10.1038/srep23802.
2016
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6 | BBC3, MYSM1, TP53
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| Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
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| Belle JI, Petrov JC, Langlais D, Robert F, Cencic R, Shen S, Pelletier J, Gros P, Nijnik A.
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| Cell Death Differ 23(5):759-75. doi: 10.1038/cdd.2015.140. Epub 2016 Jan 15.
2016
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7 | BBC3
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| Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells.
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| Ambroise G, Portier A, Roders N, Arnoult D, Vazquez A.
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| Oncotarget 6(35):38181-94. doi: 10.18632/oncotarget.5901.
2015
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8 | BBC3, HSPA8
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| Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
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| Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H.
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| Autophagy 11(9):1623-35. doi: 10.1080/15548627.2015.1075688.
2015
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9 | BBC3
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| PUMA-mediated mitochondrial apoptotic disruption by hypoxic postconditioning.
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| Li Y, Guo Q, Liu X, Wang C, Song D.
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| Apoptosis 20(8):1026-32. doi: 10.1007/s10495-015-1127-z.
2015
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10 | BBC3, MCL1
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| Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress.
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| Delbridge AR, Opferman JT, Grabow S, Strasser A.
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| Blood 125(21):3273-80. doi: 10.1182/blood-2015-01-621250. Epub 2015 Apr 6.
2015
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11 | BBC3
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| PUMA is invovled in ischemia/reperfusion-induced apoptosis of mouse cerebral astrocytes.
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| Chen H, Tian M, Jin L, Jia H, Jin Y.
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| Neuroscience 284:824-32. doi: 10.1016/j.neuroscience.2014.10.059. Epub 2014 Nov 5.
2015
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12 | BAK1, BBC3, BCL2L11, PMAIP1
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| Evaluation of the BH3-only protein Puma as a direct Bak activator.
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| Dai H, Pang YP, Ramirez-Alvarado M, Kaufmann SH.
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| J Biol Chem 289(1):89-99. doi: 10.1074/jbc.M113.505701. Epub 2013 Nov 21.
2014
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13 | BBC3
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| PUMA regulates germ cell loss and primordial follicle endowment in mice.
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| Myers M, Morgan FH, Liew SH, Zerafa N, Gamage TU, Sarraj M, Cook M, Kapic I, Sutherland A, Scott CL, Strasser A, Findlay JK, Kerr JB, Hutt KJ.
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| Reproduction 148(2):211-9. doi: 10.1530/REP-13-0666. Epub 2014 May 23.
2014
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14 | BBC3
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| PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy.
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| Tan S, Wei X, Song M, Tao J, Yang Y, Khatoon S, Liu H, Jiang J, Wu B.
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| Cell Death Dis 5:e1128. doi: 10.1038/cddis.2014.95.
2014
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15 | BBC3
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| PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy.
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| Tan S, Wei X, Song M, Tao J, Yang Y, Khatoon S, Liu H, Jiang J, Wu B.
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| Cell Death Dis 5:e1128. doi: 10.1038/cddis.2014.95.
2014
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16 | BBC3, BCL2L11, PMAIP1
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| A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia.
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| Zhang LN, Li JY, Xu W.
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| Cancer Gene Ther 20(1):1-7. doi: 10.1038/cgt.2012.84. Epub 2012 Nov 23. Review.
2013
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17 | BBC3, SOX4
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| Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA.
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| Jang SM, Kang EJ, Kim JW, Kim CH, An JH, Choi KH.
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| Biochem Biophys Res Commun 438(2):445-51. doi: 10.1016/j.bbrc.2013.07.099. Epub 2013 Jul 31.
2013
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18 | BBC3
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| Puma, but not noxa is essential for oligodendroglial cell death.
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| Hagemeier K, Lürbke A, Hucke S, Albrecht S, Preisner A, Klassen E, Hoffmann E, Cui QL, Antel J J, Brück W, Klotz L, Kuhlmann T.
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| Glia 61(10):1712-23. doi: 10.1002/glia.22552. Epub 2013 Aug 6.
2013
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19 | BAK1, BAX, BBC3, BCL2L11
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| PUMA and BIM are required for oncogene inactivation-induced apoptosis.
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| Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJ, Cheng EH.
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| Sci Signal 6(268):ra20. doi: 10.1126/scisignal.2003483.
2013
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20 | BBC3, BCL2L11
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| The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
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| Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.
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| Immunity 37(3):451-62. doi: 10.1016/j.immuni.2012.05.030. Epub 2012 Sep 6.
2012
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21 | BBC3, HRK, PMAIP1
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| ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.
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| Pike LR, Phadwal K, Simon AK, Harris AL.
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| Mol Biol Rep 39(12):10811-22. doi: 10.1007/s11033-012-1975-3. Epub 2012 Oct 23.
2012
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22 | BBC3, LGR5, TLR4
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| Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.
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| Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ.
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| J Biol Chem 287(44):37296-308. doi: 10.1074/jbc.M112.375881. Epub 2012 Sep 6.
2012
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23 | BBC3, PMAIP1, TP53, TP63
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| DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.
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| Kerr JB, Hutt KJ, Michalak EM, Cook M, Vandenberg CJ, Liew SH, Bouillet P, Mills A, Scott CL, Findlay JK, Strasser A.
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| Mol Cell 48(3):343-52. doi: 10.1016/j.molcel.2012.08.017. Epub 2012 Sep 20.
2012
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24 | BBC3
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| Repression of Puma by scratch2 is required for neuronal survival during embryonic development.
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| Rodríguez-Aznar E, Nieto MA.
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| Cell Death Differ. 18(7):1196-207. 2011
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25 | BBC3
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| Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer.
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| Roberts CG, Millar EK, O'Toole SA, McNeil CM, Lehrbach GM, Pinese M, Tobelmann P, McCloy RA, Musgrove EA, Sutherland RL, Butt AJ.
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| Oncogene 30(28):3186-97. doi: 10.1038/onc.2011.36. Epub 2011 Mar 7.
2011
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26 | BBC3, PMAIP1
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| Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1.
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| Nakajima W, Tanaka N.
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| Biochem Biophys Res Commun 413(4):643-8. doi: 10.1016/j.bbrc.2011.09.036. Epub 2011 Sep 14.
2011
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27 | BBC3
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| Regulation of memory B-cell survival by the BH3-only protein Puma.
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| Clybouw C, Fischer S, Auffredou MT, Hugues P, Alexia C, Bouillet P, Raphael M, Leca G, Strasser A, Tarlinton DM, Vazquez A.
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| Blood 118(15):4120-8. doi: 10.1182/blood-2011-04-347096. Epub 2011 Aug 25.
2011
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28 | BBC3, TP53
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| Puma is required for p53-induced depletion of adult stem cells.
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| Liu D, Ou L, Clemenson GD Jr, Chao C, Lutske ME, Zambetti GP, Gage FH, Xu Y.
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| Nat Cell Biol 12(10):993-8. Epub 2010 Sep 5.
2010
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29 | ATF4, BBC3, DDIT3
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| Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.
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| Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP.
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| J Neurosci. 30(50):16938-48. 2010
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30 | BAK1, BAX, BBC3, BCL2L11, BID
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| BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
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| Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.
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| Science 330(6009):1390-3.
2010
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31 | BBC3
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| Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members.
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| Gallenne T, Gautier F, Oliver L, Hervouet E, Noël B, Hickman JA, Geneste O, Cartron PF, Vallette FM, Manon S, Juin P.
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| J Cell Biol 185(2):279-90.
2009
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32 | BBC3, PMAIP1
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| Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.
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| Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL.
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| Cell Death Differ 16(5):684-96. Epub 2009 Jan 16.
2009
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33 | BBC3
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| JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis.
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| Cazanave SC, Mott JL, Elmi NA, Bronk SF, Werneburg NW, Akazawa Y, Kahraman A, Garrison SP, Zambetti GP, Charlton MR, Gores GJ.
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| J Biol Chem 284(39):26591-602. Epub 2009 Jul 28.
2009
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34 | BBC3, BCL2L11, HUS1, RAD9A
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| Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.
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| Meyerkord CL, Takahashi Y, Araya R, Takada N, Weiss RS, Wang HG.
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| Oncogene 27(58):7248-59. Epub 2008 Sep 15.
2008
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35 | BBC3
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| Sp1 and p73 activate PUMA following serum starvation.
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| Ming L, Sakaida T, Yue W, Jha A, Zhang L, Yu J.
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| Carcinogenesis 29(10):1878-84. Epub 2008 Jun 25.
2008
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36 | BBC3
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| Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells.
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| Wang X, Wang J, Lin S, Geng Y, Wang J, Jiang B.
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| J Exp Clin Cancer Res 27:44.
2008
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37 | BBC3
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| Expressional and mutational analysis of pro-apoptotic Bcl-2 member PUMA in hepatocellular carcinomas.
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| Ahn CH, Jeong EG, Kim SS, Lee JW, Lee SH, Kim SH, Kim MS, Yoo NJ, Lee SH.
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| Dig Dis Sci 53(5):1395-9. Epub 2007 Oct 13.
2008
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38 | BBC3, DIABLO
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| SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events.
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| Yu J, Wang P, Ming L, Wood MA, Zhang L.
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| Oncogene 26(29):4189-98. Epub 2007 Jan 22.
2007
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39 | BBC3
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| PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
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| Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR.
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| Science 309(5741):1732-5.
2005
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40 | BAX, BBC3
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| The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.
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| Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, Meflah K, Vallette FM, Juin P.
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| Mol Cell. 16(5):807-18. 2004
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41 | BBC3
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| PUMA mediates the apoptotic response to p53 in colorectal cancer cells
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| Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L.
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| Proc Natl Acad Sci U S A 100(4):1931-6. 2003
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42 | BBC3
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| p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.
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| Villunger A, Michalak EM, Coultas L, Müllauer F, Böck G, Ausserlechner MJ, Adams JM, Strasser A.
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| Science. 302(5647):1036-8 2003
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43 | BBC3
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| PUMA induces the rapid apoptosis of colorectal cancer cells.
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| Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B.
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| Mol Cell 7(3):673-82. 2001
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44 | BBC3
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| PUMA, a novel proapoptotic gene, is induced by p53.
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| Nakano K, Vousden KH.
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| Mol Cell 7(3):683-94. 2001
|