| 1 | BAP1, KURIS
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| Rare germline heterozygous missense variants in BRCA1-associated protein 1, BAP1, cause a syndromic neurodevelopmental disorder
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| Gilbert-Dussardier B, Odent S, Laumonnier F, Berger SI, Smith ACM, Bourdeaut F, Stern MH, Redon R, Krüger E, Margueron R, Bézieau S, Poschmann J, Isidor B. Schnur RE, Wentzensen IM, Denommé-Pichon AS, Fourgeux C, Verheijen FW, Faurie E, Schot R, Stevens CA, Smits DJ, Barr E, Sheffer R, Bernstein JA, Stimach CL, Kovitch E, Shashi V, Schoch K, Smith W, van Jaarsveld RH, Hurst ACE, Smith K, Baugh EH, Bohm SG, Vyhnálková E, Ryba L, Delnatte C, Neira J, Bonneau D, Toutain A, Rosenfeld JA; Undiagnosed Diseases Network, Audebert-Bellanger S, Küry S, Ebstein F, Mollé A, Besnard T, Lee MK, Vignard V, Hery T, Nizon M, Mancini GMS, Giltay JC, Cogné B, McWalter K, Deb W, Mor-Shaked H, Li H,
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| Am J Hum Genet. Feb 3;109(2):361-372. doi: 10.1016/j.ajhg.2021.12.011. Epub 2022 Jan 19. 2022
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| 2 | BAP1
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| Roles of the BAP1 Tumor Suppressor in Cell Metabolism.
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| Han A, Purwin TJ, Aplin AE.
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| Cancer Res. Jun 1;81(11):2807-2814. doi: 10.1158/0008-5472.CAN-20-3430. Epub 2021 Jan 14. 2021
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| 3 | BAP1, KLF5, WWP1
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| BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression
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| Jia X, Chen H, Ren Y, Dejizhuoga, Gesangyuzhen, Gao N, Feng H, Huang W, Liao Y, Yu H.
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| Exp Cell Res. May 1;402(1):112506. doi: 10.1016/j.yexcr.2021.112506. Epub 2021 Jan 29. 2021
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| 4 | BAP1
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| Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer
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| Carbone M, Harbour JW, Brugarolas J, Bononi A, Pagano I, Dey A, Krausz T, Pass HI, Yang H, Gaudino G.
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| Cancer Discov. Aug;10(8):1103-1120. doi: 10.1158/2159-8290.CD-19-1220. Epub 2020 Jul 20. 2020
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| 5 | BAP1
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| BAP1 Germline Mutation Associated with Bilateral Primary Uveal Melanoma.
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| Yu MD, Masoomian B, Shields JA, Shields CL.
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| Ocul Oncol Pathol. Jan;6(1):10-14. doi: 10.1159/000499570. Epub 2019 Jun 4. 2020
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| 6 | BAP1
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| Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis
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| Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y, Fan Z.
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| J Exp Med. Feb 3;217(2):e20190974. doi: 10.1084/jem.20190974 2020
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| 7 | BAP1, SLC7A11
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| Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1.
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| Zhang Y, Koppula P, Gan B.
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| Cell Cycle. Apr;18(8):773-783. doi: 10.1080/15384101.2019.1597506. Epub 2019 Mar 30. 2019
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| 8 | BAP1, SLC7A11
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| BAP1 links metabolic regulation of ferroptosis to tumour suppression
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| Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B.
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| Nat Cell Biol. Oct;20(10):1181-1192. doi: 10.1038/s41556-018-0178-0. Epub 2018 Sep 10 2018
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| 9 | BAP1, SLC7A11
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| BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression. x2018 . PMID:
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| Zhang Y, Zhuang L, Gan B.
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| Mol Cell Oncol. Nov 13;6(1):1536845. doi: 10.1080/23723556.2018.1536845 2018
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| 10 | BAP1, UCHL3, UCHL5
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| Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications.
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| Fang Y, Shen X.
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| Cancer Metastasis Rev 36(4):669-682. doi: 10.1007/s10555-017-9702-0. Review.
2017
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| 11 | BAP1, ITPR3
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| BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation.
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| Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M.
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| Nature. Jun 22;546(7659):549-553. doi: 10.1038/nature22798. Epub 2017 Jun 14. 2017
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| 12 | ASXL1, ASXL2, ASXL3, BAP1
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| BAP1/ASXL1 recruitment and activation for H2A deubiquitination.
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| Sahtoe DD, van Dijk WJ, Ekkebus R, Ovaa H, Sixma TK.
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| Nat Commun 7:10292. doi: 10.1038/ncomms10292.
2016
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| 13 | BAP1
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| BAP1 regulates cell cycle progression through E2F1 target genes and mediates transcriptional silencing via H2A monoubiquitination in uveal melanoma cells.
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| Pan H, Jia R, Zhang L, Xu S, Wu Q, Song X, Zhang H, Ge S, Leon Xu X, Fan X.
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| Int J Biochem Cell Biol 60:176-84. doi: 10.1016/j.biocel.2015.01.001. Epub 2015 Jan 9.
2015
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| 14 | BAP1
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| Analysis of BAP1 Germline Gene Mutation in Young Uveal Melanoma Patients.
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| Cebulla CM, Binkley EM, Pilarski R, Massengill JB, Rai K, Liebner DA, Marino MJ, Singh AD, Abdel-Rahman MH.
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| Ophthalmic Genet phthalmic Genet. 2015 Feb 17:1-6. [Epub ahead of print]
2015
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| 15 | ASXL1, ASXL2, BAP1
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| The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.
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| Daou S, Hammond-Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono NV, Nkwe NS, Motorina A, Pak H, Yu H, Wurtele H, Milot E, Mallette FA, Carbone M, Affar el B.
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| J Biol Chem 290(48):28643-63. doi: 10.1074/jbc.M115.661553.
2015
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| 16 | BAP1
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| Germline mutations in BAP1 impair its function in DNA double-strand break repair.
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| Ismail IH, Davidson R, Gagné JP, Xu ZZ, Poirier GG, Hendzel MJ.
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| Cancer Res 74(16):4282-94. doi: 10.1158/0008-5472.CAN-13-3109. Epub 2014 Jun 3.
2014
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| 17 | BAP1
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| Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.
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| Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S, Barbour H, Corbeil L, Hébert J, Drobetsky E, Masson JY, Di Noia JM, Affar el B.
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| Proc Natl Acad Sci U S A 111(1):285-90. doi: 10.1073/pnas.1309085110. Epub 2013 Dec 17.
2014
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| 18 | BAP1, EIF1AX, GNA11, GNAQ
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| Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma.
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| Ewens KG, Kanetsky PA, Richards-Yutz J, Purrazzella J, Shields CL, Ganguly T, Ganguly A.
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| Invest Ophthalmol Vis Sci 55(8):5160-7. doi: 10.1167/iovs.14-14550.
2014
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| 19 | BAP1
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| BAP1 is phosphorylated at serine 592 in S-phase following DNA damage.
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| Eletr ZM, Yin L, Wilkinson KD.
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| FEBS Lett 587(24):3906-11. doi: 10.1016/j.febslet.2013.10.035. Epub 2013 Nov 5.
2013
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| 20 | BAP1, HCFC1
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| BAP1 loss defines a new class of renal cell carcinoma.
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| Peńa-Llopis S, Vega-Rubín-de-Celis S, Liao A, Leng N, Pavía-Jiménez A, Wang S, Yamasaki T, Zhrebker L, Sivanand S, Spence P, Kinch L, Hambuch T, Jain S, Lotan Y, Margulis V, Sagalowsky AI, Summerour PB, Kabbani W, Wong SW, Grishin N, Laurent M, Xie XJ, Haudenschild CD, Ross MT, Bentley DR, Kapur P, Brugarolas J.
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| Nat Genet 44(7):751-9. doi: 10.1038/ng.2323. Erratum in: Nat Genet. 2012 Sep;44(9):1072.
2012
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| 21 | BAP1, HCFC1, OGT
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| Loss of the tumor suppressor BAP1 causes myeloid transformation.
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| Dey A, Seshasayee D, Noubade R, French DM, Liu J, Chaurushiya MS, Kirkpatrick DS, Pham VC, Lill JR, Bakalarski CE, Wu J, Phu L, Katavolos P, LaFave LM, Abdel-Wahab O, Modrusan Z, Seshagiri S, Dong K, Lin Z, Balazs M, Suriben R, Newton K, Hymowitz S, Garcia-Manero G, Martin F, Levine RL, Dixit VM.
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| Science 337(6101):1541-6.
2012
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| 22 | ASXL1, BAP1, HCFC1
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| The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
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| Bott M, Brevet M, Taylor BS, Shimizu S, Ito T, Wang L, Creaney J, Lake RA, Zakowski MF, Reva B, Sander C, Delsite R, Powell S, Zhou Q, Shen R, Olshen A, Rusch V, Ladanyi M.
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| Nat Genet 43(7):668-72. doi: 10.1038/ng.855.
2011
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| 23 | BAP1
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| Germline BAP1 mutations and tumor susceptibility.
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| Goldstein AM.
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| Nat Genet 43(10):925-6. doi: 10.1038/ng.956. No abstract available.
2011
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| 24 | BAP1
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| Germline mutations in BAP1 predispose to melanocytic tumors.
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| Wiesner T, Obenauf AC, Murali R, Fried I, Griewank KG, Ulz P, Windpassinger C, Wackernagel W, Loy S, Wolf I, Viale A, Lash AE, Pirun M, Socci ND, Rütten A, Palmedo G, Abramson D, Offit K, Ott A, Becker JC, Cerroni L, Kutzner H, Bastian BC, Speicher MR.
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| Nat Genet 43(10):1018-21. doi: 10.1038/ng.910.
2011
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| 25 | BAP1
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| Germline BAP1 mutations predispose to malignant mesothelioma.
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| Testa JR, Cheung M, Pei J, Below JE, Tan Y, Sementino E, Cox NJ, Dogan AU, Pass HI, Trusa S, Hesdorffer M, Nasu M, Powers A, Rivera Z, Comertpay S, Tanji M, Gaudino G, Yang H, Carbone M.
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| Nat Genet 43(10):1022-5. doi: 10.1038/ng.912.
2011
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| 26 | BAP1, COX7C, HCFC1, YY1
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| The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.
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| Yu H, Mashtalir N, Daou S, Hammond-Martel I, Ross J, Sui G, Hart GW, Rauscher FJ 3rd, Drobetsky E, Milot E, Shi Y, Affar el B.
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| Mol Cell Biol 30(21):5071-85. Epub 2010 Aug 30. 2010
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| 27 | BAP1
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| Frequent mutation of BAP1 in metastasizing uveal melanomas.
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| Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM.
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| Science 330(6009):1410-3. Epub 2010 Nov 4.
2010
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| 28 | BAP1, HCFC1
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| The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.
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| Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A.
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| J Biol Chem 284(49):34179-88. Epub 2009 Oct 8.PMID: 19815555 2009
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| 29 | BAP1, HCFC1
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| Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1.
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| Misaghi S, Ottosen S, Izrael-Tomasevic A, Arnott D, Lamkanfi M, Lee J, Liu J, O'Rourke K, Dixit VM, Wilson AC.
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| Mol Cell Biol 29(8):2181-92. Epub 2009 Feb 2.PMID: 19188440 2009
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| 30 | BAP1
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| BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
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| Ventii KH, Devi NS, Friedrich KL, Chernova TA, Tighiouart M, Van Meir EG, Wilkinson KD.
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| Cancer Res 68(17):6953-62.
2008
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| 31 | BAP1
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| BAP1 : a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
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| Jensen DE, et al.
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| Oncogene 16 : 1097-1112. 1998
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