Citations for
1BACH1, HOXB8
Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1.
Ying Y, Wang Y, Huang X, Sun Y, Zhang J, Li M, Zeng J, Wang M, Xiao W, Zhong L, Xu B, Li L, Tao Q, Wang X, Shu XS.
Oncogene 39(5):1004-1017. doi: 10.1038/s41388-019-1013-1. Epub 2019 Oct 7. 2020
2BACH1, BACH2
The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis.
Ebina-Shibuya R, Watanabe-Matsui M, Matsumoto M, Itoh-Nakadai A, Funayama R, Nakayama K, Muto A, Igarashi K.
J Biochem Biochem. 2016 Jul 7. pii: mvw041. [Epub ahead of print] 2016
3BACH1
BACH1, the master regulator gene: A novel candidate target for cancer therapy.
Davudian S, Mansoori B, Shajari N, Mohammadi A, Baradaran B.
Gene 588(1):30-7. doi: 10.1016/j.gene.2016.04.040. Epub 2016 Apr 22. Review. 2016
4BACH1, BACH2, MAFG, MAFK, MAfF, NFE2, NFE2L2
Small Maf proteins (MafF, MafG, MafK): History, structure and function.
Katsuoka F, Yamamoto M.
Gene 586(2):197-205. doi: 10.1016/j.gene.2016.03.058. Epub 2016 Apr 5. Review. 2016
5BACH1
Bach1 Induces Endothelial Cell Apoptosis and Cell-Cycle Arrest through ROS Generation.
Wang X, Liu J, Jiang L, Wei X, Niu C, Wang R, Zhang J, Meng D, Yao K.
Oxid Med Cell Longev 2016:6234043. doi: 10.1155/2016/6234043. Epub 2016 Feb 29. 2016
6BACH1
Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1.
Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, Lotz MK, Ochi M.
Arthritis Res Ther 17:285. doi: 10.1186/s13075-015-0792-1. 2015
7BACH1, TCF4
Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.
Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D.
Circ Res 117(4):364-75. doi: 10.1161/CIRCRESAHA.115.306829. Epub 2015 Jun 29. Erratum in: Circ Res. 2015 Oct 9;117(9):e79. 2015
8BACH1, BACH2, EBF1
The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
Itoh-Nakadai A, Hikota R, Muto A, Kometani K, Watanabe-Matsui M, Sato Y, Kobayashi M, Nakamura A, Miura Y, Yano Y, Tashiro S, Sun J, Ikawa T, Ochiai K, Kurosaki T, Igarashi K.
Nat Immunol 15(12):1171-80. doi: 10.1038/ni.3024. Epub 2014 Oct 26. 2014
9BACH1
Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation.
Hada H, Shiraki T, Watanabe-Matsui M, Igarashi K.
Biochim Biophys Acta 1840(7):2351-60. doi: 10.1016/j.bbagen.2014.02.029. Epub 2014 Mar 5. 2014
10BACH1, MAFK, TGFB1
Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.
Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D, Kato M.
J Biol Chem 288(28):20658-67. doi: 10.1074/jbc.M113.450478. Epub 2013 Jun 4. 2013
11BACH1, XPO1
Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
Li J, Shiraki T, Igarashi K.
FEBS Lett 586(4):448-54. Epub 2012 Jan 28. 2012
12BACH1
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis.
Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung SY, Yang Q, Hu G, Kang Y.
J Biol Chem 287(40):33533-44. Epub 2012 Aug 8. 2012
13BACH1
Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2.
Nishizawa H, Ota K, Dohi Y, Ikura T, Igarashi K.
Cancer Sci 103(5):897-903. doi: 10.1111/j.1349-7006.2012.02244.x. Epub 2012 Apr 11. 2012
14BACH1, HMOX1
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML.
J Biol Chem 286(26):23521-32. Epub 2011 May 9. 2011
15BACH1
Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes.
Okada S, Muto A, Ogawa E, Nakanome A, Katoh Y, Ikawa S, Aiba S, Igarashi K, Okuyama R.
J Biol Chem 285(31):23581-9. Epub 2010 May 25. 2010
16BACH1
Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1.
Miyazaki T, Kirino Y, Takeno M, Samukawa S, Hama M, Tanaka M, Yamaji S, Ueda A, Tomita N, Fujita H, Ishigatsubo Y.
Cancer Sci 101(6):1409-16. Epub 2010 Mar 2.PMID: 20345481 2010
17BACH1
Crystal structure of the Bach1 BTB domain and its regulation of homodimerization.
Ito N, Watanabe-Matsui M, Igarashi K, Murayama K.
Genes Cells 14(2):167-78. Epub 2008 Jan 12.PMID: 19170764 2009
18BACH1, HMOX1
BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.
Reichard JF, Sartor MA, Puga A.
J Biol Chem 283(33):22363-70. Epub 2008 Jun 11. 2008
19BACH1, TP53
Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.
Dohi Y, Ikura T, Hoshikawa Y, Katoh Y, Ota K, Nakanome A, Muto A, Omura S, Ohta T, Ito A, Yoshida M, Noda T, Igarashi K.
Nat Struct Mol Biol 15(12):1246-54. Epub 2008 Nov 16. 2008
20BACH1
Ablation of the bach1 gene leads to the suppression of atherosclerosis in bach1 and apolipoprotein E double knockout mice.
Watari Y, Yamamoto Y, Brydun A, Ishida T, Mito S, Yoshizumi M, Igarashi K, Chayama K, Ohshima T, Ozono R.
Hypertens Res 31(4):783-92.PMID: 18633191 2008
21BACH1, NFE2L2
Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1.
Reichard JF, Motz GT, Puga A.
Nucleic Acids Res 35(21):7074-86. Epub 2007 Oct 16. 2007
22GATA1, BACH1, SON, GABPA, C21orf66, RUNX1
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cave H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, Zwaan CM, Golub TR, Orkin SH.
Proc Natl Acad Sci U S A 103(9):3339-44. Epub 2006 Feb 21. 2006
23BACH1, BRCA1
BACH1 is a DNA repair protein supporting BRCA1 damage response.
Peng M, Litman R, Jin Z, Fong G, Cantor SB.
Oncogene 25(15):2245-53. 2006
24HMOX1, BACH1
Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS.
Shan Y, Lambrecht RW, Ghaziani T, Donohue SE, Bonkovsky HL.
J Biol Chem 279(50):51769-74. Epub 2004 Oct 1. 2004
25BACH1, MAFK
Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network.
Sun J, Brand M, Zenke Y, Tashiro S, Groudine M, Igarashi K.
Proc Natl Acad Sci U S A 101(6):1461-6. Epub 2004 Jan 27. 2004
26BACH1, BRCA1, BRIP1
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM.
Cell 105(1):149-60. 2001
27BACH1
Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform.
Kanezaki R, Toki T, Yokoyama M, Yomogida K, Sugiyama K, Yamamoto M, Igarashi K, Ito E.
J Biol Chem 276(10):7278-84. 2001
28BACH1
Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1.
Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O.
Genomics 47(2):300-6. 1998
29BACH1
Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1.
Blouin JL, et al.
Hum Genet 102 : 282-288. 1998
30BACH1
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription throuth the NF-E2 site.
Oyake T, et al.
Mol Cell Biol 16 : 6083-6095. 1996
31BACH1, BACH2
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.
Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M, Igarashi K.
Mol Cell Biol 16(11):6083-95. 1996