| 1 | BACE2
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| RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation.
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| Qiu K, Wang S, Wang X, Wang F, Wu Y.
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| Biomed Res Int. Jun 5;2020:1920789. doi: 10.1155/2020/1920789. 2020
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| 2 | BACE2, PMEL
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| BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.
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| Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS, De Strooper B, Raposo G, van Niel G.
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| Proc Natl Acad Sci U S A 110(26):10658-63. doi: 10.1073/pnas.1220748110. Epub 2013 Jun 10.
2013
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| 3 | BACE2, TMEM27
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| Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.
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| Esterházy D, Akpinar P, Stoffel M.
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| Biol Chem 393(6):473-84. doi: 10.1515/hsz-2012-0104.
2012
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| 4 | BACE2
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| Identification of BACE2 as an avid ß-amyloid-degrading protease.
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| Abdul-Hay SO, Sahara T, McBride M, Kang D, Leissring MA.
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| Mol Neurodegener 7:46. doi: 10.1186/1750-1326-7-46.
2012
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| 5 | BACE2
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| BACE2 expression increases in human neurodegenerative disease.
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| Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP.
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| Am J Pathol 180(1):337-50. doi: 10.1016/j.ajpath.2011.09.034. Epub 2011 Nov 7.
2012
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| 6 | BACE2
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| Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
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| Esterházy D, Stützer I, Wang H, Rechsteiner MP, Beauchamp J, Döbeli H, Hilpert H, Matile H, Prummer M, Schmidt A, Lieske N, Boehm B, Marselli L, Bosco D, Kerr-Conte J, Aebersold R, Spinas GA, Moch H, Migliorini C, Stoffel M.
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| Cell Metab 14(3):365-77. doi: 10.1016/j.cmet.2011.06.018.
2011
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| 7 | BACE1, BACE2
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| β-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression.
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| Bettegazzi B, Mihailovich M, Di Cesare A, Consonni A, Macco R, Pelizzoni I, Codazzi F, Grohovaz F, Zacchetti D.
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| Eur J Neurosci 33(2):236-43. doi: 10.1111/j.1460-9568.2010.07482.x. Epub 2010 Nov 14.
2011
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| 8 | BACE1, BACE2
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| BACE2 plays a role in the insulin receptor trafficking in pancreatic ß-cells.
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| Casas S, Casini P, Piquer S, Altirriba J, Soty M, Cadavez L, Gomis R, Novials A.
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| Am J Physiol Endocrinol Metab 299(6):E1087-95. doi: 10.1152/ajpendo.00420.2010. Epub 2010 Oct 13.
2010
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| 9 | BACE1, BACE2
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| BACE1 and BACE2 enzymatic activities in Alzheimer's disease.
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| Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP.
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| J Neurochem 112(4):1045-53. doi: 10.1111/j.1471-4159.2009.06528.x. Epub 2009 Dec 4.
2010
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| 10 | BACE2
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| BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells.
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| Finzi G, Franzi F, Placidi C, Acquati F, Palumbo E, Russo A, Taramelli R, Sessa F, La Rosa S.
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| Ultrastruct Pathol 32(6):246-51. doi: 10.1080/01913120802486217.
2008
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| 11 | APP, BACE1, BACE2
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| Protein expression of BACE1, BACE2 and APP in Down syndrome brains.
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| Cheon MS, Dierssen M, Kim SH, Lubec G.
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| Amino Acids 35(2):339-43. Epub 2007 Dec 29.
2008
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| 12 | BACE2
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| BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.
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| Sun X, He G, Song W.
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| FASEB J 20(9):1369-76. 2006
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| 13 | BACE1, BACE2
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| Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.
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| Stockley JH, Ravid R, O'Neill C.
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| FEBS Lett 580(28-29):6550-60. Epub 2006 Nov 13. 2006
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| 14 | BACE1, BACE2, RTN3, RTN4
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| Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
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| Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W.
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| Eur J Neurosci 24(5):1237-44. Epub 2006 Sep 8. 2006
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| 15 | BACE1, BACE2
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| Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
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| Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, Song W.
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| FASEB J 19(7):739-49. 2005
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| 16 | BACE2
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| Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.
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| Myllykangas L, Wavrant-De Vrieze F, Polvikoski T, Notkola IL, Sulkava R, Niinisto L, Edland SD, Arepalli S, Adighibe O, Compton D, Hardy J, Haltia M, Tienari PJ.
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| J Neurol Sci 236(1-2):17-24. 2005
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| 17 | BACE2
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| BACE-2 is overexpressed in Down's syndrome.
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| Barbiero L, Benussi L, Ghidoni R, Alberici A, Russo C, Schettini G, Pagano SF, Parati EA, Mazzoli F, Nicosia F, Signorini S, Feudatari E, Binetti G.
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| Exp Neurol 182(2):335-45. 2003
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| 18 | BACE1, BACE2
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| Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
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| Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J.
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| Biochemistry 41(27):8742-6. 2002
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| 19 | BACE2
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| BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
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| Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.
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| Proc Natl Acad Sci U S A 97(17):9712-7. 2000
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| 20 | BACE2
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| The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region.
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| Acquati F, Accarino M, Nucci C, Fumagalli P, Jovine L, Ottolenghi S, Taramelli R.
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| FEBS Lett 468(1):59-64. 2000
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| 21 | BACE2
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| A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase.
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| Solans A, Estivill X, de La Luna S.
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| Cytogenet Cell Genet 89(3-4):177-84. 2000
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| 22 | AGPAT3, ASNSL2, ATP5J2LP, BACE2, BRWD1, C21orf20, C21orf21, C21orf22, C21orf23, C21orf30, C21orf31, C21orf32, C21orf36, C21orf37, C21orf39, C21orf40, C21orf41, C21orf42, C21orf44, C21orf47, C21orf49, C21orf52, C21orf54, C21orf57, C21orf58, C2CD2, CLIC6, CYCSP41, CYCSP42, CYP4F3LP, DSCR4, EEF1A1P, EIF3FP, EIF4A1P, FAM165B, FBXW11P1, FDPSP, GAPDHP14, H2AFZP, HSPD1P7, IGSF5, IMMTP, KRT18P2, LGALS3, MACSL1, MYL6P, OR7E23P, POLR2CP, PPIAL3, PPIAP, PRDM15, PSMD15, RAD23BLP, RBM11, RBPMSLP, RIMKLB2, RIPK4, RPL10P1, RPL23AP4, RPL23P2, RPL31P1, RPL31P3, RPS20P1, RPS26P1, RPS3AP1, RPS5P3, RPS9P1, SAMSN1, SFRS9P1, SH3BGR, SLC6A6P, SPATC1L, TCP10L, TUBAP, TUBAP2, UMODL1, VDAC2P1, VN1R7P, VN1R8P, ZBTB21, ZNF294, ZNF299, ZNF299P
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| The DNA sequence of human chromosome 21.
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| Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML; Chromosome 21 mapping and sequencing consortium.
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| Nature 405(6784):311-9. Erratum in: Nature 2000 Sep 7;407(6800):110. 2000
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