| 1 | AXIN2, FTACC
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| AXIN2-related oligodontia-colorectal cancer syndrome with cleft palate as a possible new feature.
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| Roht L, Hyldebrandt HK, Stormorken AT, Nordgarden H, Sijmons RH, Bos DK, Riegert-Johnson D, Mantia-Macklin S, Ilves P, Muru K, Wojcik MH, Kahre T, Õunap K.
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| Mol Genet Genomic Med. Jun;11(6):e2157. doi: 10.1002/mgg3.2157. Epub 2023 Mar 1. 2023
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| 2 | AXIN2
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| AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer.
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| Leclerc J, Beaumont M, Vibert R, Pinson S, Vermaut C, Flament C, Lovecchio T, Delattre L, Demay C, Coulet F, Guillerm E, Hamzaoui N, Benusiglio PR, Brahimi A, Cornelis F, Delhomelle H, Fert-Ferrer S, Fournier BPJ, Hovnanian A, Legrand C, Lortholary A, Malka D, Petit F, Saurin JC, Lejeune S, Colas C, Buisine MP.
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| Genes Chromosomes Cancer. Apr;62(4):210-222. doi: 10.1002/gcc.23112. Epub 2022 Dec 21. 2023
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| 3 | AXIN2
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| Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis.
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| de Roo JJD, Chhatta A, Garcia-Perez L, Naber BAE, Vloemans SA, Salvatori DCF, Pike-Overzet K, Mikkers H, Staal FJT.
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| Cells. Aug 28;11(17):2679. doi: 10.3390/cells11172679. 2022
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| 4 | AXIN2
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| Axin2+ endometrial stem cells: the source of endometrial regeneration and cancer
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| Syed SM, Tanwar PS.
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| Mol Cell Oncol. Mar 5;7(3):1729681. doi: 10.1080/23723556.2020.1729681. 2020
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| 5 | AXIN2
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| A novel AXIN2 gene mutation in sagittal synostosis.
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| Yilmaz E, Mihci E, Guzel Nur B, Alper OM.
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| Am J Med Genet A. Sep;176(9):1976-1980. doi: 10.1002/ajmg.a.40373. Epub 2018 Aug 8. 2018
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| 6 | AXIN2
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| Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review.
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| Hlouskova A, Bielik P, Bonczek O, Balcar VJ, Šerı O.
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| Neuro Endocrinol Lett Jul;38(3):131-137 2017
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| 7 | AXIN2
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| Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
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| Babb R, Chandrasekaran D, Carvalho Moreno Neves V, Sharpe PT.
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| Sci Rep. Jun 8;7(1):3102. doi: 10.1038/s41598-017-03145-6. 2017
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| 8 | AXIN2
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| AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth. 2016 PMID:
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| Hu BR, Fairey AS, Madhav A, Yang D, Li M, Groshen S, Stephens C, Kim PH, Virk N, Wang L, Martin SE, Erho N, Davicioni E, Jenkins RB, Den RB, Xu T, Xu Y, Gill IS, Quinn DI, Goldkorn A.
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| Prostate. May;76(6):597-608. doi: 10.1002/pros.23151. Epub 2016 Jan 15. 2016
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| 9 | AXIN2
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| Loss of Axin2 Causes Ocular Defects During Mouse Eye Development. 2016. PMID:
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| Alldredge A, Fuhrmann S.
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| Invest Ophthalmol Vis Sci. Oct 1;57(13):5253-5262. doi: 10.1167/iovs.15-18599 2016
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| 10 | AXIN1, AXIN2
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| Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function.
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| Figeac N, Zammit PS.
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| Cell Signal. Aug;27(8):1652-65. doi: 10.1016/j.cellsig.2015.03.025. Epub 2015 Apr 10. 2015
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| 11 | AXIN2
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| Nuclear AXIN2 represses MYC gene expression
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| Rennoll SA, Konsavage WM Jr, Yochum GS.
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| Biochem Biophys Res Commun. Jan 3;443(1):217-22. doi: 10.1016/j.bbrc.2013.11.089. Epub 2013 Dec 2. 2014
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| 12 | AXIN2, HDAC3, RUNX2
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| Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice.
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| McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ.
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| J Biol Chem 288(8):5291-302. doi: 10.1074/jbc.M112.414995. Epub 2013 Jan 7.
2013
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| 13 | AXIN2
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| Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity.
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| Wu ZQ, Brabletz T, Fearon E, Willis AL, Hu CY, Li XY, Weiss SJ.
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| Proc Natl Acad Sci U S A 109(28):11312-7. doi: 10.1073/pnas.1203015109. Epub 2012 Jun 27.
2012
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| 14 | AXIN2, FOXM1, KRAS
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| Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium.
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| Wang IC, Snyder J, Zhang Y, Lander J, Nakafuku Y, Lin J, Chen G, Kalin TV, Whitsett JA, Kalinichenko VV.
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| Mol Cell Biol 32(19):3838-50. doi: 10.1128/MCB.00355-12. Epub 2012 Jul 23.
2012
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| 15 | AXIN2
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| Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
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| Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH.
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| Nat Neurosci. 14(8):1009-16. 2011
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| 16 | AXIN2, CEP250, CTNNB1
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| Conductin/axin2 and Wnt signalling regulates centrosome cohesion.
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| Hadjihannas MV, Brückner M, Behrens J.
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| EMBO Rep 11(4):317-24. Epub 2010 Mar 19.PMID: 20300119 2010
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| 17 | AXIN1, AXIN2
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| Axin2 regulates chondrocyte maturation and axial skeletal development.
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| Dao DY, Yang X, Flick LM, Chen D, Hilton MJ, O'Keefe RJ.
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| J Orthop Res 28(1):89-95.
2010
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| 18 | AXIN2, SOX5
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| SOX5 controls cell cycle progression in neural progenitors by interfering with the WNT-beta-catenin pathway.
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| Martinez-Morales PL, Quiroga AC, Barbas JA, Morales AV.
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| EMBO Rep 11(6):466-72. Epub 2010 May 7.
2010
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| 19 | AXIN2, TCF7L2
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| Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability.
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| Kim MS, Kim SS, Ahn CH, Yoo NJ, Lee SH.
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| Hum Pathol 40(1):58-64. Epub 2008 Aug 27.PMID: 18755497 2009
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| 20 | AXIN2
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| AXIS inhibition protein 2, orofacial clefts and a family history of cancer.
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| Menezes R, Marazita ML, Goldstein McHenry T, Cooper ME, Bardi K, Brandon C, Letra A, Martin RA, Vieira AR.
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| J Am Dent Assoc 140(1):80-4.PMID: 19119171 2009
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| 21 | AXIN2
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| [Association of single nucleotide polymorphisms of Axis inhibitor-2 gene rs224030, rs8081536, rs9913621 with Hirschsprung disease]
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| Gao H, Zhang J, Wang W, Zhang Z, Huang Y, Zhang S.
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| Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25(6):697-700. Chinese. PMID: 19065536 2008
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| 22 | AXIN2
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| Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation.
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| Liu B, Yu HM, Hsu W.
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| Dev Biol 301(1):298-308. Epub 2006 Oct 21.
2007
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| 23 | AXIN2, MUTYH, FTACC
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| Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis.
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| Lejeune S, Guillemot F, Triboulet JP, Cattan S, Mouton C; PAFNORD Group; Porchet N, Manouvrier S, Buisine MP.
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| Hum Mutat 27(10):1064. 2006
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| 24 | APC, CTNNB1, WNT1, AXIN2
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| Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis.
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| Cho KH, Baek S, Sung MH.
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| FEBS Lett 580(15):3665-70. Epub 2006 Jun 5. 2006
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| 25 | WNT1, AXIN2, SNAI1, GSK3B
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| A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
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| Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim NH, Cha SY, Ryu JK, Choi YJ, Kim J, Fearon ER, Weiss SJ.
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| Nat Cell Biol 8(12):1398-406. Epub 2006 Oct 29. 2006
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| 26 | AXIN1, AXIN2, TCF7L2
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| Colorectal cancer and genetic alterations in the Wnt pathway.
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| Segditsas S, Tomlinson I.
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| Oncogene 25(57):7531-7. Review. 2006
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| 27 | FTACC, AXIN2
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| Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis.
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| Mostowska A, Biedziak B, Jagodzinski PP.
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| J Hum Genet 51(3):262-6. Epub 2006 Jan 24. 2006
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| 28 | AXIN2
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| Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability.
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| Koinuma K, Yamashita Y, Liu W, Hatanaka H, Kurashina K, Wada T, Takada S, Kaneda R, Choi YL, Fujiwara SI, Miyakura Y, Nagai H, Mano H.
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| Oncogene. 25(1):139-46. 2006
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| 29 | AXIN2, FTACC
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| Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer.
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| Lammi L, Arte S, Somer M, Jarvinen H, Lahermo P, Thesleff I, Pirinen S, Nieminen P.
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| Am J Hum Genet 74(5):1043-50. Epub 2004 Mar 23. 2004
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| 30 | AXIN1, AXIN2
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| Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.
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| Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I.
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| Genes Dev 16(9):1066-76. 2002
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| 31 | AXIN1, AXIN2, CDH1, CTNNA1, JUP
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| Cadherin and catenin alterations in human cancer.
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| Hajra KM, Fearon ER.
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| Genes Chromosomes Cancer 34(3):255-68. Review. 2002
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| 32 | AXIN1, AXIN2
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| Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
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| Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W.
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| Oncogene 21(31):4863-71. 2002
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| 33 | AXIN2
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| Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene.
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| Dong X, Seelan RS, Qian C, Mai M, Liu W.
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| Cytogenet Cell Genet 93(1-2):26-8. 2001
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| 34 | AXIN2
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| Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway.
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| Furuhashi M, Yagi K, Yamamoto H, Furukawa Y, Shimada S, Nakamura Y, Kikuchi A, Miyazono K, Kato M.
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| Mol Cell Biol. 21(15):5132-41. 2001
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| 35 | AXIN2
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| Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.
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| Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Qian C, Christensen E, Roche PC, Smith DI, Thibodeau SN.
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| Nat Genet 26(2):146-7. No abstract available. 2000
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| 36 | AXIN2
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| Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24.
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| Mai M, et al.
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| Genomics 55(3):341-4. 1999
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| 37 | AXIN1, AXIN2
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| Modulation of Wnt signaling by Axin and Axil.
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| Kikuchi A.
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| Cytokine Growth Factor Rev 10(3-4):255-65. 1999
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| 38 | AXIN1, AXIN2
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| Functional domains of axin. Importance of the C terminus as an oligomerization domain.
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| Sakanaka C, Williams LT.
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| J Biol Chem 274(20):14090-3. 1999
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| 39 | AXIN1, AXIN2, DVL1, DVL2, DVL3
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| DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
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| Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A.
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| Mol Cell Biol 19(6):4414-22. 1999
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| 40 | AXIN2
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| Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos.
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| Yamamoto H, Kishida S, Uochi T, Ikeda S, Koyama S, Asashima M, Kikuchi A.
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| Mol Cell Biol. 18(5):2867-75. 1998
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