| 1 | AXIN1, CMDOH
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| AXIN1 bi-allelic variants disrupting the C-terminal DIX domain cause craniometadiaphyseal osteosclerosis with hip dysplasia
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| Terhal P, Venhuizen AJ, Lessel D, Tan WH, Alswaid A, Grün R, Alzaidan HI, von Kroge S, Ragab N, Hempel M, Kubisch C, Novais E, Cristobal A, Tripolszki K, Bauer P, Fischer-Zirnsak B, Nievelstein RAJ, van Dijk A, Nikkels P, Oheim R, Hahn H, Bertoli-Avella A, Maurice MM, Kornak U.
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| Am J Hum Genet. Sep 7;110(9):1470-1481. doi: 10.1016/j.ajhg.2023.07.011. Epub 2023 Aug 14. 2023
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| 2 | AXIN1
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| Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect
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| Sanson R, Lazzara SL, Cune D, Pitasi CL, Trentesaux C, Fraudeau M, Letourneur F, Saintpierre B, Le Gall M, Bossard P, Terris B, Finetti P, Bertucci F, Mamessier E, Romagnolo B, Perret C.
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| Cell Mol Gastroenterol Hepatol. 2023;15(3):689-715. doi: 10.1016/j.jcmgh.2022.10.017. Epub 2022 Nov 8. 2023
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| 3 | AXIN1
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| Axin1: A novel scaffold protein joins the antiviral network of interferon.
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| Guo Y, Bamunuarachchi G, Vaddadi K, Zhu Z, Gandikota C, Ahmed K, Pushparaj S, More S, Xiao X, Yang X, Liang Y, Mukherjee S, Baviskar P, Huang C, Li S, Oomens AGP, Metcalf JP, Liu L.
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| Mol Microbiol. Dec;118(6):731-743. doi: 10.1111/mmi.14995. Epub 2022 Nov 5. 2022
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| 4 | AXIN1, UCHL5
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| UCHL5 controls β-catenin destruction complex function through Axin1 regulation.
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| Han W, Koo Y, Chaieb L, Keum BR, Han JK.
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| Sci Rep. Mar 7;12(1):3687. doi: 10.1038/s41598-022-07642-1. 2022
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| 5 | AXIN1
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| Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation.
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| Shu B, Zhao Y, Zhao S, Pan H, Xie R, Yi D, Lu K, Yang J, Xue C, Huang J, Wang J, Zhao D, Xiao G, Wang Y, Chen D.
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| Bone Res. Aug 12;8:31. doi: 10.1038/s41413-020-0104-5. 2020
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| 6 | AXIN1, SAPCD2
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| C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. 2018PMID:
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| Jiang J, Tang S, Xia J, Wen J, Chen S, Shu X, Huen MSY, Deng Y.
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| Oncogene May;37(22):2992-3005. doi: 10.1038/s41388-018-0166-7. Epub 2018 Mar 13. 2018
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| 7 | AXIN1, TRIM65
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| TRIM65 triggers β-catenin signaling via ubiquitylation of Axin1 to promote hepatocellular carcinoma.
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| Yang YF, Zhang MF, Tian QH, Zhang CZ.
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| J Cell Sci 130(18):3108-3115. doi: 10.1242/jcs.206623. Epub 2017 Jul 28.
2017
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| 8 | AXIN1, VDR
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| Vitamin D receptor is a novel transcriptional regulator for Axin1
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| Jin D, Zhang YG, Wu S, Lu R, Lin Z, Zheng Y, Chen H, Cs-Szabo G, Sun J.
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| J Steroid Biochem Mol Biol. Jan;165(Pt B):430-437. doi: 10.1016/j.jsbmb.2016.09.002. Epub 2016 Sep 4. 2017
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| 9 | AXIN1
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| RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer.
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| Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B.
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| Nat Commun. Feb 26;7:10751. doi: 10.1038/ncomms10751. 2016
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| 10 | AXIN1, AXIN2
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| Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function.
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| Figeac N, Zammit PS.
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| Cell Signal. Aug;27(8):1652-65. doi: 10.1016/j.cellsig.2015.03.025. Epub 2015 Apr 10. 2015
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| 11 | AXIN1, NFE2L2, WNT3A
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| WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.
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| Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martin JP, Gonzalez Sancho JM, Valverde A, Dale T, Regadera J, Cuadrado A.
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| Antioxid Redox Signal ntioxid Redox Signal. 2014 Oct 21. [Epub ahead of print]
2014
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| 12 | AXIN1
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| Alterations of axis inhibition protein 1 (AXIN1) in hepatitis B virus-related hepatocellular carcinoma and overexpression of AXIN1 induces apoptosis in hepatocellular cancer cells.
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| Li J, Quan H, Liu Q, Si Z, He Z, Qi H.
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| Oncol Res 20(7):281-8.
2013
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| 13 | AXIN1, MDM2
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| MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.
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| He Y, Lian G, Lin S, Ye Z, Li Q.
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| PLoS One 8(6):e67529. Print 2013.
2013
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| 14 | AXIN1
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| Abnormal hypermethylation and clinicopathological significance of Axin gene in lung cancer.
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| Yang LH, Xu HT, Li QC, Jiang GY, Zhang XP, Zhao HY, Xu K, Wang EH.
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| Tumour Biol 34(2):749-57. doi: 10.1007/s13277-012-0604-z. Epub 2012 Nov 29.
2013
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| 15 | APC2, AXIN1
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| APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation.
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| Poulton JS, Mu FW, Roberts DM, Peifer M.
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| Development 140(20):4226-36. doi: 10.1242/dev.094425. Epub 2013 Sep 11.
2013
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| 16 | APC, AXIN1, HECTD1
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| HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
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| Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P.
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| J Biol Chem 288(6):3753-67. doi: 10.1074/jbc.M112.415240. Epub 2012 Dec 31.
2013
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| 17 | AXIN1, KIF3A, SLC2A4, TNKS2
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| The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.
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| Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC.
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| Cell Res 22(8):1246-57. doi: 10.1038/cr.2012.52. Epub 2012 Apr 3.
2012
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| 18 | AXIN1
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| Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.
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| Schneider PN, Slusarski DC, Houston DW.
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| PLoS One 7(9):e44096. doi: 10.1371/journal.pone.0044096. Epub 2012 Sep 5.
2012
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| 19 | AXIN1
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| Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
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| Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H.
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| Cell 149(6):1245-56. doi: 10.1016/j.cell.2012.05.002.
2012
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| 20 | AXIN1, TNKS
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| Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.
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| Morrone S, Cheng Z, Moon RT, Cong F, Xu W.
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| Proc Natl Acad Sci U S A 109(5):1500-5. doi: 10.1073/pnas.1116618109. Epub 2012 Jan 17.
2012
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| 21 | AXIN1, PML, TP53
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| AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
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| Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC.
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| Oncogene 30(10):1194-204. Epub 2010 Nov 8.
2011
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| 22 | AXIN1, GSK3B, STRAP
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| Role of STRAP in regulating GSK3β function and Notch3 stabilization.
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| Kashikar ND, Zhang W, Massion PP, Gonzalez AL, Datta PK.
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| Cell Cycle 10(10):1639-54. Epub 2011 May 15.
2011
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| 23 | AXIN1, PRMT1
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| Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling.
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| Cha B, Kim W, Kim YK, Hwang BN, Park SY, Yoon JW, Park WS, Cho JW, Bedford MT, Jho EH.
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| Oncogene 30(20):2379-89. Epub 2011 Jan 17.
2011
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| 24 | AXIN1
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| Axin1 expression facilitates cell death induced by aurora kinase inhibition through PARP activation.
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| Choi EJ, Kim SM, Song KJ, Lee JM, Kee SH.
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| J Cell Biochem 112(9):2392-402. doi: 10.1002/jcb.23162.
2011
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| 25 | AXIN1, USP34
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| The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.
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| Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, Angers S.
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| Mol Cell Biol 31(10):2053-65. doi: 10.1128/MCB.01094-10. Epub 2011 Mar 7.
2011
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| 26 | AXIN1
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| Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded.
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| Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SG, Maurice MM.
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| J Mol Biol 405(3):773-86. doi: 10.1016/j.jmb.2010.11.013. Epub 2010 Nov 16.
2011
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| 27 | AXIN1, AXIN2
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| Axin2 regulates chondrocyte maturation and axial skeletal development.
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| Dao DY, Yang X, Flick LM, Chen D, Hilton MJ, O'Keefe RJ.
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| J Orthop Res 28(1):89-95.
2010
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| 28 | AXIN1, SMURF2
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| The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2).
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| Kim S, Jho EH.
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| J Biol Chem 285(47):36420-6. doi: 10.1074/jbc.M110.137471. Epub 2010 Sep 21.
2010
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| 29 | AXIN1, CDH2, LRP5
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| N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.
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| Ha˙ E, Laplantine E, Geoffroy V, Frain M, Kohler T, Müller R, Marie PJ.
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| Mol Cell Biol 29(4):953-64. Epub 2008 Dec 15.
2009
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| 30 | AXIN1, ZBED3
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| Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.
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| Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L.
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| J Biol Chem 284(11):6683-9. Epub 2009 Jan 13.
2009
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| 31 | AXIN1
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| Axin localizes to mitotic spindles and centrosomes in mitotic cells.
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| Kim SM, Choi EJ, Song KJ, Kim S, Seo E, Jho EH, Kee SH.
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| Exp Cell Res 315(6):943-54. Epub 2009 Jan 30.
2009
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| 32 | AXIN1, MYC
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| The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.
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| Arnold HK, Zhang X, Daniel CJ, Tibbitts D, Escamilla-Powers J, Farrell A, Tokarz S, Morgan C, Sears RC.
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| EMBO J 28(5):500-12. Epub 2009 Jan 8.
2009
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| 33 | AXIN1
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| Axin localizes to the centrosome and is involved in microtubule nucleation.
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| Fumoto K, Kadono M, Izumi N, Kikuchi A.
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| EMBO Rep 10(6):606-13. Epub 2009 Apr 24.
2009
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| 34 | AXIN1, TNKS, TNKS2
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| Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
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| Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.
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| Nature 461(7264):614-20. Epub 2009 Sep 16.
2009
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| 35 | AXIN1, DAB2, PPP1CC
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| Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.
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| Jiang Y, Luo W, Howe PH.
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| Oncogene 28(33):2999-3007. Epub 2009 Jul 6.PMID: 19581931 2009
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| 36 | LRP6, GSK3A, GSK3B, CTNNB1, AXIN1
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| LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
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| Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.
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| Proc Natl Acad Sci U S A 105(23):8032-7. Epub 2008 May 28. 2008
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| 37 | AI1C, AIH1, AIH2, AIH3, AIHHT, AIPH1, AIPH2, AMELX, AXIN1, DD2, DGI1, DLX3, DSPP, ENAM, FTA1, FTACC, KLK4, MMP20, MSX1, OLD, PAX9, STHAG5, ZNF22
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| The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders.
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| Bailleul-Forestier I, Molla M, Verloes A, Berdal A.
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| Eur J Med Genet 51(4):273-91. Epub 2008 Mar 26. Review.
2008
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| 38 | AXIN1, AXIN2, TCF7L2
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| Colorectal cancer and genetic alterations in the Wnt pathway.
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| Segditsas S, Tomlinson I.
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| Oncogene 25(57):7531-7. Review. 2006
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| 39 | AXIN1
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| Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.
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| Oates NA, van Vliet J, Duffy DL, Kroes HY, Martin NG, Boomsma DI, Campbell M, Coulthard MG, Whitelaw E, Chong S.
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| Am J Hum Genet 79(1):155-62. Epub 2006 May 22.
2006
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| 40 | AXIN1, RNF111
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| Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
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| Liu W, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC.
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| EMBO J 25(8):1646-58. Epub 2006 Apr 6.
2006
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| 41 | AXIN1, CTNNB1
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| Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.
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| Park JY, Park WS, Nam SW, Kim SY, Lee SH, Yoo NJ, Lee JY, Park CK.
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| Liver Int 25(1):70-6. 2005
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| 42 | DIXDC1, AXIN1, MAP3K4, MAP3K1, DVL1
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| The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
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| Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC.
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| J Biol Chem 279(38):39366-73. Epub 2004 Jul 15. 2004
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| 43 | AXIN1
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| AXIN1 mutations but not deletions in cerebellar medulloblastomas.
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| Baeza N, Masuoka J, Kleihues P, Ohgaki H.
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| Oncogene 22(4):632-6. 2003
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| 44 | AXIN1, AXIN2
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| Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.
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| Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I.
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| Genes Dev 16(9):1066-76. 2002
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| 45 | AXIN1, AXIN2, CDH1, CTNNA1, JUP
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| Cadherin and catenin alterations in human cancer.
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| Hajra KM, Fearon ER.
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| Genes Chromosomes Cancer 34(3):255-68. Review. 2002
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| 46 | AXIN1, AXIN2
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| Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
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| Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W.
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| Oncogene 21(31):4863-71. 2002
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| 47 | AXIN1
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| Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
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| Dahmen RP, Koch A, Denkhaus D, Tonn JC, Sorensen N, Berthold F, Behrens J, Birchmeier W, Wiestler OD, Pietsch T.
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| Cancer Res 61(19):7039-43. 2001
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| 48 | AXIN1, TSG16D
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| AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.
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| Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y.
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| Nat Genet 24(3):245-50. No abstract available. 2000
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| 49 | AXIN1, CDX2
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| Identification of novel polymorphisms in the AXIN1++ and CDX-2 genes.
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| Lin YM, Kato T, Satoh S, Nakamura Y, Furukawa Y.
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| J Hum Genet 45(4):254-6. 2000
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| 50 | AXIN1
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| Axin prevents Wnt-3a-induced accumulation of beta-catenin.
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| Kishida M, et al.
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| Oncogene 18(4):979-85. 1999
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| 51 | AXIN1, AXIN2
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| Modulation of Wnt signaling by Axin and Axil.
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| Kikuchi A.
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| Cytokine Growth Factor Rev 10(3-4):255-65. 1999
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| 52 | AXIN1, AXIN2
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| Functional domains of axin. Importance of the C terminus as an oligomerization domain.
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| Sakanaka C, Williams LT.
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| J Biol Chem 274(20):14090-3. 1999
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| 53 | AXIN1, AXIN2, DVL1, DVL2, DVL3
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| DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
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| Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A.
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| Mol Cell Biol 19(6):4414-22. 1999
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| 54 | APC, AXIN1, CTNNB1, GSK3B
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| Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.
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| Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T.
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| Genes Cells 3 : 395-403. 1998
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| 55 | AXIN1, CTNNB1, GSK3B
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| Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.
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| Ikeda S, et al.
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| EMBO J 17 : 1371-1384. 1998
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| 56 | AXIN1
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| The mouse fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
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| Zeng L, et al.
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| Cell 90 : 181-192. 1997
|