Citations for
1AXIN1, SAPCD2
C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. 2018PMID:
Jiang J, Tang S, Xia J, Wen J, Chen S, Shu X, Huen MSY, Deng Y.
Oncogene May;37(22):2992-3005. doi: 10.1038/s41388-018-0166-7. Epub 2018 Mar 13. 2018
2AXIN1, TRIM65
TRIM65 triggers β-catenin signaling via ubiquitylation of Axin1 to promote hepatocellular carcinoma.
Yang YF, Zhang MF, Tian QH, Zhang CZ.
J Cell Sci 130(18):3108-3115. doi: 10.1242/jcs.206623. Epub 2017 Jul 28. 2017
3AXIN1, NFE2L2, WNT3A
WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.
Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martin JP, Gonzalez Sancho JM, Valverde A, Dale T, Regadera J, Cuadrado A.
Antioxid Redox Signal ntioxid Redox Signal. 2014 Oct 21. [Epub ahead of print] 2014
4AXIN1
Alterations of axis inhibition protein 1 (AXIN1) in hepatitis B virus-related hepatocellular carcinoma and overexpression of AXIN1 induces apoptosis in hepatocellular cancer cells.
Li J, Quan H, Liu Q, Si Z, He Z, Qi H.
Oncol Res 20(7):281-8. 2013
5AXIN1, MDM2
MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.
He Y, Lian G, Lin S, Ye Z, Li Q.
PLoS One 8(6):e67529. Print 2013. 2013
6AXIN1
Abnormal hypermethylation and clinicopathological significance of Axin gene in lung cancer.
Yang LH, Xu HT, Li QC, Jiang GY, Zhang XP, Zhao HY, Xu K, Wang EH.
Tumour Biol 34(2):749-57. doi: 10.1007/s13277-012-0604-z. Epub 2012 Nov 29. 2013
7APC2, AXIN1
APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation.
Poulton JS, Mu FW, Roberts DM, Peifer M.
Development 140(20):4226-36. doi: 10.1242/dev.094425. Epub 2013 Sep 11. 2013
8APC, AXIN1, HECTD1
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P.
J Biol Chem 288(6):3753-67. doi: 10.1074/jbc.M112.415240. Epub 2012 Dec 31. 2013
9AXIN1, KIF3A, SLC2A4, TNKS2
The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.
Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC.
Cell Res 22(8):1246-57. doi: 10.1038/cr.2012.52. Epub 2012 Apr 3. 2012
10AXIN1
Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.
Schneider PN, Slusarski DC, Houston DW.
PLoS One 7(9):e44096. doi: 10.1371/journal.pone.0044096. Epub 2012 Sep 5. 2012
11AXIN1
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H.
Cell 149(6):1245-56. doi: 10.1016/j.cell.2012.05.002. 2012
12AXIN1, TNKS
Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.
Morrone S, Cheng Z, Moon RT, Cong F, Xu W.
Proc Natl Acad Sci U S A 109(5):1500-5. doi: 10.1073/pnas.1116618109. Epub 2012 Jan 17. 2012
13AXIN1, PML, TP53
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC.
Oncogene 30(10):1194-204. Epub 2010 Nov 8. 2011
14AXIN1, GSK3B, STRAP
Role of STRAP in regulating GSK3β function and Notch3 stabilization.
Kashikar ND, Zhang W, Massion PP, Gonzalez AL, Datta PK.
Cell Cycle 10(10):1639-54. Epub 2011 May 15. 2011
15AXIN1, PRMT1
Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling.
Cha B, Kim W, Kim YK, Hwang BN, Park SY, Yoon JW, Park WS, Cho JW, Bedford MT, Jho EH.
Oncogene 30(20):2379-89. Epub 2011 Jan 17. 2011
16AXIN1
Axin1 expression facilitates cell death induced by aurora kinase inhibition through PARP activation.
Choi EJ, Kim SM, Song KJ, Lee JM, Kee SH.
J Cell Biochem 112(9):2392-402. doi: 10.1002/jcb.23162. 2011
17AXIN1, USP34
The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.
Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, Angers S.
Mol Cell Biol 31(10):2053-65. doi: 10.1128/MCB.01094-10. Epub 2011 Mar 7. 2011
18AXIN1
Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded.
Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SG, Maurice MM.
J Mol Biol 405(3):773-86. doi: 10.1016/j.jmb.2010.11.013. Epub 2010 Nov 16. 2011
19AXIN1, AXIN2
Axin2 regulates chondrocyte maturation and axial skeletal development.
Dao DY, Yang X, Flick LM, Chen D, Hilton MJ, O'Keefe RJ.
J Orthop Res 28(1):89-95. 2010
20AXIN1, SMURF2
The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2).
Kim S, Jho EH.
J Biol Chem 285(47):36420-6. doi: 10.1074/jbc.M110.137471. Epub 2010 Sep 21. 2010
21AXIN1, CDH2, LRP5
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.
Ha˙ E, Laplantine E, Geoffroy V, Frain M, Kohler T, Müller R, Marie PJ.
Mol Cell Biol 29(4):953-64. Epub 2008 Dec 15. 2009
22AXIN1, ZBED3
Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.
Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L.
J Biol Chem 284(11):6683-9. Epub 2009 Jan 13. 2009
23AXIN1
Axin localizes to mitotic spindles and centrosomes in mitotic cells.
Kim SM, Choi EJ, Song KJ, Kim S, Seo E, Jho EH, Kee SH.
Exp Cell Res 315(6):943-54. Epub 2009 Jan 30. 2009
24AXIN1, MYC
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.
Arnold HK, Zhang X, Daniel CJ, Tibbitts D, Escamilla-Powers J, Farrell A, Tokarz S, Morgan C, Sears RC.
EMBO J 28(5):500-12. Epub 2009 Jan 8. 2009
25AXIN1
Axin localizes to the centrosome and is involved in microtubule nucleation.
Fumoto K, Kadono M, Izumi N, Kikuchi A.
EMBO Rep 10(6):606-13. Epub 2009 Apr 24. 2009
26AXIN1, TNKS, TNKS2
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.
Nature 461(7264):614-20. Epub 2009 Sep 16. 2009
27AXIN1, DAB2, PPP1CC
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.
Jiang Y, Luo W, Howe PH.
Oncogene 28(33):2999-3007. Epub 2009 Jul 6.PMID: 19581931 2009
28LRP6, GSK3A, GSK3B, CTNNB1, AXIN1
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.
Proc Natl Acad Sci U S A 105(23):8032-7. Epub 2008 May 28. 2008
29AI1C, AIH1, AIH2, AIH3, AIHHT, AIPH1, AIPH2, AMELX, AXIN1, DD2, DGI1, DLX3, DSPP, ENAM, FTA1, FTACC, KLK4, MMP20, MSX1, OLD, PAX9, STHAG5, ZNF22
The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders.
Bailleul-Forestier I, Molla M, Verloes A, Berdal A.
Eur J Med Genet 51(4):273-91. Epub 2008 Mar 26. Review. 2008
30AXIN1, AXIN2, TCF7L2
Colorectal cancer and genetic alterations in the Wnt pathway.
Segditsas S, Tomlinson I.
Oncogene 25(57):7531-7. Review. 2006
31AXIN1
Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.
Oates NA, van Vliet J, Duffy DL, Kroes HY, Martin NG, Boomsma DI, Campbell M, Coulthard MG, Whitelaw E, Chong S.
Am J Hum Genet 79(1):155-62. Epub 2006 May 22. 2006
32AXIN1, RNF111
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
Liu W, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC.
EMBO J 25(8):1646-58. Epub 2006 Apr 6. 2006
33AXIN1, CTNNB1
Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.
Park JY, Park WS, Nam SW, Kim SY, Lee SH, Yoo NJ, Lee JY, Park CK.
Liver Int 25(1):70-6. 2005
34DIXDC1, AXIN1, MAP3K4, MAP3K1, DVL1
The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC.
J Biol Chem 279(38):39366-73. Epub 2004 Jul 15. 2004
35AXIN1
AXIN1 mutations but not deletions in cerebellar medulloblastomas.
Baeza N, Masuoka J, Kleihues P, Ohgaki H.
Oncogene 22(4):632-6. 2003
36AXIN1, AXIN2
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.
Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I.
Genes Dev 16(9):1066-76. 2002
37AXIN1, AXIN2, CDH1, CTNNA1, JUP
Cadherin and catenin alterations in human cancer.
Hajra KM, Fearon ER.
Genes Chromosomes Cancer 34(3):255-68. Review. 2002
38AXIN1, AXIN2
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W.
Oncogene 21(31):4863-71. 2002
39AXIN1
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
Dahmen RP, Koch A, Denkhaus D, Tonn JC, Sorensen N, Berthold F, Behrens J, Birchmeier W, Wiestler OD, Pietsch T.
Cancer Res 61(19):7039-43. 2001
40AXIN1, TSG16D
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.
Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y.
Nat Genet 24(3):245-50. No abstract available. 2000
41AXIN1, CDX2
Identification of novel polymorphisms in the AXIN1++ and CDX-2 genes.
Lin YM, Kato T, Satoh S, Nakamura Y, Furukawa Y.
J Hum Genet 45(4):254-6. 2000
42AXIN1
Axin prevents Wnt-3a-induced accumulation of beta-catenin.
Kishida M, et al.
Oncogene 18(4):979-85. 1999
43AXIN1, AXIN2
Modulation of Wnt signaling by Axin and Axil.
Kikuchi A.
Cytokine Growth Factor Rev 10(3-4):255-65. 1999
44AXIN1, AXIN2
Functional domains of axin. Importance of the C terminus as an oligomerization domain.
Sakanaka C, Williams LT.
J Biol Chem 274(20):14090-3. 1999
45AXIN1, AXIN2, DVL1, DVL2, DVL3
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A.
Mol Cell Biol 19(6):4414-22. 1999
46APC, AXIN1, CTNNB1, GSK3B
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.
Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T.
Genes Cells 3 : 395-403. 1998
47AXIN1, CTNNB1, GSK3B
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.
Ikeda S, et al.
EMBO J 17 : 1371-1384. 1998
48AXIN1
The mouse fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
Zeng L, et al.
Cell 90 : 181-192. 1997