Citations for
1AURKA, TPX2
Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit.
Naso FD, Sterbini V, Crecca E, Asteriti IA, Russo AD, Giubettini M, Cundari E, Lindon C, Rosa A, Guarguaglini G.
Cells 9(2). pii: E374. doi: 10.3390/cells9020374. 2020
2AURKA, DLGAP5, NEDD1
Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A.
Courthéoux T, Reboutier D, Vazeille T, Cremet JY, Benaud C, Vernos I, Prigent C.
J Cell Sci 132(10). pii: jcs231118. doi: 10.1242/jcs.231118. 2019
3AURKA, TP53BP1, TPX2
Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.
Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N.
J Cell Biol 218(2):422-432. doi: 10.1083/jcb.201803003. Epub 2019 Jan 2. 2019
4AURKA, AURKB, HASPIN
Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase.
Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J, Yang Z.
Cell Discov 3:16049. doi: 10.1038/celldisc.2016.49. eCollection 2017. 2017
5AURKA, BRCA1, CHEK2
CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.
Ertych N, Stolz A, Valerius O, Braus GH, Bastians H.
Proc Natl Acad Sci U S A 113(7):1817-22. doi: 10.1073/pnas.1525129113. Epub 2016 Feb 1. 2016
6AURKA, CFL1
Aurora kinase A induces papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity.
Maimaiti Y, Jie T, Jing Z, Changwen W, Pan Y, Chen C, Tao H.
Biochem Biophys Res Commun 473(1):212-218. doi: 10.1016/j.bbrc.2016.03.081. Epub 2016 Mar 19. 2016
7AURKA, MAPK8, MAPK9, WDR62
Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.
Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Williamson NA, Xu Z, Bogoyevitch MA, Ng DC.
J Cell Sci 128(3):527-40. 2015
8AURKA, CTNNB1, VHL
β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.
Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D, Walker CL.
J Am Soc Nephrol 26(3):553-64. doi: 10.1681/ASN.2013090984. Epub 2014 Oct 13. 2015
9AURKA, NAXE, NIN, PLK1
AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1.
Chou CH, Loh JK, Yang MC, Lin CC, Hong MC, Cho CL, Chou AK, Wang CH, Lieu AS, Howng SL, Hsu CM, Hong YR.
Cell Cycle 14(17):2764-76. doi: 10.1080/15384101.2015.1066536. 2015
10AURKA, BRCA2, FBN1, SNAI2
Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis.
Wang Z, Liu Y, Lu L, Yang L, Yin S, Wang Y, Qi Z, Meng J, Zang R, Yang G.
Oncotarget 6(9):6670-83. 2015
11AURKA, CKAP5, TACC3
The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
J Biol Chem 289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22. 2014
12AURKA, AURKB
Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling.
Yang J, Ikezoe T, Nishioka C, Udaka K, Yokoyama A.
Int J Cancer 134(5):1183-94. doi: 10.1002/ijc.28434. Epub 2013 Sep 3. 2014
13AJUBA, AURKA
A novel mechanism for activation of Aurora-A kinase by Ajuba.
Bai M, Ni J, Wu J, Wang B, Shen S, Yu L.
Gene 543(1):133-9. doi: 10.1016/j.gene.2014.03.048. 2014
14AURKA
Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
Pérez de Castro I, Aguirre-Portolés C, Fernández-Miranda G, Cańamero M, Cowley DO, Van Dyke T, Malumbres M.
Cancer Res 73(22):6804-15. doi: 10.1158/0008-5472.CAN-13-0586. 2013
15AURKA, BORA, PIN1
Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex.
Lee YC, Que J, Chen YC, Lin JT, Liou YC, Liao PC, Liu YP, Lee KH, Lin LC, Hsiao M, Hung LY, Huang CY, Lu PJ.
J Cell Sci 126(Pt 21):4862-72. doi: 10.1242/jcs.121368. Epub 2013 Aug 22. 2013
16AURKA, BCL2L11
BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1.
Moustafa-Kamal M, Gamache I, Lu Y, Li S, Teodoro JG.
Cell Death Differ 20(10):1393-403. doi: 10.1038/cdd.2013.93. Epub 2013 Aug 2. 2013
17AURKA, TACC3
Aurora A kinase and its substrate TACC3 are required for central spindle assembly.
Lioutas A, Vernos I.
EMBO Rep 14(9):829-36. doi: 10.1038/embor.2013.109. Epub 2013 Jul 26. 2013
18AURKA
Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner.
Regan JL, Sourisseau T, Soady K, Kendrick H, McCarthy A, Tang C, Brennan K, Linardopoulos S, White DE, Smalley MJ.
Cell Rep 4(1):110-23. doi: 10.1016/j.celrep.2013.05.044. Epub 2013 Jun 27. 2013
19AURKA, GMNN
Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.
Tsunematsu T, Takihara Y, Ishimaru N, Pagano M, Takata T, Kudo Y.
Nat Commun 4:1885. doi: 10.1038/ncomms2859. 2013
20AURKA, DLGAP5
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Wu JM, Chen CT, Coumar MS, Lin WH, Chen ZJ, Hsu JT, Peng YH, Shiao HY, Lin WH, Chu CY, Wu JS, Lin CT, Chen CP, Hsueh CC, Chang KY, Kao LP, Huang CY, Chao YS, Wu SY, Hsieh HP, Chi YH.
Proc Natl Acad Sci U S A 110(19):E1779-87. doi: 10.1073/pnas.1220523110. Epub 2013 Apr 22. 2013
21AURKA, DCTN1
Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.
Reboutier D, Troadec MB, Cremet JY, Chauvin L, Guen V, Salaun P, Prigent C.
J Cell Biol 201(1):65-79. doi: 10.1083/jcb.201210060. Erratum in: J Cell Biol. 2013 Apr 29;201(3):487. 2013
22AURKA
Aurora kinase-A deficiency during skin development impairs cell division and stratification.
Torchia EC, Zhang L, Huebner AJ, Sen S, Roop DR.
J Invest Dermatol 133(1):78-86. doi: 10.1038/jid.2012.249. Epub 2012 Jul 26. 2013
23AURKA, BORA, BRCA1, PLK1
BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress.
Zou J, Rezvani K, Wang H, Lee KS, Zhang D.
Cell Cycle 12(14):2255-65. doi: 10.4161/cc.25349. 2013
24AURKA, NSFL1C, UBXN2B, VCP
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
Kress E, Schwager F, Holtackers R, Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer H, Meraldi P, Gotta M.
J Cell Biol 201(4):559-75. doi: 10.1083/jcb.201209107. Epub 2013 May 6. 2013
25AURKA, PLK1, STMN1
Stathmin and microtubules regulate mitotic entry in HeLa cells by controlling activation of both Aurora kinase A and Plk1.
Silva VC, Cassimeris L.
Mol Biol Cell 24(24):3819-31. doi: 10.1091/mbc.E13-02-0108. Epub 2013 Oct 23. 2013
26AURKA, INVS, NPHP2
The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly.
Mergen M, Engel C, Müller B, Follo M, Schäfer T, Jung M, Walz G.
Nephrol Dial Transplant 28(11):2744-53. doi: 10.1093/ndt/gft316. Epub 2013 Sep 11. 2013
27AURKA, NEDD1
The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.
Pinyol R, Scrofani J, Vernos I.
Curr Biol 23(2):143-9. doi: 10.1016/j.cub.2012.11.046. Epub 2012 Dec 27. 2013
28AURKA, LIMK1
A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process.
Ritchey L, Ottman R, Roumanos M, Chakrabarti R.
Cell Cycle 11(2):296-309. doi: 10.4161/cc.11.2.18734. Epub 2012 Jan 15. 2012
29AURKA, LIMK2
LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
Johnson EO, Chang KH, Ghosh S, Venkatesh C, Giger K, Low PS, Shah K.
J Cell Sci 125(Pt 5):1204-16. doi: 10.1242/jcs.092304. 2012
30AURKA, IQGAP1
IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer.
Yin N, Shi J, Wang D, Tong T, Wang M, Fan F, Zhan Q.
Biochem Biophys Res Commun 421(1):64-9. doi: 10.1016/j.bbrc.2012.03.112. Epub 2012 Mar 29. 2012
31AURKA, CALM1
Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis.
Plotnikova OV, Nikonova AS, Loskutov YV, Kozyulina PY, Pugacheva EN, Golemis EA.
Mol Biol Cell 23(14):2658-70. doi: 10.1091/mbc.E11-12-1056. Epub 2012 May 23. 2012
32AURKA, FRY, PLK1
Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
Ikeda M, Chiba S, Ohashi K, Mizuno K.
J Biol Chem 287(33):27670-81. doi: 10.1074/jbc.M112.378968. Epub 2012 Jun 29. 2012
33AURKA, TCHP
Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.
Inoko A, Matsuyama M, Goto H, Ohmuro-Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T, Izawa I, Inagaki M.
J Cell Biol 197(3):391-405. doi: 10.1083/jcb.201106101. Epub 2012 Apr 23. 2012
34AURKA, TPX2
Control of Aurora-A stability through interaction with TPX2.
Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G.
J Cell Sci 124(Pt 1):113-22. Epub 2010 Dec 8. 2011
35AURKA, PHLDA1
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K.
J Cell Sci 124(Pt 16):2711-22. 2011
36AURKA, SMARCB1
Aurora A is a repressed effector target of the chromatin remodeling protein INI1/hSNF5 required for rhabdoid tumor cell survival.
Lee S, Cimica V, Ramachandra N, Zagzag D, Kalpana GV.
Cancer Res 71(9):3225-35. Epub 2011 Apr 26. 2011
37AURKA, SKI
Identification of Ski as a target for Aurora A kinase.
Mosquera J, Armisen R, Zhao H, Rojas DA, Maldonado E, Tapia JC, Colombo A, Hayman MJ, Marcelain K.
Biochem Biophys Res Commun 409(3):539-43. Epub 2011 May 12. 2011
38AURKA, PKD2
Aurora A kinase activity influences calcium signaling in kidney cells.
Plotnikova OV, Pugacheva EN, Golemis EA.
J Cell Biol 193(6):1021-32. Erratum in: J Cell Biol. 2011 Jul 11;194(1):157. 2011
39AURKA, HNRNPK
Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53.
Hsueh KW, Fu SL, Huang CY, Lin CH.
FEBS Lett 585(17):2671-5. Epub 2011 Aug 3. 2011
40AURKA, HAUS8
Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.
Tsai CY, Ngo B, Tapadia A, Hsu PH, Wu G, Lee WH.
J Biol Chem 286(34):30097-106. doi: 10.1074/jbc.M111.266767. Epub 2011 Jun 24. 2011
41AURKA, CDK1, PLK1
Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.
Van Horn RD, Chu S, Fan L, Yin T, Du J, Beckmann R, Mader M, Zhu G, Toth J, Blanchard K, Ye XS.
J Biol Chem 285(28):21849-57. Epub 2010 May 5.PMID: 20444701 2010
42AURKA, RALA
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.
Lim KH, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM.
Mol Cell Biol 30(2):508-23. Epub 2009 Nov 9.PMID: 19901077 2010
43AURKA, AURKB, CENPE, PPP1CC
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.
Kim Y, Holland AJ, Lan W, Cleveland DW.
Cell 142(3):444-55. 2010
44AURKA, KRAS, RASSF5
Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.
Bee C, Moshnikova A, Mellor CD, Molloy JE, Koryakina Y, Stieglitz B, Khokhlatchev A, Herrmann C.
J Biol Chem 285(21):16258-66. Epub 2010 Mar 25. 2010
45AURKA, CEP192
Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.
Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM.
Proc Natl Acad Sci U S A 107(49):21022-7. Epub 2010 Nov 19. 2010
46AURKA
Aurora-A kinase is essential for bipolar spindle formation and early development.
Cowley DO, Rivera-Pérez JA, Schliekelman M, He YJ, Oliver TG, Lu L, O'Quinn R, Salmon ED, Magnuson T, Van Dyke T.
Mol Cell Biol 29(4):1059-71. Epub 2008 Dec 15. 2009
47AURKA
Aurora A moonlights in neurite extension.
Lefkowitz GK, Gleeson JG.
Nat Cell Biol. 11(9):1053-4. 2009
48AURKA
The aurora kinase A regulates GSK-3beta in gastric cancer cells.
Dar AA, Belkhiri A, El-Rifai W.
Oncogene. 28(6):866-75. 2009
49AURKA, PARD3
Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.
Khazaei MR, Püschel AW.
J Biol Chem 284(48):33571-9. Epub 2009 Oct 6.PMID: 19812038 2009
50AURKA, CCNB1
Aurora-A interacts with Cyclin B1 and enhances its stability.
Qin L, Tong T, Song Y, Xue L, Fan F, Zhan Q.
Cancer Lett 275(1):77-85. Epub 2008 Nov 22. 2009
51AURKA, KIF2A, PLK1
Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a.
Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G.
J Cell Sci 122(Pt 9):1334-41. doi: 10.1242/jcs.044321. Epub 2009 Apr 7. 2009
52AURKA, BORA, PLK1
Aurora-A and hBora join the game of Polo.
Macurek L, Lindqvist A, Medema RH.
Cancer Res 69(11):4555-8. doi: 10.1158/0008-5472.CAN-09-0142. Review. 2009
53AURKA, MAP9
ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis.
Venoux M, Basbous J, Berthenet C, Prigent C, Fernandez A, Lamb NJ, Rouquier S.
Hum Mol Genet 17(2):215-24. Epub 2007 Oct 9. 2008
54AURKA, PLK1
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
Nature 455(7209):119-23. Epub 2008 Jul 9. 2008
55AURKA
Dissecting the role of Aurora A during spindle assembly.
Sardon T, Peset I, Petrova B, Vernos I.
EMBO J 27(19):2567-79. Epub 2008 Aug 28. 2008
56AURKA, SPAG5
Astrin regulates Aurora-A localization.
Du J, Jablonski S, Yen TJ, Hannon GJ.
Biochem Biophys Res Commun 370(2):213-9. Epub 2008 Mar 24. 2008
57AURKA
Aurora A is essential for early embryonic development and tumor suppression.
Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J.
J Biol Chem 283(46):31785-90. Epub 2008 Sep 17. 2008
58AURKA, FOS
Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A.
Yu CT, Wu JC, Liao MC, Hsu SL, Huang CY.
J Biomed Sci 15(1):79-87. Epub 2007 Oct 10. 2008
59AURKA, AURKAIP1, GSK3B
AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.
Fumoto K, Lee PC, Saya H, Kikuchi A.
Oncogene 27(32):4478-87. Epub 2008 Apr 7. 2008
60AURKA, E2F3
Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression.
He L, Yang H, Ma Y, Pledger WJ, Cress WD, Cheng JQ.
J Biol Chem 283(45):31012-20. Epub 2008 Sep 7. 2008
61AURKA, TPX2
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.
Bird AW, Hyman AA.
J Cell Biol 182(2):289-300. 2008
62AURKA
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
Nature 455(7209):119-23. 2008
63AURKA, CHFR
Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint.
Privette LM, Weier JF, Nguyen HN, Yu X, Petty EM.
Neoplasia 10(7):643-52.PMID: 18592005 2008
64AURKA, RASSF1
RASSF1A interacts with and activates the mitotic kinase Aurora-A.
Liu L, Guo C, Dammann R, Tommasi S, Pfeifer GP.
Oncogene 27(47):6175-86. Epub 2008 Jul 21. 2008
65AURKA, CKAP5, KIF2C
Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.
De Luca M, Brunetto L, Asteriti IA, Giubettini M, Lavia P, Guarguaglini G.
Oncogene 27(51):6539-49. Epub 2008 Jul 28. 2008
66AURKA, BORA, PLK1
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
Nature 455(7209):119-23. doi: 10.1038/nature07185. Epub 2008 Jul 9. 2008
67AURKA, BORA
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.
Seki A, Coppinger JA, Jang CY, Yates JR, Fang G.
Science 320(5883):1655-8. doi: 10.1126/science.1157425. 2008
68AURKA
Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients.
Landen CN Jr, Lin YG, Immaneni A, Deavers MT, Merritt WM, Spannuth WA, Bodurka DC, Gershenson DM, Brinkley WR, Sood AK.
Clin Cancer Res 13(14):4098-104. 2007
69AURKA
Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians.
Gu J, Gong Y, Huang M, Lu C, Spitz MR, Wu X.
Carcinogenesis 28(2):350-5. Epub 2006 Aug 21. 2007
70AURKA, AURKB, AURKC
Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis.
Kimmins S, Crosio C, Kotaja N, Hirayama J, Monaco L, Höög C, van Duin M, Gossen JA, Sassone-Corsi P.
Mol Endocrinol 21(3):726-39. Epub 2006 Dec 27. 2007
71AURKA, AURKAIP1
Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway.
Lim SK, Gopalan G.
Biochem J 403(1):119-27. 2007
72AURKA, AURKAIP1
Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.
Katayama H, Sasai K, Czerniak BA, Carter JL, Sen S.
J Cell Biochem 102(5):1318-31. 2007
73AURKA, AURKAIP1, OAZ1
Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.
Lim SK, Gopalan G.
Oncogene 26(46):6593-603. Epub 2007 Apr 23. 2007
74AURKA, TPX2
Binding of TPX2 to Aurora A alters substrate and inhibitor interactions.
Anderson K, Yang J, Koretke K, Nurse K, Calamari A, Kirkpatrick RB, Patrick D, Silva D, Tummino PJ, Copeland RA, Lai Z.
Biochemistry 46(36):10287-95. Epub 2007 Aug 18. 2007
75AURKA, TACC3
Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.
Ulisse S, Baldini E, Toller M, Delcros JG, Guého A, Curcio F, De Antoni E, Giacomelli L, Ambesi-Impiombato FS, Bocchini S, D'Armiento M, Arlot-Bonnemains Y.
Endocr Relat Cancer 14(3):827-37. 2007
76AURKA, TACC3
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA.
Cancer Res 67(11):5362-70. 2007
77AURKA
HEF1-dependent Aurora A activation induces disassembly of the primary cilium.
Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA.
Cell 129(7):1351-63. 2007
78AURKA, TPX2
Aurora A, mitotic entry, and spindle bipolarity.
Liu Q, Ruderman JV.
Proc Natl Acad Sci U S A 103(15):5811-6. Epub 2006 Mar 31. 2006
79AURKA
AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer.
Furukawa T, Kanai N, Shiwaku HO, Soga N, Uehara A, Horii A.
Oncogene 25(35):4831-9. Epub 2006 Mar 13. 2006
80AURKA, BORA
Mitotic activation of the kinase Aurora-A requires its binding partner Bora.
Hutterer A, Berdnik D, Wirtz-Peitz F, Zigman M, Schleiffer A, Knoblich JA.
Dev Cell 11(2):147-57. 2006
81AURKA
STK15 gene overexpression, centrosomal amplification, and chromosomal instability in the absence of STK15 mutations in laryngeal carcinoma.
Li Y, Li F, Li-Ling J, Wang X, Xu Z, Sun K.
Cancer Invest 23(8):660-4. 2005
82CHFR, AURKA
Chfr is required for tumor suppression and Aurora A regulation.
Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J.
Nat Genet 37(4):401-6. Epub 2005 Mar 27. 2005
83INCENP, AURKA, AURKB
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.
Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A.
Mol Cell 18(3):379-91. 2005
84AURKA
Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly.
Tsai MY, Zheng Y.
Curr Biol 15(23):2156-63. Erratum in: Curr Biol. 2006 Jul 11;16(13):1373. 2005
85LATS2, AURKA
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.
Toji S, Yabuta N, Hosomi T, Nishihara S, Kobayashi T, Suzuki S, Tamai K, Nojima H.
Genes Cells 9(5):383-97. 2004
86AURKA, BRCA1
BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.
Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T.
J Biol Chem. 279(19):19643-8 2004
87AURKA
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.
Dutertre S, Cazales M, Quaranta M, Froment C, Trabut V, Dozier C, Mirey G, Bouché JP, Theis-Febvre N, Schmitt E, Monsarrat B, Prigent C, Ducommun B.
J Cell Sci. 117(Pt 12):2523-31. 2004
88AURKA
Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.
Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Lin WJ, Still IH, Huang CY.
Mol Cell Proteomics. 3(1):93-104. 2004
89AURKA, UBE2N
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.
Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A.
Nat Genet 34(4):403-12. 2003
90AJUBA, AURKA
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.
Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H.
Cell 114(5):585-98. 2003
91AURKA, CKAP5, TACC1
TACC1-chTOG-Aurora A protein complex in breast cancer.
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Seraphin B, Jacquemier J, Birnbaum D.
Oncogene 22(50):8102-16. 2003
92AURKA, GABPA, GABPAP, GABPB1
Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1.
Tanaka M, Ueda A, Kanamori H, Ideguchi H, Yang J, Kitajima S, Ishigatsubo Y.
J Biol Chem 277(12):10719-26. 2002
93AURKA, AURKAIP1
Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase.
Kiat LS, Hui KM, Gopalan G.
J Biol Chem 277(47):45558-65. Epub 2002 Sep 18. 2002
94AURKA
Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function.
Chen SS, Chang PC, Cheng YW, Tang FM, Lin YS.
EMBO J. 21(17):4491-9. 2002
95AURKA
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.
Du J, Hannon GJ.
Nucleic Acids Res. 30(24):5465-75. 2002
96AURKA
Human TPX2 is required for targeting Aurora-A kinase to the spindle.
Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P, Nigg EA.
J Cell Biol. 158(4):617-23. 2002
97AURKA
Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.
Katayama H, Zhou H, Li Q, Tatsuka M, Sen S.
J Biol Chem. 276(49):46219-24. 2001
98AURKA
Cdc20 associates with the kinase aurora2/Aik.
Farruggio DC, Townsley FM, Ruderman JV.
Proc Natl Acad Sci U S A. 96(13):7306-11. 1999
99AURKA, AURKB
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert DJ,Jenkins NA, Copeland NG, Yagita H, Okumura K.
Biochem Biophys Res Commun 244(1):285-92. 1998
100AURKA
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation.
Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S.
Nat Genet 20(2):189-93. 1998
101AURKA, AURKAPS1
Assignment of STK6 to human chromosome 20q13.2-q13.3 and a pseudogene STK6P to 1q41-q42.
Kimura M, et al.
Cytogenet Cell Genet 79 : 201-203. 1997
102AURKA
Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1.
Kimura M, Kotani S, Hattori T, Sumi N, Yoshioka T, Todokoro K, Okano Y.
J Biol Chem 272(21):13766-71. 1997
103AURKA
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines.
Sen S, Zhou H, White RA.
Oncogene 14(18):2195-200. 1997