| 1 | AURKA, RAB1A
|
| Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis.
|
| Zhang W, Zhang Z, Xiang Y, Gu DD, Chen J, Chen Y, Zhai S, Liu Y, Jiang T, Liu C, He B, Yan M, Wang Z, Xu J, Cao YL, Deng B, Zeng D, Lei J, Zhuo J, Lei X, Long Z, Jin B, Chen T, Li D, Shen Y, Hu J, Gao S, Liu Q.
|
| Nat Struct Mol Biol. Jan 4. doi: 10.1038/s41594-023-01165-7. Epub ahead of print. 2024
|
| 2 | AURKA, ENSA, MASTL
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| Endosulfine alpha maintains spindle pole integrity by recruiting Aurora A during mitosis.
|
| Kim S, Jun K, Kim YH, Jung KY, Oh JS, Kim JS.
|
| BMC Cancer. Dec 21;23(1):1263. doi: 10.1186/s12885-023-11742-0. 2023
|
| 3 | AURKA, OTUD6A
|
| OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase
|
| Kim HJ, Kim J.
|
| Int J Mol Sci. Feb 16;22(4):1936. doi: 10.3390/ijms22041936. 2021
|
| 4 | AURKA, TPX2
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| Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit.
|
| Naso FD, Sterbini V, Crecca E, Asteriti IA, Russo AD, Giubettini M, Cundari E, Lindon C, Rosa A, Guarguaglini G.
|
| Cells 9(2). pii: E374. doi: 10.3390/cells9020374.
2020
|
| 5 | AURKA, FZR1
|
| AURKA destruction is decoupled from its activity at mitotic exit but is essential to suppress interphase activity.
|
| Abdelbaki A, Akman HB, Poteau M, Grant R, Gavet O, Guarguaglini G, Lindon C.
|
| J Cell Sci. Jun 16;133(12):jcs243071. doi: 10.1242/jcs.243071 2020
|
| 6 | AURKA, DLGAP5, NEDD1
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| Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A.
|
| Courthéoux T, Reboutier D, Vazeille T, Cremet JY, Benaud C, Vernos I, Prigent C.
|
| J Cell Sci 132(10). pii: jcs231118. doi: 10.1242/jcs.231118.
2019
|
| 7 | AURKA, TP53BP1, TPX2
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| Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.
|
| Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N.
|
| J Cell Biol 218(2):422-432. doi: 10.1083/jcb.201803003. Epub 2019 Jan 2.
2019
|
| 8 | AURKA, INCENP
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| Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics
|
| DeLuca KF, Meppelink A, Broad AJ, Mick JE, Peersen OB, Pektas S, Lens SMA, DeLuca JG.
|
| J Cell Biol. Jan 2;217(1):163-177. doi: 10.1083/jcb.201707160. Epub 2017 Nov 29. 2018
|
| 9 | AURKA, AURKB, HASPIN
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| Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase.
|
| Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J, Yang Z.
|
| Cell Discov 3:16049. doi: 10.1038/celldisc.2016.49. eCollection 2017.
2017
|
| 10 | AURKA, BRCA1, CHEK2
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| CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.
|
| Ertych N, Stolz A, Valerius O, Braus GH, Bastians H.
|
| Proc Natl Acad Sci U S A 113(7):1817-22. doi: 10.1073/pnas.1525129113. Epub 2016 Feb 1.
2016
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| 11 | AURKA, CFL1
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| Aurora kinase A induces papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity.
|
| Maimaiti Y, Jie T, Jing Z, Changwen W, Pan Y, Chen C, Tao H.
|
| Biochem Biophys Res Commun 473(1):212-218. doi: 10.1016/j.bbrc.2016.03.081. Epub 2016 Mar 19.
2016
|
| 12 | AURKA, MAPK8, MAPK9, WDR62
|
| Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.
|
| Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Williamson NA, Xu Z, Bogoyevitch MA, Ng DC.
|
| J Cell Sci 128(3):527-40.
2015
|
| 13 | AURKA, CTNNB1, VHL
|
| β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.
|
| Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D, Walker CL.
|
| J Am Soc Nephrol 26(3):553-64. doi: 10.1681/ASN.2013090984. Epub 2014 Oct 13.
2015
|
| 14 | AURKA, NAXE, NIN, PLK1
|
| AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1.
|
| Chou CH, Loh JK, Yang MC, Lin CC, Hong MC, Cho CL, Chou AK, Wang CH, Lieu AS, Howng SL, Hsu CM, Hong YR.
|
| Cell Cycle 14(17):2764-76. doi: 10.1080/15384101.2015.1066536.
2015
|
| 15 | AURKA, BRCA2, FBN1, SNAI2
|
| Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis.
|
| Wang Z, Liu Y, Lu L, Yang L, Yin S, Wang Y, Qi Z, Meng J, Zang R, Yang G.
|
| Oncotarget 6(9):6670-83.
2015
|
| 16 | AURKA, CKAP5, TACC3
|
| The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
|
| Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
|
| J Biol Chem 289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22.
2014
|
| 17 | AURKA, AURKB
|
| Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling.
|
| Yang J, Ikezoe T, Nishioka C, Udaka K, Yokoyama A.
|
| Int J Cancer 134(5):1183-94. doi: 10.1002/ijc.28434. Epub 2013 Sep 3.
2014
|
| 18 | AJUBA, AURKA
|
| A novel mechanism for activation of Aurora-A kinase by Ajuba.
|
| Bai M, Ni J, Wu J, Wang B, Shen S, Yu L.
|
| Gene 543(1):133-9. doi: 10.1016/j.gene.2014.03.048.
2014
|
| 19 | AURKA
|
| Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
|
| Pérez de Castro I, Aguirre-Portolés C, Fernández-Miranda G, Cańamero M, Cowley DO, Van Dyke T, Malumbres M.
|
| Cancer Res 73(22):6804-15. doi: 10.1158/0008-5472.CAN-13-0586.
2013
|
| 20 | AURKA, BORA, PIN1
|
| Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex.
|
| Lee YC, Que J, Chen YC, Lin JT, Liou YC, Liao PC, Liu YP, Lee KH, Lin LC, Hsiao M, Hung LY, Huang CY, Lu PJ.
|
| J Cell Sci 126(Pt 21):4862-72. doi: 10.1242/jcs.121368. Epub 2013 Aug 22.
2013
|
| 21 | AURKA, BCL2L11
|
| BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1.
|
| Moustafa-Kamal M, Gamache I, Lu Y, Li S, Teodoro JG.
|
| Cell Death Differ 20(10):1393-403. doi: 10.1038/cdd.2013.93. Epub 2013 Aug 2.
2013
|
| 22 | AURKA, TACC3
|
| Aurora A kinase and its substrate TACC3 are required for central spindle assembly.
|
| Lioutas A, Vernos I.
|
| EMBO Rep 14(9):829-36. doi: 10.1038/embor.2013.109. Epub 2013 Jul 26.
2013
|
| 23 | AURKA
|
| Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner.
|
| Regan JL, Sourisseau T, Soady K, Kendrick H, McCarthy A, Tang C, Brennan K, Linardopoulos S, White DE, Smalley MJ.
|
| Cell Rep 4(1):110-23. doi: 10.1016/j.celrep.2013.05.044. Epub 2013 Jun 27.
2013
|
| 24 | AURKA, GMNN
|
| Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.
|
| Tsunematsu T, Takihara Y, Ishimaru N, Pagano M, Takata T, Kudo Y.
|
| Nat Commun 4:1885. doi: 10.1038/ncomms2859.
2013
|
| 25 | AURKA, DLGAP5
|
| Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
|
| Wu JM, Chen CT, Coumar MS, Lin WH, Chen ZJ, Hsu JT, Peng YH, Shiao HY, Lin WH, Chu CY, Wu JS, Lin CT, Chen CP, Hsueh CC, Chang KY, Kao LP, Huang CY, Chao YS, Wu SY, Hsieh HP, Chi YH.
|
| Proc Natl Acad Sci U S A 110(19):E1779-87. doi: 10.1073/pnas.1220523110. Epub 2013 Apr 22.
2013
|
| 26 | AURKA, DCTN1
|
| Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.
|
| Reboutier D, Troadec MB, Cremet JY, Chauvin L, Guen V, Salaun P, Prigent C.
|
| J Cell Biol 201(1):65-79. doi: 10.1083/jcb.201210060. Erratum in: J Cell Biol. 2013 Apr 29;201(3):487.
2013
|
| 27 | AURKA
|
| Aurora kinase-A deficiency during skin development impairs cell division and stratification.
|
| Torchia EC, Zhang L, Huebner AJ, Sen S, Roop DR.
|
| J Invest Dermatol 133(1):78-86. doi: 10.1038/jid.2012.249. Epub 2012 Jul 26.
2013
|
| 28 | AURKA, BORA, BRCA1, PLK1
|
| BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress.
|
| Zou J, Rezvani K, Wang H, Lee KS, Zhang D.
|
| Cell Cycle 12(14):2255-65. doi: 10.4161/cc.25349.
2013
|
| 29 | AURKA, NSFL1C, UBXN2B, VCP
|
| The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
|
| Kress E, Schwager F, Holtackers R, Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer H, Meraldi P, Gotta M.
|
| J Cell Biol 201(4):559-75. doi: 10.1083/jcb.201209107. Epub 2013 May 6.
2013
|
| 30 | AURKA, PLK1, STMN1
|
| Stathmin and microtubules regulate mitotic entry in HeLa cells by controlling activation of both Aurora kinase A and Plk1.
|
| Silva VC, Cassimeris L.
|
| Mol Biol Cell 24(24):3819-31. doi: 10.1091/mbc.E13-02-0108. Epub 2013 Oct 23.
2013
|
| 31 | AURKA, INVS, NPHP2
|
| The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly.
|
| Mergen M, Engel C, Müller B, Follo M, Schäfer T, Jung M, Walz G.
|
| Nephrol Dial Transplant 28(11):2744-53. doi: 10.1093/ndt/gft316. Epub 2013 Sep 11.
2013
|
| 32 | AURKA, NEDD1
|
| The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.
|
| Pinyol R, Scrofani J, Vernos I.
|
| Curr Biol 23(2):143-9. doi: 10.1016/j.cub.2012.11.046. Epub 2012 Dec 27.
2013
|
| 33 | AURKA, LIMK1
|
| A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process.
|
| Ritchey L, Ottman R, Roumanos M, Chakrabarti R.
|
| Cell Cycle 11(2):296-309. doi: 10.4161/cc.11.2.18734. Epub 2012 Jan 15.
2012
|
| 34 | AURKA, LIMK2
|
| LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
|
| Johnson EO, Chang KH, Ghosh S, Venkatesh C, Giger K, Low PS, Shah K.
|
| J Cell Sci 125(Pt 5):1204-16. doi: 10.1242/jcs.092304.
2012
|
| 35 | AURKA, IQGAP1
|
| IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer.
|
| Yin N, Shi J, Wang D, Tong T, Wang M, Fan F, Zhan Q.
|
| Biochem Biophys Res Commun 421(1):64-9. doi: 10.1016/j.bbrc.2012.03.112. Epub 2012 Mar 29.
2012
|
| 36 | AURKA, CALM1
|
| Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis.
|
| Plotnikova OV, Nikonova AS, Loskutov YV, Kozyulina PY, Pugacheva EN, Golemis EA.
|
| Mol Biol Cell 23(14):2658-70. doi: 10.1091/mbc.E11-12-1056. Epub 2012 May 23.
2012
|
| 37 | AURKA, FRY, PLK1
|
| Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
|
| Ikeda M, Chiba S, Ohashi K, Mizuno K.
|
| J Biol Chem 287(33):27670-81. doi: 10.1074/jbc.M112.378968. Epub 2012 Jun 29.
2012
|
| 38 | AURKA, TCHP
|
| Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.
|
| Inoko A, Matsuyama M, Goto H, Ohmuro-Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T, Izawa I, Inagaki M.
|
| J Cell Biol 197(3):391-405. doi: 10.1083/jcb.201106101. Epub 2012 Apr 23.
2012
|
| 39 | AURKA, TPX2
|
| Control of Aurora-A stability through interaction with TPX2.
|
| Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G.
|
| J Cell Sci 124(Pt 1):113-22. Epub 2010 Dec 8.
2011
|
| 40 | AURKA, PHLDA1
|
| PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
|
| Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K.
|
| J Cell Sci 124(Pt 16):2711-22.
2011
|
| 41 | AURKA, SMARCB1
|
| Aurora A is a repressed effector target of the chromatin remodeling protein INI1/hSNF5 required for rhabdoid tumor cell survival.
|
| Lee S, Cimica V, Ramachandra N, Zagzag D, Kalpana GV.
|
| Cancer Res 71(9):3225-35. Epub 2011 Apr 26.
2011
|
| 42 | AURKA, SKI
|
| Identification of Ski as a target for Aurora A kinase.
|
| Mosquera J, Armisen R, Zhao H, Rojas DA, Maldonado E, Tapia JC, Colombo A, Hayman MJ, Marcelain K.
|
| Biochem Biophys Res Commun 409(3):539-43. Epub 2011 May 12.
2011
|
| 43 | AURKA, PKD2
|
| Aurora A kinase activity influences calcium signaling in kidney cells.
|
| Plotnikova OV, Pugacheva EN, Golemis EA.
|
| J Cell Biol 193(6):1021-32. Erratum in: J Cell Biol. 2011 Jul 11;194(1):157.
2011
|
| 44 | AURKA, HNRNPK
|
| Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53.
|
| Hsueh KW, Fu SL, Huang CY, Lin CH.
|
| FEBS Lett 585(17):2671-5. Epub 2011 Aug 3.
2011
|
| 45 | AURKA, HAUS8
|
| Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.
|
| Tsai CY, Ngo B, Tapadia A, Hsu PH, Wu G, Lee WH.
|
| J Biol Chem 286(34):30097-106. doi: 10.1074/jbc.M111.266767. Epub 2011 Jun 24.
2011
|
| 46 | AURKA, CDK1, PLK1
|
| Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.
|
| Van Horn RD, Chu S, Fan L, Yin T, Du J, Beckmann R, Mader M, Zhu G, Toth J, Blanchard K, Ye XS.
|
| J Biol Chem 285(28):21849-57. Epub 2010 May 5.PMID: 20444701 2010
|
| 47 | AURKA, RALA
|
| Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.
|
| Lim KH, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM.
|
| Mol Cell Biol 30(2):508-23. Epub 2009 Nov 9.PMID: 19901077 2010
|
| 48 | AURKA, AURKB, CENPE, PPP1CC
|
| Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.
|
| Kim Y, Holland AJ, Lan W, Cleveland DW.
|
| Cell 142(3):444-55. 2010
|
| 49 | AURKA, KRAS, RASSF5
|
| Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.
|
| Bee C, Moshnikova A, Mellor CD, Molloy JE, Koryakina Y, Stieglitz B, Khokhlatchev A, Herrmann C.
|
| J Biol Chem 285(21):16258-66. Epub 2010 Mar 25.
2010
|
| 50 | AURKA, CEP192
|
| Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.
|
| Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM.
|
| Proc Natl Acad Sci U S A 107(49):21022-7. Epub 2010 Nov 19.
2010
|
| 51 | AURKA
|
| Aurora-A kinase is essential for bipolar spindle formation and early development.
|
| Cowley DO, Rivera-Pérez JA, Schliekelman M, He YJ, Oliver TG, Lu L, O'Quinn R, Salmon ED, Magnuson T, Van Dyke T.
|
| Mol Cell Biol 29(4):1059-71. Epub 2008 Dec 15.
2009
|
| 52 | AURKA
|
| Aurora A moonlights in neurite extension.
|
| Lefkowitz GK, Gleeson JG.
|
| Nat Cell Biol. 11(9):1053-4. 2009
|
| 53 | AURKA
|
| The aurora kinase A regulates GSK-3beta in gastric cancer cells.
|
| Dar AA, Belkhiri A, El-Rifai W.
|
| Oncogene. 28(6):866-75. 2009
|
| 54 | AURKA, PARD3
|
| Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.
|
| Khazaei MR, Püschel AW.
|
| J Biol Chem 284(48):33571-9. Epub 2009 Oct 6.PMID: 19812038 2009
|
| 55 | AURKA, CCNB1
|
| Aurora-A interacts with Cyclin B1 and enhances its stability.
|
| Qin L, Tong T, Song Y, Xue L, Fan F, Zhan Q.
|
| Cancer Lett 275(1):77-85. Epub 2008 Nov 22.
2009
|
| 56 | AURKA, KIF2A, PLK1
|
| Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a.
|
| Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G.
|
| J Cell Sci 122(Pt 9):1334-41. doi: 10.1242/jcs.044321. Epub 2009 Apr 7.
2009
|
| 57 | AURKA, BORA, PLK1
|
| Aurora-A and hBora join the game of Polo.
|
| Macurek L, Lindqvist A, Medema RH.
|
| Cancer Res 69(11):4555-8. doi: 10.1158/0008-5472.CAN-09-0142. Review.
2009
|
| 58 | AURKA, MAP9
|
| ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis.
|
| Venoux M, Basbous J, Berthenet C, Prigent C, Fernandez A, Lamb NJ, Rouquier S.
|
| Hum Mol Genet 17(2):215-24. Epub 2007 Oct 9. 2008
|
| 59 | AURKA, PLK1
|
| Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
|
| Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
|
| Nature 455(7209):119-23. Epub 2008 Jul 9.
2008
|
| 60 | AURKA
|
| Dissecting the role of Aurora A during spindle assembly.
|
| Sardon T, Peset I, Petrova B, Vernos I.
|
| EMBO J 27(19):2567-79. Epub 2008 Aug 28.
2008
|
| 61 | AURKA, SPAG5
|
| Astrin regulates Aurora-A localization.
|
| Du J, Jablonski S, Yen TJ, Hannon GJ.
|
| Biochem Biophys Res Commun 370(2):213-9. Epub 2008 Mar 24.
2008
|
| 62 | AURKA
|
| Aurora A is essential for early embryonic development and tumor suppression.
|
| Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J.
|
| J Biol Chem 283(46):31785-90. Epub 2008 Sep 17.
2008
|
| 63 | AURKA, FOS
|
| Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A.
|
| Yu CT, Wu JC, Liao MC, Hsu SL, Huang CY.
|
| J Biomed Sci 15(1):79-87. Epub 2007 Oct 10.
2008
|
| 64 | AURKA, AURKAIP1, GSK3B
|
| AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.
|
| Fumoto K, Lee PC, Saya H, Kikuchi A.
|
| Oncogene 27(32):4478-87. Epub 2008 Apr 7.
2008
|
| 65 | AURKA, E2F3
|
| Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression.
|
| He L, Yang H, Ma Y, Pledger WJ, Cress WD, Cheng JQ.
|
| J Biol Chem 283(45):31012-20. Epub 2008 Sep 7.
2008
|
| 66 | AURKA, TPX2
|
| Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.
|
| Bird AW, Hyman AA.
|
| J Cell Biol 182(2):289-300.
2008
|
| 67 | AURKA
|
| Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
|
| Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
|
| Nature 455(7209):119-23. 2008
|
| 68 | AURKA, CHFR
|
| Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint.
|
| Privette LM, Weier JF, Nguyen HN, Yu X, Petty EM.
|
| Neoplasia 10(7):643-52.PMID: 18592005 2008
|
| 69 | AURKA, RASSF1
|
| RASSF1A interacts with and activates the mitotic kinase Aurora-A.
|
| Liu L, Guo C, Dammann R, Tommasi S, Pfeifer GP.
|
| Oncogene 27(47):6175-86. Epub 2008 Jul 21.
2008
|
| 70 | AURKA, CKAP5, KIF2C
|
| Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.
|
| De Luca M, Brunetto L, Asteriti IA, Giubettini M, Lavia P, Guarguaglini G.
|
| Oncogene 27(51):6539-49. Epub 2008 Jul 28.
2008
|
| 71 | AURKA, BORA, PLK1
|
| Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
|
| Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.
|
| Nature 455(7209):119-23. doi: 10.1038/nature07185. Epub 2008 Jul 9.
2008
|
| 72 | AURKA, BORA
|
| Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.
|
| Seki A, Coppinger JA, Jang CY, Yates JR, Fang G.
|
| Science 320(5883):1655-8. doi: 10.1126/science.1157425.
2008
|
| 73 | AURKA
|
| Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients.
|
| Landen CN Jr, Lin YG, Immaneni A, Deavers MT, Merritt WM, Spannuth WA, Bodurka DC, Gershenson DM, Brinkley WR, Sood AK.
|
| Clin Cancer Res 13(14):4098-104. 2007
|
| 74 | AURKA
|
| Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians.
|
| Gu J, Gong Y, Huang M, Lu C, Spitz MR, Wu X.
|
| Carcinogenesis 28(2):350-5. Epub 2006 Aug 21.
2007
|
| 75 | AURKA, AURKB, AURKC
|
| Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis.
|
| Kimmins S, Crosio C, Kotaja N, Hirayama J, Monaco L, Höög C, van Duin M, Gossen JA, Sassone-Corsi P.
|
| Mol Endocrinol 21(3):726-39. Epub 2006 Dec 27. 2007
|
| 76 | AURKA, AURKAIP1
|
| Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway.
|
| Lim SK, Gopalan G.
|
| Biochem J 403(1):119-27.
2007
|
| 77 | AURKA, AURKAIP1
|
| Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.
|
| Katayama H, Sasai K, Czerniak BA, Carter JL, Sen S.
|
| J Cell Biochem 102(5):1318-31.
2007
|
| 78 | AURKA, AURKAIP1, OAZ1
|
| Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.
|
| Lim SK, Gopalan G.
|
| Oncogene 26(46):6593-603. Epub 2007 Apr 23.
2007
|
| 79 | AURKA, TPX2
|
| Binding of TPX2 to Aurora A alters substrate and inhibitor interactions.
|
| Anderson K, Yang J, Koretke K, Nurse K, Calamari A, Kirkpatrick RB, Patrick D, Silva D, Tummino PJ, Copeland RA, Lai Z.
|
| Biochemistry 46(36):10287-95. Epub 2007 Aug 18.
2007
|
| 80 | AURKA, TACC3
|
| Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.
|
| Ulisse S, Baldini E, Toller M, Delcros JG, Guého A, Curcio F, De Antoni E, Giacomelli L, Ambesi-Impiombato FS, Bocchini S, D'Armiento M, Arlot-Bonnemains Y.
|
| Endocr Relat Cancer 14(3):827-37.
2007
|
| 81 | AURKA, TACC3
|
| Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
|
| LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA.
|
| Cancer Res 67(11):5362-70.
2007
|
| 82 | AURKA
|
| HEF1-dependent Aurora A activation induces disassembly of the primary cilium.
|
| Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA.
|
| Cell 129(7):1351-63. 2007
|
| 83 | AURKA, TPX2
|
| Aurora A, mitotic entry, and spindle bipolarity.
|
| Liu Q, Ruderman JV.
|
| Proc Natl Acad Sci U S A 103(15):5811-6. Epub 2006 Mar 31. 2006
|
| 84 | AURKA
|
| AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer.
|
| Furukawa T, Kanai N, Shiwaku HO, Soga N, Uehara A, Horii A.
|
| Oncogene 25(35):4831-9. Epub 2006 Mar 13. 2006
|
| 85 | AURKA, BORA
|
| Mitotic activation of the kinase Aurora-A requires its binding partner Bora.
|
| Hutterer A, Berdnik D, Wirtz-Peitz F, Zigman M, Schleiffer A, Knoblich JA.
|
| Dev Cell 11(2):147-57. 2006
|
| 86 | AURKA
|
| STK15 gene overexpression, centrosomal amplification, and chromosomal instability in the absence of STK15 mutations in laryngeal carcinoma.
|
| Li Y, Li F, Li-Ling J, Wang X, Xu Z, Sun K.
|
| Cancer Invest 23(8):660-4. 2005
|
| 87 | CHFR, AURKA
|
| Chfr is required for tumor suppression and Aurora A regulation.
|
| Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J.
|
| Nat Genet 37(4):401-6. Epub 2005 Mar 27. 2005
|
| 88 | INCENP, AURKA, AURKB
|
| Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.
|
| Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A.
|
| Mol Cell 18(3):379-91. 2005
|
| 89 | AURKA
|
| Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly.
|
| Tsai MY, Zheng Y.
|
| Curr Biol 15(23):2156-63. Erratum in: Curr Biol. 2006 Jul 11;16(13):1373. 2005
|
| 90 | LATS2, AURKA
|
| The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.
|
| Toji S, Yabuta N, Hosomi T, Nishihara S, Kobayashi T, Suzuki S, Tamai K, Nojima H.
|
| Genes Cells 9(5):383-97. 2004
|
| 91 | AURKA, BRCA1
|
| BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.
|
| Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T.
|
| J Biol Chem. 279(19):19643-8 2004
|
| 92 | AURKA
|
| Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.
|
| Dutertre S, Cazales M, Quaranta M, Froment C, Trabut V, Dozier C, Mirey G, Bouché JP, Theis-Febvre N, Schmitt E, Monsarrat B, Prigent C, Ducommun B.
|
| J Cell Sci. 117(Pt 12):2523-31. 2004
|
| 93 | AURKA
|
| Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.
|
| Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Lin WJ, Still IH, Huang CY.
|
| Mol Cell Proteomics. 3(1):93-104. 2004
|
| 94 | AURKA, UBE2N
|
| Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.
|
| Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A.
|
| Nat Genet 34(4):403-12. 2003
|
| 95 | AJUBA, AURKA
|
| Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.
|
| Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H.
|
| Cell 114(5):585-98. 2003
|
| 96 | AURKA, CKAP5, TACC1
|
| TACC1-chTOG-Aurora A protein complex in breast cancer.
|
| Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Seraphin B, Jacquemier J, Birnbaum D.
|
| Oncogene 22(50):8102-16. 2003
|
| 97 | AURKA, GABPA, GABPAP, GABPB1
|
| Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1.
|
| Tanaka M, Ueda A, Kanamori H, Ideguchi H, Yang J, Kitajima S, Ishigatsubo Y.
|
| J Biol Chem 277(12):10719-26. 2002
|
| 98 | AURKA, AURKAIP1
|
| Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase.
|
| Kiat LS, Hui KM, Gopalan G.
|
| J Biol Chem 277(47):45558-65. Epub 2002 Sep 18. 2002
|
| 99 | AURKA
|
| Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function.
|
| Chen SS, Chang PC, Cheng YW, Tang FM, Lin YS.
|
| EMBO J. 21(17):4491-9. 2002
|
| 100 | AURKA
|
| The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.
|
| Du J, Hannon GJ.
|
| Nucleic Acids Res. 30(24):5465-75. 2002
|
| 101 | AURKA
|
| Human TPX2 is required for targeting Aurora-A kinase to the spindle.
|
| Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P, Nigg EA.
|
| J Cell Biol. 158(4):617-23. 2002
|
| 102 | AURKA
|
| Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.
|
| Katayama H, Zhou H, Li Q, Tatsuka M, Sen S.
|
| J Biol Chem. 276(49):46219-24. 2001
|
| 103 | AURKA
|
| Cdc20 associates with the kinase aurora2/Aik.
|
| Farruggio DC, Townsley FM, Ruderman JV.
|
| Proc Natl Acad Sci U S A. 96(13):7306-11. 1999
|
| 104 | AURKA, AURKB
|
| cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
|
| Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert DJ,Jenkins NA, Copeland NG, Yagita H, Okumura K.
|
| Biochem Biophys Res Commun 244(1):285-92. 1998
|
| 105 | AURKA
|
| Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation.
|
| Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S.
|
| Nat Genet 20(2):189-93. 1998
|
| 106 | AURKA, AURKAPS1
|
| Assignment of STK6 to human chromosome 20q13.2-q13.3 and a pseudogene STK6P to 1q41-q42.
|
| Kimura M, et al.
|
| Cytogenet Cell Genet 79 : 201-203. 1997
|
| 107 | AURKA
|
| Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1.
|
| Kimura M, Kotani S, Hattori T, Sumi N, Yoshioka T, Todokoro K, Okano Y.
|
| J Biol Chem 272(21):13766-71. 1997
|
| 108 | AURKA
|
| A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines.
|
| Sen S, Zhou H, White RA.
|
| Oncogene 14(18):2195-200. 1997
|