| 1 | ATP1A1, ATP1A2, ATP1A3
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| Genotype-structure-phenotype relationships diverge in paralogs ATP1A1, ATP1A2, and ATP1A3.
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| Sweadner KJ, Arystarkhova E, Penniston JT, Swoboda KJ, Brashear A, Ozelius LJ.
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| Neurol Genet Feb 4;5(1):e303. doi: 10.1212/NXG.0000000000000303. 2019
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| 2 | ATP1A1, DICMT2
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| Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2.
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| Lassuthova P, Rebelo AP, Ravenscroft G, Lamont PJ, Davis MR, Manganelli F, Feely SM, Bacon C, Brožková DŠ, Haberlova J, Mazanec R, Tao F, Saghira C, Abreu L, Courel S, Powell E, Buglo E, Bis DM, Baxter MF, Ong RW, Marns L, Lee YC, Bai Y, Isom DG, Barro-Soria R, Chung KW, Scherer SS, Larsson HP, Laing NG, Choi BO, Seeman P, Shy ME, Santoro L, Zuchner S.
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| Am J Hum Genet 102(3):505-514. doi: 10.1016/j.ajhg.2018.01.023.
2018
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| 3 | ATP1A1, HOMGSMR2
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| Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability.
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| Schlingmann KP, Bandulik S, Mammen C, Tarailo-Graovac M, Holm R, Baumann M, König J, Lee JJY, Drögemöller B, Imminger K, Beck BB, Altmüller J, Thiele H, Waldegger S, Van't Hoff W, Kleta R, Warth R, van Karnebeek CDM, Vilsen B, Bockenhauer D, Konrad M.
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| Am J Hum Genet 103(5):808-816. doi: 10.1016/j.ajhg.2018.10.004.
2018
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| 4 | ATP1A1
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| Activation of Na+-K+-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na+-K+-ATPase/Src/Ros amplifier.
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| Yan X, Xun M, Dou X, Wu L, Zhang F, Zheng J.
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| Apoptosis 22(4):531-543. doi: 10.1007/s10495-016-1342-2.
2017
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| 5 | ATP1A1, SRC
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| Src Family Kinase Links Insulin Signaling to Short Term Regulation of Na,K-ATPase in Nonpigmented Ciliary Epithelium.
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| Shahidullah M, Mandal A, Delamere NA.
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| J Cell Physiol 232(6):1489-1500. doi: 10.1002/jcp.25654. Epub 2016 Nov 10.
2017
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| 6 | ATP1A1, ATP1A3
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| The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence.
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| Kinoshita PF, Leite JA, Orellana AM, Vasconcelos AR, Quintas LE, Kawamoto EM, Scavone C.
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| Front Physiol 7:195. doi: 10.3389/fphys.2016.00195. eCollection 2016. Review.
2016
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| 7 | ATP1A1, ATP1A2, ATP1A3, ATP1A4, GPNMB
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| Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.
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| Ono Y, Chiba S, Yano H, Nakayama N, Saio M, Tsuruma K, Shimazawa M, Iwama T, Hara H.
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| Biochem Biophys Res Commun 481(1-2):7-12. doi: 10.1016/j.bbrc.2016.11.034. Epub 2016 Nov 9.
2016
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| 8 | ATP1A1
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| Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
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| Wu IC, Chen YK, Wu CC, Cheng YJ, Chen WC, Ko HJ, Liu YP, Chai CY, Lin HS, Wu DC, Wu MT.
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| Oncotarget 7(51):85244-85258. doi: 10.18632/oncotarget.13267.
2016
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| 9 | AGTR1, ATP1A1
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| Low dose ouabain stimulates NaK ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells.
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| Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ.
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| Biochim Biophys Acta 1863(11):2624-2636. doi: 10.1016/j.bbamcr.2016.07.008. Epub 2016 Aug 3. Erratum in: Biochim Biophys Acta. 2017 Oct;1864(10 ):192 2016
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| 10 | ATP1A1
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| Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function.
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| Petrushanko IY, Mitkevich VA, Anashkina AA, Adzhubei AA, Burnysheva KM, Lakunina VA, Kamanina YV, Dergousova EA, Lopina OD, Ogunshola OO, Bogdanova AY, Makarov AA.
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| Sci Rep 6:27738. doi: 10.1038/srep27738.
2016
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| 11 | ATP1A1
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| Pathogenesis of Adrenal Aldosterone-Producing Adenomas Carrying Mutations of the Na(+)/K(+)-ATPase.
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| Stindl J, Tauber P, Sterner C, Tegtmeier I, Warth R, Bandulik S.
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| Endocrinology 156(12):4582-91. doi: 10.1210/en.2015-1466. Epub 2015 Sep 29.
2015
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| 12 | ATP1A1
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| Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma.
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| Zhuang L, Xu L, Wang P, Jiang Y, Yong P, Zhang C, Zhang H, Meng Z, Yang P.
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| Oncotarget 6(29):28183-93. doi: 10.18632/oncotarget.4726.
2015
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| 13 | ATP1A1, FGF2
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| A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.
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| Zacherl S, La Venuta G, Müller HM, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W.
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| J Biol Chem 290(6):3654-65. doi: 10.1074/jbc.M114.590067. Epub 2014 Dec 22.
2015
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| 14 | ATP1A1, RAB27A
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| A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.
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| Booth AE, Tarafder AK, Hume AN, Recchi C, Seabra MC.
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| PLoS One 9(7):e102851. doi: 10.1371/journal.pone.0102851. eCollection 2014. Erratum in: PLoS One. 2016;11(2):e0148719.
2014
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| 15 | ATP1A1, MAPK14
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| Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells.
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| Wang YB, Leroy V, Maunsbach AB, Doucet A, Hasler U, Dizin E, Ernandez T, de Seigneux S, Martin PY, Féraille E.
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| J Am Soc Nephrol 25(2):250-9. doi: 10.1681/ASN.2013040429. Epub 2013 Oct 31.
2014
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| 16 | ATP1A1, SRC
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| Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction.
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| Ye Q, Lai F, Banerjee M, Duan Q, Li Z, Si S, Xie Z.
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| J Biol Chem 288(8):5803-14. doi: 10.1074/jbc.M112.442608. Epub 2013 Jan 3.
2013
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| 17 | ATP1A1, CACNA1D, KCNJ5
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| Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
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| Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AE, Davenport AP, Dekkers T, Tops B, Küsters B, Ceral J, Yeo GS, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ.
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| Nat Genet 45(9):1055-60. doi: 10.1038/ng.2716. Epub 2013 Aug 4.
2013
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| 18 | ATP1A1, ATP2B3
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| Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
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| Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M.
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| Nat Genet 45(4):440-4, 444e1-2. doi: 10.1038/ng.2550.
2013
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| 19 | ATP1A1, ATP1A3
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| Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.
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| Edwards IJ, Bruce G, Lawrenson C, Howe L, Clapcote SJ, Deuchars SA, Deuchars J.
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| J Neurosci 33(24):9913-9. doi: 10.1523/JNEUROSCI.5584-12.2013.
2013
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| 20 | ATP1A1, ATP2B3
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| Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
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| Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M.
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| Nat Genet 45(4):440-4, 444e1-2. doi: 10.1038/ng.2550. Epub 2013 Feb 17.
2013
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| 21 | ATP1A1, ZNRF1, ZNRF2
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| ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.
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| Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C.
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| J Cell Sci 125(Pt 19):4662-75. doi: 10.1242/jcs.110296. Epub 2012 Jul 13.
2012
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| 22 | ATP1A1, FXYD1
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| Multiple roles for the Na,K-ATPase subunits, Atp1a1 and Fxyd1, during brain ventricle development.
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| Chang JT, Lowery LA, Sive H.
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| Dev Biol 368(2):312-22. doi: 10.1016/j.ydbio.2012.05.034. Epub 2012 Jun 7.
2012
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| 23 | ATP1A1, FXYD1
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| Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions.
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| Cirri E, Katz A, Mishra NK, Belogus T, Lifshitz Y, Garty H, Karlish SJ, Apell HJ.
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| Biochemistry 50(18):3736-48. doi: 10.1021/bi2001714. Epub 2011 Apr 15.
2011
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| 24 | ATP1A1, ATP1A2, ATP1A3
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| Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.
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| Goldstein I, Lerer E, Laiba E, Mallet J, Mujaheed M, Laurent C, Rosen H, Ebstein RP, Lichtstein D.
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| Biol Psychiatry 65(11):985-91. Epub 2008 Dec 5.
2009
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| 25 | ATP1A1, FXYD1
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| Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman.
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| Han F, Tucker AL, Lingrel JB, Despa S, Bers DM.
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| Am J Physiol Cell Physiol 297(3):C699-705. doi: 10.1152/ajpcell.00063.2009. Epub 2009 Jul 1.
2009
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| 26 | ITPR3, ANK2, ATP1A1
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| Ankyrin B modulates the function of Na,K-ATPase/inositol 1,4,5-trisphosphate receptor signaling microdomain.
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| Liu X, Spicarov‡ Z, Rydholm S, Li J, Brismar H, Aperia A.
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| J Biol Chem 283(17):11461-8. Epub 2008 Feb 26. 2008
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| 27 | ATP1A1
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| Distinct role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer.
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| Zhang S, Malmersjö S, Li J, Ando H, Aizman O, Uhlén P, Mikoshiba K, Aperia A.
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| J Biol Chem 281(31):21954-62. Epub 2006 May 24.PMID: 16723354 2006
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| 28 | ATP1A1
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| Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species.
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| Chen Z, Krmar RT, Dada L, Efendiev R, Leibiger IB, Pedemonte CH, Katz AI, Sznajder JI, Bertorello AM.
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| Am J Respir Cell Mol Biol 35(1):127-32. Epub 2006 Feb 23.PMID: 16498080 2006
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| 29 | ATP1A1, ATP1A2, ATP1A3
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| Population genetic analysis of Na, K-ATPase alpha-genes RFLP's among Russians in Moscow region.
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| Petronis A, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 2024-2025. 1991
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| 30 | ATP1A1
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| The human Na,K-ATPase alpha1 gene : characterization of the 5'-flanking region and identification of a restriction fragment length polymorphism.
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| Shull MM, et al.
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| Genomics 6 : 451-460. 1990
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| 31 | ATP1A1, ATP12A, ATP1A2, ATP1B1, ATP1BL1
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| Chromosomal localization of human Na+, K+ -ATPase alpha- and beta-subunit genes.
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| Yang-Feng TL, et al.
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| Genomics 2 : 128-138. 1988
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| 32 | ATP1A1
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| Human placental Na+, K+ -ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization.
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| Chehab FF, et al.
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| Proc Natl Acad Sci U S A 84 : 7901-7905. 1987
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| 33 | ATP1A1, ATP1A2, ATP1A3, ATP1A4
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| Multiple genes encode the human Na+,K+-ATPase catalytic subunit.
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| Shull MM, et al.
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| Proc Natl Acad Sci U S A 84 : 4039-4043. 1987
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| 34 | ATP1A1, ATP1A3, ATP1B1
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| Family of Na+, K+ -ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.
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| Sverdlov ED, et al.
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| FEBS Lett 221 : 129-133. 1987
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