Citations for
1ACTN2, ACTN3, ATF4, ATF6, XBP1
Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes
Harada N, Gotoda Y, Hatakeyama A, Nakagawa T, Miyatake Y, Kuroda M, Masumoto S, Tsutsumi R, Nakaya Y, Sakaue H.
J Muscle Res Cell Motil. Sep;41(2-3):199-209. doi: 10.1007/s10974-020-09582-7. Epub 2020 May 25 2020
2ATF4, LDHA
Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.
Pathria G, Scott DA, Feng Y, Sang Lee J, Fujita Y, Zhang G, Sahu AD, Ruppin E, Herlyn M, Osterman AL, Ronai ZA.
EMBO J 37(20). pii: e99735. doi: 10.15252/embj.201899735. Epub 2018 Sep 12. 2018
3ATF4, ATG5
ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure.
Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, Liu Z, Ying H, Liu Y, Zhai Q, Chen S, Guo F.
Diabetes 66(5):1146-1158. doi: 10.2337/db16-1546. Epub 2017 Feb 17. 2017
4ATF4, EIF2A, FGF21
Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4.
Alonge KM, Meares GP, Hillgartner FB.
J Biol Chem 292(13):5239-5252. doi: 10.1074/jbc.M116.762922. Epub 2017 Feb 10. 2017
5ATF4, DDX3X
DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.
Adjibade P, Grenier St-Sauveur V, Bergeman J, Huot ME, Khandjian EW, Mazroui R.
Sci Rep 7(1):13832. doi: 10.1038/s41598-017-14262-7. 2017
6ATF4, SREBF1, USP7
ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation.
Chen H, Yuan R, Zhang Y, Zhang X, Chen L, Zhou X, Yuan Z, Nie Y, Li M, Mo D, Chen Y.
Biochim Biophys Acta 1859(11):1459-1469. doi: 10.1016/j.bbagrm.2016.07.010. Epub 2016 Jul 21. 2016
7ATF4
Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells.
Ren LP, Yu X, Song GY, Zhang P, Sun LN, Chen SC, Hu ZJ, Zhang XM.
Mol Med Rep 14(2):1649-58. doi: 10.3892/mmr.2016.5453. Epub 2016 Jun 27. 2016
8ATF4
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.
Fusakio ME, Willy JA, Wang Y, Mirek ET, Al Baghdadi RJ, Adams CM, Anthony TG, Wek RC.
Mol Biol Cell 27(9):1536-51. doi: 10.1091/mbc.E16-01-0039. Epub 2016 Mar 9. 2016
9ATF4, SESN2
Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.
Garaeva AA, Kovaleva IE, Chumakov PM, Evstafieva AG.
Cell Cycle 15(1):64-71. doi: 10.1080/15384101.2015.1120929. 2016
10ATF4, TBL2
TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.
Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.
J Cell Biochem 117(2):500-9. doi: 10.1002/jcb.25301. 2016
11ARHGDIA, ATF4
Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα
Pasini S, Liu J, Corona C, Peze-Heidsieck E, Shelanski M, Greene LA.
Sci Rep. Nov 14;6:36952. doi: 10.1038/srep36952 2016
12ATF4, EIF2AK3, TBL2
The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.
Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.
Biochem Biophys Res Commun 462(4):383-8. doi: 10.1016/j.bbrc.2015.04.144. Epub 2015 May 12. 2015
13ATF4, HMOX1
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.
Dey S, Sayers CM, Verginadis II, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJ, Fuchs SY, Diehl JA, Koumenis C.
J Clin Invest 125(7):2592-608. doi: 10.1172/JCI78031. Epub 2015 May 26. 2015
14ATF4
Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory.
Pasini S, Corona C, Liu J, Greene LA, Shelanski ML.
Cell Rep 11(2):183-91. 2015
15ATF4, RET
A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.
Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF.
J Biol Chem 290(18):11749-61. doi: 10.1074/jbc.M114.619833. Epub 2015 Mar 20. 2015
16APLN, ATF4
Apelin is transcriptionally regulated by ER stress-induced ATF4 expression via a p38 MAPK-dependent pathway.
Jeong K, Oh Y, Kim SJ, Kim H, Park KC, Kim SS, Ha J, Kang I, Choe W.
Apoptosis 19(9):1399-410. doi: 10.1007/s10495-014-1013-0. 2014
17ATF4
ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression.
Wang C, Li H, Meng Q, Du Y, Xiao F, Zhang Q, Yu J, Li K, Chen S, Huang Z, Liu B, Guo F.
J Cell Mol Med 18(1):80-90. doi: 10.1111/jcmm.12166. Epub 2013 Nov 6. 2014
18ATF4
ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment.
Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G.
J Bone Miner Res 28(9):1870-84. doi: 10.1002/jbmr.1958. 2013
19ATF4
atf4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells.
Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G.
Int J Biol Sci 9(3):256-66. doi: 10.7150/ijbs.5898. Epub 2013 Feb 27. 2013
20ATF4
Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification.
Duan XH, Chang JR, Zhang J, Zhang BH, Li YL, Teng X, Zhu Y, Du J, Tang CS, Qi YF.
Apoptosis 18(9):1132-44. doi: 10.1007/s10495-013-0861-3. 2013
21ATF4, CEBPB
Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein ‚ (C/EBP‚) differentially regulates integrated stress response.
Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC.
J Biol Chem 287(26):21936-49. doi: 10.1074/jbc.M112.351783. Epub 2012 May 3. 2012
22ATF4, VIM
Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis.
Lian N, Lin T, Liu W, Wang W, Li L, Sun S, Nyman JS, Yang X.
J Biol Chem 287(43):35975-84. doi: 10.1074/jbc.M112.372458. Epub 2012 Sep 4. 2012
23ATF4, BGLAP, IHH
Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.
Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X.
Development 139(3):601-11. doi: 10.1242/dev.069575. Epub 2011 Dec 21. 2012
24ATF4, FOXO1
FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis.
Kode A, Mosialou I, Silva BC, Joshi S, Ferron M, Rached MT, Kousteni S.
J Biol Chem 287(12):8757-68. doi: 10.1074/jbc.M111.282897. Epub 2012 Feb 1. 2012
25ATF4, BRCC3, FAM175B
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
Ambivero CT, Cilenti L, Zervos AS.
Biochim Biophys Acta 1823(12):2149-56. doi: 10.1016/j.bbamcr.2012.08.020. Epub 2012 Sep 6. 2012
26ATF4, TWIST1, TWIST2
The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts.
Danciu TE, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT.
J Cell Biochem 113(1):70-9. doi: 10.1002/jcb.23329. 2012
27ATF4, GADD45A
Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy.
Ebert SM, Dyle MC, Kunkel SD, Bullard SA, Bongers KS, Fox DK, Dierdorff JM, Foster ED, Adams CM.
J Biol Chem 287(33):27290-301. doi: 10.1074/jbc.M112.374777. Epub 2012 Jun 12. 2012
28ATF4, PRKN
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, TrŁmbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF.
Cell Death Differ 18(5):769-82. Epub 2010 Nov 26. 2011
29ATF4, EIF2AK4, NUPR1
Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway.
Averous J, Lambert-Langlais S, Cherasse Y, Carraro V, Parry L, B'chir W, Jousse C, Maurin AC, Bruhat A, Fafournoux P.
Biochem Biophys Res Commun 413(1):24-9. Epub 2011 Aug 16. 2011
30ATF4, FGF2, PTH
The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
Fei Y, Xiao L, Hurley MM.
Biochem Biophys Res Commun 412(1):160-4. Epub 2011 Jul 22. 2011
31ATF4, NACA, TXLNG
Combinatorial control of ATF4-dependent gene transcription in osteoblasts.
St-Arnaud R, Hekmatnejad B.
Ann N Y Acad Sci 1237:11-8. doi: 10.1111/j.1749-6632.2011.06197.x. Review. 2011
32ATF4, EGLN1, EGLN2, EGLN3
PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.
Hiwatashi Y, Kanno K, Takasaki C, Goryo K, Sato T, Torii S, Sogawa K, Yasumoto K.
Exp Cell Res 317(20):2789-99. doi: 10.1016/j.yexcr.2011.09.005. Epub 2011 Sep 17. 2011
33ATF4, MAP1LC3B
Regulation of autophagy by ATF4 in response to severe hypoxia.
Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL.
Oncogene 29(31):4424-35. Epub 2010 May 31. 2010
34ATF4
Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response.
Dey S, Baird TD, Zhou D, Palam LR, Spandau DF, Wek RC.
J Biol Chem 285(43):33165-74. Epub 2010 Aug 23. 2010
35ATF4, BBC3, DDIT3
Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.
Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP.
J Neurosci. 30(50):16938-48. 2010
36ATF4, DDIT4
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.
Whitney ML, Jefferson LS, Kimball SR.
Biochem Biophys Res Commun 379(2):451-5. Epub 2008 Dec 27. 2009
37ATF3, ATF4
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.
Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T, Ron D, Chen W, Trenkle W, Wiestner A, Ye Y.
Proc Natl Acad Sci U S A. 106(7):2200-5. 2009
38ATF4
Associations of ATF4 gene polymorphisms with schizophrenia in male patients.
Qu M, Tang F, Wang L, Yan H, Han Y, Yan J, Yue W, Zhang D.
Am J Med Genet B Neuropsychiatr Genet 147B(6):732-6. 2008
39ATF4, EIF2AK3, TRAF3
The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis.
Lee DY, Sugden B.
Blood 111(4):2280-9. Epub 2007 Nov 27. 2008
40CEBPA, CEBPE, ATF4
ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.
Gombart AF, Grewal J, Koeffler HP.
J Leukoc Biol 81(6):1535-47. Epub 2007 Mar 8. 2007
41ATF4, DDIT3, KAT2B
The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.
Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A.
Nucleic Acids Res 35(17):5954-65. Epub 2007 Aug 28. 2007
42ATF4, TRIB3
TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.
Ord D, Meerits K, Ord T.
Exp Cell Res 313(16):3556-67. Epub 2007 Jul 25.PMID: 17707795 2007
43ATF4, CREB1, NDC80
Functional characterization of the promoter of human kinetochore protein HEC1: novel link between regulation of the cell cycle protein and CREB family transcription factors.
Cheng L, Li L, Qiao X, Liu J, Yao X.
Biochim Biophys Acta 1769(9-10):593-602. Epub 2007 Aug 9.PMID: 17822787 2007
44ATF4, TXLNG
FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.
Yu VW, Ambartsoumian G, Verlinden L, Moir JM, Prud'homme J, Gauthier C, Roughley PJ, St-Arnaud R.
J Cell Biol 169(4):591-601. 2005
45TRIB3, DDIT3, ATF4
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.
Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H.
EMBO J 24(6):1243-55. Epub 2005 Mar 10. 2005
46CENPF, ATF4
Mitosin/CENP-F as a negative regulator of activating transcription factor-4.
Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, Zhu X.
J Biol Chem 280(14):13973-7. Epub 2005 Jan 26. 2005
47ARAP3, ATF4, DISC1, MAP1A, NDEL1, TRAF3IP1
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Morris JA, Kandpal G, Ma L, Austin CP.
Hum Mol Genet 12(13):1591-608. 2003
48ATF4
Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4).
De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C.
FEBS Lett. 547(1-3):15-9. 2003
49ATF4
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.
Siu F, Bain PJ, LeBlanc-Chaffin R, Chen H, Kilberg MS.
J Biol Chem 277(27):24120-7. 2002
50ATF4, NFE2L2
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation.
He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, Alam J.
J Biol Chem 276(24):20858-65. 2001
51ATF4
Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.
Podust LM, Krezel AM, Kim Y.
J Biol Chem. 276(1):505-13. 2001
52ATF4, ATF5
The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.
White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH.
Proc Natl Acad Sci U S A 97(25):13967-72. 2000
53ATF4
Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development.
Murphy P, KolstÝ A.
Mech Dev. 97(1-2):141-8. 2000
54ATF4
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.
Tanaka T, Tsujimura T, Takeda K, Sugihara A, Maekawa A, Terada N, Yoshida N, Akira S.
Genes Cells 3(12):801-10. 1998
55ATF4, DAPK3
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
Mol Cell Biol 18(3):1642-51. 1998
56ATF4, MGAT3, SYNGR1, SYNGR2, SYNGR2P1, SYNGR3, SYNGR4, TAB1
Characterization of the human synaptogyrin gene family.
Kedra D, Pan HQ, Seroussi E, Fransson I, Guilbaud C, Collins JE, Dunham I, Blennow E, Roe BA, Piehl F, Dumanski JP.
Hum Genet 103(2):131-41. 1998
57ATF4
Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein.
Liang G, Hai T.
J Biol Chem. 272(38):24088-95. 1997
58ATF4
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
Karpinski BA, Morle GD, Huggenvik J, Uhler MD, Leiden JM.
Proc Natl Acad Sci U S A 89(11):4820-4. 1992
59ATF4
cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.
Nishizawa M, Nagata S.
FEBS Lett. 299(1):36-8. 1992
60ATF4
Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.
Tsujimoto A, et al.
J Virol 65 : 1420-1426. 1991