1 | ATF4, RUNX2, SP7
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| Regulation and Role of Transcription Factors in Osteogenesis.
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| Chan WCW, Tan Z, To MKT, Chan D.
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| Int J Mol Sci. May 21;22(11):5445. doi: 10.3390/ijms22115445. 2021
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2 | ACTN2, ACTN3, ATF4, ATF6, XBP1
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| Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes
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| Harada N, Gotoda Y, Hatakeyama A, Nakagawa T, Miyatake Y, Kuroda M, Masumoto S, Tsutsumi R, Nakaya Y, Sakaue H.
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| J Muscle Res Cell Motil. Sep;41(2-3):199-209. doi: 10.1007/s10974-020-09582-7. Epub 2020 May 25 2020
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3 | ATF4, DELE1, EIF2A
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| Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. .
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| Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M.
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| Nature Mar;579(7799):427-432. doi: 10.1038/s41586-020-2078-2. Epub 2020 Mar 4. 2020
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4 | ATF4, HBS1L, MYB
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| ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin.
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| Boontanrart MY, Schröder MS, Stehli GM, Banović M, Wyman SK, Lew RJ, Bordi M, Gowen BG, DeWitt MA, Corn JE.
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| Cell Rep. Aug 4;32(5):107993. doi: 10.1016/j.celrep.2020.107993 2020
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5 | ATF4, LDHA
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| Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.
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| Pathria G, Scott DA, Feng Y, Sang Lee J, Fujita Y, Zhang G, Sahu AD, Ruppin E, Herlyn M, Osterman AL, Ronai ZA.
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| EMBO J 37(20). pii: e99735. doi: 10.15252/embj.201899735. Epub 2018 Sep 12.
2018
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6 | ATF4, ATG5
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| ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure.
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| Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, Liu Z, Ying H, Liu Y, Zhai Q, Chen S, Guo F.
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| Diabetes 66(5):1146-1158. doi: 10.2337/db16-1546. Epub 2017 Feb 17.
2017
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7 | ATF4, EIF2A, FGF21
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| Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4.
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| Alonge KM, Meares GP, Hillgartner FB.
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| J Biol Chem 292(13):5239-5252. doi: 10.1074/jbc.M116.762922. Epub 2017 Feb 10.
2017
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8 | ATF4, DDX3X
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| DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.
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| Adjibade P, Grenier St-Sauveur V, Bergeman J, Huot ME, Khandjian EW, Mazroui R.
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| Sci Rep 7(1):13832. doi: 10.1038/s41598-017-14262-7.
2017
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9 | ATF4, SREBF1, USP7
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| ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation.
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| Chen H, Yuan R, Zhang Y, Zhang X, Chen L, Zhou X, Yuan Z, Nie Y, Li M, Mo D, Chen Y.
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| Biochim Biophys Acta 1859(11):1459-1469. doi: 10.1016/j.bbagrm.2016.07.010. Epub 2016 Jul 21.
2016
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10 | ATF4
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| Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells.
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| Ren LP, Yu X, Song GY, Zhang P, Sun LN, Chen SC, Hu ZJ, Zhang XM.
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| Mol Med Rep 14(2):1649-58. doi: 10.3892/mmr.2016.5453. Epub 2016 Jun 27.
2016
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11 | ATF4
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| Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.
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| Fusakio ME, Willy JA, Wang Y, Mirek ET, Al Baghdadi RJ, Adams CM, Anthony TG, Wek RC.
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| Mol Biol Cell 27(9):1536-51. doi: 10.1091/mbc.E16-01-0039. Epub 2016 Mar 9.
2016
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12 | ATF4, SESN2
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| Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.
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| Garaeva AA, Kovaleva IE, Chumakov PM, Evstafieva AG.
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| Cell Cycle 15(1):64-71. doi: 10.1080/15384101.2015.1120929.
2016
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13 | ATF4, TBL2
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| TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.
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| Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.
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| J Cell Biochem 117(2):500-9. doi: 10.1002/jcb.25301.
2016
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14 | ARHGDIA, ATF4
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| Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα
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| Pasini S, Liu J, Corona C, Peze-Heidsieck E, Shelanski M, Greene LA.
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| Sci Rep. Nov 14;6:36952. doi: 10.1038/srep36952 2016
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15 | ATF4, EIF2AK3, TBL2
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| The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.
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| Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.
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| Biochem Biophys Res Commun 462(4):383-8. doi: 10.1016/j.bbrc.2015.04.144. Epub 2015 May 12.
2015
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16 | ATF4, HMOX1
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| ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.
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| Dey S, Sayers CM, Verginadis II, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJ, Fuchs SY, Diehl JA, Koumenis C.
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| J Clin Invest 125(7):2592-608. doi: 10.1172/JCI78031. Epub 2015 May 26.
2015
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17 | ATF4
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| Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory.
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| Pasini S, Corona C, Liu J, Greene LA, Shelanski ML.
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| Cell Rep 11(2):183-91.
2015
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18 | ATF4, RET
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| A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.
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| Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF.
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| J Biol Chem 290(18):11749-61. doi: 10.1074/jbc.M114.619833. Epub 2015 Mar 20.
2015
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19 | APLN, ATF4
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| Apelin is transcriptionally regulated by ER stress-induced ATF4 expression via a p38 MAPK-dependent pathway.
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| Jeong K, Oh Y, Kim SJ, Kim H, Park KC, Kim SS, Ha J, Kang I, Choe W.
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| Apoptosis 19(9):1399-410. doi: 10.1007/s10495-014-1013-0.
2014
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20 | ATF4
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| ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression.
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| Wang C, Li H, Meng Q, Du Y, Xiao F, Zhang Q, Yu J, Li K, Chen S, Huang Z, Liu B, Guo F.
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| J Cell Mol Med 18(1):80-90. doi: 10.1111/jcmm.12166. Epub 2013 Nov 6.
2014
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21 | ATF4
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| ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment.
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| Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G.
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| J Bone Miner Res 28(9):1870-84. doi: 10.1002/jbmr.1958.
2013
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22 | ATF4
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| atf4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells.
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| Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G.
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| Int J Biol Sci 9(3):256-66. doi: 10.7150/ijbs.5898. Epub 2013 Feb 27.
2013
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23 | ATF4
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| Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification.
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| Duan XH, Chang JR, Zhang J, Zhang BH, Li YL, Teng X, Zhu Y, Du J, Tang CS, Qi YF.
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| Apoptosis 18(9):1132-44. doi: 10.1007/s10495-013-0861-3.
2013
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24 | ATF4, CEBPB
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| Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein â (C/EBPâ) differentially regulates integrated stress response.
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| Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC.
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| J Biol Chem 287(26):21936-49. doi: 10.1074/jbc.M112.351783. Epub 2012 May 3.
2012
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25 | ATF4, VIM
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| Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis.
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| Lian N, Lin T, Liu W, Wang W, Li L, Sun S, Nyman JS, Yang X.
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| J Biol Chem 287(43):35975-84. doi: 10.1074/jbc.M112.372458. Epub 2012 Sep 4. 2012
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26 | ATF4, BGLAP, IHH
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| Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.
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| Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X.
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| Development 139(3):601-11. doi: 10.1242/dev.069575. Epub 2011 Dec 21.
2012
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27 | ATF4, FOXO1
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| FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis.
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| Kode A, Mosialou I, Silva BC, Joshi S, Ferron M, Rached MT, Kousteni S.
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| J Biol Chem 287(12):8757-68. doi: 10.1074/jbc.M111.282897. Epub 2012 Feb 1.
2012
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28 | ATF4, BRCC3, FAM175B
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| ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
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| Ambivero CT, Cilenti L, Zervos AS.
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| Biochim Biophys Acta 1823(12):2149-56. doi: 10.1016/j.bbamcr.2012.08.020. Epub 2012 Sep 6. 2012
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29 | ATF4, TWIST1, TWIST2
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| The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts.
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| Danciu TE, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT.
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| J Cell Biochem 113(1):70-9. doi: 10.1002/jcb.23329.
2012
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30 | ATF4, GADD45A
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| Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy.
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| Ebert SM, Dyle MC, Kunkel SD, Bullard SA, Bongers KS, Fox DK, Dierdorff JM, Foster ED, Adams CM.
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| J Biol Chem 287(33):27290-301. doi: 10.1074/jbc.M112.374777. Epub 2012 Jun 12.
2012
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31 | ATF4, PRKN
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| Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
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| Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF.
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| Cell Death Differ 18(5):769-82. Epub 2010 Nov 26. 2011
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32 | ATF4, EIF2AK4, NUPR1
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| Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway.
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| Averous J, Lambert-Langlais S, Cherasse Y, Carraro V, Parry L, B'chir W, Jousse C, Maurin AC, Bruhat A, Fafournoux P.
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| Biochem Biophys Res Commun 413(1):24-9. Epub 2011 Aug 16.
2011
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33 | ATF4, FGF2, PTH
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| The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
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| Fei Y, Xiao L, Hurley MM.
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| Biochem Biophys Res Commun 412(1):160-4. Epub 2011 Jul 22.
2011
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34 | ATF4, NACA, TXLNG
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| Combinatorial control of ATF4-dependent gene transcription in osteoblasts.
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| St-Arnaud R, Hekmatnejad B.
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| Ann N Y Acad Sci 1237:11-8. doi: 10.1111/j.1749-6632.2011.06197.x. Review.
2011
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35 | ATF4, EGLN1, EGLN2, EGLN3
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| PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.
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| Hiwatashi Y, Kanno K, Takasaki C, Goryo K, Sato T, Torii S, Sogawa K, Yasumoto K.
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| Exp Cell Res 317(20):2789-99. doi: 10.1016/j.yexcr.2011.09.005. Epub 2011 Sep 17.
2011
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36 | ATF4, MAP1LC3B
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| Regulation of autophagy by ATF4 in response to severe hypoxia.
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| Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL.
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| Oncogene 29(31):4424-35. Epub 2010 May 31.
2010
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37 | ATF4
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| Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response.
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| Dey S, Baird TD, Zhou D, Palam LR, Spandau DF, Wek RC.
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| J Biol Chem 285(43):33165-74. Epub 2010 Aug 23.
2010
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38 | ATF4, BBC3, DDIT3
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| Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.
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| Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP.
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| J Neurosci. 30(50):16938-48. 2010
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39 | ATF4, DDIT4
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| ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.
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| Whitney ML, Jefferson LS, Kimball SR.
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| Biochem Biophys Res Commun 379(2):451-5. Epub 2008 Dec 27.
2009
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40 | ATF3, ATF4
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| ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.
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| Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T, Ron D, Chen W, Trenkle W, Wiestner A, Ye Y.
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| Proc Natl Acad Sci U S A. 106(7):2200-5. 2009
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41 | ATF4
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| Associations of ATF4 gene polymorphisms with schizophrenia in male patients.
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| Qu M, Tang F, Wang L, Yan H, Han Y, Yan J, Yue W, Zhang D.
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| Am J Med Genet B Neuropsychiatr Genet 147B(6):732-6.
2008
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42 | ATF4, EIF2AK3, TRAF3
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| The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis.
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| Lee DY, Sugden B.
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| Blood 111(4):2280-9. Epub 2007 Nov 27.
2008
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43 | CEBPA, CEBPE, ATF4
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| ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.
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| Gombart AF, Grewal J, Koeffler HP.
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| J Leukoc Biol 81(6):1535-47. Epub 2007 Mar 8. 2007
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44 | ATF4, DDIT3, KAT2B
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| The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.
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| Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A.
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| Nucleic Acids Res 35(17):5954-65. Epub 2007 Aug 28. 2007
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45 | ATF4, TRIB3
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| TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.
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| Ord D, Meerits K, Ord T.
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| Exp Cell Res 313(16):3556-67. Epub 2007 Jul 25.PMID: 17707795 2007
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46 | ATF4, CREB1, NDC80
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| Functional characterization of the promoter of human kinetochore protein HEC1: novel link between regulation of the cell cycle protein and CREB family transcription factors.
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| Cheng L, Li L, Qiao X, Liu J, Yao X.
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| Biochim Biophys Acta 1769(9-10):593-602. Epub 2007 Aug 9.PMID: 17822787 2007
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47 | ATF4, TXLNG
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| FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.
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| Yu VW, Ambartsoumian G, Verlinden L, Moir JM, Prud'homme J, Gauthier C, Roughley PJ, St-Arnaud R.
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| J Cell Biol 169(4):591-601. 2005
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48 | TRIB3, DDIT3, ATF4
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| TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.
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| Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H.
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| EMBO J 24(6):1243-55. Epub 2005 Mar 10. 2005
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49 | CENPF, ATF4
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| Mitosin/CENP-F as a negative regulator of activating transcription factor-4.
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| Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, Zhu X.
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| J Biol Chem 280(14):13973-7. Epub 2005 Jan 26. 2005
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50 | ARAP3, ATF4, DISC1, MAP1A, NDEL1, TRAF3IP1
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| DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
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| Morris JA, Kandpal G, Ma L, Austin CP.
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| Hum Mol Genet 12(13):1591-608. 2003
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51 | ATF4
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| Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4).
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| De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C.
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| FEBS Lett. 547(1-3):15-9. 2003
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52 | ATF4
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| ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.
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| Siu F, Bain PJ, LeBlanc-Chaffin R, Chen H, Kilberg MS.
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| J Biol Chem 277(27):24120-7. 2002
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53 | ATF4, NFE2L2
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| Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation.
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| He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, Alam J.
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| J Biol Chem 276(24):20858-65. 2001
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54 | ATF4
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| Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.
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| Podust LM, Krezel AM, Kim Y.
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| J Biol Chem. 276(1):505-13. 2001
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55 | ATF4, ATF5
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| The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.
|
| White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH.
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| Proc Natl Acad Sci U S A 97(25):13967-72. 2000
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56 | ATF4
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| Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development.
|
| Murphy P, Kolstø A.
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| Mech Dev. 97(1-2):141-8. 2000
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57 | ATF4
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| Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.
|
| Tanaka T, Tsujimura T, Takeda K, Sugihara A, Maekawa A, Terada N, Yoshida N, Akira S.
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| Genes Cells 3(12):801-10. 1998
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58 | ATF4, DAPK3
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| ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
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| Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
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| Mol Cell Biol 18(3):1642-51. 1998
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59 | ATF4, MGAT3, SYNGR1, SYNGR2, SYNGR2P1, SYNGR3, SYNGR4, TAB1
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| Characterization of the human synaptogyrin gene family.
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| Kedra D, Pan HQ, Seroussi E, Fransson I, Guilbaud C, Collins JE, Dunham I, Blennow E, Roe BA, Piehl F, Dumanski JP.
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| Hum Genet 103(2):131-41. 1998
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60 | ATF4
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| Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein.
|
| Liang G, Hai T.
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| J Biol Chem. 272(38):24088-95. 1997
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61 | ATF4
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| Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
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| Karpinski BA, Morle GD, Huggenvik J, Uhler MD, Leiden JM.
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| Proc Natl Acad Sci U S A 89(11):4820-4. 1992
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62 | ATF4
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| cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.
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| Nishizawa M, Nagata S.
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| FEBS Lett. 299(1):36-8. 1992
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63 | ATF4
|
| Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.
|
| Tsujimoto A, et al.
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| J Virol 65 : 1420-1426. 1991
|