Citations for
1ATF3, NR5A1
Steroidogenic Factor 1 (NR5A1) Activates ATF3 Transcriptional Activity.
Emura N, Wang CM, Yang WH, Yang WH.
Int J Mol Sci. Feb 20;21(4):1429. doi: 10.3390/ijms21041429. 2020
2ATF3, PPARG
ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells.
Jang MK, Jung MH.
Biochem Biophys Res Commun 456(1):80-5. doi: 10.1016/j.bbrc.2014.11.037. Epub 2014 Nov 21. 2015
3ATF3, THEM4
Novel Link of Anti-apoptotic ATF3 with Pro-apoptotic CTMP in the Ischemic Brain.
Huang CY, Chen JJ, Wu JS, Tsai HD, Lin H, Yan YT, Hsu CY, Ho YS, Lin TN.
Mol Neurobiol 51(2):543-57. doi: 10.1007/s12035-014-8710-0. Epub 2014 Apr 26. 2015
4ATF3, PPARG
ATF3 represses PPARγ expression and inhibits adipocyte differentiation.
Jang MK, Jung MH.
Biochem Biophys Res Commun 454(1):58-64. doi: 10.1016/j.bbrc.2014.10.028. Epub 2014 Oct 14. 2014
5ATF3
ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma.
Xie JJ, Xie YM, Chen B, Pan F, Guo JC, Zhao Q, Shen JH, Wu ZY, Wu JY, Xu LY, Li EM.
Oncotarget 5(18):8569-82. 2014
6ATF3
ATF3 regulates multiple targets and may play a dual role in cardiac hypertrophy and injury.
Zhou H, Guo H, Zong J, Dai J, Yuan Y, Bian ZY, Tang QZ.
Int J Cardiol 174(3):838-9. doi: 10.1016/j.ijcard.2014.04.160. Epub 2014 Apr 21. Review. No abstract available. 2014
7ATF3
ATF3 is a novel regulator of mouse neutrophil migration.
Boespflug ND, Kumar S, McAlees JW, Phelan JD, Grimes HL, Hoebe K, Hai T, Filippi MD, Karp CL.
Blood 123(13):2084-93. doi: 10.1182/blood-2013-06-510909. Epub 2014 Jan 27. 2014
8ATF3
ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription.
Lee YS, Kobayashi M, Kikuchi O, Sasaki T, Yokota-Hashimoto H, Susanti VY, Ido Kitamura Y, Kitamura T.
Endocr J 61(1):85-90. Epub 2013 Oct 20. 2014
9ATF3
ATF3 plays a role in adipocyte hypoxia-mediated mitochondria dysfunction in obesity.
Jang MK, Son Y, Jung MH.
Biochem Biophys Res Commun 431(3):421-7. doi: 10.1016/j.bbrc.2012.12.154. Epub 2013 Jan 16. 2013
10ATF3, NFKB1, NOD2
NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms.
Zheng S, Abraham C.
Mol Cell Biol 33(24):4857-71. doi: 10.1128/MCB.00797-13. Epub 2013 Oct 7. 2013
11ATF3
Transcription factor ATF3 links host adaptive response to breast cancer metastasis.
Wolford CC, McConoughey SJ, Jalgaonkar SP, Leon M, Merchant AS, Dominick JL, Yin X, Chang Y, Zmuda EJ, O'Toole SA, Millar EK, Roller SL, Shapiro CL, Ostrowski MC, Sutherland RL, Hai T.
J Clin Invest 123(7):2893-906. doi: 10.1172/JCI64410. Epub 2013 Jun 10. 2013
12AGRP, ATF3
Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice.
Lee YS, Sasaki T, Kobayashi M, Kikuchi O, Kim HJ, Yokota-Hashimoto H, Shimpuku M, Susanti VY, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S, Kitamura T.
Diabetologia 56(6):1383-93. doi: 10.1007/s00125-013-2879-z. Epub 2013 Mar 6. 2013
13ATF3, SENP2, SENP7
SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene.
Wang CM, Brennan VC, Gutierrez NM, Wang X, Wang L, Yang WH.
J Cell Biochem Cell Biochem. 2012 Sep 18. doi: 10.1002/jcb.24396. [Epub ahead of print] 2012
14AR, ATF3
The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor.
Wang H, Jiang M, Cui H, Chen M, Buttyan R, Hayward SW, Hai T, Wang Z, Yan C.
Mol Cell Biol 32(16):3190-202. doi: 10.1128/MCB.00159-12. Epub 2012 Jun 4. 2012
15ATF3, CEBPA
ATF3 inhibits adipocyte differentiation of 3T3-L1 cells.
Jang MK, Kim CH, Seong JK, Jung MH.
Biochem Biophys Res Commun 421(1):38-43. doi: 10.1016/j.bbrc.2012.03.104. Epub 2012 Mar 27. 2012
16ATF3, TP53
Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells.
Taketani K, Kawauchi J, Tanaka-Okamoto M, Ishizaki H, Tanaka Y, Sakai T, Miyoshi J, Maehara Y, Kitajima S.
Oncogene 31(17):2210-21. doi: 10.1038/onc.2011.397. Epub 2011 Sep 19. 2012
17ATF3, JDP2
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
Maruyama K, Fukasaka M, Vandenbon A, Saitoh T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya H, Takakura N, Standley D, Takeuchi O, Akira S.
Immunity 37(6):1024-36. doi: 10.1016/j.immuni.2012.08.022. Epub 2012 Nov 29. 2012
18ATF3, HDAC3, HDAC6, JDP2
The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
Darlyuk-Saadon I, Weidenfeld-Baranboim K, Yokoyama KK, Hai T, Aronheim A.
Biochim Biophys Acta 1819(11-12):1142-53. doi: 10.1016/j.bbagrm.2012.09.005. Epub 2012 Sep 16. 2012
19ATF3
A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage.
Zhang SJ, Buchthal B, Lau D, Hayer S, Dick O, Schwaninger M, Veltkamp R, Zou M, Weiss U, Bading H.
J Neurosci. 31(13):4978-90. 2011
20ATF3, CD82, NDRG1
KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer.
Liu W, Iiizumi-Gairani M, Okuda H, Kobayashi A, Watabe M, Pai SK, Pandey PR, Xing F, Fukuda K, Modur V, Hirota S, Suzuki K, Chiba T, Endo M, Sugai T, Watabe K.
J Biol Chem 286(21):18949-59. Epub 2011 Mar 21. 2011
21ATF3, PDX1
ATF3 represses PDX-1 expression in pancreatic β-cells.
Jang MK, Park HJ, Jung MH.
Biochem Biophys Res Commun 412(2):385-90. Epub 2011 Jul 29. 2011
22ATF3, PDX1, TBC1D4
ATF3 inhibits PDX-1-stimulated transactivation.
Kim WH, Jang MK, Kim CH, Shin HK, Jung MH.
Biochem Biophys Res Commun 414(4):681-7. doi: 10.1016/j.bbrc.2011.09.132. Epub 2011 Oct 2. 2011
23ATF3, ESR1, ESR2, SRD5A2
Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?
van der Zanden LF, van Rooij IA, Feitz WF, Vermeulen SH, Kiemeney LA, Knoers NV, Roeleveld N, Franke B.
J Clin Endocrinol Metab 95(5):2384-90. Epub 2010 Mar 9.PMID: 20215396 2010
24ATF3, MDM2
MDM2 mediates ubiquitination and degradation of activating transcription factor 3.
Mo P, Wang H, Lu H, Boyd DD, Yan C.
J Biol Chem 285(35):26908-15. Epub 2010 Jun 30.PMID: 20592017 2010
25ATF3
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.
Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T.
Mol Endocrinol 24(7):1423-33. Epub 2010 Jun 2.PMID: 20519332 2010
26ATF3
Activating transcription factor 3 is a positive regulator of human IFNG gene expression.
Filén S, Ylikoski E, Tripathi S, West A, Björkman M, Nyström J, Ahlfors H, Coffey E, Rao KV, Rasool O, Lahesmaa R.
J Immunol 184(9):4990-9. Epub 2010 Mar 19.PMID: 20304822 2010
27ATF3
A key role for ATF3 in regulating mast cell survival and mediator release.
Gilchrist M, Henderson WR Jr, Morotti A, Johnson CD, Nachman A, Schmitz F, Smith KD, Aderem A.
Blood 115(23):4734-41. Epub 2010 Mar 4.PMID: 20203264 2010
28ATF3
Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.
Wang H, Mo P, Ren S, Yan C.
J Biol Chem 285(17):13201-10. Epub 2010 Feb 18.PMID: 20167600 2010
29ADIPOR1, ADIPOR2, ATF3
ATF3 negatively regulates adiponectin receptor 1 expression.
Park HJ, Kang YM, Kim CH, Jung MH.
Biochem Biophys Res Commun 400(1):72-7. Epub 2010 Aug 7. 2010
30ATF3
ATF3-mediated epigenetic regulation protects against acute kidney injury.
Li HF, Cheng CF, Liao WJ, Lin H, Yang RB.
J Am Soc Nephrol. 21(6):1003-13. 2010
31ATF3
ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells.
Yin X, Wolford CC, Chang YS, McConoughey SJ, Ramsey SA, Aderem A, Hai T.
J Cell Sci. 123(Pt 20):3558-65. 2010
32ATF3, OEATC1
ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress.
Turchi L, Fareh M, Aberdam E, Kitajima S, Simpson F, Wicking C, Aberdam D, Virolle T.
Cell Death Differ 16(5):728-37. Epub 2009 Feb 13. 2009
33ATF3
Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells.
Miyazaki K, Inoue S, Yamada K, Watanabe M, Liu Q, Watanabe T, Adachi MT, Tanaka Y, Kitajima S.
Nucleic Acids Res 37(5):1438-51. Epub 2009 Jan 9.PMID: 19136462 2009
34ATF3, ATF4
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.
Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T, Ron D, Chen W, Trenkle W, Wiestner A, Ye Y.
Proc Natl Acad Sci U S A. 106(7):2200-5. 2009
35ATF3, KLF6
KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.
Huang X, Li X, Guo B.
J Biol Chem 283(44):29795-801. Epub 2008 Aug 28.PMID: 18755691 2008
36ATF3
The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis.
Wang A, Arantes S, Yan L, Kiguchi K, McArthur MJ, Sahin A, Thames HD, Aldaz CM, Macleod MC.
BMC Cancer 8:268.PMID: 18808719 2008
37ATF3
Expression of ATF3 and axonal outgrowth are impaired after delayed nerve repair.
Saito H, Dahlin LB.
BMC Neurosci 9:88.PMID: 18801180 2008
38ATF3
Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias.
Beleza-Meireles A, Töhönen V, Söderhäll C, Schwentner C, Radmayr C, Kockum I, Nordenskjöld A.
Eur J Endocrinol 158(5):729-39.PMID: 18426833 2008
39ATF3
Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway.
Brown SL, Sekhar KR, Rachakonda G, Sasi S, Freeman ML.
Cancer Res 68(2):364-8.PMID: 18199529 2008
40ATF3
ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells.
Rosenberger CM, Clark AE, Treuting PM, Johnson CD, Aderem A.
Proc Natl Acad Sci U S A. 105(7):2544-9. 2008
41ATF3, TLR4, IL6, IL12B
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Kennedy K, Hai T, Bolouri H, Aderem A.
Nature 441(7090):173-8. 2006
42ATF3
Activating Transcription Factor 3 Is Estrogen-Responsive in utero and Upregulated during Sexual Differentiation.
Liu B, Agras K, Willingham E, Vilela ML, Baskin LS.
Horm Res 65(5):217-22. Epub 2006 Mar 28. 2006
43ATF3
Activating transcription factor 3 is up-regulated in patients with hypospadias.
Liu B, Wang Z, Lin G, Agras K, Ebbers M, Willingham E, Baskin LS.
Pediatr Res 58(6):1280-3. 2005
44ATF3, EGR1
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Bottone FG Jr, Moon Y, Alston-Mills B, Eling TE.
J Pharmacol Exp Ther 315(2):668-77. Epub 2005 Aug 3. 2005
45ATF3, TP53
Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.
Yan C, Lu D, Hai T, Boyd DD.
EMBO J 24(13):2425-35. Epub 2005 Jun 2. 2005
46ATF3, MMP2
ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter.
Yan C, Wang H, Boyd DD.
J Biol Chem 277(13):10804-12. 2002
47ATF3
An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli.
Hashimoto Y, Zhang C, Kawauchi J, Imoto I, Adachi MT, Inazawa J, Amagasa T, Hai T, Kitajima S.
Nucleic Acids Res 30(11):2398-406. 2002
48ATF3
Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and possible involvement in cell death of vascular endothelial cells.
Nawa T, Nawa MT, Adachi MT, Uchimura I, Shimokawa R, Fujisawa K, Tanaka A, Numano F, Kitajima S.
Atherosclerosis 161(2):281-91. 2002
49ATF3
Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine.
hang C, Kawauchi J, Adachi MT, Hashimoto Y, Oshiro S, Aso T, Kitajima S.
Biochem Biophys Res Commun 289(3):718-24. 2001
50ATF3, IGFBP1, RPS7, TEC
Identification and characterization of differentially expressed genes in the early response phase during liver regeneration.
Xu W, Wang S, Wang G, Wei H, He F, Yang X.
Biochem Biophys Res Commun 278(2):318-25. 2000
51ATF3, CENPF
Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.
Pimkhaokham A, Shimada Y, Fukuda Y, Kurihara N, Imoto I, Yang ZQ, Imamura M, Nakamura Y, Amagasa T, Inazawa J.
Jpn J Cancer Res 91(11):1126-33. 2000
52ATF3
ATF3 gene. Genomic organization, promoter, and regulation.
Liang G, Wolfgang CD, Chen BP, Chen TH, Hai T.
J Biol Chem 271(3):1695-701. 1996
53ATF3, DDIT3
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.
Chen BP, Wolfgang CD, Hai T.
Mol Cell Biol. 16(3):1157-68. 1996
54ATF3
ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.
Chen BP, Liang G, Whelan J, Hai T.
J Biol Chem 269(22):15819-26. 1994
55ATF3
Cyclic AMP-independent ATF family members interact with NF-kappa B and function in the activation of the E-selectin promoter in response to cytokines.
Kaszubska W, Hooft van Huijsduijnen R, Ghersa P, DeRaemy-Schenk AM, Chen BP, Hai T, DeLamarter JF, Whelan J.
Mol Cell Biol. 13(11):7180-90. 1993