| 1 | ARHGEF2, CGN, RHOA |
| Role of Cingulin in Agonist-induced Vascular Endothelial Permeability. | |
| Tian Y, Gawlak G, Tian X, Shah AS, Sarich N, Citi S, Birukova AA. | |
| J Biol Chem 291(45):23681-23692. Epub 2016 Sep 2. 2016 | |
| 2 | ARHGEF10, ARHGEF12, ARHGEF2, ARHGEF28, PLEKHG1 |
| Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells. | |
| Abiko H, Fujiwara S, Ohashi K, Hiatari R, Mashiko T, Sakamoto N, Sato M, Mizuno K. | |
| J Cell Sci 128(9):1683-95. doi: 10.1242/jcs.157503. Epub 2015 Mar 20. 2015 | |
| 3 | ARHGEF2, NPPA |
| Control of vascular permeability by atrial natriuretic peptide via a GEF-H1-dependent mechanism. | |
| Tian X, Tian Y, Gawlak G, Sarich N, Wu T, Birukova AA. | |
| J Biol Chem 289(8):5168-83. doi: 10.1074/jbc.M113.493924. Epub 2013 Dec 18. 2014 | |
| 4 | ARHGEF2, CAMSAP3 |
| Non-centrosomal microtubules regulate F-actin organization through the suppression of GEF-H1 activity. | |
| Nagae S, Meng W, Takeichi M. | |
| Genes Cells 18(5):387-96. doi: 10.1111/gtc.12044. Epub 2013 Feb 22. 2013 | |
| 5 | ARHGEF2, ASAP1 |
| GEFH1 binds ASAP1 and regulates podosome formation. | |
| Shiba Y, Randazzo PA. | |
| Biochem Biophys Res Commun 406(4):574-9. Epub 2011 Feb 23. 2011 | |
| 6 | ARHGEF2, MARK2 |
| Dynamic regulation of GEF-H1 localization at microtubules by Par1b/MARK2. | |
| Yoshimura Y, Miki H. | |
| Biochem Biophys Res Commun 408(2):322-8. Epub 2011 Apr 12. 2011 | |
| 7 | ARHGEF2, DYNLT1 |
| Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. | |
| Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. | |
| Nat Neurosci. 12(6):735-44. 2009 | |
| 8 | ARHGEF2 |
| GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. | |
| Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM. | |
| Dev Cell 12(5):699-712. Erratum in: Dev Cell. 2007 Jun;12(6):1007. 2007 | |
| 9 | ARHGEF2 |
| Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells. | |
| Mizuarai S, Yamanaka K, Kotani H. | |
| Cancer Res 66(12):6319-26. 2006 | |
| 10 | ARHGEF2 |
| The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. | |
| Bakal CJ, Finan D, LaRose J, Wells CD, Gish G, Kulkarni S, DeSepulveda P, Wilde A, Rottapel R. | |
| Proc Natl Acad Sci U S A. 102(27):9529-34. 2005 | |
| 11 | ARHGEF2, CGN |
| Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. | |
| Aijaz S, D'Atri F, Citi S, Balda MS, Matter K. | |
| Dev Cell 8(5):777-86. 2005 | |
| 12 | ARHGEF2 |
| p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. | |
| Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM. | |
| J Biol Chem 279(18):18392-400. Epub 2004 Feb 17. 2004 | |
| 13 | ARHGEF2 |
| Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. | |
| Krendel M, Zenke FT, Bokoch GM. | |
| Nat Cell Biol. 4(4):294-301. 2002 | |
| 14 | ARHGEF2 |
| Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. | |
| Ren Y, Li R, Zheng Y, Busch H. | |
| J Biol Chem 273(52):34954-60. 1998 | |
| 15 | AATK, ACIN1, ACOT11, ACSBG1, ADAMTS4, ADGRV1, AKAP11, ANKLE2, ARHGAP26, ARHGEF2, ASTN2, ATP2C2, ATP9A, BICD2, BZRAP1, C12orf51, CAND2, CEP135, CLASP1, CLASP2, CLUAP1, CLUH, CNOT3, COBL, CPNE3, CRTC1, CRY2, CSTF2T, CUL3, CUL4B, DAAM1, DAGLA, DEPDC5, DNAJC13, DOCK10, DZIP3, FBXW11, FKBP15, G3BP2, HEPH, HIP1R, HIPK1, ICOSLG, KIAA0649, KIAA0652, KIF13B, KIF1C, KIF21A, L3MBTL1, LDB3, MAGI2, MAP4K4, MFAP3L, MGEA5, MRC2, MTMR4, N4BP1, NPHP4, OBSL1, PAN2, PHACTR2, PHF2, PHLDB1, PLXND1, PPFIA3, PTCD1, RAB11FIP3, RBM19, RICH2, RNF40, RNF8, ROCK2, RRP12, SAPS2, SETX, SIN3B, SLC24A1, SMCHD1, SNAP91, SOCS5, SS18L1, SWAP70, TBC1D9B, TELO2, TNRC15, TSC22D2, UBE4B, UHRF1BP1L, ULK2, ZBED4, ZC3H11A, ZNF623 |
| Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. | |
| Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N,Ohara O. | |
| DNA Res 5(3):169-76. 1998 | |
| 16 | ARHGEF2 |
| Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues. | |
| Aasheim HC, Pedeutour F, Smeland EB. | |
| Oncogene 14(14):1747-52. 1997 | |
| 17 | ARHGEF1, ARHGEF2 |
| Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. | |
| Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G. | |
| J Biol Chem 271(41):25452-8. 1996 | |