Citations for
1ARHGEF10, ARHGEF12, ARHGEF2, ARHGEF28, PLEKHG1
Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells.
Abiko H, Fujiwara S, Ohashi K, Hiatari R, Mashiko T, Sakamoto N, Sato M, Mizuno K.
J Cell Sci 128(9):1683-95. doi: 10.1242/jcs.157503. Epub 2015 Mar 20. 2015
2ARHGEF12, CYLD
CYLD regulates RhoA activity by modulating LARG ubiquitination.
Yang Y, Sun L, Tala, Gao J, Li D, Zhou J, Liu M.
PLoS One 8(2):e55833. doi: 10.1371/journal.pone.0055833. Epub 2013 Feb 6. 2013
3ARHGEF12
Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.
Martz MK, Grabocka E, Beeharry N, Yen TJ, Wedegaertner PB.
Mol Biol Cell 24(18):2785-94. doi: 10.1091/mbc.E12-07-0533. Epub 2013 Jul 24. 2013
4ARHGEF12
LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer.
Ong DC, Ho YM, Rudduck C, Chin K, Kuo WL, Lie DK, Chua CL, Tan PH, Eu KW, Seow-Choen F, Wong CY, Hong GS, Gray JW, Lee AS.
Oncogene 28(47):4189-200. Epub 2009 Sep 7.PMID: 19734946 2009
5ARHGEF12
A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.
Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ.
Cell Signal 21(11):1569-78. Epub 2009 Jun 26.PMID: 19560536 2009
6ARHGEF12
Unc5B associates with LARG to mediate the action of repulsive guidance molecule.
Hata K, Kaibuchi K, Inagaki S, Yamashita T.
J Cell Biol 184(5):737-50.PMID: 19273616 2009
7ARHGEF12
Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.
Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokita R, Minami S, Kodama T, Hamakubo T, Kozasa T.
J Biol Chem 284(8):5000-9. Epub 2008 Dec 12.PMID: 19074425 2009
8ARHGEF1, ARHGEF12
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.
Dubash AD, Wennerberg K, García-Mata R, Menold MM, Arthur WT, Burridge K.
J Cell Sci 120(Pt 22):3989-98. Epub 2007 Oct 30.PMID: 17971419 2007
9ARHGEF12
Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential.
Chikumi H, Barac A, Behbahani B, Gao Y, Teramoto H, Zheng Y, Gutkind JS.
Oncogene 23(1):233-40.PMID: 14712228 2004
10PLXNB1, ARHGEF11, ARHGEF12
Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.
Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S.
Biochem Biophys Res Commun 297(1):32-7. 2002
11ARHGEF12, KMT2A
Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.
Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA.
Proc Natl Acad Sci U S A 97(5):2145-50. 2000
12ARHGEF12
Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.
Fukuhara S, Chikumi H, Gutkind JS.
FEBS Lett 485(2-3):183-8. 2000