1 | ARHGEF10, ARHGEF12, ARHGEF2, ARHGEF28, PLEKHG1
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| Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells.
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| Abiko H, Fujiwara S, Ohashi K, Hiatari R, Mashiko T, Sakamoto N, Sato M, Mizuno K.
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| J Cell Sci 128(9):1683-95. doi: 10.1242/jcs.157503. Epub 2015 Mar 20.
2015
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2 | ARHGEF12, CYLD
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| CYLD regulates RhoA activity by modulating LARG ubiquitination.
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| Yang Y, Sun L, Tala, Gao J, Li D, Zhou J, Liu M.
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| PLoS One 8(2):e55833. doi: 10.1371/journal.pone.0055833. Epub 2013 Feb 6.
2013
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3 | ARHGEF12
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| Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.
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| Martz MK, Grabocka E, Beeharry N, Yen TJ, Wedegaertner PB.
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| Mol Biol Cell 24(18):2785-94. doi: 10.1091/mbc.E12-07-0533. Epub 2013 Jul 24.
2013
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4 | ARHGEF12
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| LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer.
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| Ong DC, Ho YM, Rudduck C, Chin K, Kuo WL, Lie DK, Chua CL, Tan PH, Eu KW, Seow-Choen F, Wong CY, Hong GS, Gray JW, Lee AS.
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| Oncogene 28(47):4189-200. Epub 2009 Sep 7.PMID: 19734946 2009
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5 | ARHGEF12
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| A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.
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| Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ.
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| Cell Signal 21(11):1569-78. Epub 2009 Jun 26.PMID: 19560536 2009
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6 | ARHGEF12
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| Unc5B associates with LARG to mediate the action of repulsive guidance molecule.
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| Hata K, Kaibuchi K, Inagaki S, Yamashita T.
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| J Cell Biol 184(5):737-50.PMID: 19273616 2009
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7 | ARHGEF12
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| Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.
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| Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokita R, Minami S, Kodama T, Hamakubo T, Kozasa T.
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| J Biol Chem 284(8):5000-9. Epub 2008 Dec 12.PMID: 19074425 2009
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8 | ARHGEF1, ARHGEF12
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| A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.
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| Dubash AD, Wennerberg K, García-Mata R, Menold MM, Arthur WT, Burridge K.
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| J Cell Sci 120(Pt 22):3989-98. Epub 2007 Oct 30.PMID: 17971419 2007
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9 | ARHGEF12
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| Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential.
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| Chikumi H, Barac A, Behbahani B, Gao Y, Teramoto H, Zheng Y, Gutkind JS.
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| Oncogene 23(1):233-40.PMID: 14712228 2004
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10 | PLXNB1, ARHGEF11, ARHGEF12
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| Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.
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| Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S.
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| Biochem Biophys Res Commun 297(1):32-7. 2002
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11 | ARHGEF12, KMT2A
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| Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.
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| Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA.
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| Proc Natl Acad Sci U S A 97(5):2145-50. 2000
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12 | ARHGEF12
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| Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.
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| Fukuhara S, Chikumi H, Gutkind JS.
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| FEBS Lett 485(2-3):183-8. 2000
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