Citations for
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
Guilluy C, Brégeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G.
Nat Med 16(2):183-90. Epub 2010 Jan 24.PMID: 20098430 2010
Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity.
Hartney JM, Brown J, Chu HW, Chang LY, Pelanda R, Torres RM.
Am J Pathol 176(3):1157-68. Epub 2010 Jan 21.PMID: 20093499 2010
Loss of Lsc/p115 protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice.
Zizer E, Beilke S, Bäuerle T, Schilling K, Möhnle U, Adler G, Fischer KD, Wagner M.
Gastroenterology 139(4):1344-54. Epub 2010 Jun 20.PMID: 20600037 2010
P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium.
Slattum G, McGee KM, Rosenblatt J.
J Cell Biol 186(5):693-702. Epub 2009 Aug 31.PMID: 19720875 2009
Endothelin-1 up-regulates p115RhoGEF in embryonic rat cardiomyocytes during the hypertrophic response.
Porchia F, Papucci M, Gargini C, Asta A, De Marco G, Agretti P, Tonacchera M, Mazzoni MR.
J Recept Signal Transduct Res 28(3):265-83.PMID: 18569527 2008
Lsc activity is controlled by oligomerization and regulates integrin adhesion.
Hu J, Strauch P, Rubtsov A, Donovan EE, Pelanda R, Torres RM.
Mol Immunol 45(7):1825-36. Epub 2007 Dec 21.PMID: 18157933 2008
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.
Dubash AD, Wennerberg K, García-Mata R, Menold MM, Arthur WT, Burridge K.
J Cell Sci 120(Pt 22):3989-98. Epub 2007 Oct 30.PMID: 17971419 2007
Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation.
Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM.
Am J Respir Crit Care Med 176(1):10-9. Epub 2007 Apr 26.PMID: 17463415 2007
Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF.
Grabocka E, Wedegaertner PB.
Oncogene 24(13):2155-65. 2005
Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response.
Rubtsov A, Strauch P, Digiacomo A, Hu J, Pelanda R, Torres RM.
Immunity 23(5):527-38.PMID: 16286020 2005
Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment.
Bhattacharyya R, Wedegaertner PB.
FEBS Lett 540(1-3):211-6. 2003
Identification of a novel guanine nucleotide exchange factor for the Rho GTPase.
Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G.
J Biol Chem 271(41):25452-8. 1996